Novel formulation of large hollow nanoparticles aggregates as potential carriers in inhaled delivery of nanoparticulate drugs

Industrial and Engineering Chemistry Research

Volumn 45, Issue 10, 2006, Pages 3697-3706

  Hadinoto, Kunn ^a   Phanapavudhikul, Ponpan ^a   Kewu, Zhu ^a   Tan, Reginald B H ^a,b  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CONCENTRATION (PROCESS); DRUG PRODUCTS; MORPHOLOGY; NANOSTRUCTURED MATERIALS; PARTICLE SIZE ANALYSIS; SUSPENSIONS (COMPONENTS);

DRUG DELIVERY; FLOWABILITY; HOLLOW CARRIER PARTICLES; NANOPARTICULATE DRUGS;

PHARMACODYNAMICS;

CONCENTRATION (PROCESS); DRUG PRODUCTS; MORPHOLOGY; NANOSTRUCTURED MATERIALS; PARTICLE SIZE ANALYSIS; PHARMACODYNAMICS; SUSPENSIONS (COMPONENTS);

EID: 33744539659     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie0513191     Document Type: Article

References (23)

1. Edwards, D. A. Delivery of Biological Agents by Aerosols. AlChE J. 2002, 48 (1), 2-6.
2. Heyder, J.; Gebhart, J.; Rudolf, G.; Schiller, C.; Stahlhofen, W. Deposition of Particles in the Human Respiratory Tract in the Size Range of 0.005-15 μm. J. Aerosol Sci. 1986, 17, 811-825.
3. Hardy, J. G.; Chadwick, T. S. Sustained Release of Drug Delivery to the Lungs. Clin. Pharmacokinet. 2000, 39, 1-4.
4. Edwards, D. A.; Hanes, J.; Caponetti, G.; Hrkach, J.; Ben-Jebria, A.; Eskew, M.; Mintzes, J.; Deaver, D.; Lotan, N.; Langer, R. Large Porous Particles for Pulmonary Drug Delivery. Science 1997, 276, 1868-1871.
5. Vanbever, R.; Mintzes, J.; Wang, J.; Nice, J.; Chen, D.; Batycky, R.; Langer, R.; Edwards, D. A. Formulation and Physical Characterization of Large Porous Particles for Inhalation. Pharm. Res. 1999, 16 (11), 1735-1742.
6. Dellamary, L.; Tarara, T.; Smith, D.; Woelk, C.; Adractas, A.; Costello, M.; Gill, H.; Weers, G. Hollow Porous Particles in Metered Dose Inhalers. Pharm. Res. 2000, 17 (2), 168-174.
7. Steckel, H.; Brandes, H. A Novel Spray-Drying Technique to Produce Low-Density Particles for Pulmonary Drug Delivery. Int. J. Pharm. 2004, 278, 187-195.
8. 2 as Antisolvent with Enhanced Mass Transfer. Ind. Eng. Chem. Res. 2001, 40, 3530-3539.
9. Dailey, L. A.; Kleemann, E.; Wittmar, M.; Gessler, T.; Schmehl, T.; Roberts, C.; Seeger, W.; Kissel, T. Surfactant-Free Biodegradable Nanoparticles for Aerosol Therapy Based on the Branched Polyesters, DEAPA-PVAL-g-PLGA. Pharm. Res. 2003, 20 (12), 2011-2020.
10. Kipp, J. E. The Role of Solid Nanoparticle Technology in the Parenteral Delivery of Poorly Water-Soluble Drugs. Int. J. Pharm. 2004, 284, 109-122.
11. Shargel, L.; Yu, A. B. Applied Biopharmaceutics and Pharmacokinetics, 4th Edition; McGraw-Hill: New York, 1999.
12. Lee, J. H. Drug Nano and Microparticles Processed into Solid Dosage Forms: Physical Properties. J. Pharm. Sci. 2003, 92 (10), 2057-2068.
13. Sham, J.; Zhang, Y.; Finlay, W. H.; Roa, W. H.; Lobenberg, R. Formulation and Characterization of Spray-Dried Powders Containing Nanoparticles for Aerosol Delivery to the Lung. Int. J. Pharm. 2004, 269, 457-467.
14. Dailey, L. A.; Schmehl, T.; Gessler, T.; Wittmar, M.; Grimminger, F.; Seeger, W.; Kissel, T. Nebulization of Biodegradable Nanoparticles: Impact of Nebulizer Technology and Nanoparticle Characteristics on Aerosol Features. J. Controlled Release 2003, 86, 131-144.
15. Tsapis, N.; Bennet, D.; Jackson, B.; Weitz, D. A.; Edwards, D. A. Trojan Particles: Large Porous Carriers of Nanoparticles for Drug Delivery. Proc. Natl. Acad. Sci. 2002, 99 (19), 12001-12005.
16. Tapolsky, G.; Li, Y.; Jiao, Y. Magnetically Targetable Particles Comprising Magnetic Components and Biocompatible Polymers for Site-Specific Delivery of Biologically Active Agents. World Patent No. WO 2005/025508 A2, 2005.
17. Phanapavudhikul, P.; Waters, J. A.; Ortiz, E. S. Para-Magnetic Composite Microparticles as Heavy Metal Ion-Exchangers. Eur. Cells Mater. 2002, 3 (Suppl. 2), 118-121.
18. Govender, T.; Stolnik, S.; Garnett, M. C.; Ilium, L.; Davis, S. S. PLGA Nanoparticles Prepared by Nanoprecipitation: Drug Loading and Release Studies of a Water Soluble Drug. J. Controlled Release 1999, 57, 171-185.
19. Tsapis, N.; Dufresne, E. R.; Sinha, S. S.; Riera, C. S.; Hutchinson, J. W.; Mahadevan, L.; Weitz, D. A. Onset of Buckling in Drying Droplets of Colloidal Suspensions. Phys. Rev. Lett. 2005, 94 (1), Art. No. 018302.
20. Iskandar, F.; Gradon, L.; Okuyama, K.; Control of the Morphology of Nanostructured Particles Prepared by the Spray Drying of a Nanoparticle Sol. J. Colloid Interface Sci. 2003, 265, 296-303.
21. Elversson, J.; Millqvist-Fureby, A.; Alderborn, G.; Elofsson, U. Droplet and Particle Size Relationship and Shell Thickness of Inhalable Lactose Particles during Spray Drying. J. Pharm. Sci. 2003, 92 (4), 900-910.
22. Hinds, W. C. Aerosol Technology, Wiley: New York, 1982.
23. Moon, W. S.; Chung, H. J.; Park, S. B.; Woo, S. I. Effects of Lead Acetate Concentration on the Droplet Size in Liquid Source Misted Chemical Decomposition. Thin Solid Films 2000, 358, 86-89.