Stereoselective inactivation of Torpedo californica acetylcholinesterase by isomalathion: Inhibitory reactions with (1R)- and (1S)-isomers proceed by different mechanisms

Chemical Research in Toxicology

Volumn 16, Issue 8, 2003, Pages 958-965

  Doorn, Jonathan A ^a,d   Thompson, Charles M ^b   Christner, Robert B ^c   Richardson, Rudy J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MONTANA   (United States)

^c CIPHERGEN BIOSYSTEMS INC   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; DIETHYLTHIOSUCCINYL DERIVATIVE; LIGAND; MALATHION; PHOSPHATE; PHOSPHORIC ACID DIMETHYL ESTER; PRALIDOXIME; PRALIDOXIME IODIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; HYPOTHESIS; ISOMER; MASS SPECTROMETRY; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ANALYSIS; TORPEDO CALIFORNICA;

ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; CHOLINESTERASE INHIBITORS; MALATHION; MASS SPECTROMETRY; MODELS, MOLECULAR; STEREOISOMERISM; TORPEDO;

ANIMALIA; TORPEDO; TORPEDO CALIFORNICA;

EID: 0042863406     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx030026e     Document Type: Article

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