Microcirculation: Its significance in clinical and molecular medicine

Journal of Internal Medicine

Volumn 241, Issue 5, 1997, Pages 349-362

  Fagrell, B ^a   Intaglietta, M ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

clinical; microcirculation; molecular medicine; reperfusion; tumour

Indexed keywords

ARTICLE; CAPILLAROSCOPY; CAPILLARY PRESSURE; CHRONIC VEIN INSUFFICIENCY; DIABETIC MICROANGIOPATHY; HUMAN; LASER DOPPLER FLOWMETRY; LYMPHEDEMA; MICROCIRCULATION; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; TRANSCUTANEOUS OXYGEN MONITORING; TUMOR BLOOD FLOW;

EID: 0030958692     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.1997.125148000.x     Document Type: Article

References (118)

1. 2). J Perinat Med 1973; 1: 183-91.
2. Nilsson GE, Tenland T, Öberg PÅ. Evaluation of a laser Doppler flowmeter for measurement for tissue blood flow. IEEE Trans Biomed Eng 1980; 27: 597-604.
3. Bollinger A, Fagrell B. Clinical capillaroscopy - a guide to its use in clinical research and practice. Stuttgart: Hogrefe & Huber, 1990.
4. Fagrell B, Rosén L, Eriksson S-E. Comparison between a new computerised and an analogue video-photometric, cross-correlation technique for measuring capillary blood cell velocity in humans. Int J Microcirc: Clin Exp 1994; 14: 133-8.
5. Bollinger A, Jäger K, Roten A, Timeus Ch, Mahler F. Diffusion, pericapillary distribution and clearance of Na-fluorescein in the human nailfold. Pflügers Arch 1971; 382: 137-43.
6. Moneta G, Brülisauer M, Jäger K, Bollinger A. Infrared fluorescence video microscopy of skin capillaries with indocyanine green. Int J Microcirc: Clin Exp 1987; 6: 25-34.
7. Brüllisauer M, Bollinger A. Measurement of different human skin microvascular dimensions by combination of video microscopy with Na-fluorescein (NaF) and indocyanine green (ICG) in normals and patients with systemic sclerosis, Int J Microcirc: Clin Exp 1991; 10: 21-31.
8. Bollinger A, Jäger K, Sgier F, Seglias J. Fluorescence microlymphography. Circulation 1981; 64: 1195-1200.
9. Pfister G, Saesseli B, Hoffmann U. Geiger M, Bollinger A. Diameters of lymphatic capillaries in patients with different forms of primary lymphedema. Lymphology 1990; 23: 140-44.
10. Intaglietta M, Pawula RF, Tompkins WR. Pressure measurements in the mammalian microvasculature. Microvasc Res 1970; 2: 212-15.
11. Mahler F, Muheim MH, Intaglietta M, Bollinger A, Anliker M. Blood pressure fluctuations in human nailfold capillaries. Am J Physiol 1979; 236: H888-93.
12. Spiegel M, Vest B, Shore A et al. Lymphatic capillary pressure in patients with primary lymphedema. Microvasc Res 1993; 46: 128-34.
13. Bongard O, Bounameaux H, Fagrell B. Effects of oxygen inhalation on skin microcirculation in patients with peripheral arterial occlusive disease. Circulation 1992; 86: 878-86.
14. Riva C, Ross B, Benedek GB. Laser Doppler measurements of blood flow in capillary tubes and retinal arteries. Invest Ophthalmol 1972; 11: 936-44.
15. Holloway GA, Watkins DW. Laser Doppler measurement of cutaneous blood flow. J Invest Dermatol 1977; 69: 306-9.
16. Lefant C. Integrative physiology: You must plant trees before you can harvest a forest. The Physiologist 1996; 39: 1.
17. Parving H-H, Viberti GC, Keen H, Christiansen JS, Lassen NA. Hemodynamic factors in the genesis of diabetic microangiopathy. Metabolism 1983; 32: 943-9.
18. Williams SA, Wassermann S, Rawlinson DW et al. Dynamic measurement of human capillary blood pressure. Clin Sci 1988; 74: 507-12.
19. Sandemann DD, Shore AC, Tooke JE. Relation of skin capillary pressure in patients with insulin-dependent diabetes mellitus to complications and metabolic control. N Engl J Med 1992; 327: 760-64.
20. Tooke JE. The nature and consequences of microvascular disease in diabetes mellitus. In: Schwartz CJ, Born GVR, eds. New Horizons in diabetes mellitus and cardiovascular disease. London: Science Press, 1995: 139-45.
