-
1
-
-
0028818897
-
Acetylcholinesterase inhibition by fasciculin: Crystal structure of the complex
-
10.1016/0092-8674(95)90128-0 1:CAS:528:DyaK2MXpt1Olt70%3D 8521480
-
Y Bourne P Taylor P Marchot 1995 Acetylcholinesterase inhibition by fasciculin: Crystal structure of the complex Cell 83 503 512 10.1016/0092-8674(95)90128-0 1:CAS:528:DyaK2MXpt1Olt70%3D 8521480
-
(1995)
Cell
, vol.83
, pp. 503-512
-
-
Bourne, Y.1
Taylor, P.2
Marchot, P.3
-
2
-
-
33749402097
-
Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding
-
DOI 10.1074/jbc.M603018200
-
Y Bourne Z Radic G Sulzenbacher E Kim P Taylor P Marchot 2006 Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding Journal of Biological Chemistry 281 29256 29267 10.1074/jbc.M603018200 1:CAS:528:DC%2BD28XpvFamsLg%3D 16837465 (Pubitemid 44507069)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.39
, pp. 29256-29267
-
-
Bourne, Y.1
Radic, Z.2
Sulzenbacher, G.3
Kim, E.4
Taylor, P.5
Marchot, P.6
-
3
-
-
0013945471
-
Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs
-
1:STN:280:DyaF2s7nvV2jtQ%3D%3D 5970686
-
J-P Changeux 1966 Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs Molecular Pharmacology 2 369 392 1:STN:280:DyaF2s7nvV2jtQ%3D%3D 5970686
-
(1966)
Molecular Pharmacology
, vol.2
, pp. 369-392
-
-
Changeux, J.-P.1
-
4
-
-
33745550034
-
Structural insights into substrate traffic and inhibition in acetylcholinesterase
-
DOI 10.1038/sj.emboj.7601175, PII 7601175
-
JP Colletier D Fournier HM Greenblatt J Stojan JL Sussman G Zaccai, et al. 2006 Structural insights into substrate traffic and inhibition in acetylcholinesterase EMBO Journal 25 2746 2756 10.1038/sj.emboj.7601175 1:CAS:528:DC%2BD28XlvFKhsbw%3D 16763558 (Pubitemid 43980382)
-
(2006)
EMBO Journal
, vol.25
, Issue.12
, pp. 2746-2756
-
-
Colletier, J.-P.1
Fournier, D.2
Greenblatt, H.M.3
Stojan, J.4
Sussman, J.L.5
Zaccai, G.6
Silman, I.7
Weik, M.8
-
5
-
-
0035968202
-
Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites
-
10.1074/jbc.M009596200 11313335
-
GV De Ferrari WD Mallender NC Inestrosa TL Rosenberry 2001 Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites Journal of Biological Chemistry 276 23282 23287 10.1074/jbc.M009596200 11313335
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 23282-23287
-
-
De Ferrari, G.V.1
Mallender, W.D.2
Inestrosa, N.C.3
Rosenberry, T.L.4
-
6
-
-
33644811612
-
A new and rapid colorimetric determination of acetylcholinesterase activity
-
10.1016/0006-2952(61)90145-9 1:CAS:528:DyaF3MXht1Gns7o%3D 13726518
-
GL Ellman KD Courtney V Andres Jr RM Featherstone 1961 A new and rapid colorimetric determination of acetylcholinesterase activity Biochemical Pharmacology 7 88 95 10.1016/0006-2952(61)90145-9 1:CAS:528:DyaF3MXht1Gns7o%3D 13726518
-
(1961)
Biochemical Pharmacology
, vol.7
, pp. 88-95
-
-
Ellman, G.L.1
Courtney, K.D.2
Andres Jr, V.3
Featherstone, R.M.4
-
7
-
-
0027368530
-
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase
-
DOI 10.1073/pnas.90.19.9031
-
M Harel I Schalk L Ehret-Sabatier F Bouet M Goeldner C Hirth, et al. 1993 Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase Proceedings of the National Academy of Sciences of the United States of America 90 9031 9035 10.1073/pnas.90.19.9031 1:CAS:528:DyaK3sXmsVCgtrc%3D 8415649 (Pubitemid 23306445)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.19
