Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 4175-4179

  Wang, Ke ^a   Liu, Zhan Zhu ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Amino acid; Bisindolylmaleimide; Cytotoxic activity; Synthesis

Indexed keywords

BISINDOLYLMALEIMIDE; CISPLATIN; DIMETHY 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL}ACETYL)AMINO]BUTANEDIOATEY; DIMETHYL 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL}ACETYL)AMINO]PENTANEDIOATE; ETHYL 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL} ACETYL)AMINO]ACETATE; METHY 3 HYDROXY 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL}ACETYL)AMINO]BUTANOATE; METHYL 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL}ACETYL)AMINO] 3 PHENYLPROPANOATE; METHYL 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL}ACETYL)AMINO] 4 METHYLPENTANOATE; METHYL 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL}ACETYL)AMINO]PROPANOATE; METHYL 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOYL}ACETYL)AMINO] 3 METHYLBUTANOATE; METHYL 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOYL}ACETYL)AMINO] 3 METHYLPENTANOATE; METHYL 3 (1H 3 INDOLYL) 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL}ACETYL)AMINO]PROPANOATE; METHYL 3 (3,4 DIHYDROXYPHENYL) 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL}ACETYL)AMINO]PROPANOATE; METHYL 3 (4 HYDROXYPHENYL) 2 [(2 {3 [4 (1H 3 INDOLYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL}ACETYL)AMINO]PROPANOATE; METHYL 3 HYDROXY 2 {[1 ({3 [4 (1H 3 INDOYL) 1 METHYL 2,5 DIOXO 2,5 DIHYDRO 1H 3 PYRROLYL] 1H 1 INDOLYL}METHYL)ACETYL]AMINO}PROPANOATE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN MCF 7; CYTOTOXICITY; HUMAN; HUMAN CELL; SYNTHESIS;

AMINO ACIDS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; ESTERS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MALEIMIDES;

EID: 77955549357     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.06.009     Document Type: Article

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