Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite

Journal of Medicinal Chemistry

Volumn 46, Issue 20, 2003, Pages 4351-4359

  Hirai, Shingo ^a   Kikuchi, Haruhisa ^a   Kim, Hye Sook ^b   Begum, Khurshida ^b   Wataya, Yusuke ^b   Tasaka, Hidehisa ^a   Miyazawa, Yuriko ^a   Yamamoto, Keisuke ^a   Oshima, Yoshiteru ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 HYDROXYOCTAHYDROFURO[3,2 B]PYRIDIN 2 YLMETHYL) 6 HYDROXY 3H QUINAZOLIN 4 ONE; 3 (2,7 DIHYDROXYOCTAHYDROFURO[3,2 B]PYRIDIN 2 YLMETHYL) 3H QUINAZOLIN 4 ONE; 3 [3 (3 HYDROXY 6 OXOPIPERIDIN 2 YL) 2 OXOPROPYL] 3H QUINAZOLIN 4 ONE; 3 [3 (3 HYDROXYPIPERIDIN 2 YL) 2 OXOPROPYL] 3H QUINAZOLIN 2,4 DIONE; 3 [3 (3 HYDROXYPIPERIDIN 2 YL) 2 OXOPROPYL] 6 HYDROXY 3H QUINAZOLIN 4 ONE; 3 [3 (3,4 DIHYDROXYPIPERIDIN 2 YL) 2 OXOPROPYL] 3H QUINAZOLIN 4 ONE; DICHROA FEBRIFUGA EXTRACT; DRUG METABOLITE; FEBRIFUGINE; ISOFEBRIFUGINE; PLANT EXTRACT; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; DICHROA FEBRIFUGA; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; PLANT ROOT; PLASMODIUM BERGHEI; PLASMODIUM MALARIAE; VOMITING;

ADMINISTRATION, ORAL; ANIMALS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAPERITONEAL; LIVER; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PIPERIDINES; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; QUINAZOLINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0141680797     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0302086     Document Type: Article

References (14)

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