, pp. 9031-9035
-
-
Harel, M.1
Schalk, I.2
Ehret-Sabatier, L.3
Bouet, F.4
Goeldner, M.5
Hirth, C.6
Axelsen, P.H.7
Silman, I.8
Sussman, J.L.9
-
8
-
-
0029646114
-
Crystal structure of an acetylcholinesterase-fasciculin complex: Interaction of a three-fingered toxin from snake venom with its target
-
DOI 10.1016/S0969-2126(01)00273-8
-
M Harel GJ Kleywegt RBG Ravelli I Silman JL Sussman 1995 Crystal structure of an acetylcholinesterase-fasciculin complex: Interaction of a three-fingered toxin from snake venom with its target Structure 3 1355 1366 10.1016/S0969-2126(01)00273-8 1:CAS:528:DyaK28XitFGgug%3D%3D 8747462 (Pubitemid 3012267)
-
(1995)
Structure
, vol.3
, Issue.12
, pp. 1355-1366
-
-
Harel, M.1
Kleywegt, G.J.2
Ravelli, R.B.3
Silman, I.4
Sussman, J.L.5
-
9
-
-
15844422678
-
The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase
-
DOI 10.1021/ja952232h
-
M Harel DM Quinn HK Nair I Silman JL Sussman 1996 The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase Journal of the American Chemical Society 118 2340 2346 10.1021/ja952232h 1:CAS:528:DyaK28Xht1Wntb8%3D (Pubitemid 26124248)
-
(1996)
Journal of the American Chemical Society
, vol.118
, Issue.10
, pp. 2340-2346
-
-
Harel, M.1
Quinn, D.M.2
Nair, H.K.3
Silman, I.4
Sussman, J.L.5
-
10
-
-
45749094206
-
Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site
-
DOI 10.1021/ja7109822
-
M Harel LK Sonoda I Silman JL Sussman TL Rosenberry 2008 The crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site Journal of the American Chemical Society 130 7856 7861 10.1021/ja7109822 1:CAS:528:DC%2BD1cXms1Gitr8%3D 18512913 (Pubitemid 351875060)
-
(2008)
Journal of the American Chemical Society
, vol.130
, Issue.25
, pp. 7856-7861
-
-
Harel, M.1
Sonoda, L.K.2
Silman, I.3
Sussman, J.L.4
Rosenberry, T.L.5
-
11
-
-
0038219567
-
Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate
-
DOI 10.1021/bi027065u
-
JL Johnson B Cusack MP Davies A Fauq TL Rosenberry 2003 Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate Biochemistry 42 5438 5452 10.1021/bi027065u 1:CAS:528:DC%2BD3sXivFaguro%3D 12731886 (Pubitemid 36560441)
-
(2003)
Biochemistry
, vol.42
, Issue.18
, pp. 5438-5452
-
-
Johnson, J.L.1
Cusack, B.2
Davies, M.P.3
Fauq, A.4
Rosenberry, T.L.5
-
12
-
-
0034604236
-
Acetylthiocholine binds to Asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway
-
DOI 10.1021/bi000210o
-
WD Mallender T Szegletes TL Rosenberry 2000 Acetylthiocholine binds to Asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway Biochemistry 39 7753 7763 10.1021/bi000210o 1:CAS:528:DC%2BD3cXjvVahtLY%3D 10869180 (Pubitemid 30439603)
-
(2000)
Biochemistry
, vol.39
, Issue.26
, pp. 7753-7763
-
-
Mallender, W.D.1
Szegletes, T.2
Rosenberry, T.L.3
-
13
-
-
84958258163
-
Enzymic hydrolysis and synthesis of acetylcholine
-
1:CAS:528:DyaG38XitVOrtw%3D%3D
-
D Nachmansohn IB Wilson 1951 Enzymic hydrolysis and synthesis of acetylcholine Advances in Enzymology 12 259 339 1:CAS:528:DyaG38XitVOrtw%3D%3D
-
(1951)
Advances in Enzymology
, vol.12
, pp. 259-339
-
-
Nachmansohn, D.1
Wilson, I.B.2
-
14
-
-
33845282579
-
Acetylcholinesterase: Enzyme structure, reaction dynamics, and virtual transition states
-
10.1021/cr00081a005 1:CAS:528:DyaL2sXlsV2kurs%3D
-
