Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 265-269

  Thiermann, Horst ^a   Seeger, Thomas ^a   Gonder, Sascha ^a   Herkert, Nadja ^a   Antkowiak, Bernd ^b   Zilker, Thomas ^c   Eyer, Florian ^c   Worek, Franz ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Muscle force; Neuromuscular dysfunction; Organophosphorus compounds; Oximes; Poisoning

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; NEOSTIGMINE; OBIDOXIME; ORGANOPHOSPHORUS COMPOUND; PARATHION;

AGING; ARTICLE; COCULTURE; CONTROLLED STUDY; DIAPHRAGM MUSCLE; ENZYME ACTIVITY; ENZYME ASSAY; ERYTHROCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTERCOSTAL MUSCLE; MUSCLE FORCE; NEUROMUSCULAR DISEASE; NEUROMUSCULAR ELECTRICAL STIMULATION; NEUROMUSCULAR TRANSMISSION; NEUROTOXICITY; PHRENIC NERVE; SPINAL CORD; TOXICITY TESTING; TOXICOKINETICS;

ANIMALIA;

EID: 77955519070     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.12.027     Document Type: Article

References (32)

1. Eyer P. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicol. Rev. 2003, 22:165-190.
2. De Jong L.P., Verhagen M.A., Langenberg J.P., Hagedorn I., Loffler M. The bispyridinium-dioxime HLo-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman. Biochem. Pharmacol. 1989, 38:633-640.
3. Aurbek N., Thiermann H., Szinicz L., Eyer P., Worek F. Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase. Toxicology 2006, 224:91-99.
4. Bartling A., Worek F., Szinicz L., Thiermann H. Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase. Toxicology 2007, 233:166-172.
5. Worek F., Thiermann H., Szinicz L. Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines. Arch. Toxicol. 2004, 78:212-217.
6. Worek F., Thiermann H., Szinicz L., Eyer P. Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes. Biochem. Pharmacol. 2004, 68:2237-2248.
7. Worek F., Aurbek N., Koller M., Becker C., Eyer P., Thiermann H. Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates. Biochem. Pharmacol. 2007, 73:1807-1817.
8. Worek F., Szinicz L., Thiermann H. Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach. Chem. Biol. Interact. 2005, 157/158:349-352.
9. Taylor P., Radic Z. The cholinesterases: from genes to proteins. Annu. Rev. Pharmacol. Toxicol. 1994, 34:281-320.
10. Eckert S., Eyer P., Muckter H., Worek F. Development of a dynamic model for real-time determination of membrane-bound acetylcholinesterase activity upon perfusion with inhibitors and reactivators. Biochem. Pharmacol. 2006, 72:358-365.
11. Eckert S., Eyer P., Melzer M., Thiermann H., Worek F. Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods. Biochem. Pharmacol. 2008, 75:1561-1566.
12. Herkert N.M., Lallement G., Clarencon D., Thiermann H., Worek F. Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity. Toxicology 2009, 258:79-83.
13. Eckert S., Eyer P., Herkert N., Bumm R., Weber G., Thiermann H., Worek F. Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity. Biochem. Pharmacol. 2008, 75:698-703.
14. Herkert N.M., Eckert S., Eyer P., Bumm R., Weber G., Thiermann H., Worek F. Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors. Toxicology 2008, 246:188-192.
15. Worek F., Reiter G., Eyer P., Szinicz L. Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates. Arch. Toxicol. 2002, 76:523-529.
16. Worek F., Baecker M., Thiermann H., Szinicz L., Mast U., Klimmek R., Eyer P. Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning. Hum. Exp. Toxicol. 1997, 16:466-472.
17. Thiermann H., Eyer P., Worek F., Szinicz L. Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon. Toxicology 2005, 214:190-197.
18. Thiermann H., Eyer P., Worek F., Szinicz L. Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon. Toxicology 2005, 214:190.
19. Smith A.P., van der Weil H.J., Wolthuis O.L. Analysis of oxime-induced neuromuscular recovery in guinea-pig, rat and man following soman poisoning in vitro. Eur. J. Pharmacol. 1981, 70:371-379.
20. Seeger T., Worek F., Szinicz L., Thiermann H. Reevaluation of indirect field stimulation technique to demonstrate oxime effectiveness in OP-poisoning in muscles in vitro. Toxicology 2007, 233:209-213.
21. Spenger C., Braschler U.F., Streit J., Luscher H.R. An organotypic spinal cord-dorsal root ganglion-skeletal muscle coculture of embryonic rat. I. The morphological correlates of the spinal reflex arc. Eur. J. Neurosci. 1991, 3:1037-1053.
22. Streit J., Spenger C., Luscher H.R. An organotypic spinal cord-dorsal root ganglion-skeletal muscle coculture of embryonic rat. II. Functional evidence for the formation of spinal reflex arcs in vitro. Eur. J. Neurosci. 1991, 3:1054-1068.
23. Jeyaratnam J. Acute pesticide poisoning: a major global health problem. World Health Stat. Quart. 1990, 43:139-144.
24. Worek F., Mast U., Kiderlen D., Diepold C., Eyer P. Improved determination of acetylcholinesterase activity in human whole blood. Clin. Chim. Acta 1999, 288:73-90.
25. Thiermann H., Mast U., Klimmek R., Eyer P., Hibler A., Pfab R., Felgenhauer N., Zilker T. Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum. Exp. Toxicol. 1997, 16:473-480.
26. Eyer F., Worek F., Eyer P., Felgenhauer N., Haberkorn M., Zilker T., Thiermann H. Obidoxime in acute organophosphate poisoning. 1. Clinical effectiveness. Clin. Toxicol. 2009, 47:798-806.
27. Besser R., Gutmann L., Dillmann U., Weilemann L.S., Hopf H.C. End-plate dysfunction in acute organophosphate intoxication. Neurology 1989, 39:561-567.
28. Thiermann H., Zilker T., Eyer F., Felgenhauer N., Eyer P., Worek F. Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients. Toxicol. Lett. 2009, (Epub ahead of print).
29. Thiermann H., Worek F., Eyer P., Eyer F., Felgenhauer N., Zilker T. Obidoxime in acute organophosphate poisoning. 2. PK/PD relationships. Clin. Toxicol. 2009, 47:807-813.
30. Eyer P. Optimal oxime dosage regimen, a pharmacokinetic approach. Role of Oximes in the Treatment of Anticholinesterase Agent Poisoning 1996, 33-51. Spektrum Akademischer Verlag, Heidelberg. L. Szinicz, P. Eyer, R. Klimmek (Eds.).
31. Worek F., Szinicz L., Eyer P., Thiermann H. Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model. Toxicol. Appl. Pharmacol. 2005, 209:193-202.
32. Thiermann H., Kehe K., Steinritz D., Mikler J., Hill I., Zilker T., Eyer P., Worek F. Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds. Arh. Hig. Rada Toksikol. 2007, 58:359-366.