Design, synthesis, and biological evaluation of ketoprofen analogs as potent cyclooxygenase-2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 5855-5860

  Zarghi, Afshin ^a   Ghodsi, Razieh ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cyclooxygenase 2 inhibition; Ketoprofen analogs; Molecular modeling; Quinoline 4 carboxylic acid

Indexed keywords

2 [4 (ACETAMIDO)PHENYL] 6 BONZOYL QUINOLINE 4 CARBOXYLIC ACID; 2 [4 (ACETAMIDO)PHENYL] 8 BENZOYL QUINOLINE 4 CARBOXYLIC ACID; 2 [4 (AMINO)PHENYL] 6 BEZOYL QUINOLINE 4 CARBOXYLIC ACID; 2 [4 (AMINO)PHENYL] 8 BENZOYL QUINOLINE 4 CARBOXYLIC ACID; 2 [4 (AZIDO)PHENYL] 6 BENZOYL QUINOLINE 4 CARBOXYLIC ACID; 2 [4 (AZIDO)PHENYL] 8 BENZOYL QUINOLINE 4 CARBOXYLIC ACID; 6 BENZOYL 2 [4 (METHYLSULFONYL)PHENYL]QUINOLINE 4 CARBOXYLIC ACID; 6 BENZOYL 2[4 (METHYLTHIO)PHENYL]QUINOLINE 4 CARBOXYLIC ACID; 8 BENZOYL 2 [4 (METHYLSULFONYL)PHENYL]QUINOLINE 4 CARBOXYLIC ACID; 8 BENZOYL 2 [4 (METHYLTHIO)PHENYL]QUINOLINE 4 CARBOXYLIC ACID; ARGININE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ISOENZYME; KETOPROFEN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; EVALUATION; IC 50; MOLECULAR MODEL; PHARMACOPHORE; SUBSTITUTION REACTION;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; KETOPROFEN; MICE; MODELS, MOLECULAR; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955473892     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.094     Document Type: Article

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