Multifunctional role of His159 in the catalytic reaction of Serine palmitoyltransferase

Journal of Biological Chemistry

Volumn 284, Issue 23, 2009, Pages 15487-15495

  Shiraiwa, Yuka ^a   Ikushiro, Hiroko ^a,b   Hayashi, Hideyuki ^a,b  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION BAND; ACID CATALYST; AROMATIC AMINO ACID; CATALYTIC REACTIONS; DISSOCIATION CONSTANT; GLOBAL ANALYSIS; L-SERINE; QUINONOID INTERMEDIATES; SERINE PALMITOYLTRANSFERASE; SIDE REACTIONS; SYNTHASE; TIME-RESOLVED SPECTRA; WILD TYPES;

AMINATION; AMINES; AROMATIC COMPOUNDS; CATALYSIS; CATALYSTS; DISSOCIATION; ENZYMES; ORGANIC ACIDS; STEREOCHEMISTRY;

AMINO ACIDS;

ALANINE; HISTIDINE; PYRIDOXAL 5 PHOSPHATE; QUINONE DERIVATIVE; SERINE PALMITOYLTRANSFERASE; APOPROTEIN; PALMITOYL COENZYME A; RECOMBINANT PROTEIN; SERINE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CLAISEN CONDENSATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME MECHANISM; PRIORITY JOURNAL; PROTON TRANSPORT; RESIDUE ANALYSIS; STRUCTURE ACTIVITY RELATION; TRANSAMINATION; WILD TYPE; BINDING SITE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; KINETICS; METABOLISM; POLYMERASE CHAIN REACTION;

ALANINE; AMINO ACID SUBSTITUTION; APOPROTEINS; BINDING SITES; CATALYSIS; HISTIDINE; KINETICS; PALMITOYL COENZYME A; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; SERINE; SERINE C-PALMITOYLTRANSFERASE; SUBSTRATE SPECIFICITY;

EID: 67650106540     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808916200     Document Type: Article

References (20)

1. Hanada, K. (2003) Biochim. Biophys. Acta 1632, 16-30
2. Hayashi, H. (1995) J. Biochem. (Tokyo) 118, 463-473
3. Mehta, P. K., and Christen, P. (2000) Adv. Enzymol. Rel. Areas Mol. Biol. 74, 129-184
4. Salzmann, D., Christen, P., Mehta, P. K., and Sandmeier, E. (2000) Biochem. Biophys. Res. Commun. 270, 576-580
5. Schneider, G., Kack, H., and Lindqvist, Y. (2000) Structure 8, R1-R6
6. Eliot, A. C., and Kirsch, J. F. (2004) Annu. Rev. Biochem. 73, 383-415
7. Alexeev, D., Alexeeva, M., Baxter, R. L., Campopiano, D. J., Webster, S. P., and Sawyer, L. (1998) J. Mol. Biol. 284, 401-419
8. Hunter, G. A., and Ferreira, G. C. (1999) Biochemistry 38, 3711-3718
9. Webster, S. P., Alexeev, D., Campopiano, D. J., Watt, R. M., Alexeeva, M., Sawyer, L., and Baxter, R. L. (2000) Biochemistry 39, 516-528
10. Schmidt, A., Sivaraman, J., Li, Y., Larocque, R., Barbosa, J. A., Smith, C., Matte, A., Schrag, J. D., and Cygler, M. (2001) Biochemistry 40, 5151-5160
11. Astner, I., Schulze, J. O., van den Heuvel, J., Jahn, D., Schubert, W. D., and Heinz, D. W. (2005) EMBO J. 24, 3166-3177
12. Yard, B. A., Carter, L. G., Johnson, K. A., Overton, I. M., Dorward, M., Liu, H., McMahon, S. A., Oke, M., Puech, D., Barton, G. J., Naismith, J. H., and Campopiano, D. J. (2007) J. Mol. Biol. 370, 870-886
13. Ikushiro, H., Fujii, S., Shiraiwa, Y., and Hayashi, H. (2008) J. Biol. Chem. 283, 7542-7553
14. Ikushiro, H., Hayashi, H., and Kagamiyama, H. (2004) Biochemistry 43, 1082-1092
15. Ikushiro, H., Hayashi, H., and Kagamiyama, H. (2001) J. Biol. Chem. 276, 18249-18256
16. Valls, F., Sancho, M. T., Fernandez-Muino, M. A., and Checa, M. A. (2001) J. Agric. Food Chem. 49, 38-41
17. Hayashi, H., Mizuguchi, H., and Kagamiyama, H. (1993) Biochemistry 32, 812-818
18. Hädener, A., Alefounder, P. R., Hart, G. J., Abell, C., and Battersby, A. R. (1990) Biochem. J. 271, 487-491
19. Onuffer, J. J., and Kirsch, J. F. (1994) Prot. Eng. 7, 413-424
20. Hunter, G. A., Zhang, J., and Ferreira, G. C. (2007) J. Biol. Chem. 282, 23025-23035