Topical application of ketoconazole stimulates hair growth in C3H/HeN mice

Journal of Dermatology

Volumn 32, Issue 4, 2005, Pages 243-247

  Jiang, Ju ^a   Tsuboi, Ryoji ^b   Kojima, Yuko ^c   Ogawa, Hideoki ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

Antiandrogen; Antifungal; Hair growth; Ketoconazole; Mouse

Indexed keywords

ANTIANDROGEN; ANTIFUNGAL AGENT; KETOCONAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCULATION; CONTROLLED STUDY; DANDRUFF; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; HAIR GROWTH; MALE; MALE TYPE ALOPECIA; MOUSE; MOUSE STRAIN; NONHUMAN; PHOTOGRAPHY; QUANTITATIVE ANALYSIS; SEBORRHEIC DERMATITIS;

EID: 19744363022     PISSN: 03852407     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2005.tb00756.x     Document Type: Article

References (23)

1. Van Custem J: The antifungal activity of ketoconazole, Am J Med, 74: 9-15, 1983.
2. Van Gerven F, Odds FC: The anu-Malassezia furfur activity in vitro and in experimental dermatitis of six imidazole antifungal agents: bifonazole, clotrimazole, flutrimazole, ketoconazole, miconazole and sertaconazole, Mycoses, 38: 389-393, 1995.
3. KCZ Cream Research Group (Takahashi H, et al.): Clinical evaluation of 2% ketoconazole cream in superficial mycoses, The Clinical Report, 25: 4609-4625, 1991. (in Japanese)
4. Nakabayashi A: Identification of causative species in Malassezia-associated dermatoses, Nippon Ishinkin Gakkai Zasshi, 43: 65-68, 2002. (in Japanese)
5. Skinner RB, Noah PW, Taylor RM, et al: Double-blind treatment with 2% ketoconazole cream, J Am Acad Dermatol, 12: 852-856, 1985.
6. Green CA, Farr PM, Shuster S: Treatment of seborrhoeic dermatitis with ketoconazole: II. Response of seborrhoeic dermatitis of the face, scalp and trunk to topical ketoconazole, Br J Dermatol, 116: 217-221, 1987.
7. KCZ Cream Research Group (Harada S, et al.): Clinical effect of KCZ (ketoconazole) cream on seborrheic dermatitis, J Clin Ther Med, 10: 1277-1290, 1994. (in Japanese)
8. Stratigos JD, Antoniou C, Katsambas A, et al: Ketoconazole 2% cream versus hydrocortisone 1% cream in the treatment of seborrheic dermatitis: A double-blind comparative study, J Am Acad Dermatol, 19: 850-853, 1988.
9. Katsambas A, Antoniou CH, Frangouli E, Avgerinou G, Michailidis D, Stratigos J: A double-blind trial of treatment of seborrheic dermatitis with 2% ketoconazole cream compared with 1% hydrocortisone cream, Br J Dermatol, 121: 353-357, 1989.
10. Igarashi A, Harada S, Toda K: A randomized comparison of ketoconazole lotion and ketoconazole cream for the treatment of seborrheic dermatitis, J Clin Ther Med, 19: 355-369, 2003. (in Japanese)
11. Danby FW, Maddin WS, Margesson LJ, Rosenthal D: A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff, J Am Acad Dermatol, 29: 1008-1012, 1993.
12. Peter RU, Richarz-Barthauer U: Successful treatment and prophylaxis of scalp seborrhoeic dermatitis and dandruff with 2% ketoconazole shampoo: Results of a multicentre, double-blind, placebo-controlled trial, Br J Dermatol, 132: 441-445, 1995.
13. Pierard-Franchimont C, De Doncker P, Cauwenbergh G, et al: Ketoconazole shampoo: Effect of long-term use in androgenic alopecia, Dermatology, 196: 474-477, 1998.
14. Khandpur S, Suman M, Reddy BM: Comparative efficacy of various treatment regimens for androgenic alopecia in men, J Dermatol, 29: 489-498, 2002.
15. Ogawa H, Hattori M: Regulation mechanisms of hair growth, in Seiji M, Bernstein IA (eds): Normal and Abnormal Epidermal Differentiation, University of Tokyo Press, Tokyo, 1983, pp 159-170.
16. Sonino N: The use of ketoconazole as an inhibitor of steroid production, N Engl J Med, 317: 812-818, 1987.
17. Shaw JC: Antiandrogen therapy in dermatology, Int J Dermatol, 35: 770-778, 1996.
18. Vidal-Puig AJ, Munoz-Torres M, Jodar-Gimeno E, et al: Ketoconazole therapy: hormonal and clinical effects in non-tumoral hyperandrogenism, Eur J Endocrinol, 130: 333-338, 1994.
19. Perez H: Ketoconazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men, Med Hypotheses, 62: 112-115, 2004.
20. Beetens JR, Loots W, Somers Y, et al: Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo, Biochem Pharmacol, 35: 883-891, 1986.
21. Brown M, Evans TW, Poyner T, et al: The role of ketoconazole 2% shampoo in the treatment and prophylactic management of dandruff, J Dermatol Treat, 1: 177-179, 1990.
22. Yoshimura T, Kudoh K, Aiba S, Tagami H: Anti-inflammatory effects of topical ketoconazole for the inflammation induced on the skin of hairless guinea-pigs by repeated applications of heat-killed spores of Malassezia furfur. A comparative study with hydrocortisone l7-butyrate, J Dermatol Treat, 6: 113-116, 1995.
23. Pierard GE, Pierard-Franchimont C, Nikkeles-Tassoudji N, et al: Improvement in the inflammatory aspect of androgenic alopecia: A pilot study with antimicrobial lotion, J Dermatol Treat, 7: 153-157, 1996.