-
1
-
-
0028920013
-
Patterns of survival in mantle cell lymphoma
-
Zucca E, Roggero E, Pinotti G, et al. Patterns of survival in mantle cell lymphoma. Ann Oncol. 1995;6(3):257-262.
-
(1995)
Ann Oncol
, vol.6
, Issue.3
, pp. 257-262
-
-
Zucca, E.1
Roggero, E.2
Pinotti, G.3
-
2
-
-
27244452464
-
High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine
-
Romaguera JE, Fayad L, Rodriguez MA, et al. High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine. J Clin Oncol. 2005;23(28):7013-7023.
-
(2005)
J Clin Oncol
, vol.23
, Issue.28
, pp. 7013-7023
-
-
Romaguera, J.E.1
Fayad, L.2
Rodriguez, M.A.3
-
3
-
-
20144376591
-
Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: Results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG)
-
Lenz G, Dreyling M, Hoster E, et al. Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG). J Clin Oncol. 2005;23(9):1984-1992.
-
(2005)
J Clin Oncol
, vol.23
, Issue.9
, pp. 1984-1992
-
-
Lenz, G.1
Dreyling, M.2
Hoster, E.3
-
4
-
-
8744274334
-
The addition of rituximab to a combination of fludarabine, cyclophosphamide, mitoxantrone (FCM) significantly increases the response rate and prolongs survival as compared with FCM alone in patients with relapsed and refractory follicular and mantle cell lymphomas: Results of a prospective randomized study of the German Low-Grade Lymphoma Study Group
-
Forstpointner R, Dreyling M, Repp R, et al. The addition of rituximab to a combination of fludarabine, cyclophosphamide, mitoxantrone (FCM) significantly increases the response rate and prolongs survival as compared with FCM alone in patients with relapsed and refractory follicular and mantle cell lymphomas: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood. 2004;104(10):3064-3071.
-
(2004)
Blood
, vol.104
, Issue.10
, pp. 3064-3071
-
-
Forstpointner, R.1
Dreyling, M.2
Repp, R.3
-
5
-
-
70449727887
-
Phase II study of yttrium-90-ibritumomab tiuxetan in patients with relapsed or refractory mantle cell lymphoma
-
Wang M, Oki Y, Pro B, et al. Phase II study of yttrium-90-ibritumomab tiuxetan in patients with relapsed or refractory mantle cell lymphoma. J Clin Oncol. 2009;27(31):5213-5218.
-
(2009)
J Clin Oncol
, vol.27
, Issue.31
, pp. 5213-5218
-
-
Wang, M.1
Oki, Y.2
Pro, B.3
-
6
-
-
61849128387
-
Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survivals compared with patients with relapsed disease following treatment with single agent bort-ezomib: Results of a multicentre Phase 2 clinical trial
-
O'Connor OA, Moskowitz C, Portlock C, et al. Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survivals compared with patients with relapsed disease following treatment with single agent bort-ezomib: results of a multicentre Phase 2 clinical trial. Br J Haematol. 2009;145(1):34-39.
-
(2009)
Br J Haematol
, vol.145
, Issue.1
, pp. 34-39
-
-
O'Connor, O.A.1
Moskowitz, C.2
Portlock, C.3
-
7
-
-
64149112784
-
Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma
-
Habermann TM, Lossos IS, Justice G, et al. Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma. Br J Haematol. 2009;145(3): 344-349.
-
(2009)
Br J Haematol
, vol.145
, Issue.3
, pp. 344-349
-
-
Habermann, T.M.1
Lossos, I.S.2
Justice, G.3
-
8
-
-
68949165966
-
Mantle cell lymphoma: Are current therapies changing the course of disease?
-
Geisler C. Mantle cell lymphoma: are current therapies changing the course of disease? Curr Oncol Rep. 2009;11(5):371-377.
-
(2009)
Curr Oncol Rep
, vol.11
, Issue.5
, pp. 371-377
-
-
Geisler, C.1
-
9
-
-
0016713286
-
Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
Sehgal SN, Baker H, Vézina C. Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot (Tokyo). 1975;28(10):727-732.
