Studies of Pyrrolo[1,2-α]benzimidazolequinone DT-diaphorase substrate activity, topoisomerase II inhibition activity, and DNA reductive alkylation

Journal of Medicinal Chemistry

Volumn 40, Issue 9, 1997, Pages 1327-1339

  Skibo, Edward B ^a   Gordon, Samantha ^a   Bess, Laura ^a   Boruah, Romesh ^a   Heileman, Matthew J ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 ACETAMIDOPYRROLO[1,2 A]BENZIMIDAZOLEQUINONE; 6 AZIRIDINYLPYRROLO[1,2 A]BENZIMIDAZOLEQUINONE; DNA TOPOISOMERASE (ATP HYDROLYSING); PYRROLO[1,2 A]QUINOLINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER CHEMOTHERAPY; CYTOTOXICITY; DNA ALKYLATION; DRUG DNA INTERACTION; ENZYME INHIBITION;

ALKYLATION; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BENZIMIDAZOLES; DNA; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, AGAR GEL; ENZYME INHIBITORS; KINETICS; LIVER; MOLECULAR STRUCTURE; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION; PYRROLES; QUINONES; RATS; RATS, INBRED STRAINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0030968873     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960546p     Document Type: Article

References (35)

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