21. Shore AC, Jaap AJ, Tooke JE. Capillary pressure in insulin dependent diabetic patients of long disease duration with and without microangiopathy. Diabetic Med 1992; 9 (suppl 2): S11.
22. Mathiesen ER, Hommel E, Giese J, Parving H-H. Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminaria. BMJ 1991; 303: 81-7.
23. Jaap AJ, Tooke JE. The pathophysiology of microvascular disease in non-insulin-dependent diabetes. Clin Sci 1995; 89: 3-12.
24. Shore AC, Jaap AJ, Tooke JE. Capillary pressure in patients with NIDDM. Diabetes 1994; 43: 1198-202.
25. Jaap AJ, Shore AC, Tooke JE. Capillary filtration coefficient in Type 2 (non-insulin dependent diabetes). J Diab Comp 1994; 8: 111-16.
26. Sandemann DD, Pym CA, Green EM et al. Microvascular vasodilatation in feet of newly diagnosed non-insulin dependent diabetic patients. BMJ 1991; 302: 1122-3.
27. Jaap AJ, Hammersley MS, Shore AC, Tooke JE. Reduced microvascular hyperaemia in subjects at risk of developing type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1994; 37: 214-16.
28. Jaap AJ, Donohoe M, Shore AC, Tooke JE. Limited microvascular vasodilation in patients with acromegaly. J Endocrinol 1993; 137 (suppl): P45.
29. Jaap AJ, Shore AC, Tooke JE. Relationship of insulin resistance and β-cell dysfunction to reduced microvascular hyperaemia in subjects with impaired glucose tolerance. Diabetic Med 1995; 44: 114A.
30. Jörneskog G, Brismar K, Fagrell B. Low molecular weight heparin seems to improve the capillary circulation and healing of chronic foot ulcers in diabetic patients. VASA 1993; 22: 137-42.
31. Jörneskog G, Brismar K, Fagrell B. Skin capillary circulation is more impaired in the toes of diabetic than non-diabetic patients with peripheral vascular disease. Diabetic Med 1995; 12: 36-41.
32. Jörneskog G, Brismar K, Fagrell B. Skin capillary circulation is severely impaired in toes of patients with IDDM, with and without late diabetic complications. Diabetologia 1995; 38: 474-80.
33. Jörneskog G, Fagrell B. Discrepancy in skin capillary circulation between fingers and toes in patients with type 1 diabetes. Int J Microcirc 1996; 16: 313-19.
34. Bollinger A, Frey J, Jäger K et al. Patterns of diffusion through skin capillaries in patients with long term diabetes. N Engl J Med 1982; 307: 1305-10.
35. Williams SA, MacGregor GA, Smaje LH, Wasserman SM, Tooke JE. Capillary hypertension and abnormal pressure dynamics in patients with essential hypertension. Clin Sci 1990; 79 (supp 1): 5-8.
36. Shore AC, Tooke JE. Microvascular function in human essential hypertension. J Hypertens 1994; 12: 717-28.
37. Duprez D, de Buyzere M, de Backer T et al. Impaired microcirculation in mild-to-moderate essential arterial hypertension. J Hypertens 1992; 10: 251-4.
38. Lemne C, de Faire U, Fagrell B. Mental stress induces different reactions in nutritional and themoregulatory human skin microcirculation: a study in borderline hypertensives and normotensives. J Human Hypertens 1994; 8: 559-63.
39. Tonnesen KH. Transcutaneous oxygen tension in imminent foot gangrene. Acta Anaesthesiol Scand 1978; 68 (suppl): 107-10.
40. Matsen FA, Wyss CR, Pedegana LR et al. Transcutaneous oxygen tension measurement in peripheral vascular disease. Surg Gynecol Obstet 1980; 150: 525-8.
41. 2 measurements in health and peripheral arterial occlusive disease. Surgery 1982; 91: 156-63.
42. 2 in normal subjects and in patients suffering from severe arterial occlusive disease. Clin Physiol 1984; 4: 393-401.
43. Kram HB, White RA, Tabrisky J et al. Transcutaneous oxygen recovery and toe pulse reappearance time in the assessment of peripheral vascular disease. Circulation 1985; 72: 1022-7.
44. Slagsvold CE, Kvernebo K, Stranden E, Kroese A. Postischemic transcutaneous oxygen tension response in assessment of peripheral atherosclerosis. Vasc Surg 1988; 102: 102-9.