DM Quinn 1987 Acetylcholinesterase: Enzyme structure, reaction dynamics, and virtual transition states Chemical Reviews 87 955 979 10.1021/cr00081a005 1:CAS:528:DyaL2sXlsV2kurs%3D
-
(1987)
Chemical Reviews
, vol.87
, pp. 955-979
-
-
Quinn, D.M.1
-
15
-
-
0016593463
-
Acetylcholinesterase
-
1:CAS:528:DyaE1cXhslyrtg%3D%3D
-
TL Rosenberry 1975a Acetylcholinesterase Advances in Enzymology 43 103 218 1:CAS:528:DyaE1cXhslyrtg%3D%3D
-
(1975)
Advances in Enzymology
, vol.43
, pp. 103-218
-
-
Rosenberry, T.L.1
-
16
-
-
1542555313
-
Catalysis by acetylcholinesterase. Evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base catalysis
-
10.1073/pnas.72.10.3834 1:CAS:528:DyaE28XhsVSktw%3D%3D
-
TL Rosenberry 1975b Catalysis by acetylcholinesterase. Evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base catalysis Proceedings of the National Academy of Sciences of the United States of America 72 3834 3838 10.1073/pnas.72.10.3834 1:CAS:528:DyaE28XhsVSktw%3D%3D
-
(1975)
Proceedings of the National Academy of Sciences of the United States of America
, vol.72
, pp. 3834-3838
-
-
Rosenberry, T.L.1
-
17
-
-
0018777146
-
Quantitative simulation of endplate currents at neuro-muscular junctions based on the reactions of acetylcholine with acetylcholine receptor and acetylcholinesterase
-
10.1016/S0006-3495(79)85249-2 1:CAS:528:DyaE1MXktlChsLk%3D 262418
-
TL Rosenberry 1979 Quantitative simulation of endplate currents at neuro-muscular junctions based on the reactions of acetylcholine with acetylcholine receptor and acetylcholinesterase Biophysical Journal 26 263 290 10.1016/S0006-3495(79)85249-2 1:CAS:528:DyaE1MXktlChsLk%3D 262418
-
(1979)
Biophysical Journal
, vol.26
, pp. 263-290
-
-
Rosenberry, T.L.1
-
18
-
-
0015241519
-
Studies of catalysis by acetylcholinesterase: Fluorescent titration with a carbamoylating agent
-
10.1021/bi00798a016 1:CAS:528:DyaE38XhtlSm 5168614
-
TL Rosenberry SA Bernhard 1971 Studies of catalysis by acetylcholinesterase: Fluorescent titration with a carbamoylating agent Biochemistry 10 4114 4120 10.1021/bi00798a016 1:CAS:528:DyaE38XhtlSm 5168614
-
(1971)
Biochemistry
, vol.10
, pp. 4114-4120
-
-
Rosenberry, T.L.1
Bernhard, S.A.2
-
19
-
-
0015497449
-
Studies on catalysis by acetylcholinesterase: Synergistic effects of inhibitors during hydrolysis of acetic acid esters
-
10.1021/bi00773a018 1:CAS:528:DyaE3sXhsVKj 5079901
-
TL Rosenberry SA Bernhard 1972 Studies on catalysis by acetylcholinesterase: Synergistic effects of inhibitors during hydrolysis of acetic acid esters Biochemistry 11 4308 4321 10.1021/bi00773a018 1:CAS:528:DyaE3sXhsVKj 5079901
-
(1972)
Biochemistry
, vol.11
, pp. 4308-4321
-
-
Rosenberry, T.L.1
Bernhard, S.A.2
-
21
-
-
57449090909
-
Analysis of the reaction of carbachol with acetylcholinesterase using thioflavin T as a coupled fluorescence reporter
-
10.1021/bi8015197 1:CAS:528:DC%2BD1cXhtlGqsL3L
-
TL Rosenberry LK Sonoda SE Dekat B Cusack JL Johnson 2008a Analysis of the reaction of carbachol with acetylcholinesterase using thioflavin T as a coupled fluorescence reporter Biochemistry 47 13056 13063 10.1021/bi8015197 1:CAS:528:DC%2BD1cXhtlGqsL3L
-
(2008)
Biochemistry
, vol.47
, pp. 13056-13063
-
-
Rosenberry, T.L.1
Sonoda, L.K.2
Dekat, S.E.3
Cusack, B.4
Johnson, J.L.5
-
22
-
-
50649109814
-
Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis
-
