Profound elevation of CD8+ T cells expressing the intraepithelial lymphocyte marker CD103 (αE/β7 Integrin) in high-grade serous ovarian cancer

Gynecologic Oncology

Volumn 118, Issue 3, 2010, Pages 228-236

  Webb, John R ^a,b   Wick, Darin A ^a   Nielsen, Julie S ^a,c   Tran, Eric ^a,b   Milne, Katy ^a   McMurtrie, Elissa ^a   Nelson, Brad H ^a,b,c  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF VICTORIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

CD8; Integrin; Lymphocytes; Ovarian; T cells

Indexed keywords

BETA7 INTEGRIN; CD103 ANTIGEN; CD4 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR7; L SELECTIN; LYMPHOCYTE SURFACE MARKER; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; ASCITES FLUID; CANCER GRADING; CD8+ T LYMPHOCYTE; COHORT ANALYSIS; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; OVARY CANCER; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY TRACT MUCOSA;

ANTIGENS, CD; ANTIGENS, NEOPLASM; ASCITES; CD8-POSITIVE T-LYMPHOCYTES; CYSTADENOCARCINOMA, SEROUS; EPITOPES, T-LYMPHOCYTE; FEMALE; FLOW CYTOMETRY; HUMANS; INTEGRIN ALPHA CHAINS; LYMPHOCYTES, TUMOR-INFILTRATING; MEMBRANE PROTEINS; OVARIAN NEOPLASMS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS;

EID: 77955553420     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2010.05.016     Document Type: Article

References (34)

