Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer

PLoS ONE

Volumn 3, Issue 10, 2008, Pages

  Milne, Katy ^a   Barnes, Rebecca O ^a   Girardin, Adam ^a,b   Mawer, Melanie A ^a   Nesslinger, Nancy J ^a   Ng, Alvin ^a   Nielsen, Julie S ^a   Sahota, Robert ^a   Tran, Eric ^a,b   Webb, John R ^a,b   Wong, May Q ^a   Wick, Darin A ^a   Wray, Andrew ^a   McMurtrie, Elissa ^a   Köbel, Martin ^c   Kalloger, Steven E ^c   Gilks, C Blake ^c   Watson, Peter H ^a,b,d   Nelson, Brad H ^a,b,d  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF VICTORIA   (Canada)

^c VANCOUVER GENERAL HOSPITAL   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD20 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CELL MARKER; GAMMA INTERFERON; GRANZYME B; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 2 RECEPTOR ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NY ESO 1 ANTIGEN; PROTEIN TIA 1; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; CTAG1B PROTEIN, HUMAN; MEMBRANE PROTEIN; TUMOR ANTIGEN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; ASCITES; BLOOD SAMPLING; CANCER GRADING; CANCER TISSUE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; OVARY CANCER; SOLID TUMOR; AGED; BLOOD; CD4+ T LYMPHOCYTE; IMMUNOLOGY; LYMPHOCYTE COUNT; MIDDLE AGED; OVARY TUMOR; TUMOR ASSOCIATED LEUKOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; AUTOANTIBODIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE COUNT; LYMPHOCYTES, TUMOR-INFILTRATING; MEMBRANE PROTEINS; MIDDLE AGED; OVARIAN NEOPLASMS;

EID: 54849420085     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003409     Document Type: Article

References (89)

1. Bookman MA (2005) Standard treatment in advanced ovarian cancer in 2005: the state of the art. Int J Gynecol Cancer 15 Suppl 3: 212-220.
2. Ozols RF, Bundy BN, Greer BE, Fowler JM, Clarke-Pearson D, et al. (2003) Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol 21: 3194-3200.
3. du Bois A, Luck HJ, Meier W, Adams HP, Mobus V, et al. (2003) A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/ paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst 95: 1320-1329.
4. Holschneider CH, Berek JS (2000) Ovarian cancer: epidemiology, biology, and prognostic factors. Semin Surg Oncol 19: 3-10.
5. Ozols RF (2000) Management of advanced ovarian cancer consensus summary. Advanced Ovarian Cancer Consensus Faculty. Semin Oncol 27: 47-49.
6. Nelson BH (2008) The impact of T-cell immunity on ovarian cancer outcomes. Immunol Rev 222: 101-116.
7. Gimotty PA, Zhang L, Alagkiozidis I, Cadungog M, Adams S, et al. (2007) Immune prognostic factors in ovarian cancer: lessons from translational research. Dis Markers 23: 445-452.
8. Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, et al. (2003) Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 348: 203-213.
9. Raspollini MR, Castiglione F, Rossi Degl'innocenti D, Amunni G, Villanucci A, et al. (2005) Tumour-infiltrating gamma/delta T-lymphocytes are correlated with a brief disease-free interval in advanced ovarian serous carcinoma. Ann Oncol 16: 590-596.
10. Tomsova M, Melichar B, Sedlakova I, Steiner I (2008) Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma. Gynecol Oncol 108: 415-420.
11. Sato E, Olson SH, Ahn J, Bundy B, Nishikawa H, et al. (2005) Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/ regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 102: 18538-18543.
12. Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, et al. (2007) Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci USA 104: 3360-3365.
13. Bamias A, Tsiatas ML, Kafantari E, Liakou C, Rodolakis A, et al. (2007) Significant differences of lymphocytes isolated from ascites of patients with ovarian cancer compared to blood and tumor lymphocytes. Association of CD3(+)CD56(+) cells with platinum resistance. Gynecol Oncol.
14. Marth C, Fiegl H, Zeimet AG, Muller-Holzner E, Deibl M, et al. (2004) Interferon-gamma expression is an independent prognostic factor in ovarian cancer. Am J Obstet Gynecol 191: 1598-1605.