-
(1975)
J Antibiot (Tokyo)
, vol.28
, Issue.10
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vézina, C.3
-
11
-
-
38949172405
-
Immunosuppression and tumor development in organ transplant recipients: The emerging dualistic role of rapamycin
-
Gaumann A, Schlitt HJ, Geissler EK. Immunosuppression and tumor development in organ transplant recipients: the emerging dualistic role of rapamycin. Transpl Int. 2008;21(3):207-217.
-
(2008)
Transpl Int
, vol.21
, Issue.3
, pp. 207-217
-
-
Gaumann, A.1
Schlitt, H.J.2
Geissler, E.K.3
-
12
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer. 2004;4(5):335-348.
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.5
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
13
-
-
72049117072
-
Mammalian target of rapamycin: Discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth
-
Gibbons JJ, Abraham RT, Yu K. Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth. Semin Oncol. 2009;36 Suppl 3:S3-S17.
-
(2009)
Semin Oncol
, vol.36
, Issue.3 SUPPL. 3
-
-
Gibbons, J.J.1
Abraham, R.T.2
Yu, K.3
-
14
-
-
0028344699
-
Yeast TOR (DRR) proteins: Amino-acid sequence alignment and identification of structural motifs
-
Cafferkey R, McLaughlin MM, Young PR, Johnson RK, Livi G P. Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs. Gene. 1994;141(1):133-136.
-
(1994)
Gene
, vol.141
, Issue.1
, pp. 133-136
-
-
Cafferkey, R.1
McLaughlin, M.M.2
Young, P.R.3
Johnson, R.K.4
Livi, G.P.5
-
15
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18(16):1926-1945.
-
(2004)
Genes Dev
, vol.18
, Issue.16
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
16
-
-
29244481490
-
Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway
-
Jozwiak J, Jozwiak S, Grzela T, Lazarczyk M. Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway. Neuromolecular Med. 2005;7(4):287-296.
-
(2005)
Neuromolecular Med
, vol.7
, Issue.4
, pp. 287-296
-
-
Jozwiak, J.1
Jozwiak, S.2
Grzela, T.3
Lazarczyk, M.4
-
17
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol. 2002;4(9):658-665.
-
(2002)
Nat Cell Biol
, vol.4
, Issue.9
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
18
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006;124(3):471-484.
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
19
-
-
18144399578
-
MTOR-targeted therapy of cancer with rapamycin derivatives
-
Vignot S, Faivre S, Aguirre D, Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol. 2005;16(4):525-537.
-
(2005)
Ann Oncol
, vol.16
, Issue.4
, pp. 525-537
-
-
Vignot, S.1
Faivre, S.2
Aguirre, D.3
Raymond, E.4
-
20
-
-
24744439255
-
Molecular organization of target of rapamycin complex 2
-
Wullschleger S, Loewith R, Oppliger W, Hall MN. Molecular organization of target of rapamycin complex 2. J Biol Chem. 2005; 280(35):30697-30704.
-
(2005)
J Biol Chem
, vol.280
, Issue.35
, pp. 30697-30704
-
-
Wullschleger, S.1
Loewith, R.2
Oppliger, W.3
Hall, M.N.4
-
21
-
-
75749105049
-
MTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
-
Julien LA, Carriere A, Moreau J, Roux P P. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol. 2010;30(4):908-921.
-
(2010)
Mol Cell Biol
, vol.30
, Issue.4
, pp. 908-921
-
-
Julien, L.A.1
Carriere, A.2
Moreau, J.3
Roux, P.P.4
-
22
-
-
0033153166
-
Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
-
Gingras AC, Gygi S P, Raught B, et al. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999;13(11): 1422-1437.
-
(1999)
Genes Dev
, vol.13
, Issue.11
, pp. 1422-1437
-
-
Gingras, A.C.1
Gygi, S.P.2
Raught, B.3
-
23
-
-
33748752709
-
Malignant hematopoietic cells induce an increased expression of VEGFR-1 and VEGFR-3 on bone marrow endothelial cells via AKT and mTOR signalling pathways
-
Mirshahi P, Toprak SK, Faussat AM, et al. Malignant hematopoietic cells induce an increased expression of VEGFR-1 and VEGFR-3 on bone marrow endothelial cells via AKT and mTOR signalling pathways. Biochem Biophys Res Commun. 2006;349(3):1003-1010.
