-
1
-
-
0035884231
-
The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
-
Arteaga CL. 2001. The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol, 19(18 Suppl):32S-40S.
-
(2001)
J Clin Oncol
, vol.19
, Issue.18 SUPPL.
-
-
Arteaga, C.L.1
-
2
-
-
0034744243
-
Angiogenesis and cancer metastasis: Antiangiogenic therapy of human pancreatic adenocarcinoma
-
Baker CH, Solorzano CC, et al. 2001. Angiogenesis and cancer metastasis: antiangiogenic therapy of human pancreatic adenocarcinoma. Int J Clin Oncol, 6:59-65.
-
(2001)
Int J Clin Oncol
, vol.6
, pp. 59-65
-
-
Baker, C.H.1
Solorzano, C.C.2
-
3
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G, Song S, et al. 2003. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest, 111:1287-95.
-
(2003)
J Clin Invest
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
-
4
-
-
51749121946
-
A phase II study of docetaxel in combination with ZD1839 (gefitinib) in previously treated patients with metastatic pancreatic cancer
-
(25 18S)
-
Blaszkowsky LS, Earle C, et al. 2007. A phase II study of docetaxel in combination with ZD1839 (gefitinib) in previously treated patients with metastatic pancreatic cancer. J Clin Oncol, 2007 ASCO Ann Meeting Proc, 25(25 18S):15080.
-
(2007)
J Clin Oncol, 2007 ASCO Ann Meeting Proc
, vol.25
, pp. 15080
-
-
Blaszkowsky, L.S.1
Earle, C.2
-
5
-
-
0028985078
-
Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study
-
Bramhall SR, Allum WH, et al. 1995. Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br J Surg, 82:111-5.
-
(1995)
Br J Surg
, vol.82
, pp. 111-115
-
-
Bramhall, S.R.1
Allum, W.H.2
-
7
-
-
0347062475
-
Activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGFR(KDR)-TKI), ina model od ZD1839 (Iressa) resistance
-
Bruns CJ, Kohl G. 2003. Activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGFR(KDR)-TKI), ina model od ZD1839 (Iressa) resistance. Proc Am Soc Clin Oncol, 44:4880.
-
(2003)
Proc Am Soc Clin Oncol
, vol.44
, pp. 4880
-
-
Bruns, C.J.1
Kohl, G.2
-
8
-
-
0037058302
-
Effect of the vascular endothelial growth factor receptor-2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice
-
Bruns CJ, Shrader M, et al. 2002. Effect of the vascular endothelial growth factor receptor-2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice. Int J Cancer, 102:101-8.
-
(2002)
Int J Cancer
, vol.102
, pp. 101-108
-
-
Bruns, C.J.1
Shrader, M.2
-
9
-
-
0036894180
-
VEGF-RII influences the prognosis of pancreatic cancer
-
discussion 749
-
Buchler P, Reber HA, et al. 2002. VEGF-RII influences the prognosis of pancreatic cancer. Ann Surg, 236:738-49; discussion 749.
-
(2002)
Ann Surg
, vol.236
, pp. 738-749
-
-
Buchler, P.1
Reber, H.A.2
-
10
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA 3rd, Moore MJ, et al. 1997. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol, 15:2403-13.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris III, H.A.1
Moore, M.J.2
-
11
-
-
33644658126
-
The tyrosine kinase inhibitor imatinib fails to inhibit pancreatic cancer progression
-
Chen J, Rocken C, et al. 2006. The tyrosine kinase inhibitor imatinib fails to inhibit pancreatic cancer progression. Cancer Lett, 233:328-37.
-
(2006)
Cancer Lett
, vol.233
, pp. 328-337
-
-
Chen, J.1
Rocken, C.2
-
12
-
-
0033650988
-
New paradigms for the treatment of cancer: The role of anti-angiogenesis agents
-
Cherrington JM, Strawn LM, et al. 2000. New paradigms for the treatment of cancer: the role of anti-angiogenesis agents. Adv Cancer Res, 79:1-38.
-
(2000)
Adv Cancer Res
, vol.79
, pp. 1-38
-
-
Cherrington, J.M.1
Strawn, L.M.2
-
13
-
-
0037386774
-
Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
-
Ciardiello F, Caputo R, et al. 2003. Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin Cancer Res, 9:1546-56.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1546-1556
-
-
Ciardiello, F.1
Caputo, R.2
-
14
-
-
34247094323
-
Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model
-
Conrad C, Ischenko I, et al. 2007. Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model. Anticancer Drugs, 18:569-79.
