Synthesis of methyl (±)-3,5-bis(substitutedmethyl)pyrrolidine-2- carboxylates: A convenient approach to proline-mimetics

Tetrahedron

Volumn 66, Issue 34, 2010, Pages 6797-6805

  Ferreira Da Costa, Joana ^a   Caamaño, Olga ^a   Fernández, Franco ^a   García Mera, Xerardo ^a   Midón, Pilar ^a   Rodríguez Borges, José Enrique ^b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Peptides; Proline mimetics; Pyrrolidine 2 carboxylates; Synthesis

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; METHYL 1 (TERT BUTOXYCARBONYL) 3,5 BIS [(4 PHENYL 1H 1,2,3 TRIAZOL 1 YL)METHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 3,5 BIS [[4 (2 NITROMETHYL)PHENYL] 1H 1,2,3 TRIAZOL 1 YLMETHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 3,5 BIS [[4 (4 HIDROXYMETHYL)PHENYL] 1H 1,2,3 TRIAZOL 1 YLMETHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 3,5 BIS(CYANOMETHYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 3,5 BIS(HYDROXYMETHYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 3,5 BIS(METHYLOXYMETHYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 3,5 BIS[[(METHYLSULFONYL)OXY]METHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 3,5 BIS[[(TERT BUTYLDIMETHYLSILYL)OXY]METHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 5 (HYDROXYMETHYL) 3 (ETHYLOXYMETHYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 5 (HYDROXYMETHYL) 3 (METHYLOXYMETHYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 5 (HYDROXYMETHYL) 3 [[(METHYLSULFONYL)OXY]METHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 (TERT BUTOXYCARBONYL) 5 [[(3,5 DINITROBENZOYL)OXY]METHYL] 3 (METHOXYMETHYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 BENZYL 3,5 [[BIS(METHYLSULFONYL)OXY]METHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 BENZYL 3,5 BIS[(4 PHENYLTRIAZOL) 1 YL METHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 BENZYL 3,5 BIS[[(4 TOLYLSULFONYL)OXY]METHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 BENZYL 3,5 BIS[[(TERT BUTYLDIMETHYLSILYL)OXY]METHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 BENZYL 5 (HYDROXYMETHYL) 3 [[(4 TOLYLSULFONYL)OXY]METHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 3 (AZIDOMETHYL) 1 BENZYL 5 (HYDROXYMETHYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 3,5 BIS(AZIDOMETHYL) 1 (TERT BUTOXYCARBONYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 3,5 BIS(AZIDOMETHYL) 1 BENZYLPYRROLIDINE 2 CARBOXYLATE; METHYL 3,5 BIS(AZIDOMETHYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 3,5 BIS(HYDROXYMETHYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 3,5 BIS[(4 PHENYL 1H 1,2,3 TRIAZOL 1 YL)METHYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 3,5 BIS[[(TERT BUTYLDIMETHYLSILYL)OXY]METHYL]PYRROLIDINE 2 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

EID: 77955468950     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.06.053     Document Type: Article

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