Peptide deformylase inhibitors with retro-amide scaffold: Synthesis and structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4317-4319

  Lee, Seung Kyu ^a   Choi, Kwang Hyun ^a   Lee, Sang Jae ^a   Suh, Se Won ^a   Kim, B Moon ^a   Lee, Bong Jin ^a  

^a Seoul National University   (South Korea)

Author keywords

Antibacterial; PDF; Retro amide; SAR

Indexed keywords

ACTINONIN; ALANINE; CYCLOBUTYLMETHYL; CYCLOPENTYLMETHYL; CYCLOPENYLETHYL; CYCLOPROPYLMETHYL; I LEUCINE; I PENTYL; I PROPYL; LEUCINE; PEPTIDE DEFORMYLASE INHIBITOR; PHENYL GROUP; PHENYLALANINE; PROLINE; T LEUCINE; THIOPHENE 2 YL; UNCLASSIFIED DRUG; VALINE;

ALKYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HAEMOPHILUS INFLUENZAE; IC 50; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; NONHUMAN; STREPTOCOCCUS PNEUMONIA; STRUCTURE ACTIVITY RELATION;

AMIDES; AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLOPENTANES; ENZYME INHIBITORS; HYDROXAMIC ACIDS; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP;

HAEMOPHILUS INFLUENZAE; MORAXELLA CATARRHALIS; STREPTOCOCCUS PNEUMONIAE;

EID: 77955422780     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.088     Document Type: Article

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