Low-level exposure to HIV induces virus-specific T cell responses and immune activation in exposed HIV-seronegative individuals

Journal of Immunology

Volumn 185, Issue 2, 2010, Pages 982-989

  Restrepo, Clara ^a   Rallón, Norma I ^a   Del Romero, Jorge ^b   Rodríguez, Carmen ^b   Hernando, Victoria ^b   López, Mariola ^a   Peris, Alejandra ^a   Lozano, Sara ^a   Sempere Ortells, José M ^c   Soriano, Vincent ^a   Benito, José M ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b CENTRO SANITARIO SANDOVAL   (Spain)

^c UNIVERSITY OF ALICANTE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD38 ANTIGEN; CD45RA ANTIGEN; HLA DR ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; VIRUS RNA; CCL4 PROTEIN, HUMAN; GAMMA INTERFERON; MACROPHAGE INFLAMMATORY PROTEIN 1BETA;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; EXPOSED SERONEGATIVE; EXPOSURE; HIGH RISK BEHAVIOR; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOPHENOTYPING; PRIORITY JOURNAL; SEROLOGY; SEROPREVALENCE; SEXUAL BEHAVIOR; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; BLOOD; CYTOLOGY; FEMALE; FLOW CYTOMETRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MIDDLE AGED; SERODIAGNOSIS; T LYMPHOCYTE;

ADULT; ANTIGENS, CD38; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL4; FEMALE; FLOW CYTOMETRY; HIV; HIV INFECTIONS; HIV SERONEGATIVITY; HLA-DR ANTIGENS; HUMANS; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; T-LYMPHOCYTES;

EID: 77955496369     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000221     Document Type: Article

References (39)

