Evaluation of medical countermeasures against organophosphorus compounds: The value of experimental data and computer simulations

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 259-264

  Worek, Franz ^a   Aurbek, Nadine ^a   Herkert, Nadja M ^a   John, Harald ^a   Eddleston, Michael ^b   Eyer, Peter ^c   Thiermann, Horst ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

AChE; Computer model; Organophosphorus compounds; Oximes; Reactivation

Indexed keywords

ACETYLCHOLINESTERASE; DIMETHOATE; OBIDOXIME; PRALIDOXIME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME KINETICS; EXPERIMENTAL STUDY; IN VITRO STUDY; INTOXICATION; MALE; MATHEMATICAL COMPUTING; MINIPIG; NONHUMAN; TOXICOKINETICS;

ANIMALIA;

EID: 77955514400     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.11.009     Document Type: Article

References (33)

1. Gunnell D., Eddleston M., Phillips M.R., Konradsen F. The global distribution of fatal pesticide self-poisoning: systematic review. BMC Public Health 2007, 7:357.
2. Newmark J. Nerve agents. Neurologist 2007, 13:20-32.
3. Heath A.J.W., Meredith T. Atropine in the management of anticholinesterase poisoning. Clinical and Experimental Toxicology of Organophosphates and Carbamates 1992, 543-554. Butterworth & Heinemann, Oxford. B. Ballantyne, T.C. Marrs (Eds.).
4. Eyer E., Oximes F.W. Chemical Warfare Agents: Toxicology and Treatment 2007, 305-329. John Wiley & Sons Ltd, Chichester. T.C. Marrs, R.L. Maynard, F.R. Sidell (Eds.).
5. Worek F., Eyer P., Aurbek N., Szinicz L., Thiermann H. Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis. Toxicol. Appl. Pharmacol. 2007, 219:226-234.
6. De Silva H.J., Wijewickrema R., Senanayake N. Does pralidoxime affect outcome of management in acute organophosphorus poisoning. Lancet 1992, 339:1136-1138.
7. Peter J.V., Moran J.L., Graham P. Oxime therapy and outcomes in human organophosphate poisoning: an evaluation using meta-analytic techniques. Crit. Care Med. 2006, 34:502-510.
8. Eddleston M., Szinicz L., Eyer P., Buckley N. Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials. Q. J. Med. 2002, 95:275-283.
9. Eddleston M., Eyer P., Worek F., Juszczak E., Alder N., Mohamed F., Senarathna L., Hittarage A., Azher S., Jeganathan K., Jayamanne S., von Meyer L., Dawson A.H., Sheriff M.H.R., Buckley N.A. Pralidoxime in acute organophosphorus insecticide poisoning-a randomised controlled trial. PLoS Med. 2009, 6:e1000104.
10. Eyer F., Worek F., Eyer P., Felgenhauer K., Haberkorn M., Zilker T., Thiermann H. Obidoxime in acute organophosphate poisoning: 1-Clinical effectiveness. Clin. Toxicol. 2009, 47:798-806.
11. Thiermann H., Szinicz L., Eyer F., Worek F., Eyer P., Felgenhauer N., Zilker T. Modern strategies in therapy of organophosphate poisoning. Toxicol. Lett. 1999, 107:233-239.
12. Holmstedt B. Pharmacology of organophosphorus cholinesterase inhibitors. Pharmacol. Rev. 1959, 11:567-688.
13. Worek F., Reiter G., Eyer P., Szinicz L. Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates. Arch. Toxicol. 2002, 76:523-529.
14. Luo C., Tong M., Chilukuri N., Brecht K., Maxwell D.M., Saxena A. An in vitro comparative study on the reactivation of nerve agent-inhibited guinea pig and human acetylcholinesterases by oximes. Biochemistry 2007, 46:11771-11779.
15. Luo C., Dawson M., Chambers C., Chilukuri N., Radic Z., Taylor P., Doctor B.P., Saxena A. Species-related differences in the oxime-induced reactivation of organophosphate-inhibited acetylcholinesterases. Chem. Biol. Interact. 2005, 157-158:393-394.
16. Eckert S., Eyer P., Mückter H., Worek F. Development of a dynamic model for real-time determination of membrane-bound acetylcholinesterase activity upon perfusion with inhibitors and reactivators. Biochem. Pharmacol. 2006, 72:358-365.
17. Eckert S., Eyer P., Herkert N., Bumm R., Weber G., Thiermann H., Worek F. Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin and paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity. Biochem. Pharmacol. 2008, 75:698-703.
18. Thiermann H., Szinicz L., Eyer P., Zilker T., Worek F. Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning. Chem. Biol. Interact. 2005, 157-158:345-347.
19. Worek F., Szinicz L., Eyer P., Thiermann H. Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model. Toxicol. Appl. Pharmacol. 2005, 209:193-202.
20. Eyer P., Radtke M., Worek F. Reactions of isodimethoate with human red cell acetylcholinesterase. Biochem. Pharmacol. 2008, 75:2045-2053.
21. Worek F., Aurbek N., Wetherell J., Pearce P., Mann T., Thiermann H. Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: pig versus minipig acetylcholinesterase. Toxicology 2008, 244:35-41.
22. Eyer P., Worek F., Kiderlen D., Sinko G., Stuglin A., Simeon-Rudolf V., Reiner E. Molar absorption coefficients for the reduced Ellman reagent: reassessment. Anal. Biochem. 2003, 312:224-227.
23. Worek F., Mast U., Kiderlen D., Diepold C., Eyer P. Improved determination of acetylcholinesterase activity in human whole blood. Clin. Chim. Acta 1999, 288:73-90.
24. Worek F., Thiermann H., Szinicz L., Eyer P. Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes. Biochem. Pharmacol. 2004, 68:2237-2248.
25. Worek F., Diepold C., Eyer P. Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics. Arch. Toxicol. 1999, 73:7-14.
26. H. John, M. Eddleston, F. Worek, H. Thiermann, Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI MS/MS and flow-injection ESI-MS/MS. J. Chromatogr. B, submitted.
27. Grasshoff C., Thiermann H., Gillessen T., Zilker T., Szinicz L. Internal standard high-performance liquid chromatography method for the determination of obidoxime in urine of organophosphate-poisoned patients. J. Chromatogr. B 2001, 753:203-208.
28. Eyer P., Szinicz L., Thiermann H., Worek F., Zilker T. Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality. Toxicology 2007, 233:108-119.
29. Eddleston M., Buckley N.A., Eyer P., Dawson A.H. Management of acute organophosphorus pesticide poisoning. Lancet 2008, 371:597-607.
30. Tsatsakis A.M., Manousakis A., Anastasaki M., Tzatzarakis M., Katsanoulas K., Delaki C., Agouridakis P. Clinical and toxicological data in fenthion and omethoate acute poisoning. J. Environ. Sci. Health B 1998, 33:657-670.
31. Pavlic M., Haidekker A., Grubwieser P., Rabl W. Fatal intoxication with omethoate. Int. J. Legal Med. 2002, 116:238-241.
32. Eyer F., Meischner V., Kiderlen D., Thiermann H., Worek F., Haberkorn M., Felgenhauer K., Zilker T., Eyer P. Human parathion poisoning: a toxicokinetic analysis. Toxicol. Rev. 2003, 22:143-163.
33. Thiermann H., Worek F., Eyer F., Eyer P., Felgenhauer K., Zilker T. Obidoxime in acute organophosphate poisoning: 2-PK/PD relationships. Clin. Toxicol. 2009, 47:807-813.