15. Kusuda T, Shigemasa K, Arihiro K, Fujii T, Nagai N, et al. (2005) Relative expression levels of Th1 and Th2 cytokine mRNA are independent prognostic factors in patients with ovarian cancer. Oncol Rep 13: 1153-1158.
16. Duncan TJ, Rolland P, Deen S, Scott IV, Liu DT, et al. (2007) Loss of IFN gamma receptor is an independent prognostic factor in ovarian cancer. Clin Cancer Res 13: 4139-4145.
17. Akahiro J, Konno R, Ito K, Okamura K, Yaegashi N (2004) Impact of serum interleukin-18 level as a prognostic indicator in patients with epithelial ovarian carcinoma. Int J Clin Oncol 9: 42-46.
18. Rolland P, Deen S, Scott I, Durrant L, Spendlove I (2007) Human leukocyte antigen class I antigen expression is an independent prognostic factor in ovarian cancer. Clin Cancer Res 13: 3591-3596.
19. Moore DH, Fowler WC Jr, Olafsson K (1990) Class I histocompatibility antigen expression: a prognostic factor for aneuploid ovarian cancers. 38: 458-461.
20. Wolf D, Wolf AM, Rumpold H, Fiegl H, Zeimet AG, et al. (2005) The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res 11: 8326-8331.
21. Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, et al. (2004) Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10: 942-949.
22. Woo EY, Chu CS, Goletz TJ, Schlienger K, Yeh H, et al. (2001) Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res 61: 4766-4772.
23. Luborsky JL, Barua A, Shatavi SV, Kebede T, Abramowicz J, et al. (2005) Anti-tumor antibodies in ovarian cancer. Am J Reprod Immunol 54: 55-62.
24. Stone B, Schummer M, Paley PJ, Thompson L, Stewart J, et al. (2003) Serologic analysis of ovarian tumor antigens reveals a bias toward antigens encoded on 17q International Journal of Cancer 104: 73-84.
25. Chatterjee M, Mohapatra S, Ionan A, Bawa G, Ali-Fehmi R, et al. (2006) Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays. Cancer Res 66: 1181-1190.
26. Wasserfall CH, Atkinson MA (2006) Autoantibody markers for the diagnosis and prediction of type 1 diabetes. Autoimmun Rev 5: 424-428.
27. Gilks CB, Ionescu DN, Kalloger SE, Kobel M, Irving J, et al. (2008) Tumor cell type can be reproducibly diagnosed and is of independent prognostic significance in patients with maximally debulked ovarian carcinoma. Human Pathology; In press.
28. Pipkin ME, Lieberman J (2007) Delivering the kiss of death: progress on understanding how perforin works. Curr Opin Immunol 19: 301-308.
29. Kawakami A, Tian Q, Duan X, Streuli M, Schlossman SF, et al. (1992) Identification and functional characterization of a TIA-1-related nucleolysin. Proc Natl Acad Sci USA 89: 8681-8685.
30. Kanavaros P, Boulland ML, Petit B, Arnulf B, Gaulard P (2000) Expression of cytotoxic proteins in peripheral T-cell and natural killer-cell (NK) lymphomas: association with extranodal site, NK or Tgammadelta phenotype, anaplastic morphology and CD30 expression. Leuk Lymphoma 38: 317-326.
31. Ziegler SF (2007) FOXP3: not just for regulatory T cells anymore. Eur J Immunol 37: 21-23.
32. Zou W (2006) Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6: 295-307.
33. Odunsi K, Jungbluth AA, Stockert E, Qian F, Gnjatic S, et al. (2003) NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer. Cancer Res 63: 6076-6083.
34. Yakirevich E, Sabo E, Lavie O, Mazareb S, Spagnoli GC, et al. (2003) Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens in serous ovarian neoplasms. Clin Cancer Res 9: 6453-6460.
35. Negus RP, Stamp GW, Hadley J, Balkwill FR (1997) Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines. Am J Pathol 150: 1723-1734.
36. Shah CA, Allison KH, Garcia RL, Gray HJ, Goff BA, et al. (2008) Intratumoral T cells, tumor-associated macrophages, and regulatory T cells: association with p53 mutations, circulating tumor DNA and survival in women with ovarian cancer. Gynecol Oncol 109: 215-219.
37. Kooi S, Zhang HZ, Patenia R, Edwards CL, Platsoucas CD, et al. (1996) HLA class I expression on human ovarian carcinoma cells correlates with T-cell infiltration in vivo and T-cell expansion in vitro in low concentrations of recombinant interleukin-2. 174: 116-128.
