Device Thrombogenicity Emulator (DTE) - Design optimization methodology for cardiovascular devices: A study in two bileaflet MHV designs

Journal of Biomechanics

Volumn 43, Issue 12, 2010, Pages 2400-2409

  Xenos, Michalis ^a   Girdhar, Gaurav ^a   Alemu, Yared ^a   Jesty, Jolyon ^b   Slepian, Marvin ^c   Einav, Shmuel ^a   Bluestein, Danny ^a  

^a St Francis Hospital The Heart Center   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Computational fluid dynamics; Mechanical circulation support (MCS); Mechanical heart valves (MHV); Platelet activation; Platelet assays; Prosthetic heart valves (PHV); Thrombogenic performance

Indexed keywords

ANTI-COAGULATION; BILEAFLET; CARDIOVASCULAR DEVICES; DESIGN MODIFICATIONS; DESIGN OPTIMIZATION; EXPERIMENTAL APPROACHES; FLOW CONDITION; FLOW REGIONS; HOT SPOT; MECHANICAL HEART VALVES; NUMERICAL SIMULATION; PLATELET ACTIVATION; PROSTHETIC HEART VALVE; PROTHROMBINASE; ST. JUDE MEDICAL; STRESS LOADING; THROMBOGENIC PERFORMANCE; THROMBOGENICITY;

ASSAYS; BLOOD SUBSTITUTES; COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; DESIGN; EQUIPMENT TESTING; FLUID DYNAMICS; HEART; HEART VALVE PROSTHESES; MATHEMATICAL MODELS; OPTIMIZATION; PLATELETS; STRESS ANALYSIS;

VALVES (MECHANICAL);

ARTICLE; BLOOD FLOW; COMPARATIVE STUDY; CONTROLLED STUDY; DEVICE THROMBOGENICITY EMULATOR; EQUIPMENT DESIGN; HEART VALVE PROSTHESIS; HEMODYNAMIC SHEARING DEVICE; METHODOLOGY; PRIORITY JOURNAL; PROSTHETIC VALVE THROMBOSIS; SIMULATION; STRESS; THROMBOCYTE ACTIVATION; THROMBOGENICITY;

ANTICOAGULANTS; BIOMECHANICS; HEART VALVE PROSTHESIS; HEMORHEOLOGY; HUMANS; MODELS, CARDIOVASCULAR; MODELS, STATISTICAL; PLATELET ACTIVATION; PROSTHESIS DESIGN; STRESS, MECHANICAL; THROMBOSIS;

EID: 77955560669     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2010.04.020     Document Type: Article

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