-
(2006)
Biochem Biophys Res Commun
, vol.349
, Issue.3
, pp. 1003-1010
-
-
Mirshahi, P.1
Toprak, S.K.2
Faussat, A.M.3
-
24
-
-
57449111076
-
Marastoni S. mTOR pathway and mTOR inhibitors as agents for cancer therapy
-
Baldo P, Cecco S, Giacomin E, Lazzarini R, Ros B, Marastoni S. mTOR pathway and mTOR inhibitors as agents for cancer therapy. Curr Cancer Drug Targets. 2008;8(8):647-665.
-
(2008)
Curr Cancer Drug Targets
, vol.8
, Issue.8
, pp. 647-665
-
-
Baldo, P.1
Cecco, S.2
Giacomin, E.3
Lazzarini, R.4
Ros, B.5
-
25
-
-
61849157793
-
Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease
-
Brown VI, Seif AE, Reid GS, Teachey DT, Grupp SA. Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease. Immunol Res. 2008;42(1-3):84-105.
-
(2008)
Immunol Res
, vol.42
, Issue.1-3
, pp. 84-105
-
-
Brown, V.I.1
Seif, A.E.2
Reid, G.S.3
Teachey, D.T.4
Grupp, S.A.5
-
26
-
-
23744494993
-
Rapamycin stimulates apop-tosis of childhood acute lymphoblastic leukemia cells
-
Avellino R, Romano S, Parasole R, et al. Rapamycin stimulates apop-tosis of childhood acute lymphoblastic leukemia cells. Blood. 2005; 106(4):1400-1406.
-
(2005)
Blood
, vol.106
, Issue.4
, pp. 1400-1406
-
-
Avellino, R.1
Romano, S.2
Parasole, R.3
-
27
-
-
65349114832
-
Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia
-
Crazzolara R, Cisterne A, Thien M, et al. Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia. Blood. 2009;113(14):3297-3306.
-
(2009)
Blood
, vol.113
, Issue.14
, pp. 3297-3306
-
-
Crazzolara, R.1
Cisterne, A.2
Thien, M.3
-
28
-
-
56349118798
-
Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mTOR signaling pathway, enhancing G1 cell cycle arrest and apoptosis
-
Gu L, Gao J, Li Q, et al. Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mTOR signaling pathway, enhancing G1 cell cycle arrest and apoptosis. Leukemia. 2008;22(11):2091-2096.
-
(2008)
Leukemia
, vol.22
, Issue.11
, pp. 2091-2096
-
-
Gu, L.1
Gao, J.2
Li, Q.3
-
29
-
-
2542504461
-
Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells
-
Kharas MG, Deane JA, Wong S, et al. Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood. 2004;103(11):4268-4275.
-
(2004)
Blood
, vol.103
, Issue.11
, pp. 4268-4275
-
-
Kharas, M.G.1
Deane, J.A.2
Wong, S.3
-
30
-
-
0042744837
-
Survival of acute myeloid leukemia cells requires PI3 kinase activation
-
Xu Q, Simpson SE, Scialla TJ, Bagg A, Carroll M. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood. 2003; 102(3):972-980.
-
(2003)
Blood
, vol.102
, Issue.3
, pp. 972-980
-
-
Xu, Q.1
Simpson, S.E.2
Scialla, T.J.3
Bagg, A.4
Carroll, M.5
-
31
-
-
34249308840
-
The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelo-dysplastic syndromes and infuences cell survival and proliferation
-
Follo MY, Mongiorgi S, Bosi C, et al. The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelo-dysplastic syndromes and infuences cell survival and proliferation. Cancer Res. 2007;67(9):4287-4294.
-
(2007)
Cancer Res
, vol.67
, Issue.9
, pp. 4287-4294
-
-
Follo, M.Y.1
Mongiorgi, S.2
Bosi, C.3
-
32
-
-
67651146528
-
Effect of autophagy on multiple myeloma cell viability
-
Hoang B, Benavides A, Shi Y, Frost P, Lichtenstein A. Effect of autophagy on multiple myeloma cell viability. Mol Cancer Ther. 2009; 8(7):1974-1984.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.7
, pp. 1974-1984
-
-
Hoang, B.1
Benavides, A.2
Shi, Y.3
Frost, P.4
Lichtenstein, A.5
-
33
-
-
34147104488
-
AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells
-
Frost P, Shi Y, Hoang B, Lichtenstein A. AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells. Oncogene. 2007;26(16):2255-2262.