-
(2007)
Anticancer Drugs
, vol.18
, pp. 569-579
-
-
Conrad, C.1
Ischenko, I.2
-
15
-
-
0032423809
-
Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer
-
Dong M, Nio Y, et al. 1998. Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer. Anticancer Res, 18:4613-9.
-
(1998)
Anticancer Res
, vol.18
, pp. 4613-4619
-
-
Dong, M.1
Nio, Y.2
-
16
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
Dvorak HF. 2002. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol, 20:4368-80.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
17
-
-
0029146793
-
Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer
-
Ebert M, Yokoyama M, et al. 1995. Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer. Int J Cancer, 62:529-35.
-
(1995)
Int J Cancer
, vol.62
, pp. 529-535
-
-
Ebert, M.1
Yokoyama, M.2
-
18
-
-
33645766948
-
A review of systemic therapy for advanced pancreatic cancer
-
El-Rayes BF, Philip PA. 2003. A review of systemic therapy for advanced pancreatic cancer. Clin Adv Hematol Oncol, 1:430-4.
-
(2003)
Clin Adv Hematol Oncol
, vol.1
, pp. 430-434
-
-
El-Rayes, B.F.1
Philip, P.A.2
-
19
-
-
43549125117
-
Erlotinib as a single-agent therapy in patients with advanced pancreatic cancer
-
Abstr 202
-
Epelbaum R, Gluzman SJ, et al. 2007. Erlotinib as a single-agent therapy in patients with advanced pancreatic cancer. ASCO 2007 Gastrointestinal Cancers Symposium. Abstr 202.
-
(2007)
ASCO 2007 Gastrointestinal Cancers Symposium
-
-
Epelbaum, R.1
Gluzman, S.J.2
-
20
-
-
0032852528
-
Molecular and biological properties of vascular endothelial growth factor
-
Ferrara N. 1999. Molecular and biological properties of vascular endothelial growth factor. J Mol Med, 77:527-43.
-
(1999)
J Mol Med
, vol.77
, pp. 527-543
-
-
Ferrara, N.1
-
21
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. 1971. Tumor angiogenesis: therapeutic implications. N Engl J Med, 285:1182-6.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
22
-
-
33645736689
-
Phase II trial of Gleevec (Imatinib mesylate) in patients with metastatic unresectable pancreatic cancer
-
Gharibo MM, Juvidian P, et al. 2005. Phase II trial of Gleevec (Imatinib mesylate) in patients with metastatic unresectable pancreatic cancer. J Clin Oncol, 2005 ASCO Ann Meeting Proc, 23(16S):4183.
-
(2005)
J Clin Oncol, 2005 ASCO Ann Meeting Proc
, vol.23
, Issue.16 S
, pp. 4183
-
-
Gharibo, M.M.1
Juvidian, P.2
-
23
-
-
0032875460
-
Mechanism of action and in vivo role of platelet-derived growth factor
-
Heldin CH, Westermark B. 1999. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev, 79:1283-316.
-
(1999)
Physiol Rev
, vol.79
, pp. 1283-1316
-
-
Heldin, C.H.1
Westermark, B.2
-
24
-
-
38549176328
-
CA19-9 tumour-marker response to chemotherapy in patients with advanced pancreatic cancer enrolled in a randomised controlled trial
-
Hess V, Glimelius B, et al. 2008. CA19-9 tumour-marker response to chemotherapy in patients with advanced pancreatic cancer enrolled in a randomised controlled trial. Lancet Oncol, 9:132-8.
-
(2008)
Lancet Oncol
, vol.9
, pp. 132-138
-
-
Hess, V.1
Glimelius, B.2
-
25
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM. 2005. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol, 23:1011-27.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
26
-
-
33744982627
-
EGF receptor activation: Push comes to shove
-
Hubbard SR. 2006. EGF receptor activation: push comes to shove. Cell, 125:1029-31.
-
(2006)
Cell
, vol.125
, pp. 1029-1031
-
-
Hubbard, S.R.1
-
27
-
-
0346333243
-
Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model
-
Hwang RF, Yokoi K, et al. 2003. Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model. Clin Cancer Res, 9:6534-44.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 6534-6544
-
-
Hwang, R.F.1
Yokoi, K.2
-
28
-
-
29044433659
-
Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: A phase I study
-
Iannitti D, Dipetrillo T, et al. 2005. Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: a phase I study. Am J Clin Oncol, 28:570-5.
-
(2005)
Am J Clin Oncol
, vol.28
, pp. 570-575
-
-
Iannitti, D.1
Dipetrillo, T.2
-
29
-
-
0032976338
-
Prognostic significance of angiogenesis in human pancreatic cancer
-
Ikeda N, Adachi M, et al. 1999. Prognostic significance of angiogenesis in human pancreatic cancer. Br J Cancer, 79:1553-63.
