Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women

Journal of Infectious Diseases

Volumn 182, Issue 5, 2000, Pages 1365-1374

  Biasin, Mara ^a   Lo Caputo, Sergio ^c   Speciale, Livianna ^b   Colombo, Fulvia ^a   Racioppi, Luigi ^e   Zagliani, Arianna ^a   Blé, Claudio ^c   Vichi, Francesca ^c   Cianferoni, Luciano ^d   Masci, Anna Maria ^e   Villa, Maria Luisa ^a   Ferrante, Pasquale ^b   Mazzotta, Francesco ^c   Clerici, Mario ^a  

^a Dipartimento di Immunologia   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UOC Malattie Infettive   (Italy)

^d SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOSTIMULATION; MONONUCLEAR CELL; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; SEXUAL TRANSMISSION; T LYMPHOCYTE ACTIVATION; UTERINE CERVIX MUCOSA;

CYTOKINES; FEMALE; GENITALIA, FEMALE; HIV SERONEGATIVITY; HUMAN; IMMUNITY, MUCOSAL; IMMUNOPHENOTYPING; INTERFERON TYPE II; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; RECEPTORS, CCR5; RECEPTORS, CXCR4; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES;

EID: 0033783606     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315873     Document Type: Article

References (56)

1. Immune responses in HIV-exposed seronegatives: Have they repelled the virus?
2. Protective immunity against HIV infection: Has nature done the experiment for us?
3. Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: Evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects
4. T cell responses to HIV in infected individuals with and without zidovudine therapy and in HIV exposed sexual partners
5. Cellular immune factors associated with mother-to-infant transmission of HIV
6. HIV-specific T helper activity in HIV seronegative health care workers accidentally exposed to HIV-contaminated blood
7. HIV-specific cytotoxic T cell activity in an HIV exposed but uninfected infant
8. Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to (HIV-1)-infected mothers
9. Cytotoxic T lymphocyte response in peripheral blood of children born to HIV-infected mothers
10. HIV nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV infected patients
11. Env-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids
12. HIV-specific cytotoxic T cells in HIV-exposed but uninfected Gambian women
13. Antigen-driven C-C chemokine-mediated HIV-1 suppression by CD4(+) T cells from exposed uninfected individuals expressing the wild-type CCR-5 allele
14. HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals
15. Correlates of HIV-1 specific mucosal IgA in a cohort of highly exposed, HIV-1 seronegative Kenyan sex workers
16. Epidemiologic and biologic characterization of a cohort of human immunodeficiency virus type 1 highly exposed, persistently seronegative female sex workers in northern Thailand
17. Mucosal IgA from HIV-exposed seronegative individuals neutralizes primary HIV-1 isolates
18. Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons
19. HIV-1 specific mucosal cytotoxic T lymphocyte responses in the cervix of HIV-1 resistant prostitutes in Nairobi
20. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures
21. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
22. HIV-1 resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene
23. The 641 allele of CCR2 delays HIV-I disease progression and is associated with a mutation within the CCR5 regulatory region
24. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
25. An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
26. Dynamics and modulation of HIV-1 transcripts in vitro and in vivo
27. Comparable biological and molecular determinants of HIV-1 infected long-term non-progressors and recently infected individuals
28. Interleukin-2 production used to detect antigenic peptide recognition of HIV synthetic peptides recognition by T helper lymphocytes from asymptomatic HIV-seropositive individuals
29. T cell antigenic sites tend to be amphipathic structures
30. Detection of cytotoxic T lymphocytes specific for synthetic peptides of gp160 in HIV-seropositive individuals
31. AIDS 4: Global data
32. Sexual transmission of human immunodeficiency virus: Virus entry into the male and female genital tract
33. Mucosal immunity, HIV transmission and AIDS
34. HIV-1 replication is controlled at the level of T cell activation and proviral integration
35. HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
36. Human immunodeficiency virus infection of cells arrested in the cell cycle
37. Activation of virus replication after vaccination of HIV-1 infected individuals
38. The in vitro induction of human immunodeficiency virus (HIV) replication in purified protein derivative-positive HIV-infected persons by recall antigen response to Mycobacterium tuberculosis is the result of a balance of the effects of endogenous interleukin-2 and proinflammatory and antiinflammatory cytokines
39. Interleukin-12: A cytokine at the interface of inflammation and immunity
40. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
41. The Th1-Th2 hypothesis of HIV infection: New insights
42. + cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12
43. Selective induction of protective MHC class I-restricted CTL in the intestinal lamina propria of rhesus monkeys by transient SIV infection of the colonic mucosa
44. Functional subsets of CD4 T cells in rheumatoid synovitis
45. Heterogeneity of rheumatoid arthritis: From phenotypes to genotypes
46. + T cells
47. Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response
48. Induction of MHC-class 1 restricted human suppressor T cells by peptide priming in vitro
49. - T cell populations
50. Interferon-gamma increases expression of chemokine receptors CCR1, CCR3, and CCR5, but not CXCR4 in monocytoid U937 cells
51. C-X-C and C-C chemokine expression and secretion by the human colonic epithelial cell line, HT-29: Differential effect of T lymphocyte-derived cytokines
52. Recent advances in chemokines and chemokine receptors
53. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
54. Enhanced HIV expression during Th2-oriented responses explained by the opposite regulatory effect of IL-4 and IFN-gamma of fusin/CXCR4