-
(2007)
Oncogene
, vol.26
, Issue.16
, pp. 2255-2262
-
-
Frost, P.1
Shi, Y.2
Hoang, B.3
Lichtenstein, A.4
-
34
-
-
68649117850
-
Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma
-
Farag SS, Zhang S, Jansak BS, et al. Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma. Leuk Res. 2009;33(11):1475-1480.
-
(2009)
Leuk Res
, vol.33
, Issue.11
, pp. 1475-1480
-
-
Farag, S.S.1
Zhang, S.2
Jansak, B.S.3
-
35
-
-
14944339657
-
Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR
-
Dutton A, Reynolds GM, Dawson CW, Young LS, Murray PG. Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR. J Pathol. 2005;205(4):498-506.
-
(2005)
J Pathol
, vol.205
, Issue.4
, pp. 498-506
-
-
Dutton, A.1
Reynolds, G.M.2
Dawson, C.W.3
Young, L.S.4
Murray, P.G.5
-
36
-
-
70449494636
-
Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2
-
Gupta M, Ansell SM, Novak AJ, Kumar S, Kaufmann SH, Witzig TE. Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2. Blood. 2009;114(14):2926-2935.
-
(2009)
Blood
, vol.114
, Issue.14
, pp. 2926-2935
-
-
Gupta, M.1
Ansell, S.M.2
Novak, A.J.3
Kumar, S.4
Kaufmann, S.H.5
Witzig, T.E.6
-
37
-
-
68449088229
-
Targeting mammalian target of rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines
-
Pop I V, Pop LM, Ghetie MA, Vitetta ES. Targeting mammalian target of rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines. Leuk Lymphoma. 2009;50(7):1155-1162.
-
(2009)
Leuk Lymphoma
, vol.50
, Issue.7
, pp. 1155-1162
-
-
Pop, I.V.1
Pop, L.M.2
Ghetie, M.A.3
Vitetta, E.S.4
-
38
-
-
70350100969
-
Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma
-
Gasperini P, Tosato G. Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma. Leukemia. 2009;23(10):1867-1874.
-
(2009)
Leukemia
, vol.23
, Issue.10
, pp. 1867-1874
-
-
Gasperini, P.1
Tosato, G.2
-
39
-
-
0042090489
-
Rapamycin inhibits the interleukin 10 signal transduc-tion pathway and the growth of Epstein Barr virus B-cell lymphomas
-
Nepomuceno RR, Balatoni CE, Natkunam Y, Snow AL, Krams SM, Martinez OM. Rapamycin inhibits the interleukin 10 signal transduc-tion pathway and the growth of Epstein Barr virus B-cell lymphomas. Cancer Res. 2003;63(15):4472-4480.
-
(2003)
Cancer Res
, vol.63
, Issue.15
, pp. 4472-4480
-
-
Nepomuceno, R.R.1
Balatoni, C.E.2
Natkunam, Y.3
Snow, A.L.4
Krams, S.M.5
Martinez, O.M.6
-
40
-
-
33845500278
-
Syk-dependent mTOR activation in follicular lymphoma cells
-
Leseux L, Hamdi SM, Al Saati T, et al. Syk-dependent mTOR activation in follicular lymphoma cells. Blood. 2006;108(13):4156-4162.
-
(2006)
Blood
, vol.108
, Issue.13
, pp. 4156-4162
-
-
Leseux, L.1
Hamdi, S.M.2
Saati, T.A.3
-
41
-
-
67149099805
-
A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation
-
Gupta M, Dillon SR, Ziesmer SC, et al. A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation. Blood. 2009;113(21): 5206-5216.
-
(2009)
Blood
, vol.113
, Issue.21
, pp. 5206-5216
-
-
Gupta, M.1
Dillon, S.R.2
Ziesmer, S.C.3
-
42
-
-
12744279721
-
Mammalian target of rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: A new therapeutic option
-
Ringshausen I, Peschel C, Decker T. Mammalian target of rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: a new therapeutic option. Leuk Lymphoma. 2005;46(1):11-19.
