Kinetics and mechanism of inhibition of serine esterases by fluorinated aminophosphonates

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 177-184

  Makhaeva, G F ^a   Aksinenko, A Y ^a   Sokolov, V B ^a   Baskin, I I ^b   Palyulin, V A ^b   Zefirov, N S ^b   Hein, N D ^c   Kampf, J W ^c   Wijeyesakere, S J ^c   Richardson, R J ^c  

^a INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Acetylcholinesterase (AChE); Butyrylcholinesterase (BChE); Carboxylesterase (CaE); Fluorinated aminophosphonates (FAPs); Neuropathy target esterase (NTE); P C bond scission

Indexed keywords

BUTYRYLCHOLINESTERASE INHIBITOR; CARBON; CARBOXYLESTERASE INHIBITOR; CHOLINESTERASE INHIBITOR; DIALKYLPHOSPHONATE DERIVATIVE; DIALKYLPHOSPHORYL; DIBUTYLPHOSPHORYL; DIETHYLPHOSPHORYL; ENZYME INHIBITOR; ESTERASE INHIBITOR; FLUORINATED AMINOPHOSPHONATE DERIVATIVE; MONOALKYLPHOSPHORYL; MONOBUTYLPHOSPHORYL; MONOETHYLPHOSPHORYL; NEUROTOXIC ESTERASE INHIBITOR; PEPTIDE; PHOSPHONIC ACID DERIVATIVE; PHOSPHORUS; PHOSPHORUS DERIVATIVE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DEALKYLATION; ENZYME INHIBITION; ENZYME KINETICS; MOLECULAR MODEL; PHOSPHORYLATION; PREDICTION;

EID: 77955515871     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.12.018     Document Type: Article

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