Bupivacaine uncouples the mitochondrial oxidative phosphorylation, inhibits respiratory chain complexes I and III and enhances ROS production: Results of a study on cell cultures

Mitochondrion

Volumn 10, Issue 5, 2010, Pages 487-496

  Cela, Olga ^a   Piccoli, Claudia ^a   Scrima, Rosella ^a   Quarato, Giovanni ^a   Marolla, Alessandra ^a   Cinnella, Gilda ^a   Dambrosio, Michele ^a   Capitanio, Nazzareno ^a  

^a UNIVERSITY OF FOGGIA   (Italy)

Author keywords

Complex I; Complex III; Local anesthetic; OXPHOS uncoupling; Reactive oxygen species; Respiratory chain inhibition

Indexed keywords

BUPIVACAINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL RESPIRATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PRIORITY JOURNAL;

ANIMALS; BUPIVACAINE; CELL LINE; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX III; HUMANS; MICE; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; UNCOUPLING AGENTS;

EID: 77955432346     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2010.05.005     Document Type: Article

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