38. Helal Tel A, Alla AE, Laban MA, Fahmy RM (2004) Immunophenotyping of tumor-infiltrating mononuclear cells in ovarian carcinoma. Pathol Oncol Res 10: 80-84.
39. Buckanovich RJ, Facciabene A, Kim S, Benencia F, Sasaroli D, et al. (2008) Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. Nat Med 14: 28-36.
40. Hayashi K, Yonamine K, Masuko-Hongo K, Iida T, Yamamoto K, et al. (1999) Clonal expansion of T cells that are specific for autologous ovarian tumor among tumor-infiltrating T cells in humans. Gynecol Oncol 74: 86-92.
41. Pappas J, Jung WJ, Barda AK, Lin WL, Fincke JE, et al. (2005) Substantial proportions of identical beta-chain T-cell receptor transcripts are present in epithelial ovarian carcinoma tumors. Cell Immunol 234: 81-101.
42. Halapi E, Yamamoto Y, Juhlin C, Jeddi-Tehrani M, Grunewald J, et al. (1993) Restricted T cell receptor V-beta and J-beta usage in T cells from interleukin-2-cultured lymphocytes of ovarian and renal carcinomas. Cancer Immunol Immunother 36: 191-197.
43. Peoples GE, Davey MP, Goedegebuure PS, Schoof DD, Eberlein TJ (1993) T cell receptor V beta 2 and V beta 6 mediate tumor-specific cytotoxicity by tumor-infiltrating lymphocytes in ovarian cancer. J Immunol 151: 5472-5480.
44. Peoples GE, Yoshino I, Douville CC, Andrews JV, Goedegebuure PS, et al. (1994) TCR V beta 3+ and V beta 6+ CTL recognize tumor-associated antigens related to HER2/neu expression in HLA-A2+ ovarian cancers. J Immunol 152: 4993-4999.
45. Goedegebuure PS, Douville CC, Doherty JM, Linehan DC, Lee KY, et al. (1997) Simultaneous production of T helper-1-like cytokines and cytolytic activity by tumor-specific T cells in ovarian and breast cancer. Cell Immunol 175: 150-156.
46. Dadmarz RD, Ordoubadi A, Mixon A, Thompson CO, Barracchini KC, et al. (1996) Tumor-infiltrating lymphocytes from human ovarian cancer patients recognize autologous tumor in an MHC class II-restricted fashion. Cancer J Sci Am 2: 263-272.
47. Ioannides CG, Platsoucas CD, Rashed S, Wharton JT, Edwards CL, et al. (1991) Tumor cytolysis by lymphocytes infiltrating ovarian malignant ascites. Cancer Res 51: 4257-4265.
48. Peoples GE, Schoof DD, Andrews JV, Goedegebuure PS, Eberlein TJ (1993) T-cell recognition of ovarian cancer. Surgery 114: 227-234.
49. Peoples GE, Goedegebuure PS, Andrews JV, Schoof DD, Eberlein TJ (1993) HLA-A2 presents shared tumor-associated antigens derived from endogenous proteins in ovarian cancer. J Immunol 151: 5481-5491.
50. Freedman RS, Platsoucas CD (1996) Immunotherapy for peritoneal ovarian carcinoma metastasis using ex vivo expanded tumor infiltrating lymphocytes. Cancer Treat Res 82: 115-146.
51. Yoshino I, Peoples GE, Goedegebuure PS, Maziarz R, Eberlein TJ (1994) Association of HER2/neu expression with sensitivity to tumor-specific CTL in human ovarian cancer. J Immunol 152: 2393-2400.
52. Peoples GE, Goedegebuure PS, Smith R, Linehan DC, Yoshino I, et al. (1995) Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide. Proc Natl Acad Sci USA 92: 432-436.
53. Linehan DC, Peoples GE, Hess DT, Summerhayes IC, Parikh AS, et al. (1995) In vitro stimulation of ovarian tumour-associated lymphocytes with a peptide derived from HER2/neu induces cytotoxicity against autologous tumour. Surg Oncol 4: 41-49.
54. Lambeck A, Leffers N, Hoogeboom BN, Sluiter W, Hamming I, et al. (2007) P53-specific T cell responses in patients with malignant and benign ovarian tumors: Implications for p53 based immunotherapy. Int J Cancer.
