Flow-induced platelet activation and damage accumulation in a mechanical heart valve: Numerical studies

Artificial Organs

Volumn 31, Issue 9, 2007, Pages 677-688

  Alemu, Yared ^a   Bluestein, Danny ^a  

^a St Francis Hospital The Heart Center   (United States)

Author keywords

Activation; Blood flow; Computational fluid dynamics; Damage; Mechanical heart valve; Numerical methods; Platelets; Thromboembolism

Indexed keywords

CHEMICAL ACTIVATION; COMPUTATION THEORY; COMPUTATIONAL FLUID DYNAMICS; HEMODYNAMICS; NAVIER STOKES EQUATIONS; NON NEWTONIAN FLOW; PLATELETS; VALVES (MECHANICAL);

BLOOD FLOW; CUMULATIVE EFFECTS; DAMAGE; DAMAGES ACCUMULATION; EFFECT OF STRESS; FLOW INDUCED; MECHANICAL HEART VALVES; PLATELET ACTIVATION; STRESS HISTORY; THROMBOEMBOLISM;

NUMERICAL METHODS;

ARTICLE; BLOOD FLOW; HEART VALVE; HEART VALVE REPLACEMENT; PRIORITY JOURNAL; SENESCENCE; SIMULATION; STATISTICAL SIGNIFICANCE; THROMBOCYTE ACTIVATION; THROMBOGENESIS;

MURINE HEPATITIS VIRUS;

EID: 34548183335     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2007.00446.x     Document Type: Article

References (60)

