DNA vaccination as an approach to malaria control: Current status and strategies

Current Topics in Microbiology and Immunology

Volumn 226, Issue , 1997, Pages 37-56

  Doolan, D L ^a   Hedstrom, R C ^b   Gardner, M J ^c   Sedegah, M ^d   Wang, H ^a   Gramzinski, R A ^b   Maroatith, M ^c   Hobart, P ^d   Hoffman, S L ^a  

^a NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^b J CRAIG VENTER INSTITUTE   (United States)

^c PEKING UNION MEDICAL COLLEGE   (China)

^d VICAL INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DNA VACCINE; MALARIA VACCINE; PLASMID VECTOR; PROTOZOAL PROTEIN; SIGNAL PEPTIDE; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; CYTOTOXIC T LYMPHOCYTE; GENE SEQUENCE; IMMUNE RESPONSE; IMMUNIZATION; INTRADERMAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; MALARIA CONTROL; MEROZOITE; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PRIMATE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVIEW; SPOROZOITE; T LYMPHOCYTE ACTIVATION;

ANIMALS; AOTUS TRIVIRGATUS; DISEASE MODELS, ANIMAL; HUMANS; MALARIA; MALARIA VACCINES; PLASMODIUM YOELII; RODENTIA; VACCINES, DNA;

ANIMALIA; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PRIMATES;

EID: 0031470120     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (63)