-
(1999)
Br J Cancer
, vol.79
, pp. 1553-1563
-
-
Ikeda, N.1
Adachi, M.2
-
30
-
-
3042548695
-
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
-
Inai T, Mancuso M, et al. 2004. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol, 165:35-52.
-
(2004)
Am J Pathol
, vol.165
, pp. 35-52
-
-
Inai, T.1
Mancuso, M.2
-
31
-
-
0033991167
-
Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer
-
Itakura J, Ishiwata T, et al. 2000. Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int J Cancer, 85:27-34.
-
(2000)
Int J Cancer
, vol.85
, pp. 27-34
-
-
Itakura, J.1
Ishiwata, T.2
-
32
-
-
33846457870
-
Cancer statistics, 2007
-
Jemal A, Siegel R, et al. 2007. Cancer statistics, 2007. CA Cancer J Clin, 57:43-66.
-
(2007)
CA Cancer J Clin
, vol.57
, pp. 43-66
-
-
Jemal, A.1
Siegel, R.2
-
33
-
-
33745229989
-
Tyrosine kinase inhibitors and gemcitabine: New treatment options in pancreatic cancer?
-
Kleespies A, Jauch KW, et al. 2006. Tyrosine kinase inhibitors and gemcitabine: new treatment options in pancreatic cancer? Drug Resist Updat, 9:1-18.
-
(2006)
Drug Resist Updat
, vol.9
, pp. 1-18
-
-
Kleespies, A.1
Jauch, K.W.2
-
34
-
-
34447297368
-
A phase I study of the VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK 222584) and gemcitabine in patients with advanced pancreatic cancer
-
Kuo T, Kaiser FA, et al. 2006. A phase I study of the VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK 222584) and gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol, 2006 ASCO Ann Meeting Proc, 24(18S):4122.
-
(2006)
J Clin Oncol, 2006 ASCO Ann Meeting Proc
, vol.24
, Issue.18 S
, pp. 4122
-
-
Kuo, T.1
Kaiser, F.A.2
-
35
-
-
0026595557
-
The epidermal growth factor receptor in human pancreatic cancer
-
Lemoine NR, Hughes CM, et al. 1992. The epidermal growth factor receptor in human pancreatic cancer. J Pathol, 166:7-12.
-
(1992)
J Pathol
, vol.166
, pp. 7-12
-
-
Lemoine, N.R.1
Hughes, C.M.2
-
36
-
-
0033061032
-
Protein tyrosine kinase inhibitors as novel therapeutic agents
-
Levitzki A. 1999. Protein tyrosine kinase inhibitors as novel therapeutic agents. Pharmacol Ther, 82:231-9.
-
(1999)
Pharmacol Ther
, vol.82
, pp. 231-239
-
-
Levitzki, A.1
-
37
-
-
0028968949
-
Tyrosine kinase inhibition: An approach to drug development
-
Levitzki A, Gazit A. 1995. Tyrosine kinase inhibition: an approach to drug development. Science, 267:1782-8.
-
(1995)
Science
, vol.267
, pp. 1782-1788
-
-
Levitzki, A.1
Gazit, A.2
-
38
-
-
21644469223
-
Gefitinib ('Iressa', ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation
-
Li J, Kleeff J, et al. 2004. Gefitinib ('Iressa', ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation. Int J Oncol, 25:203-10.
-
(2004)
Int J Oncol
, vol.25
, pp. 203-210
-
-
Li, J.1
Kleeff, J.2
-
39
-
-
20644464360
-
Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial
-
Louvet C, Labianca R, et al. 2005. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol, 23:3509-16.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3509-3516
-
-
Louvet, C.1
Labianca, R.2
-
40
-
-
0035342593
-
Pancreatic cancer cell-derived vascular endothelial growth factor is biologically active in vitro and enhances tumorigenicity in vivo
-
Luo J, Guo P, et al. 2001. Pancreatic cancer cell-derived vascular endothelial growth factor is biologically active in vitro and enhances tumorigenicity in vivo. Int J Cancer, 92:361-9.
-
(2001)
Int J Cancer
, vol.92
, pp. 361-369
-
-
Luo, J.1
Guo, P.2
-
42
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
Mendelsohn J, Baselga J. 2003. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol, 21:2787-99.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2787-2799
-
-
Mendelsohn, J.1
Baselga, J.2
-
43
-
-
33746485766
-
Epidermal growth factor receptor targeting in cancer
-
Mendelsohn J, Baselga J. 2006. Epidermal growth factor receptor targeting in cancer. Semin Oncol, 33:369-85.