55. Peoples GE, Anderson BW, Fisk B, Kudelka AP, Wharton JT, et al. (1998) Ovarian cancer-associated lymphocyte recognition of folate binding protein peptides. Ann Surg Oncol 5: 743-750.
56. Peoples GE, Anderson BW, Lee TV, Murray JL, Kudelka AP, et al. (1999) Vaccine implications of folate binding protein, a novel cytotoxic T lymphocyte-recognized antigen system in epithelial cancers. Clin Cancer Res 5: 4214-4223.
57. Geisler JP, Hatterman-Zogg MA, Rathe JA, Buller RE (2002) Frequency of BRCA1 dysfunction in ovarian cancer. J Natl Cancer Inst 94: 61-67.
58. Hilton JL, Geisler JP, Rathe JA, Hattermann-Zogg MA, DeYoung B, et al. (2002) Inactivation of BRCA1 and BRCA2 in ovarian cancer. J Natl Cancer Inst 94: 1396-1406.
59. Nijman HW, van Diest PJ, Poort-Keesom RJ, von Mensdorff-Pouilly S, Verstraeten RA, et al. (2001) T cell infiltration and MHC I and II expression in the presence of tumor antigens: An immunohistochemical study in patients with serous epithelial ovarian cancer. Eur J Obstet Gynecol Reprod Biol 94: 114-120.
60. Santin AD, Bellone S, Palmieri M, Bossini B, Cane S, et al. (2004) Restoration of tumor specific human leukocyte antigens class I-restricted cytotoxicity by dendritic cell stimulation of tumor infiltrating lymphocytes in patients with advanced ovarian cancer. Int J Gynecol Cancer 14: 64-75.
61. Ioannides CG, Freedman RS, Platsoucas CD, Rashed S, Kim YP (1991) Cytotoxic T cell clones isolated from ovarian tumor-infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells. J Immunol 146: 1700-1707.
62. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, et al. (2006) Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313: 1960-1964.
63. Goodell V, Salazar LG, Urban N, Drescher CW, Gray H, et al. (2006) Antibody immunity to the p53 oncogenic protein is a prognostic indicator in ovarian cancer. J Clin Oncol 24: 762-768.
64. Vogl FD, Frey M, Kreienberg R, Runnebaum IB (2000) Autoimmunity against p53 predicts invasive cancer with poor survival in patients with an ovarian mass. Br J Cancer 83: 1338-1343.
65. Mayerhofer K, Tempfer C, Kucera E, Hefler L, Zeisler H, et al. (1999) Humoral p53 antibody response is a prognostic parameter in ovarian cancer. Anticancer Res 19: 875-878.
66. Hogdall EV, Hogdall CK, Blaakaer J, Heegaard NH, Glud E, et al. (2002) P53 autoantibodies in sera from Danish ovarian cancer patients and their correlation with clinical data and prognosis. Apmis 110: 545-553.
67. Gadducci A, Ferdeghini M, Buttitta F, Cosio S, Fanucchi A, et al. (1999) Assessment of the prognostic relevance of serum anti-p53 antibodies in epithelial ovarian cancer. 72: 76-81.
68. Crane IJ, Forrester JV (2005) Th1 and Th2 lymphocytes in autoimmune disease. Crit Rev Immunol 25: 75-102.
69. Qin Z, Richter G, Schuler T, Ibe S, Cao X, et al. (1998) B cells inhibit induction of T cell-dependent tumor immunity. Nat Med 4: 627-630.
70. Demaria S, Volm MD, Shapiro RL, Yee HT, Oratz R, et al. (2001) Development of tumor-infiltrating lymphocytes in breast cancer after neoadjuvant paclitaxel chemotherapy. Clin Cancer Res 7: 3025-3030.
71. Ladoire S, Arnould L, Apetoh L, Coudert B, Martin F, et al. (2008) Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells. Clin Cancer Res 14: 2413-2420.
72. Tsavaris N, Kosmas C, Vadiaka M, Kanelopoulos P, Boulamatsis D (2002) Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes. Br J Cancer 87: 21-27.
73. Carson WE 3rd, Shapiro CL, Crespin TR, Thornton LM, Andersen BL (2004) Cellular immunity in breast cancer patients completing taxane treatment. Clin Cancer Res 10: 3401-3409.