1. Blackman MJ, Heidrich HG, Donachie S, McBride JS, Holder AA (1990) A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies. J Exp Med 172:379-382
2. Burns JM, Majarian WR, Young JF, Daly TM, Long ÇA (1989) A protective monoclonal antibody recognizes an epitope in the carboxyl-terminal cysteine-rich domain in the precursor of the major merozoite surface antigen of the rodent malarial parasite, Plasmoilium yoclii. J Immunol Methods 143:2670-2676
3. Chapman BS, Thayer RM, Vincent KA, Haigwood NL (1991) Effect of intron A from human cytomeglavirus (Towne) immediate-early gene on heterologous expression in mammalian cells. Nucleic Acids Research 14:3979-3986
4. Charoenvit Y, Mellouk S, Cole C, Bechara R, Leef MF, Sedegah M, Yuan LF, Robey FA, Beaudoin RL, HofTman SL (1991) Monoclonal, but not polyclonal, antibodies protect against Plasmoilium yoclii sporozoites. J Immunol 146:1020-1025
5. Charoenvit Y, Mellouk S, Sedegah M, Toyoshima T, Leef MF, de la Vega P, Beaudoin RL, Aikawa M, Fallarme V, Hodman SL (1995) 17 kDa Plasmodium yoelii hepatic and erythrocytic stage protein is the target of protective antibodies. Exp Parasitol 80:419-429
6. Collins, WE (1994) In: Baer JF, Weller RE, Kakoma I (eds) Aoius: The owl monkey. Academic, New York, pp 245-258
7. Cullen BR (1986) Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell 46:973-982
8. Daly TM, Long CA (1993) A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmoilium yoclii yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice. Infect Immun 61:2462-2467
9. Daly TM, Long CA (1995) Humoral response to a carboxyl-terminal region of the merozoite surface protein-1 plays a predominant role in controlling blood-stage infection in rodent malaria. J Immunol 155:236-243
10. Danko I, Fritz JD, Jiao S, Hogan K, Latendresse JS, WolfT JA (1994) Pharmacological enhancement of in vivo foreign gene expression in muscle. Gene Therapy 1:114-121
11. Diggs CL, Ballou WR, Miller LH (1993) The major merozoite surface protein as a malaria vaccine target. "Parasitol Today 9:300-302
12. 8+ T cell, interferon-y, nitric oxide dependent immunity. J Exp Med 183:1739-1746
13. Doolan DL, Hedstrom RC, Rogers WO, Charoenvit Y, Rogers M, de la Vega P, HolTman SL (1996b) Characterization of the protective hepatocyte erythrocyte protein 17 kDa gene of Plasmoilium yoclii: homolog of P.fah-ipanun exported protein-l. J Biol Chem 271:17861-17868
14. Doolan DL, HolTman SL (1997) Multi-gene vaccination against malaria: a multi-stage, multi-immune response approach. Parasitol Today 13:171-178
15. Etlinger HM, Caspers P, Matile H, Schoenfeld HJ, Stueber D, Takacs B (1991) Ability of recombinant or native proteins to protect monkeys against heterologous challenge with Plasmoilium falcipiirhmt. Infect Immun 59:3498-3503
16. Parley PJ, Srivastava R, Long C (1994) Sequence of the gene encoding the N-terminal portion of the Plasmoilium yoclii yoclii 17XL merozoite surface protein-I (MSP-1). Gene 151:335-336
17. Flynn JL, Weiss WR, Norris KA, Seifert US, Kumar S, So M (1990) Generation of a cytotoxic T-lymphocyte response using a Salmonella antigen-delivery system. Mol Microbiol 4:2111-2118
18. Freeman RR, Holder AA (1983) Characteristics of the protective response of BALB/c mice immunized with a purified Plasmoilium yoclii schizont antigen. Clin Exp Immunol 54:609-616
19. Good MF (1994) Antigenic diversity and MHC genetics in sporozoite immunity. Immunol Lett 41:95-98
20. Gramzinski RA, Maris DM, Obaldia N, Rossan R, Sedegah M, Wang R, Hobart P, Margalith M, HofTman SL (1996) Optimization of antibody responses to a Plasmoilium fulcipariim DNA vaccine in Aotus monkeys. Vaccine Res 5:173-183
21. Hartikka J, Sawdey M, Cornefert-Jensen F, Margalith M, Barnhart K, Vahlsing L, Meek J, Marquet M, Hobart P, Norman J, Manthorpe M (1996) An improved plasniid DNA expression vector for direct injection into skeletal muscle. Human Gene Ther 7:1205-1217
22. Hedstrom RC, Sedegah M, HofTman SL (1994) Prospects and strategies for development of DNA vaccines against malaria. Res Immunol 145:476-483
