Targeting the ICB2 site of the topoisomerase IIα promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 15, 2010, Pages 5553-5561

  Franks, Andrew ^a   Tronrud, Christopher ^a   Kiakos, Konstantinos ^b   Kluza, Jerome ^b   Munde, Manoj ^c   Brown, Toni ^a   MacKay, Hilary ^a   Wilson, W David ^c   Hochhauser, Daniel ^b   Hartley, John A ^b   Lee, Moses ^a  

^a HOPE COLLEGE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c GEORGIA STATE UNIVERSITY   (United States)

Author keywords

DNA; Gene expression; Minor groove binders; NF Y; Polyamides; Sequence specificity; Topoisomerase II

Indexed keywords

ANTINEOPLASTIC AGENT; DEOXYRIBONUCLEASE I; DNA TOPOISOMERASE; DNA TOPOISOMERASE II ALPHA; FORMAMIDO PYRROLE IMIDAZOLE PYRROLE H PIN POLYAMIDE; IMIDAZOLE DERIVATIVE; MONOMER; NUCLEAR FACTOR Y; POLYAMIDE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); FORMAMIDE DERIVATIVE; IMIDAZOLE; NYLON; TUMOR ANTIGEN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CELL NUCLEUS; CIRCULAR DICHROISM; COMPETITIVE INHIBITION; DNA BINDING; DNA DENATURATION; DNA FOOTPRINTING; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; GEL MOBILITY SHIFT ASSAY; GENE TARGETING; ISOTHERMAL TITRATION CALORIMETRY; LEUKEMIA CELL; MELANOMA CELL; NONHUMAN; PROMOTER REGION; SURFACE PLASMON RESONANCE; UPREGULATION; WESTERN BLOTTING; ANIMAL; BINDING SITE; CALORIMETRY; CELL LINE; CHEMISTRY; GENETICS; MOUSE; PROTEIN DENATURATION; SYNTHESIS; TRANSITION TEMPERATURE;

ANIMALS; ANTIGENS, NEOPLASM; BINDING SITES; CALORIMETRY; CELL LINE; CIRCULAR DICHROISM; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; FORMAMIDES; IMIDAZOLES; MICE; NYLONS; PROMOTER REGIONS, GENETIC; PROTEIN DENATURATION; PYRROLES; SURFACE PLASMON RESONANCE; TRANSITION TEMPERATURE; DNA TOPOISOMERASES, TYPE II;

EID: 77955430422     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.041     Document Type: Article

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