-
(2005)
Leuk Lymphoma
, vol.46
, Issue.1
, pp. 11-19
-
-
Ringshausen, I.1
Peschel, C.2
Decker, T.3
-
43
-
-
0037207525
-
Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin
-
Decker T, Hipp S, Ringshausen I, et al. Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin. Blood. 2003;101(1):278-285.
-
(2003)
Blood
, vol.101
, Issue.1
, pp. 278-285
-
-
Decker, T.1
Hipp, S.2
Ringshausen, I.3
-
44
-
-
59049091983
-
A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL
-
Decker T, Sandherr M, Goetze K, Oelsner M, Ringshausen I, Peschel C. A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL. Ann Hematol. 2009;88(3):221-227.
-
(2009)
Ann Hematol
, vol.88
, Issue.3
, pp. 221-227
-
-
Decker, T.1
Sandherr, M.2
Goetze, K.3
Oelsner, M.4
Ringshausen, I.5
Peschel, C.6
-
45
-
-
34648824397
-
Genetic and molecular pathogenesis of mantle cell lymphoma: Perspectives for new targeted therapeutics
-
Jares P, Colomer D, Campo E. Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics. Nat Rev Cancer. 2007;7(10):750-762.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.10
, pp. 750-762
-
-
Jares, P.1
Colomer, D.2
Campo, E.3
-
46
-
-
0036231124
-
Mantle cell lymphoma: A biological and therapeutic paradigm
-
Decaudin D. Mantle cell lymphoma: a biological and therapeutic paradigm. Leuk Lymphoma. 2002;43(4):773-781.
-
(2002)
Leuk Lymphoma
, vol.43
, Issue.4
, pp. 773-781
-
-
Decaudin, D.1
-
47
-
-
0029071657
-
D-type cyclins
-
Sherr CJ. D-type cyclins. Trends Biochem Sci. 1995;20(5):187-190.
-
(1995)
Trends Biochem Sci
, vol.20
, Issue.5
, pp. 187-190
-
-
Sherr, C.J.1
-
48
-
-
46749155539
-
Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma
-
Dal Col J, Zancai P, Terrin L, et al. Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma. Blood. 2008;111(10):5142-5151.
-
(2008)
Blood
, vol.111
, Issue.10
, pp. 5142-5151
-
-
Dal, C.J.1
Zancai, P.2
Terrin, L.3
-
49
-
-
33747846726
-
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma
-
Rudelius M, Pittaluga S, Nishizuka S, et al. Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood. 2006;108(5):1668-1676.
-
(2006)
Blood
, vol.108
, Issue.5
, pp. 1668-1676
-
-
Rudelius, M.1
Pittaluga, S.2
Nishizuka, S.3
-
50
-
-
33846516354
-
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
-
Haritunians T, Mori A, O'Kelly J, Luong QT, Giles FJ, Koeffer H P. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia. 2007; 21(2):333-339.
-
(2007)
Leukemia
, vol.21
, Issue.2
, pp. 333-339
-
-
Haritunians, T.1
Mori, A.2
O'Kelly, J.3
Luong, Q.T.4
Giles, F.J.5
Koeffer, H.P.6
-
51
-
-
38049151149
-
PKC zeta mTOR pathway: A new target for rituximab therapy in follicular lymphoma
-
Leseux L, Laurent G, Laurent C, et al. PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma. Blood. 2008; 111(1):285-291.
-
(2008)
Blood
, vol.111
, Issue.1
, pp. 285-291
-
-
Leseux, L.1
Laurent, G.2
Laurent, C.3
-
52
-
-
48249090836
-
Therapeutic activity of mTOR inhibitors in mantle cell lymphoma
-
Younes A. Therapeutic activity of mTOR inhibitors in mantle cell lymphoma. Autophagy 2008;4(5):707-709.
-
(2008)
Autophagy
, vol.4
, Issue.5
, pp. 707-709
-
-
Younes, A.1
-
53
-
-
34248647440
-
Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma
-
Peponi E. Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma. Am J Pathol. 2006;169(6):2171-2180.