1. N. Cerf-Bensussan, A. Jarry, N. Brousse, B. Lisowska-Grospierre, D. Guy-Grand, and C. Griscelli A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes Eur J Immunol 17 1987 1279 1285
2. M. Kruschwitz, G. Fritzsche, R. Schwarting, K. Micklem, D.Y. Mason, and B. Falini Ber-ACT8: new monoclonal antibody to the mucosa lymphocyte antigen J Clin Pathol 44 1991 636 645
3. J. Lohmeyer, J. Friedrich, F. Grimminger, U. Maus, R. Tenter, and H. Morr Expression of mucosa-related integrin alphaEbeta7 on alveolar T cells in interstitial lung diseases Clin Exp Immunol 116 1999 340 346
4. G.A. Hadley, S.T. Bartlett, C.S. Via, E.A. Rostapshova, and S. Moainie The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL J Immunol 159 1997 3748 3756
5. M.P. Schon, A. Arya, E.A. Murphy, C.M. Adams, U.G. Strauch, and W.W. Agace Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice J Immunol 162 1999 6641 6649
6. E. Uss, A.T. Rowshani, B. Hooibrink, N.M. Lardy, R.A. van Lier, and I.J. ten Berge CD103 is a marker for alloantigen-induced regulatory CD8+ T cells J Immunol 177 2006 2775 2783
7. C.M. Parker, K.L. Cepek, G.J. Russell, S.K. Shaw, D.N. Posnett, and R. Schwarting A family of beta 7 integrins on human mucosal lymphocytes Proc Natl Acad Sci U S A 89 1992 1924 1928
8. K.L. Ling, N. Dulphy, P. Bahl, M. Salio, K. Maskell, and J. Piris Modulation of CD103 expression on human colon carcinoma-specific CTL J Immunol 178 2007 2908 2915
9. A. Le Floc'h, A. Jalil, I. Vergnon, B. Le Maux Chansac, V. Lazar, G. Bismuth, S. Chouaib, and F. Mami-Chouaib Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis J Exp Med 204 2007 559 570
10. J.J. French, J. Cresswell, W.K. Wong, K. Seymour, R.M. Charnley, and J.A. Kirby T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy? Br J Cancer 87 2002 1034 1041
11. E. Quinn, N. Hawkins, Y.L. Yip, C. Suter, and R. Ward CD103+ intraepithelial lymphocytes-a unique population in microsatellite unstable sporadic colorectal cancer Eur J Cancer 39 2003 469 475
12. J. Cresswell, H. Robertson, D.E. Neal, T.R. Griffiths, and J.A. Kirby Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomas Clin Exp Immunol 126 2001 397 402
13. K. Franciszkiewicz, A. Le Floc'h, A. Jalil, F. Vigant, T. Robert, and I. Vergnon Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention Cancer Res 69 2009 6249 6255
14. K. Milne, M. Kobel, S.E. Kalloger, R.O. Barnes, D. Gao, and C.B. Gilks Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors PLoS ONE 4 2009 e6412
15. R. El-Asady, R. Yuan, K. Liu, D. Wang, R.E. Gress, and P.J. Lucas TGF-{beta}-dependent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease J Exp Med 201 2005 1647 1657
16. P.S. Glader, C.G. Lofdahl, and K.A. von Wachenfeldt alphaEbeta7 expression on CD8+ T-cells in COPD BAL fluid and on TGF-beta stimulated T-cells in vitro Lung 183 2005 123 138
17. P. Romero, A. Zippelius, I. Kurth, M.J. Pittet, C. Touvrey, and E.M. Iancu Four functionally distinct populations of human effector-memory CD8+ T lymphocytes J Immunol 178 2007 4112 4119
18. S.D. Koch, E. Uss, R.A. van Lier, and I.J. ten Berge Alloantigen-induced regulatory CD8 + CD103+ T cells Hum Immunol 69 2008 737 744
19. H. Keino, S. Masli, S. Sasaki, J.W. Streilein, and J. Stein-Streilein CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance Invest Ophthalmol Vis Sci 47 2006 1533 1542
20. K. Milne, R.O. Barnes, A. Girardin, M.A. Mawer, N.J. Nesslinger, and A. Ng Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer PLoS ONE 3 2008 e3409
21. M.E. Dudley, J.R. Wunderlich, T.E. Shelton, J. Even, and S.A. Rosenberg Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients J Immunother 26 2003 332 342
22. K.L. Cepek, C.M. Parker, J.L. Madara, and M.B. Brenner Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells J Immunol 150 1993 3459 3470
23. K.L. Cepek, S.K. Shaw, C.M. Parker, G.J. Russell, J.S. Morrow, and D.L. Rimm Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin Nature 372 1994 190 193
24. W.W. Agace, J.M. Higgins, B. Sadasivan, M.B. Brenner, and C.M. Parker T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines Curr Opin Cell Biol 12 2000 563 568
25. M. Watabe, A. Nagafuchi, S. Tsukita, and M. Takeichi Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line J Cell Biol 127 1994 247 256
26. S.S. Sung, S.M. Fu, CE Rose Jr., F. Gaskin, S.T. Ju, and S.R. Beaty A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins J Immunol 176 2006 2161 2172
27. B. Johansson-Lindbom, M. Svensson, O. Pabst, C. Palmqvist, G. Marquez, R. Forster, and W.W. Agace Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing J Exp Med 202 2005 1063 1073
28. P.E. Rao, A.L. Petrone, and P.D. Ponath Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta} J Immunol 174 2005 1446 1455
29. V.Q. Van, J. Darwiche, M. Raymond, S. Lesage, S. Bouguermouh, and M. Rubio Cutting edge: CD47 controls the in vivo proliferation and homeostasis of peripheral CD4+ CD25+ Foxp3+ regulatory T cells that express CD103 J Immunol 181 2008 5204 5208
30. L. Zhang, J.R. Conejo-Garcia, D. Katsaros, P.A. Gimotty, M. Massobrio, and G. Regnani Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer N Engl J Med 348 2003 203 213
31. E. Sato, S.H. Olson, J. Ahn, B. Bundy, H. Nishikawa, and F. Qian Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer Proc Natl Acad Sci U S A 102 2005 18538 18543
32. N. Leffers, M.J. Gooden, R.A. de Jong, B.N. Hoogeboom, K.A. ten Hoor, and H. Hollema Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer Cancer Immunol Immunother 58 2009 449 459
33. W.W. Agace T-cell recruitment to the intestinal mucosa Trends Immunol 29 2008 514 522
34. S. Liu, T. Etto, T. Rodriguez-Cruz, Y. Li, C. Wu, and O.J. Fulbright TGF-beta1 induces preferential rapid expansion and persistence of tumor antigen-specific CD8+ T cells for adoptive immunotherapy J Immunother 33 2010 371 381