1. Akins CW. Results with mechanical cardiac valvular prostheses. Ann Thorac Surg 1995 60 : 1836 44.
2. Butchart EG, Ionescu A, Payne N, Giddings J, Grunkemeier GL, Fraser AG. A new scoring system to determine thromboembolic risk after heart valve replacement. Circulation 2003 108 (Suppl 1 II68 74.
3. Bluestein D, Rambod E, Gharib M. Vortex shedding as a mechanism for free emboli formation in mechanical heart valves. J Biomech Eng 2000 122 : 125 34.
4. Sabbah HN, Stein PD. Fluid dynamic stresses in the region of a porcine bioprosthetic valve. Henry Ford Hosp Med J 1982 30 : 134 8.
5. Yoganathan AP, Woo YR, Sung HW. Turbulent shear stress measurements in the vicinity of aortic heart valve prostheses. J Biomech 1986 19 : 433 42.
6. Stein PD, Walburn FJ, Sabbah HN. Turbulent stresses in the region of aortic and pulmonary valves. J Biomech Eng 1982 104 : 238 44.
7. Omoto R, Matsumura M, Asano H, et al. Doppler ultrasound examination of prosthetic function and ventricular blood flow after mitral valve replacement. Herz 1986 11 : 346 50.
8. DeWall RA, Qasim N, Carr L. Evolution of mechanical heart valves. Ann Thorac Surg 2000 69 : 1612 21.
9. Bluestein D. Towards optimization of the thrombogenic potential of blood recirculating cardiovascular devices using modeling approaches. Expert Rev Med Devices 2006 3 : 267 70.
10. Bluestein D. Research approaches for studying flow induced thromboembolic complications in blood recirculating devices. Expert Rev Med Devices 2004 1 : 65 80.
11. Travis BR, Marzec UM, Leo HL, et al. Bileaflet aortic valve prosthesis pivot geometry influences platelet secretion and anionic phospholipid exposure. Ann Biomed Eng 2001 29 : 657 64.
12. Brown CH, 3rd., Lemuth RF, Hellums JD, Leverett LB, Alfrey CP. Response of human platelets to sheer stress. Trans Am Soc Artif Intern Organs 1975 21 : 35 9.
13. Sutera SP, Mehrjardi MH. Deformation and fragmentation of human red blood cells in turbulent shear flow. Biophys J 1975 15 : 1 10.
14. Brown CH, 3rd., Leverett LB, Lewis CW, Alfrey CP, Jr., Hellums JD. Morphological, biochemical, and functional changes in human platelets subjected to shear stress. J Lab Clin Med 1975 86 : 462 71.
15. Hung TC, Hochmuth RM, Joist JH, Sutera SP. Shear-induced aggregation and lysis of platelets. Trans Am Soc Artif Intern Organs 1976 22 : 285 91.
16. Ramstack JM, Zuckerman L, Mockros LF. Shear-induced activation of platelets. J Biomech 1979 12 : 113 25.
17. Travis BR, Leo HL, Shah PA, Frakes DH, Yoganathan AP. An analysis of turbulent shear stresses in leakage flow through a bileaflet mechanical prostheses. J Biomech Eng 2002 124 : 155 65.
18. Liu JS, Lu PC, Chu SH. Turbulence characteristics downstream of bileaflet aortic valve prostheses. J Biomech Eng 2000 122 : 118 24.
19. Klaus S, Korfer S, Mottaghy K, Reul H, Glasmacher B. In vitro blood damage by high shear flow: human versus porcine blood. Int J Artif Organs 2002 25 : 306 12.
20. Jones SA. A relationship between Reynolds stresses and viscous dissipation: implications to red cell damage. Ann Biomed Eng 1995 23 : 21 8.
21. Shandas R, Kwon J, Valdes-Cruz L. A method for determining the reference effective flow areas for mechanical heart valve prostheses: in vitro validation studies. Circulation 2000 101 : 1953 9.
22. Leytin V, Allen DJ, Mykhaylov S, et al. Pathologic high shear stress induces apoptosis events in human platelets. Biochem Biophys Res Commun 2004 320 : 303 10.
23. Bluestein D, Li YM, Krukenkamp IB. Free emboli formation in the wake of bi-leaflet mechanical heart valves and the effects of implantation techniques. J Biomech 2002 35 : 1533 40.
24. Hellums J, Peterson D, Stathopoulos N, Moake J, Giorgio T. Studies on the mechanisms of shear-induced platelet activation. In : Hartman A, Kuschinsky W, eds. Cerebral Ischemia and Hemorheology. New York : Springer and Verlag, 1987 80 89.
25. Fogelson AL. Continuum models of platelet-aggregation - formulation and mechanical - properties. Siam J Appl Math 1992 52 : 1089 1110.
26. Tuszynski GP, Rothman VL, Murphy A, Siegler K, Knudsen KA. Thrombospondin promotes platelet aggregation. Blood 1988 72 : 109 15.
27. Merten M, Chow T, Hellums JD, Thiagarajan P. A new role for P-selectin in shear-induced platelet aggregation. Circulation 2000 102 : 2045 50.
28. Janes SL, Wilson DJ, Chronos N, Goodall AH. Evaluation of whole blood flow cytometric detection of platelet bound fibrinogen on normal subjects and patients with activated platelets. Thromb Haemost 1993 70 : 659 66.
29. Bevers EM, Comfurius P, Zwaal RF. Mechanisms involved in platelet procoagulant response. Adv Exp Med Biol 1993 344 : 195 207.
30. Arora D, Behr M, Pasquali M. A tensor-based measure for estimating blood damage. Artif Organs 2004 28 : 1002 15.
31. Pinotti M, Rosa ES. Computational prediction of hemolysisin a centrifugal ventricular assist device. Artif Organs 1995 19 : 267 73.