-
(2006)
Am J Pathol
, vol.169
, Issue.6
, pp. 2171-2180
-
-
Peponi, E.1
-
54
-
-
27144455334
-
Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells
-
Hipp S, Ringshausen I, Oelsner M, Bogner C, Peschel C, Decker T. Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells. Haematologica. 2005; 90(10):1433-1434.
-
(2005)
Haematologica
, vol.90
, Issue.10
, pp. 1433-1434
-
-
Hipp, S.1
Ringshausen, I.2
Oelsner, M.3
Bogner, C.4
Peschel, C.5
Decker, T.6
-
55
-
-
0032878975
-
CDK1 and cyclin A expression is linked to cell proliferation and associated with prognosis in non-Hodgkin's lymphomas
-
Wolowiec D, Berger F, Ffrench P, Bryon PA, Ffrench M. CDK1 and cyclin A expression is linked to cell proliferation and associated with prognosis in non-Hodgkin's lymphomas. Leuk Lymphoma. 1999;35(1-2):147-157.
-
(1999)
Leuk Lymphoma
, vol.35
, Issue.1-2
, pp. 147-157
-
-
Wolowiec, D.1
Berger, F.2
Ffrench, P.3
Bryon, P.A.4
Ffrench, M.5
-
56
-
-
58149382600
-
Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma
-
Gelebart P, Anand M, Armanious H, et al. Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. Blood. 2008; 112(13):5171-5179.
-
(2008)
Blood
, vol.112
, Issue.13
, pp. 5171-5179
-
-
Gelebart, P.1
Anand, M.2
Armanious, H.3
-
57
-
-
40749094917
-
Temsirolimus downregu-lates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma
-
Yazbeck V Y, Buglio D, Georgakis G V, et al. Temsirolimus downregu-lates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma. Exp Hematol. 2008;36(4):443-450.
-
(2008)
Exp Hematol
, vol.36
, Issue.4
, pp. 443-450
-
-
Yazbeck, V.Y.1
Buglio, D.2
Georgakis, G.V.3
-
58
-
-
58949086093
-
Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation
-
Giatromanolaki A, Koukourakis MI, Pezzella F, et al. Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation. Hematol Oncol. 2008;26(4):219-224.
-
(2008)
Hematol Oncol
, vol.26
, Issue.4
, pp. 219-224
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Pezzella, F.3
-
59
-
-
0035186128
-
Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real-time quantitative polymerase chain reaction
-
Koomagi R, Zintl F, Sauerbrey A, Volm M. Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real-time quantitative polymerase chain reaction. Clin Cancer Res. 2001;7(11):3381-3384.
-
(2001)
Clin Cancer Res
, vol.7
, Issue.11
, pp. 3381-3384
-
-
Koomagi, R.1
Zintl, F.2
Sauerbrey, A.3
Volm, M.4
-
60
-
-
0242550768
-
Prognostic significance of microvessel density and vascular endothelial growth factor (VEGF) expression in non-Hodgkin's lymphoma
-
Hazar B, Paydas S, Zorludemir S, Sahin B, Tuncer I. Prognostic significance of microvessel density and vascular endothelial growth factor (VEGF) expression in non-Hodgkin's lymphoma. Leuk Lymphoma. 2003;44(12):2089-2093.
-
(2003)
Leuk Lymphoma
, vol.44
, Issue.12
, pp. 2089-2093
-
-
Hazar, B.1
Paydas, S.2
Zorludemir, S.3
Sahin, B.4
Tuncer, I.5
-
61
-
-
0036162385
-
High expression of MCL1 gene related to vascular endothelial growth factor is associated with poor outcome in non-Hodgkin's lymphoma
-
Kuramoto K, Sakai A, Shigemasa K, et al. High expression of MCL1 gene related to vascular endothelial growth factor is associated with poor outcome in non-Hodgkin's lymphoma. Br J Haematol. 2002;116 (1): 158-161.