45. 2 measurement. J Bone Joint Surg (Br) 1988; 70: 465-7.
46. 2 changes as a predictor of amputation level. J Vasc Surg 1985; 2: 220-7.
47. del Guercio R, Leonardo G, Arpaia MR. Evaluation of postischemic hyperemia on the skin using laser Doppler velocimetry: Study on patients with dadicatio intermittens. Microvasc Res 1986; 32: 289-99.
48. Bongard O, Fagrell B. Discrepancies between total and nutritional skin microcirculation in patients with peripheral arterial occlusive disease (PAOD). VASA 1990; 19: 105-11.
49. Seifert H, Jäger K, Bollinger A. Analysis of flow motion by the laser Doppler technique in patients with peripheral arterial occlusive disease. Int J Microcir 1988; 7: 223-36.
50. Creutzig A, Caspary L, Hertel RF, Alexander K. Temperature dependent laser Doppler fluximetry in healthy and patients with peripheral arterial occlusive disease. Int J Microcirc 1987; 6: 381-90.
51. Östergren J, Schöps P, Fagrell B. Evaluation of a laser Doppler multiprobe for detecting skin microcirculatory disturbances in patients with obliterative arteriosclerosis. Int Angiol 1988; 7: 37-41.
52. Schaeffler A, Rieger H. Spontaneous oscillations of laser Doppler skin blood flux in peripheral arterial occlusive disease. Int J Microcirc 1992; 11: 249-61.
53. Hoffmann U, Franzeck U, Bollinger A. Low frequency oscillations of skin blood flux in peripheral arterial occlusive disease. VASA 1994: 23: 120-4.
54. Karantilian RG, Lynch TG, Zirul VT et al. The value of laser Doppler velocimetry and transcutaneous oxygen tension determination in predicting healing of ischemic forefoot ulcerations and amputations in diabetic and nondiabetic patients. Vasc Surg 1986; 4: 511-16.
55. 2 and laser Doppler flow signal on intraarterial infusion of PGE1 and nucleotide phosphates in patients with peripheral arterial occlusive disease. VASA 1987; suppl 17: 17-22.
56. Fagrell B. Vital capillary microscopy - a clinical method for studying changes of the nutritional skin capillaries in legs with arteriosclerosis obliterans. Scand J Clin Lab Invest 1973; suppl 133.
57. Fagrell B, Lundberg G. A simplified evaluation of vital capillary microscopy for predicting skin viability in patients with severe arterial insufficiency. Clin Physiol 1984; 4: 403-11.
58. Schwartz RW, Freedman AM. Richardson DR et al. Capillary blood flow: video densitometry in the atherosclerotic patient. J Vasc Surg 1984; 1: 800-8.
59. Morris-Jones W, Preston E, Greaney M, Duleep K. Gangrene of the toes with palpable peripheral pulses. Ann Surg 1981; 193: 462-6.
60. Arnoldi CC, Linderholm H. On the pathogenesis of the venous leg ulcer. Acta Chir Scand 1968; 134: 427-40.
61. Fagrell B. Local microcirculation in chronic venous incompetence and leg ulcers. Vasc Surg 1979; 13: 217-25.
62. Fagrell B. Microcirculatory disturbances - the final cause for venous leg ulcers? VASA 1982; 11: 101-3.
63. Haselbach P, Vollenweider U, Moneta G, Bollinger A. Microangiopathy in severe chronic venous insufficiency evaluated by fluorescence video-microscopy. Phlebology 1986; 1: 159-69.
64. Franzeck UK, Bollinger A, Huch R, Huch A. Transcutaneous oxygen tension and capillary morphologic characteristics and density in patients with chronic venous incompetence. Circulation 1984; 40: 806-11.
65. Burnard KG, Whimster I, Naido A, Browse NL. Pericapillary fibrin in the ulcer-bearing skin of the leg: the cause of lipodermatosclerosis and venous ulcerations. BMJ 1982; 285: 1071-2.
66. Leu AJ, Yanar A, Pfister G, Franzeck U, Bollinger A. Mikroangiopathie bei chronisher venöser Insuffizienz. Dtsch Med Wochenschr 1991; 116: 447-53.
67. 2 and laser Doppler blood flow measurements in 40 patients with venous leg ulcers. Acta Dermatol Venereol 1987; 67: 160-82.
68. 2 measurements. VASA 1988; 17: 259-61.
69. 2 diffusion block? VASA 1991; 20: 142-6.
70. Michel CC. Oxygen diffusion in oedematous tissue and through pericapillary cuffs. Phlebology 1990; 5: 223-30.
