Novel synthesis of pyrrolo[2,3-d] pyrimidines bearing sulfonamide moieties as potential antitumor and radioprotective agents

Arzneimittel-Forschung/Drug Research

Volumn 56, Issue 4, 2006, Pages 301-308

  Ismail, Magda M F ^a,d   Ghorab, Mostafa M ^b   Noaman, Eman ^b   Ammar, Yousry A ^c   Heiba, Helmy I ^b   Sayed, Marwa Y ^b  

^a Al Azhar University   (Egypt)

^b NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

^c Assiut Branch   (Egypt)

^d AL AZHAR UNIVERSITY   (Egypt)

Author keywords

Antitumor agents; Pyrrolo 2,3 d pyrimidines, antitumor and radioprotective activity, synthesis; Pyrrolo 3,2 e 1,2,4 triazolo 4,3 c pyrimidines, antitumor and radioprotective activity, synthesis; Radioprotective agents; Sulfonamide moiety

Indexed keywords

4 (2 AMINO 3 CYANO 4 PHENYLPYRROL 1 YL)BENZENESULFONAMIDE; 4 (2 OXO 2 PHENYLETHYLAMINO) BENZENESULFONAMIDE; 4 (3 METHYL 9 PHENYLPYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (4 AMINO 5 PHENYLPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (4 AZIDO 5 PHENYLPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (4 CHLORO 5 PHENYLPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (4 HYDRAZINO 4 N' PHENYLHYDRAZINO 5 PHENYLPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (4 ISOTHIOCYANATO 5 PHENYLPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (4 OXO 5 PHENYL 3,4 DIHYDROPYRROLO[2,3 D]PYRIMIDIN 7 YL) BENZENESULFONAMIDE; 4 (6 OXO 1 PHENYL 6H 3,4,5A,11 TETRAAZACYCLOPENTA[A]ANTHRACEN 3 YL)BENZESULFONAMIDE; 4 (9 PHENYLPYRROLO[3,2 3][1,2,4]TRIAZOLO[4,3 C]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 [4 (4 AMINO N BENZENESULFAMOYL) 5 PHENYLPYRROLO[2,3 D]PYRIMIDIN 7 YL]BENZENESULFONAMIDE; 4 [4 (4 PHENYLAMINO) 5 PHENYLPYRROLO[2,3 D]PYRIMIDIN 7 YL]BENZENESULFONAMIDE; 4 [4 (4 SULFAMOYLPHENYLAMINO) 5 PHENYLPYRROLO[2,3 D]PYRIMIDIN 7 YL]BENZENESULFONAMIDE; BENZENESULFONAMIDE DERIVATIVE; GLUTATHIONE; PYRROLOPYRIMIDINE DERIVATIVE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; GAMMA IRRADIATION; IC 50; LIPID PEROXIDATION; MOUSE; NONHUMAN; RADIATION PROTECTION;

EID: 33646425034     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296725     Document Type: Article

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