-
(2006)
Semin Oncol
, vol.33
, pp. 369-385
-
-
Mendelsohn, J.1
Baselga, J.2
-
44
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Goldstein D, et al. 2007. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol, 25:1960-6.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
-
45
-
-
0036311535
-
High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas
-
Niedergethmann M, Hildenbrand R, et al. 2002. High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas. Pancreas, 25:122-9.
-
(2002)
Pancreas
, vol.25
, pp. 122-129
-
-
Niedergethmann, M.1
Hildenbrand, R.2
-
46
-
-
33846405332
-
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial
-
Oettle H, Post S, et al. 2007. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA, 297:267-77.
-
(2007)
JAMA
, vol.297
, pp. 267-277
-
-
Oettle, H.1
Post, S.2
-
47
-
-
0034600849
-
The ErbB signaling network: Receptor heterodimerization in development and cancer
-
Olayioye MA, Neve RM, et al. 2000. The ErbB signaling network: receptor heterodimerization in development and cancer. Embo J, 19:3159-67.
-
(2000)
Embo J
, vol.19
, pp. 3159-3167
-
-
Olayioye, M.A.1
Neve, R.M.2
-
48
-
-
2942670180
-
PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
-
Ostman A. 2004. PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev, 15:275-86.
-
(2004)
Cytokine Growth Factor Rev
, vol.15
, pp. 275-286
-
-
Ostman, A.1
-
49
-
-
36249012644
-
Epidermal growth factor receptor-targeted therapy for pancreatic cancer
-
Papageorgio C, Perry MC. 2007. Epidermal growth factor receptor-targeted therapy for pancreatic cancer. Cancer Invest, 25:647-57.
-
(2007)
Cancer Invest
, vol.25
, pp. 647-657
-
-
Papageorgio, C.1
Perry, M.C.2
-
50
-
-
36549083856
-
Phase III study of gemcitabine plus cetuximab versus gemcitabine in patients woth locally advanced or metastatic pancreatic adenocarcinoma: SWOG S0205 study
-
Philip P, Benedetti J, et al. 2007. Phase III study of gemcitabine plus cetuximab versus gemcitabine in patients woth locally advanced or metastatic pancreatic adenocarcinoma: SWOG S0205 study. J Clin Oncol, 25:965s.
-
(2007)
J Clin Oncol
, vol.25
-
-
Philip, P.1
Benedetti, J.2
-
51
-
-
0036790060
-
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
-
Pietras K, Rubin K, et al. 2002. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res, 62:5476-84.
-
(2002)
Cancer Res
, vol.62
, pp. 5476-5484
-
-
Pietras, K.1
Rubin, K.2
-
52
-
-
33845455448
-
Adjuvant therapy for pancreatic cancer: Current status, future directions
-
Regine WF, Abrams RA. 2006. Adjuvant therapy for pancreatic cancer: current status, future directions. Semin Oncol, 33(Suppl 11):S10-3.
-
(2006)
Semin Oncol
, vol.33
, Issue.SUPPL. 11
-
-
Regine, W.F.1
Abrams, R.A.2
-
53
-
-
0037296357
-
The epidermal growth factor receptor-tyrosine kinase: A promising therapeutic target in solid tumors
-
Ritter CA, Arteaga CL. 2003. The epidermal growth factor receptor-tyrosine kinase: a promising therapeutic target in solid tumors. Semin Oncol, 30(Suppl 1):3-11.
-
(2003)
Semin Oncol
, vol.30
, Issue.SUPPL. 1
, pp. 3-11
-
-
Ritter, C.A.1
Arteaga, C.L.2
-
54
-
-
4644327989
-
Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
-
Rocha Lima CM, Green MR, et al. 2004. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol, 22:3776-83.
-
(2004)
J Clin Oncol
, vol.22
, pp. 3776-3783
-
-
Rocha Lima, C.M.1
Green, M.R.2
-
55
-
-
24944453855
-
Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
-
Rugo HS, Herbst RS, et al. 2005. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol, 23:5474-83.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5474-5483
-
-
Rugo, H.S.1
Herbst, R.S.2
-
56
-
-
33749265749
-
GW572016, gemcitabine and GW572016, gemcitabine, oxaliplatin, a two-stage, phase I study for advanced pancreaticobiliary cancer
-
Safran H, Miner K et al. 2006. GW572016, gemcitabine and GW572016, gemcitabine, oxaliplatin, a two-stage, phase I study for advanced pancreaticobiliary cancer. J Clin Oncol, 2006 ASCO Ann Meeting Proc, 24(18S):4002.