1. Kulkarni, P. S., S. T. Butera, and A. C. Duerr. 2003. Resistance to HIV-1 infection: lessons learned from studies of highly exposed persistently seronegative (HEPS) individuals. AIDS Rev. 5: 87-103.
2. Jennes, W., B. Vuylsteke, M. Y. Borget, V. Traore-Ettiegne, C. Maurice, M. Nolan, J. N. Nkengasong, and L. Kestens. 2004. HIV-specific T helper responses and frequency of exposure among HIV-exposed seronegative female sex workers in Abidjan, Cote d'Ivoire. J. Infect. Dis. 189: 602-610.
3. Hladik, F., A. Desbien, J. Lang, L. Wang, Y. Ding, S. Holte, A. Wilson, Y. Xu, M. Moerbe, S. Schmechel, and M. J. McElrath. 2003. Most highly exposed seronegative men lack HIV-1-specific, IFN-gamma-secreting T cells. J. Immunol. 171: 2671-2683.
4. Makedonas, G., J. Bruneau, H. Lin, R. P. Sékaly, F. Lamothe, and N. F. Bernard. 2002. HIV-specific CD8 T-cell activity in uninfected injection drug users is associated with maintenance of seronegativity. AIDS 16: 1595-1602.
5. Salkowitz, J. R., S. F. Purvis, H. Meyerson, P. Zimmerman, T. R. O'Brien, L. Aledort, M. E. Eyster, M. Hilgartner, C. Kessler, B. A. Konkle, et al. 2001. Characterization of high-risk HIV-1 seronegative hemophiliacs. Clin. Immunol. 98: 200-211.
6. Clerici, M., J. M. Levin, H. A. Kessler, A. Harris, J. A. Berzofsky, A. L. Landay, and G. M. Shearer. 1994. HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood. JAMA 271: 42-46.
7. Hygino, J., P. G. Lima, R. G. Filho, A. A. Silva, C. S. Saramago, R. M. Andrade, D. M. Andrade, A. F. Andrade, R. Brindeiro, A. Tanuri, and C. A. Bento. 2008. Altered immunological reactivity in HIV-1-exposed uninfected neonates. Clin. Immunol. 127: 340-347.
8. Promadej, N., C. Costello, M. M. Wernett, P. S. Kulkarni, V. A. Robison, K. E. Nelson, T. W. Hodge, V. Suriyanon, A. Duerr, and J. M. McNicholl. 2003. Broad human immunodeficiency virus (HIV)-specific T cell responses to conserved HIV proteins in HIV-seronegative women highly exposed to a single HIV-infected partner. J. Infect. Dis. 187: 1053-1063.
9. Suy, A., P. Castro, M. Nomdedeu, F. García, A. López, E. Fumero, T. Gallart, L. Lopalco, O. Coll, J. M. Gatell, and M. Plana. 2007. Immunological profile of heterosexual highly HIV-exposed uninfected individuals: predominant role of CD4 and CD8 T-cell activation. J. Infect. Dis. 196: 1191-1201.
10. Schenal, M., S. Lo Caputo, F. Fasano, F. Vichi, M. Saresella, P. Pierotti, M. L. Villa, F. Mazzotta, D. Trabattoni, and M. Clerici. 2005. Distinct patterns of HIV-specific memory T lymphocytes in HIV-exposed uninfected individuals and in HIV-infected patients. AIDS 19: 653-661. (Pubitemid 40593070)
11. Lo Caputo, S., D. Trabattoni, F. Vichi, S. Piconi, L. Lopalco, M. L. Villa, F. Mazzotta, and M. Clerici. 2003. Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men. AIDS 17: 531-539. (Pubitemid 36293106)
12. Jennes, W., S. Sawadogo, S. Koblavi-Dème, B. Vuylsteke, C. Maurice, T. H. Roels, T. Chorba, J. N. Nkengasong, and L. Kestens. 2003. Cellular human immunodeficiency virus (HIV)-protective factors: a comparison of HIV-exposed seronegative female sex workers and female blood donors in Abidjan, Côte d'Ivoire. J. Infect. Dis. 187: 206-214.
13. Paxton, W. A., S. Kang, and R. A. Koup. 1998. The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression. AIDS Res. Hum. Retroviruses 14(Suppl 1): S89-92.
14. Furci, L., L. Lopalco, P. Loverro, M. Sinnone, G. Tambussi, A. Lazzarin, and P. Lusso. 2002. Non-cytotoxic inhibition of HIV-1 infection by unstimulated CD8+ T lymphocytes from HIV-exposed-uninfected individuals. AIDS 16: 1003-1008. (Pubitemid 34499423)
15. Quinn, T. C., M. J. Wawer, N. Sewankambo, D. Serwadda, C. Li, F. Wabwire-Mangen, M. O. Meehan, T. Lutalo, and R. H. Gray; Rakai Project Study Group. 2000. Viral load and heterosexual transmission of human immunodeficiency virus type 1. N. Engl. J. Med. 342: 921-929.
16. Furci, L., G. Scarlatti, S. Burastero, G. Tambussi, C. Colognesi, C. Quillent, R. Longhi, P. Loverro, B. Borgonovo, D. Gaffi, et al. 1997. Antigen-driven C-C chemokine-mediated HIV-1 suppression by CD4(+) T cells from exposed uninfected individuals expressing the wild-type CCR-5 allele. J. Exp. Med. 186: 455-460.
17. Skurnick, J. H., P. Palumbo, A. DeVico, B. L. Shacklett, F. T. Valentine, M. Merges, R. Kamin-Lewis, J. Mestecky, T. Denny, G. K. Lewis, et al. 2002. Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. J. Infect. Dis. 185: 428-438.
18. Pallikkuth, S., A. Wanchu, A. Bhatnagar, R. K. Sachdeva, and M. Sharma. 2007. Human immunodeficiency virus (HIV) gag antigen-specific T-helper and granule-dependent CD8 T-cell activities in exposed but uninfected heterosexual partners of HIV type 1-infected individuals in North India. Clin. Vaccine Immunol. 14: 1196-1202.