32. Hellums JD. 1993 Whitaker lecture: biorheology in thrombosis research. Ann Biomed Eng 1994 22 : 445 55.
33. Pinotti M, Rosa ES. Computational prediction of hemolysis in a centrifugal ventricular assist device. Artif Organs 1995 19 : 267 73.
34. Goubergrits L, Affeld K. Numerical estimation of blood damage in artificial organs. Artif Organs 2004 28 : 499 507.
35. Bludszuweit C. Model for a general mechanical blood damage prediction. Artif Organs 1995 19 : 583 9.
36. Apel J, Paul R, Klaus S, Siess T, Reul H. Assessment of hemolysis related quantities in a microaxial blood pump by computational fluid dynamics. Artif Organs 2001 25 : 341 7.
37. Bluestein M, Mockros LF. Hemolytic effects of energy dissipation in flowing blood. Med Biol Eng 1969 7 : 1 16.
38. Yeleswarapu KK, Antaki JF, Kameneva MV, Rajagopal KR. A mathematical model for shear-induced hemolysis. Artif Organs 1995 19 : 576 82.
39. Grigioni M, Morbiducci U, D'Avenio G, Di Benedetto G, Del Gaudio C. A novel formulation for blood trauma prediction by a modified power-law mathematical model. Biomech Model Mechanobiol 2005 4 : 249 60.
40. King MJ, David T, Fisher J. Three-dimensional study of the effect of two leaflet opening angles on the time-dependent flow through a bileaflet mechanical heart valve. Med Eng Phys 1997 19 : 235 41.
41. Kelly SG, Verdonck PR, Vierendeels JA, Riemslagh K, Dick E, Van Nooten GG. A three-dimensional analysis of flow in the pivot regions of an ATS bileaflet valve. Int J Artif Organs 1999 22 : 754 63.
42. Krafczyk M, Cerrolaza M, Schulz M, Rank E. Analysis of 3D transient blood flow passing through an artificial aortic valve by Lattice-Boltzmann methods. J Biomech 1998 31 : 453 62.
43. Grigioni M, Daniele C, Del Gaudio C, et al. Three-dimensional numeric simulation of flow through an aortic bileaflet valve in a realistic model of aortic root. ASAIO J 2005 51 : 176 83.
44. Bluestein D, Niu L, Schoephoerster RT, Dewanjee MK. Fluid mechanics of arterial stenosis: relationship to the development of mural thrombus. Ann Biomed Eng 1997 25 : 344 56.
45. Kiris C, Kwak D, Rogers S, Chang ID. Computational approach for probing the flow through artificial heart devices. J Biomech Eng 1997 119 : 452 60.
46. Wilcox DC. Simulation of transition with a two-equation turbulence model. AIAA J 1994 32 : 247 55.
47. Yin W, Alemu Y, Affeld K, Jesty J, Bluestein D. Flow-induced platelet activation in bileaflet and monoleaflet mechanical heart valves. Ann Biomed Eng 2004 32 : 1058 66.
48. Yin W, Gallocher S, Pinchuk L, Schoephoerster RT, Jesty J, Bluestein D. Flow induced platelet activation in a St. Jude MHV, a trileaflet polymeric heart valve and a St. Jude tissue valve. Artif Organs 2005 29 : 826 31.
49. Ge L, Jones SC, Sotiropoulos F, Healy TM, Yoganathan AP. Numerical simulation of flow in mechanical heart valves: grid resolution and the assumption of flow symmetry. J Biomech Eng 2003 125 : 709 18.
50. Ge L, Leo HL, Sotiropoulos F, Yoganathan AP. Flow in a mechanical bileaflet heart valve at laminar and near-peak systole flow rates: CFD simulations and experiments. J Biomech Eng 2005 127 : 782 97.
51. Edmunds LH, Norwood WI, Low DW. Atlas of Cardiothoracic Surgery. Philadelphia, PA : Lea and Febiger, 1990.
52. Chaux A, Blanche C. Technical aspects of valvular replacement with the St. Jude prosthesis. J Cardiovasc Surg (Torino) 1987 28 : 363 8.
53. Bluestein D, Einav S. Transition to turbulence in pulsatile flow through heart valves - a modified stability approach. J Biomech Eng 1994 116 : 477 87.
54. Bluestein D, Einav S. Techniques in the analysis of stability of pulsatile flow through heart valves. In : Leondes CT, ed. Biomechanics Systems Techniques and Applications: Cardiovascular Techniques, Vol. II. Boca Raton, FL : CRC Press LLC, 2001 4-1 4-39.
55. Gosman A, Ioannides L. Aspects of computer simulation of liquid-fuelled combustors. AIAA J Energy 1983 7 : 482 90.
56. Merrill EW, Gilliland ER, Cokelet G, Shin H, Britten A, Wells RE, Jr. Rheology of human blood, near and at zero flow. Effects of temperature and hematocrit level. Biophys J 1963 3 : 199 213.
57. Schulz-Heik K, Ramachandran J, Bluestein D, Jesty J. The extent of platelet activation under shear depends on platelet count: differential expression of anionic phospholipid and factor Va. Pathophysiol Haemost Thromb 2005 34 : 255 62.
58. Leverett LB, et al. Red blood cell damage by shear stress. Biophys J 1972 12 : 257 73.
59. Wurzinger LJ, Blasberg P, Schmid-Schonbein H. Towards a concept of thrombosis in accelerated flow: rheology, fluid dynamics, and biochemistry. Biorheology 1985 22 : 437 50.
60. Grigioni M, Daniele C, Morbiducci U, D'Avenio G, Di Benedetto G, Barbaro V. The power-law mathematical model for blood damage prediction: analytical developments and physical inconsistencies. Artif Organs 2004 28 : 467 75.