74. Chan OT, Yang LX (2000) The immunological effects of taxanes. Cancer Immunol Immunother 49: 181-185.
75. Fitzpatrick FA, Wheeler R (2003) The immunopharmacology of paclitaxel (Taxol), docetaxel (Taxotere), and related agents. Int Immunopharmacol 3: 1699-1714.
76. Tsuda N, Chang DZ, Mine T, Efferson C, Garcia-Sastre A, et al. (2007) Taxol increases the amount and T cell activating ability of self-immune stimulatory multimolecular complexes found in ovarian cancer cells. Cancer Res 67: 8378-8387.
77. Riesbeck K (1999) Cisplatin at clinically relevant concentrations enhances interleukin-2 synthesis by human primary blood lymphocytes. Anticancer Drugs 10: 219-227.
78. Tsuda H, Kitahashi S, Umesaki N, Kanaoka Y, Kawabata M, et al. (1994) Abrogation of suppressor cells activity by cis-diamminedichloroplatinum (CDDP) treatment using therapeutic doses in ovarian cancer patients. Gynecol Oncol 52: 218-221.
79. Bagnoli M, Balladore E, Luison E, Alberti P, Raspagliesi F, et al. (2007) Sensitization of p53-mutated epithelial ovarian cancer to CD95-mediated apoptosis is synergistically induced by cisplatin pretreatment. Mol Cancer Ther 6: 762-772.
80. Stewart JA, Belinson JL, Moore AL, Dorighi JA, Grant BW, et al. (1990) Phase I trial of intraperitoneal recombinant interleukin-2/ lymphokine-activated killer cells in patients with ovarian cancer. Cancer Res 50: 6302-6310.
81. Steis RG, Urba WJ, VanderMolen LA, Bookman MA, Smith JW 2nd, et al. (1990) Intraperitoneal lymphokine-activated killer-cell and interleukin-2 therapy for malignancies limited to the peritoneal cavity. J Clin Oncol 8: 1618-1629.
82. Urba WJ, Clark JW, Steis RG, Bookman MA, Smith JW 2nd, et al. (1989) Intraperitoneal lymphokine-activated killer cell/interleukin-2 therapy in patients with intra-abdominal cancer: immunologic considerations. J Natl Cancer Inst 81: 602-611.
83. Aoki Y, Takakuwa K, Kodama S, Tanaka K, Takahashi M, et al. (1991) Use of adoptive transfer of tumor-infiltrating lymphocytes alone or in combination with cisplatin-containing chemotherapy in patients with epithelial ovarian cancer. Cancer Res 51: 1934-1939.
84. Ikarashi H, Fujita K, Takakuwa K, Kodama S, Tokunaga A, et al. (1994) Immunomodulation in patients with epithelial ovarian cancer after adoptive transfer of tumor-infiltrating lymphocytes. Cancer Res 54: 190-196.
85. Fujita K, Ikarashi H, Takakuwa K, Kodama S, Tokunaga A, et al. (1995) Prolonged disease-free period in patients with advanced epithelial ovarian cancer after adoptive transfer of tumor-infiltrating lymphocytes. Clin Cancer Res 1: 501-507.
86. Freedman RS, Edwards CL, Kavanagh JJ, Kudelka AP, Katz RL, et al. (1994) Intraperitoneal adoptive immunotherapy of ovarian carcinoma with tumor-infiltrating lymphocytes and low-dose recombinant interleukin-2: a pilot trial. J Immunother Emphasis Tumor Immunol 16: 198-210.
87. Freedman RS, Platsoucas CD, Deisseroth AB (1996) Use of a retroviral vector to study the trafficking patterns of purified ovarian tumor infiltrating lymphocytes (TIL) used in intraperitoneal adoptive immunotherapy of ovarian cancer patients. A pilot study. Hum Gene Ther 7: 1351-1365.
88. Freedman RS, Kudelka AP, Kavanagh JJ, Verschraegen C, Edwards CL, et al. (2000) Clinical and biological effects of intraperitoneal injections of recombinant interferon-gamma and recombinant interleukin 2 with or without tumor-infiltrating lymphocytes in patients with ovarian or peritoneal carcinoma. Clin Cancer Res 6: 2268-2278.
89. Fujimoto K, Tomonaga M, Goto S (2006) A case of recurrent ovarian cancer successfully treated with adoptive immunotherapy and lentinan. Anticancer Res 26: 4015-4018.