23. Hoffman SL, Isenbarger D, Long GW, Sedegah M, Szarfman A, Waters L, Hollingdale MR, van der Miede PH, Finbloom DS, Ballou WR (1989) Sporozoite vaccine induces genetically restricted T cell elimination of malaria from hepatocytes. Science 244:1078-1081
24. HofTman SL, Weiss W, Mellouk S, Sedegah M (1990) Irradiated sporozoite vaccine induces cytotoxic T lymphocytes that recognize malaria antigens on the surface of infected hepatocytes. Immunol Letters 25:33-38
25. Hoffman SL, Franke ED, Hollingdale MR, Druilhe P (1996) Attacking the infected hepatocyte. In: Hoflman SL (ed) Malaria vaccine development. ASM, Washington DC, pp 35-76
26. Hoffman SL, Crutcher JM, Puri SK, Ansari AA, Villinger F, Franke ED, Singh PP, Finkelman F, Gately MK, Dutta GP, Sedegah M (1997) Sterile protection of monkeys against malaria after administration ofinterleukin-12. Nature Med 3:80-83
27. Holder AA, Freeman RR (1981) Immunization against blood-stage rodent malaria using purified parasite antigens. Nature 294:361-364
28. Khusmith S, Charoenvit Y, Kumar S, Sedegah M, Beaudoin RL, HofTman SL (1991) Protection against malaria by vaccination with sporozoite surface protein 2 plus CS protein. Science 252:715-718
29. Khusmith S, Sedegah M, Huffman SL (1994) Complete protection against Plasmodium yoelil by adoptive transfer of a CDS + cytotoxic T cell clone recognizing sporozoite surface protein 2. Infect Immun 62:2979-2983
30. Lal AA, De La Cruz VF, Welsh JA, Charoenvit Y, Maloy WL, McCutchan TF (1987) Structure of the gene encoding the circumsporozoite protein of PlasmoJium yoclii. J Biol Cheni 262:2937-2940
31. Lee KP, June CH, Thompson CB (1991) The CD28 signal transduction pathway in T cell activation. Advances in regulation of cell growth, 2:141-160
32. Lewis AP (1989) Cloning and analysis of the gene encoding the 230-kilodaIton merozoite surface antigen of Plasmodium yoclii. Mol Biochem Parasitol 36:271-282
33. Li S, Rodrigues M, Rodriguez D, Rodriguez JR, Esteban M, Palese P, Nussenzweig RS, Zavala F (1993) Priming with recombinant influenza virus followed by administration of recombinant vacinia virus induces CDST-cell-mediated protective immunity against malaria. Proc Natl Acad Sei USA 90:5214-5218
34. Ling IT, Ogun SA, Holder AA (1994) Immunization against malaria with a recombinant protein. Parasite Immunol 16:63-67
35. Luke CJ, Carner K, Liang X, Barbour AG (1997) An OspA-based DNA vaccine protects mice against infection with Borrelia burgdorferi. J Infect Dis 175:91-97
36. Manthorpe M, Cornefert Jensen F, Hartikka J, Felgner J, Rundell A, Margalith M, Dwarki V (1993) Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice. Human Gene Therapy 4:419-431
37. Panina Bordignon P, Tan A, Termijtelen A, Demotz S, Corradin G, Lanzavecchia A (1989) Universally immunogenic.T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur J Immunol 19:2237-2242
38. Pearce E, Caspar P, Grzych J, Lewis FA, Slier A (1991) Downregulation of ThI cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J Exp Med 173:159-166
39. Perales JC, Ferkol T, Beegen H, Ratnoff OD, Hanson RW (1994) Gene transfer In vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake. Proc Natl Acad Sei USA 91:4086-4090
40. Perrin LH, Merkli B, Loche M, Chizzolini C, Smart J, Richle R (1984) Antimalarial immunity in Saimiri monkeys. Immunization with surface components of asexual blood stages. J Exp Med 160:441-451
41. Raz E, Watanabe A, Baird SM, Eisenberg RA, Parr TB, Lotz M, Kipps TJ, Carson DA (1993) Systemic immunological effects of cytokine genes injected into skeletal muscle. Proc Natl Acad Sei USA 90:4523-4527
42. Renia L, Grillot D, Marussig M, Corradin G, Miltgen F, Lambert PU, Mazier D, Del Giudice G (1993) 1 Effector functions of circumsporozoite peptide-primed CD4T cell clones against Plasmodium yoclii liver stages. J Immunol 150:1471-1478
43. Rodrigues MM, Cordey AS, Arreaza G, Corradin G, Romero P, Maryanski JL, Nussenzweig RS, Zavala F ( 1991 ) CDScytolytic T cell clones derived against the Plasmodium yoclii circumsporozoite protein protect against malaria. Int Immunol 3:579-585
