(26) Species-related differences in the oxime-induced reactivation of organophosphate-inhibited acetylcholinesterases

Chemico-Biological Interactions

Volumn 157-158, Issue , 2005, Pages 393-394

  Luo, Chunyuan ^a   Dawson, Maureen ^a   Chambers, Carolyn ^a   Chilukuri, Nageswararao ^a   Radić, Zoran ^b   Taylor, Palmer ^b   Doctor, Bhupendra P ^a   Saxena, Ashima ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acetyl cholinesterase; Guinea pig; Human; Organophosphate; Reactivation

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 7 (O,O DIETHYLPHOSPHINYLOXY) 1 METHYLQUINOLINIUM METHYLSULFATE; 7 [(ETHOXY)(METHYL)PHOSPHINOYLOXY] 1 METHYLQUINOLINIUM IODIDE; ACETYLCHOLINESTERASE; OBIDOXIME; ORGANOPHOSPHATE; OXIME; PRALIDOXIME; TRIMEDOXIME; UNCLASSIFIED DRUG; CHOLINESTERASE INHIBITOR; ORGANOPHOSPHORUS COMPOUND;

CHOLINESTERASE INHIBITION; CONFERENCE PAPER; ENZYME ACTIVATION; SPECIES DIFFERENCE; ANIMAL; ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; HUMAN; METABOLISM;

CAVIA PORCELLUS;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINESTERASE INHIBITORS; ENZYME ACTIVATION; HUMANS; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; SPECIES SPECIFICITY;

EID: 28744453341     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.10.071     Document Type: Conference Paper

References (2)

1. C. Luo, A. Saxena, M. Smith, G. Garcia, Z. Radic, P. Taylor, and B.P. Doctor Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium Biochemistry 38 1999 9937 9947
2. F. Worek, G. Reiter, P. Eyer, and L. Szinicz Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates Arch. Toxicol. 76 2002 523 529