71. Coleridge Smith PD, Thomas P, Scurr JH, Dormandy JR. Causes of venous ulceration: a new hypothesis. BMJ 1988; 296: 1726-7.
72. Cheate TR, McMullin GM, Farrah J, Coleridge Smith P, Scurr JH. Skin damage in chronic venous insufficiency: does an oxygen diffusion barrier really exist? J R Soc Med 1990; 83: 493-4.
73. Kolari PJ, Pekanmäki K. Effects of intermittent compression treatment on skin perfusion and oxygenation in lower legs with venous ulcers. VASA 1987; 16: 312-17.
74. Bollinger A, Jäger K, Sgier F, Seglias J. Fluorescence microlymphography. Circulation 1981; 64: 1195-1200.
75. Bollinger A, Jäger K, Siegenthler W. Microangiopathy of progressive systemic sclerosis, evaluation by dynamic fluorescence video microscopy. Arch Int Med 1986; 146: 1541-5.
76. Bollinger A, Saesseli B, Hoffmann U, Franzeck UK. Intravital detection of skin capillary anerysms by Videomicroscopy with indocyaninen green in patients with progressive systemic sclerosis and related disorders. Circulation 1991; 83: 546-51.
77. Beardsley T. Trends in cancer epidemiology: a war not won. Scient Am 1994; 270: 118-126.
78. Jain RK. Barriers to Drug Delivery in Solid Tumors. Sci Am 1994; 271: 58-65.
79. Folkman J. Tumor angiogenesis. In: Holland JF et al., eds. Cancer Medicine. Philadelphia: Lea & Febiger, 1993.
80. Jain RK. 1995 Whitaker Lecture: delivery of molecules, particles and cells to solid tumors. Ann Biomed Eng 1996 ;24: 457-73.
81. Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK. Time dependent behavior of interstitial pressure in solid tumors: Implication for drug delivery. Cancer Res 1995; 55: 5451-8.
82. Eskey CJ, Koretsky AP, Domach MM, Jain RK. 2H NMR imaging of tumor blood flow: spatial and temporal heterogeneity in tissue-isolated mammary adenocarcinoma. Cancer Res 1992; 52: 6010-19.
83. Martin GR, Jain RK. Non-invasive measurement of perivascular ph profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. Cancer Res 1994; 54: 5670-74.
84. 2 profiles in a human tumor in SCID mice. Proc Natl Acad Sci 1994; 91: 2081-5.
85. Eskey CJ, Koretsky AP, Domach MM, Jain RK. Role of oxygen versus glucose in energy metabolism in a mammary carcinoma perfused ex vivo: Direct measurement by 31p NMR. Proc Natl Acad Sci 1993; 90: 2646-50.
86. Young JS, Lumsden CE, Stalker AL. The significance of the tissue pressure of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit. J Pathol Bacteriol 1950; 62: 313-313.
87. Gullino PM, Clark SH, Grantham FH. The interstitial fluid of solid tumors. Cancer Res 1964; 24: 780-97.
88. Jain RK, Baxter LT. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure. Cancer Res 1988; 48: 7022-32.
89. Boucher Y, Baxter LT, Jain RJ. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: Implications for therapy. Cancer Res 1990; 50: 4478-84.
90. Boucher Y, Kirkwood JM, Opacid D, Desantis M, Jain RK. Interstitial hypertension in superficial metastatic melanomas in humans. Cancer Res 1991; 51: 6691-4.
91. Roh HD, Boucher Y, Kainick S et al. Interstitial hypertension in carcinoma of uterine cervix in patients: Possible correlation with tumor oxygenation and radiation response. Cancer Res 1991; 51: 6695-8.
92. Boucher Y, Jain RK. Microvascular pressure is the principal driving force for interstitial hypertension solid tumors: implication for vascular collapse. Cancer Res 1992; 52: 5110-14.
93. Less JR, Posner MC, Boucher Y et al. Interstitial hypertension head and neck tumors in patients: Correlation with tumor size. Cancer Res 1992; 52: 1993-5.
94. Gutmann R, Leunig M, Feyh J et al. Interstitial hypertension in head and neck tumors in patients: correlation with tumor size. Cancer Res 1992; 52: 1993-5.
95. DiResta GR, Lee J, Larson SM, Arbit E. Characterization of neuroblastoma xenograft in rat flank. I. Growth, interstitial fluid pressure and interstitial fluid velocity distribution profile. Microvasc Res 1993; 46: 158-177.