-
(2002)
Br J Haematol
, vol.116
, Issue.1
, pp. 158-161
-
-
Kuramoto, K.1
Sakai, A.2
Shigemasa, K.3
-
62
-
-
0036765823
-
Immunohistochemical detection of C-kit (CD117) and vascular endothelial growth factor (VEGF) overexpres-sion in mantle cell lymphoma
-
Potti A, Ganti AK, Kargas S, Koch M. Immunohistochemical detection of C-kit (CD117) and vascular endothelial growth factor (VEGF) overexpres-sion in mantle cell lymphoma. Anticancer Res. 2002;22(5):2899-2901.
-
(2002)
Anticancer Res
, vol.22
, Issue.5
, pp. 2899-2901
-
-
Potti, A.1
Ganti, A.K.2
Kargas, S.3
Koch, M.4
-
63
-
-
72149134653
-
Vascular endothelial growth factor polymorphisms in mantle cell lymphoma
-
Galimberti S, Nagy B, Palumbo GA, et al. Vascular endothelial growth factor polymorphisms in mantle cell lymphoma. Acta Haematol. 2010; 123(2):91-95.
-
(2010)
Acta Haematol
, vol.123
, Issue.2
, pp. 91-95
-
-
Galimberti, S.1
Nagy, B.2
Palumbo, G.A.3
-
64
-
-
34347242470
-
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
-
Roux P P, Shahbazian D, Vu H, et al. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem. 2007;282(19):14056-14064.
-
(2007)
J Biol Chem
, vol.282
, Issue.19
, pp. 14056-14064
-
-
Roux, P.P.1
Shahbazian, D.2
Vu, H.3
-
65
-
-
0025237563
-
V-myc and v-raf act synergistically to induce B-cell tumors in pristane-primed adult BALBC mice
-
Kurie JM, Morse HC III, Principato MA, et al. v-myc and v-raf act synergistically to induce B-cell tumors in pristane-primed adult BALBC mice. Oncogene. 1990;5(4):577-582.
-
(1990)
Oncogene
, vol.5
, Issue.4
, pp. 577-582
-
-
Kurie, J.M.1
Morse, H.C.2
Principato, M.A.3
-
66
-
-
35548974781
-
RAF-1 over-expression does condition survival of patients affected by aggressive mantle cell lymphoma
-
Nagy B, Galimberti S, Benedetti E, et al. RAF-1 over-expression does condition survival of patients affected by aggressive mantle cell lymphoma. Leuk Res. 2007;31(11):1595-1597.
-
(2007)
Leuk Res
, vol.31
, Issue.11
, pp. 1595-1597
-
-
Nagy, B.1
Galimberti, S.2
Benedetti, E.3
-
67
-
-
0037326715
-
Abnormal expression of apoptosis-related genes in hematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
-
Nagy B, Lundán T, Larramendy ML, et al. Abnormal expression of apoptosis-related genes in hematological malignancies: overexpression of MYC is poor prognostic sign in mantle cell lymphoma. Br J Haematol. 2003;120(3):4434-4441.
-
(2003)
Br J Haematol
, vol.120
, Issue.3
, pp. 4434-4441
-
-
Nagy, B.1
Lundán, T.2
Larramendy, M.L.3
-
68
-
-
49449108291
-
MTORC1 promotes survival through translational control of Mcl-1
-
Mills JR, Hippo Y, Robert F, et al. mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A. 2008; 105(31): 10853-10858.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.31
, pp. 10853-10858
-
-
Mills, J.R.1
Hippo, Y.2
Robert, F.3
-
69
-
-
33644851486
-
Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma
-
Rinaldi A, Kwee I, Taborelli M, et al. Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma. Br J Haematol. 2006;132(3):303-316.
-
(2006)
Br J Haematol
, vol.132
, Issue.3
, pp. 303-316
-
-
Rinaldi, A.1
Kwee, I.2
Taborelli, M.3
-
70
-
-
72049097131
-
Clinical trial experience with temsirolimus in patients with advanced renal cell carcinoma
-
Hudes GR, Berkenblit A, Feingold J, Atkins MB, Rini BI, Dutcher J. Clinical trial experience with temsirolimus in patients with advanced renal cell carcinoma. Semin Oncol. 2009;36 Suppl 3:S26-S36.