19. Suresh, P., A. Wanchu, A. Bhatnagar, R. K. Sachdeva, and M. Sharma. 2007. Spontaneous and antigen-induced chemokine production in exposed but uninfected partners of HIV type 1-infected individuals in North India. AIDS Res. Hum. Retroviruses 23: 261-268.
20. Koning, F. A., C. A. Jansen, J. Dekker, R. A. Kaslow, N. Dukers, D. van Baarle, M. Prins, and H. Schuitemaker. 2004. Correlates of resistance to HIV-1 infection in homosexual men with high-risk sexual behaviour. AIDS 18: 1117-1126.
21. Kebba, A., P. Kaleebu, S. Rowland, R. Ingram, J. Whitworth, N. Imami, and F. Gotch. 2004. Distinct patterns of peripheral HIV-1-specific interferon- gamma responses in exposed HIV-1-seronegative individuals. J. Infect. Dis. 189: 1705-1713.
22. Biasin, M., S. L. Caputo, L. Speciale, F. Colombo, L. Racioppi, A. Zagliani, C. Blé, F. Vichi, L. Cianferoni, A. M. Masci, et al. 2000. Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women. J. Infect. Dis. 182: 1365-1374.
23. Veazey, R., and and A. Lackner. 2003. The mucosal immune system and HIV-1 infection. AIDS Rev. 5: 245-252.
24. Reimann, J., and and R. Schirmbeck. 1999. Alternative pathways for processing exogenous and endogenous antigens that can generate peptides for MHC class Irestricted presentation. Immunol. Rev. 172: 131-152.
25. Bienzle, D., K. S. MacDonald, F. M. Smaill, C. Kovacs, M. Baqi, B. Courssaris, M. A. Luscher, S. L. Walmsley, and K. L. Rosenthal. 2000. Factors contributing to the lack of human immunodeficiency virus type 1 (HIV-1) transmission in HIV-1-discordant partners. J. Infect. Dis. 182: 123-132.
26. Kaul, R., T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, et al. 2001. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest. 107: 1303-1310.
27. Makedonas, G., J. Bruneau, M. Alary, C. M. Tsoukas, C. M. Lowndes, F. Lamothe, and N. F. Bernard. 2005. Comparison of HIV-specific CD8 T-cell responses among uninfected individuals exposed to HIV parenterally and mucosally. AIDS 19: 251-259.
28. Betts, M. R., M. C. Nason, S. M. West, S. C. De Rosa, S. A. Migueles, J. Abraham, M. M. Lederman, J. M. Benito, P. A. Goepfert, M. Connors, et al. 2006. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107: 4781-4789.
29. Yang, O. O., W. J. Boscardin, J. Matud, M. A. Hausner, L. E. Hultin, P. M. Hultin, R. Shih, J. Ferbas, F. P. Siegal, M. Shodell, et al. 2002. Immunologic profile of highly exposed yet HIV type 1-seronegative men. AIDS Res. Hum. Retroviruses 18: 1051-1065.
30. Koning, F. A., S. A. Otto, M. D. Hazenberg, L. Dekker, M. Prins, F. Miedema, and H. Schuitemaker. 2005. Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection. J. Immunol. 175: 6117-6122.
31. Bégaud, E., L. Chartier, V. Marechal, J. Ipero, J. Léal, P. Versmisse, G. Breton, A. Fontanet, C. Capoulade-Metay, H. Fleury, et al. 2006. Reduced CD4 T cell activation and in vitro susceptibility to HIV-1 infection in exposed uninfected Central Africans. Retrovirology 3: 35. (Pubitemid 44150948)
32. Bernard, N. F., C. M. Yannakis, J. S. Lee, and C. M. Tsoukas. 1999. Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons. J. Infect. Dis. 179: 538-547.
33. Barreiro, P., J. del Romero, M. Leal, V. Hernando, R. Asencio, C. de Mendoza, P. Labarga, M. Núñez, J. T. Ramos, J. González- Lahoz, and V. Soriano; Spanish HIV-Discordant Study Group. 2006. Natural pregnancies in HIV-serodiscordant couples receiving successful antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 43: 324-326.
34. Barreiro, P., J. A. Castilla, P. Labarga, and V. Soriano. 2007. Is natural conception a valid option for HIV-serodiscordant couples? Hum. Reprod. 22: 2353-2358.
35. Vernazza, P., B. Hirschel, E. Bernasconi, and M. Flepp. 2008. Les personnes séropositives ne souffrant d'aucune autre MST et suivant un traitment antirétroviral efficie ne transmettent pas le VIH par voie sexuelle. Bull Med Suisses 89: 165-169.
36. Kalichman, S. C., G. Di Berto, and L. Eaton. 2008. Human immunodeficiency virus viral load in blood plasma and semen: review and implications of empirical findings. Sex. Transm. Dis. 35: 55-60.
37. Marcelin, A. G., R. Tubiana, S. Lambert-Niclot, G. Lefebvre, S. Dominguez, M. Bonmarchand, D. Vauthier-Brouzes, F. Marguet, N. Mousset-Simeon, G. Peytavin, and C. Poirot. 2008. Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma. AIDS 22: 1677-1679.
38. Sheth, P. M., C. Kovacs, K. S. Kemal, R. B. Jones, J. M. Raboud, R. Pilon, C. la Porte, M. Ostrowski, M. Loutfy, H. Burger, et al; Toronto Mucosal Immunology Group. 2009. Persistent HIV RNA shedding in semen despite effective anti-retroviral therapy. AIDS 23: 2050-2054.
39. Wilson, D. P., M. G. Law, A. E. Grulich, D. A. Cooper, and J. M. Kaldor. 2008. Relation between HIV viral load and infectiousness: a model-based analysis. Lancet 372: 314-320.