96. Curti BD, Urba WJ, Alvord WG, Janik JE. Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: Changes during treatment. Cancer Res 1993; 53: 2204-7.
97. Nathanson DS, Nelson L. Interstitial fluid pressure in breast cancer, benign breast conditions and breast parenchyma. Ann Surg Oncol 1994; 1: 333-8.
98. Gullino PM, Grantham F. Studies on the exchange of fluids between host and tumor. I. A method for growing tissue-isolated tumors in laboratory animals. J Natl Cancer Inst 1961; 27: 679-93.
99. Butler TP, Grantham FH, Gullino PM. Bulk transfer of fluid in the interstitial compartment of mammary tumors. Cancer Res 1975; 35: 3084-8.
100. Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK. Effect of transvascular fluid exchange on arterio-venous pressure relationship: Implication for temporal and spatial heterogenities in tumor blood flow. Microvasc Res 1996; 1: 27-16.
101. Jain RK, Boucher Y, Stacy-Clear A, Moore R, Kopans D. Method for locating tumors prior to needle biopsy. US patent number 5.396,897, March 14, 1995.
102. Jain RK, Koenig G, Dellian M et al. Leukocyte-endothelial adhesion and angiogenesis in tumors. Cancer Metastasis Rev 1996; 15: 195-204.
103. Jain RK. Delivery of molecular medicine to solid tumors. Science 1996; 271: 1079-80.
104. Winslow RM. Hemoglobin-based red cell substitutes. Baltimore: Johns Hopkins University Press, 1992.
105. Tsai AG, Kerger H, Intaglietta M. Microcirculatory consequences of blood substitution with aa-Hemoglobin. In: Winslow RM. Vandegriff, Intaglietta M, eds. Blood substitutes: physiological basis of efficacy. Boston: Birkhaüser. 1995; 155-74.
106. Vandegriff KD, Winslow RM. A theoretical analysis of oxygen transport: A new strategy for the design of hemoglobin-based red cell substitutes. In: Winslow RM. Vandegriff. Intaglietta M, eds. Blood substitutes: physiological basis of efficacy. Boston: Birkhaüser, 1995; 143-54.
107. Migita RA, Gonzales A, Gonzales M, Vandegriff KD, Winslow RM. Blood volume and cardiac index in rats following 50% isovolemic exchange transfusion with hemoglobin-based oxygen carrier. J Appl Physiol 1996, in press.
108. Winslow RM. Blood substitute oxygen carrier designed for clinical applications. In: Winslow RM, Vandegriff, Intaglietta M, eds. Blood substitutes: physiological basis of efficacy. Boston: Birkhaüser, 1995; 60-73.
109. Suit H. Tumor oxygenation and radiosensitivity. In: Winslow RM, Vandegriff, Intaglietta M, eds. Blood substitutes: physiological basis of efficacy. Boston; Birkhauser, 1995; 1187-99.
110. Winslow RM. Blood substitutes: a moving target. Nature Med 1995; 11: 1212-15.
111. Land W, Messmer K. The impact of ischemia/reperfusion injury on specific and non-specific, early and late chronic events after organ transplantation. Transplant Rev 1996; 10: 108-27.
112. Messmer K, Menger MD, Land W, eds. Microcirculation in organ transplantation. Basel: Karger, 1995.
113. Menger MD, Lehr HA, Messmer K. Role of oxygen radicals in the microcirculation manifestations of post-ischemic injury. Klin Wochenschr 1991; 69: 1050-5.
114. Land W, Schneeberger H, Schleibner ST. The beneficial effect of human recombinant Superoxide dismutase on both acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation 1994; 57: 211-17.
115. Gmaz-Nikulin E, Nikulin A, Plamenac P, Hegewald G. Gaon D. Pancreatic lesions in shock and their significance. J Pathol 1981; 135: 223-36.
116. Steinberg W, Tenner S. Acute pancreatitis. N Enlg J Med 1994; 330: 1198-210.
117. Hoffmann TF, Leiderer R, Waldner H, Arbogast S. Messmer K. Ischemia reperfusion of the pancreas: a new in vivo model for acute pancreatitis in rats. Res Exp Med 1995; 195: 125-44.
118. Hoffmann TF, Leiderer R, Waldner H, Messmer K. Bradykinin antagonists HOE-140 and CP-059 7 diminish microcirculatory injury after ischaemia-reperfusion of the pancreas in rats. Br J Surg 1996; 83: 189-95.