-
(2006)
J Clin Oncol, 2006 ASCO Ann Meeting Proc
, vol.24
, Issue.18 S
, pp. 4002
-
-
Safran, H.1
Miner, K.2
-
57
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. 2000. Cell signaling by receptor tyrosine kinases. Cell, 103:211-25.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
58
-
-
31544460436
-
Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer
-
Siu LL, Awada A, et al. 2006. Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer. Clin Cancer Res, 12:144-51.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 144-151
-
-
Siu, L.L.1
Awada, A.2
-
59
-
-
34147154161
-
A phase I study of Axitinib (AG-013736), a potent inhibitor of VEGFRs, in combination with gemcitabine (GEM) in patients (pts) with advanced pancreatic cancer
-
Spano JP, Kim S, et al. 2006. A phase I study of Axitinib (AG-013736), a potent inhibitor of VEGFRs, in combination with gemcitabine (GEM) in patients (pts) with advanced pancreatic cancer. J Clin Oncol, 2006 ASCO Ann Meeting Proc, 24(18S):13092.
-
(2006)
J Clin Oncol, 2006 ASCO Ann Meeting Proc
, vol.24
, Issue.18 S
, pp. 13092
-
-
Spano, J.P.1
Kim, S.2
-
60
-
-
85100498428
-
Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study
-
Spano JP, Chodkiewicz C, et al. 2008. Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study. Lancet. XXXX.
-
(2008)
Lancet
-
-
Spano, J.P.1
Chodkiewicz, C.2
-
61
-
-
0038386613
-
Src family kinases in tumor progression and metastasis
-
Summy JM, Gallick GE. 2003. Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev, 22:337-58.
-
(2003)
Cancer Metastasis Rev
, vol.22
, pp. 337-358
-
-
Summy, J.M.1
Gallick, G.E.2
-
62
-
-
0031439247
-
Cellular functions regulated by Src family kinases
-
Thomas SM, Brugge JS. 1997. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol, 13:513-609.
-
(1997)
Annu Rev Cell Dev Biol
, vol.13
, pp. 513-609
-
-
Thomas, S.M.1
Brugge, J.S.2
-
63
-
-
48949095510
-
A randomized, double-blind, placebo (P) controlled, multicenter phase III trial to evaluate the efficacy and safety of adding bevacizumab (B) to erlotinib (E) and gemcitabine (G) in patients (pts) with metastatic pancreatic cancer
-
abstr 4507
-
Vervenne W, Humblet Y, et al. 2008. A randomized, double-blind, placebo (P) controlled, multicenter phase III trial to evaluate the efficacy and safety of adding bevacizumab (B) to erlotinib (E) and gemcitabine (G) in patients (pts) with metastatic pancreatic cancer. J Clin Oncol, 2008 ASCO Annual Meeting, 26(Suppl):abstr 4507).
-
(2008)
J Clin Oncol, 2008 ASCO Annual Meeting
, vol.26
, Issue.SUPPL.
-
-
Vervenne, W.1
Humblet, Y.2
-
64
-
-
39149112958
-
Sorafenib plus gemcitabine for advanced pancreatic cancer: A phase II trial of the University of Chicago Phase II Consortium
-
Wallace JA, Nattam S, et al. 2007. Sorafenib plus gemcitabine for advanced pancreatic cancer: A phase II trial of the University of Chicago Phase II Consortium. Journal of Clinical Oncol, 2007 ASCO Ann Meeting Proc, 25(18S) 4608.
-
(2007)
Journal of Clinical Oncol, 2007 ASCO Ann Meeting Proc
, vol.25
, Issue.18 S
, pp. 4608
-
-
Wallace, J.A.1
Nattam, S.2
-
65
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, et al. 2004. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res, 64:7099-109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
-
66
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
Wood JM, Bold G, et al. 2000. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res, 60:2178-89.
-
(2000)
Cancer Res
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
-
67
-
-
0027293748
-
Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness
-
Yamanaka Y, Friess H, et al. 1993. Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res, 13:565-9.
-
(1993)
Anticancer Res
, vol.13
, pp. 565-569
-
-
Yamanaka, Y.1
Friess, H.2
-
69
-
-
28544451083
-
Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model
-
Yokoi K, Sasaki T, et al. 2005. Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model. Cancer Res, 65:10371-80.
-
(2005)
Cancer Res
, vol.65
, pp. 10371-10380
-
-
Yokoi, K.1
Sasaki, T.2
|