10.1016/j.cbi.2008.06.002 1:CAS:528:DC%2BD1cXhtVygu77J
-
TL Rosenberry LK Sonoda SE Dekat B Cusack JL Johnson 2008b Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis Chemico-Biological Interactions 175 235 241 10.1016/j.cbi.2008.06.002 1:CAS:528:DC%2BD1cXhtVygu77J
-
(2008)
Chemico-Biological Interactions
, vol.175
, pp. 235-241
-
-
Rosenberry, T.L.1
Sonoda, L.K.2
Dekat, S.E.3
Cusack, B.4
Johnson, J.L.5
-
23
-
-
0025778840
-
Atomic structure of acetylcholinesterase from Torpedo californica: A prototypic acetylcholine-binding protein
-
10.1126/science.1678899 1:CAS:528:DyaK3MXlslyitrc%3D 1678899
-
JL Sussman M Harel F Frolow C Oefner A Goldman L Toker, et al. 1991 Atomic structure of acetylcholinesterase from Torpedo californica: A prototypic acetylcholine-binding protein Science 253 872 879 10.1126/science.1678899 1:CAS:528:DyaK3MXlslyitrc%3D 1678899
-
(1991)
Science
, vol.253
, pp. 872-879
-
-
Sussman, J.L.1
Harel, M.2
Frolow, F.3
Oefner, C.4
Goldman, A.5
Toker, L.6
-
24
-
-
0000140355
-
Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands
-
DOI 10.1021/bi972158a
-
T Szegletes WD Mallender TL Rosenberry 1998 Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands Biochemistry 37 4206 4216 10.1021/bi972158a 1:CAS:528:DyaK1cXhsVOltbg%3D 9521743 (Pubitemid 28166443)
-
(1998)
Biochemistry
, vol.37
, Issue.12
, pp. 4206-4216
-
-
Szegletes, T.1
Mallender, W.D.2
Rosenberry, T.L.3
-
25
-
-
0033524414
-
Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect
-
DOI 10.1021/bi9813577
-
T Szegletes WD Mallender PJ Thomas TL Rosenberry 1999 Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect Biochemistry 38 122 133 10.1021/bi9813577 1:CAS:528:DyaK1cXnvVKlsL8%3D 9890890 (Pubitemid 29035678)
-
(1999)
Biochemistry
, vol.38
, Issue.1
, pp. 122-133
-
-
Szegletes, T.1
Mallender, W.D.2
Thomas, P.J.3
Rosenberry, T.L.4
-
26
-
-
0032402388
-
Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge
-
DOI 10.1002/(SICI)1097-0282(199812)46:7<465::AID-BIP4>3.0.CO;2-Y
-
S Tara AH Elcock PD Kirchhoff JM Briggs Z Radic P Taylor, et al. 1998 Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge Biopolymers 46 7 465 474 10.1002/(SICI)1097-0282(199812)46: 7<465::AID-BIP4>3.0.CO;2-Y 1:CAS:528:DyaK1cXnsl2jsLk%3D 9838872 (Pubitemid 28536554)
-
(1998)
Biopolymers
, vol.46
, Issue.7
, pp. 465-474
-
-
Tara, S.1
Elcock, A.H.2
Kirchhoff, P.D.3
Briggs, J.M.4
Radic, Z.5
Taylor, P.6
McCammon, J.A.7
-
27
-
-
0016823110
-
Interaction of fluorescence probes with acetylcholinesterase. the site and specificity of propidium binding
-
10.1021/bi00680a029 1:CAS:528:DyaE2MXktVemu74%3D 1125207
-
P Taylor S Lappi 1975 Interaction of fluorescence probes with acetylcholinesterase. The site and specificity of propidium binding Biochemistry 14 1989 1997 10.1021/bi00680a029 1:CAS:528:DyaE2MXktVemu74%3D 1125207
-
(1975)
Biochemistry
, vol.14
, pp. 1989-1997
-
-
Taylor, P.1
Lappi, S.2
-
28
-
-
0018839204
-
Modulation of acetylcholinesterase activity by peripheral site ligands
-
1:CAS:528:DyaL3cXlt1OrsLc%3D 7412762
-
G Tomlinson B Mutus I McLennan 1980 Modulation of acetylcholinesterase activity by peripheral site ligands Molecular Pharmacology 18 33 39 1:CAS:528:DyaL3cXlt1OrsLc%3D 7412762
-
(1980)
Molecular Pharmacology
, vol.18
, pp. 33-39
-
-
Tomlinson, G.1
Mutus, B.2
McLennan, I.3
|