44. Rodrigues MM, Li S, Murata K, Rodriguez D, Rodriguez JR, Bacik I, Bennink JR, Yewdell JW, Garcia Sastre A, Nussenzweig RS, Esteban M, Palese P, Zavala F (1994) Influenza and vaccinia viruses expressing malaria CDS + T and B cell epitopes. Comparison of their immunogenicity and capacity to induce protective immunity. J Immunol 153:4636-4648
45. Rogers WO, Rogers MD, Hedstrom RC, Huffman SL (1992) Characterization of the gene encoding sporozoite surface protein 2, a protective Plasmodium yoelii sporozoite antigen. Mol Biochem Parasitol 53:45-52
46. Romero P, Maryanski JL, Corradin G, Nussenzweig RS, Nussenzweig V, Zavala F (1989) Cloned cytoto.xic T cells recognize an epilope in the circumsporozoile protein and protect against malaria. Nature 341:323-325
47. Schofield L, Villaquiran J, Ferreira A, Schellekens H, Nussenzweig RS, Nussenzweig V (1987) Gammainterferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites. Nature 330:664-666
48. Sedegah M, Beaudoin RL, de la Vega P, Leef MF, Ozcel MA, Jones E, Charoenvit Y, Yuan LF, Gross M, Majarian WR, Robey FA, Weiss WR, HofTman SL (1988) Use of a vaccinia construct expressing the circumsporozoite protein in the analysis of protective immunity to Plasmodium yoelii. In: L Lasky (ed) Technological advances in vaccine development. Liss, New York, pp 295-309
49. Sedegah M, Beaudoin RL, Majarian WR, Cochran MD, Chiang CH, Sadof J, Aggarwal A, Charoenvit Y, Hodman SL (1990) Evaluation of vaccines designed to induce protective cellular immunity against the I circumsporozoite protein: vaccinia, pseudorabies, and salmonella transformed with circumsporozoite gene. Bull World Health Organ 68 (Suppl): 109-114
50. Sedegah M, Chiang CH, Weiss WR, Mellouk S, Cochran MD, Houghton RA, Beaudoin RL, Smith D, Hodman SL (1992) Recombinant pseudorabies virus carrying a plasmodium gene: herpesvirus as a new live viral vector for inducing T- and B-cell immunity. Vaccine 10:578-584
51. Sedegah M, Finkelman F, Holfman SL (1994a) Interleukin-I2 induction of interferon-gamma-dependent protection against malaria. Proc Nail Acad Sei USA 91:10700-10702
52. Sedegah M, Hedstrom RC, Hobart P, Hoffman SL (1994b) Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc Natl Acad Sei USA 91:9866-9870
53. Siddiqui WA, Tarn LQ, Kramer KJ, Hui GS, Case SE, Yamaga KM, Chang SP, Chan EB, Kan SC (1987) Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmotlium falcipanun malaria. Proc Natl Acad Sei USA 84:3014-3018
54. Stoute JA, Slaoui M, Heppner DG, Monin P, Kester K, Desmons P, Wellde BT, Garçon N, Krzych U, Marchand M, Ballou WR, Cohen JD (1997) A preliminary evaluation of a recombinant circumsporozoite protein vacine against Plasmodium falcipanan malaria. N Eng J Med 336:86-91
55. Valmori D, Pessi A, Bianchi E, Corradin G (1992) Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human.vaccination. J Immunol Methods 149:717-721
56. Wang B, Ugen KE, Srikantan V, Agadjanyan MG, Dang K, Refaeli Y, Sato AI, Boyer J, Williams WV, Weiner DB (1993) Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc Natl Acad Sei USA 90:4156-4160
57. Wang R, Charoenvit Y, Corradin G, De la Vega P, Franke ED, HolTman SL (1996) Protection against malaria by Plasmodium yoelii sporozoite surface protein 2 linear peptide induction of CD4+ T cell and IFN-y dependent elimination of infected hepatocytes. J Immunol 457:4061-4067
58. 8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. Proc Natl Acad Se USA 85:573-576
59. Weiss WR, Good MF, Hollingdale MR, Miller LH, Berzofsky JA (1989) Genetic control of immunity to Plasmoilium yoelii sporozoites. J Immunol 143:4263-4266
60. Weiss WR, Mellouk S, Houghten RA, Sedegah M, Kumar S, Good MF, Berzofsky JA, Miller LH, HofTman SL (1990) Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes. J Exp Med 171:763-773
61. Weiss WR, Berzofsky JA, Houghten RA, Sedegah M, Hollingdale MR, Hodman SL (1992) A Tcell clone ' directed at the circumsporozoite protein which protects mice against both P. yoelii and P. berghei. J Immunol 149:2103-2109
62. WHO (1990) Tropical diseases in media spotlight. W.H.O. TDR News 31:3
63. Xiang Z, Ertl HCJ (1995) Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2:129-135