-
(2009)
Semin Oncol
, vol.36
, Issue.SUPPL. 3
-
-
Hudes, G.R.1
Berkenblit, A.2
Feingold, J.3
Atkins, M.B.4
Rini, B.I.5
Dutcher, J.6
-
71
-
-
0042197413
-
Mammalian target of rapamycin: A new molecular target for breast cancer
-
Mita MM, Mita A, Rowinsky EK. Mammalian target of rapamycin: a new molecular target for breast cancer. Clin Breast Cancer. 2003;4(2):126-137.
-
(2003)
Clin Breast Cancer
, vol.4
, Issue.2
, pp. 126-137
-
-
Mita, M.M.1
Mita, A.2
Rowinsky, E.K.3
-
72
-
-
34447293996
-
The role of mTOR inhibitors for treatment of sarcomas
-
Mita MM, Tolcher AW. The role of mTOR inhibitors for treatment of sarcomas. Curr Oncol Rep. 2007;9(4):316-322.
-
(2007)
Curr Oncol Rep
, vol.9
, Issue.4
, pp. 316-322
-
-
Mita, M.M.1
Tolcher, A.W.2
-
73
-
-
0346499118
-
Novel therapeutic molecular targets for prostate cancer: The mTOR signaling pathway and epidermal growth factor receptor
-
discussion S44
-
Tolcher AW. Novel therapeutic molecular targets for prostate cancer: the mTOR signaling pathway and epidermal growth factor receptor. J Urol. 2004;171:S41-S43; discussion S44.
-
(2004)
J Urol
, vol.171
-
-
Tolcher, A.W.1
-
74
-
-
72049083386
-
Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies
-
Coiffer B, Ribrag V. Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies. Leuk Lymphoma. 2009;50(12):1916-1930.
-
(2009)
Leuk Lymphoma
, vol.50
, Issue.12
, pp. 1916-1930
-
-
Coiffer, B.1
Ribrag, V.2
-
75
-
-
72049114956
-
Intravenous temsirolimus in cancer patients: Clinical pharmacology and dosing considerations
-
Boni J P, Hug B, Leister C, Sonnichsen D. Intravenous temsirolimus in cancer patients: clinical pharmacology and dosing considerations. Semin Oncol. 2009;36 Suppl 3:S18-S25.
-
(2009)
Semin Oncol
, vol.36
, Issue.SUPPL. 3
-
-
Boni, J.P.1
Hug, B.2
Leister, C.3
Sonnichsen, D.4
-
76
-
-
23944481410
-
Phase II trial of singleagent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
-
Witzig TE, Geyer SM, Ghobrial I, et al. Phase II trial of singleagent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J Clin Oncol. 2005;23(23):5347-5356.
-
(2005)
J Clin Oncol
, vol.23
, Issue.23
, pp. 5347-5356
-
-
Witzig, T.E.1
Geyer, S.M.2
Ghobrial, I.3
-
77
-
-
67349127898
-
The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents
-
Sankhala K, Mita A, Kelly K, Mahalingam D, Giles F, Mita M. The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents. Target Oncol. 2009;4(2):135-142.
-
(2009)
Target Oncol
, vol.4
, Issue.2
, pp. 135-142
-
-
Sankhala, K.1
Mita, A.2
Kelly, K.3
Mahalingam, D.4
Giles, F.5
Mita, M.6
-
78
-
-
49049087320
-
Lowdose, single-agent temsirolimus for relapsed mantle cell lymphoma: A phase 2 trial in the North Central Cancer Treatment Group
-
Ansell SM, Inwards DJ, Rowland KM Jr, et al. Lowdose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the North Central Cancer Treatment Group. Cancer. 2008;113(3):508-514.
-
(2008)
Cancer
, vol.113
, Issue.3
, pp. 508-514
-
-
Ansell, S.M.1
Inwards, D.J.2
Rowland Jr, K.M.3
-
79
-
-
68949102180
-
Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
-
Hess G, Herbrecht R, Romaguera J, et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol. 2009;27(23):3822-3829.
-
(2009)
J Clin Oncol
, vol.27
, Issue.23
, pp. 3822-3829
-
-
Hess, G.1
Herbrecht, R.2
Romaguera, J.3
-
80
-
-
77955347818
-
Temsirolimus for the treatment of patients with relapsed or refractory mantle cell lymphoma. Supportive effcacy analyses from the phase 3 study
-
Abstract 0973
-
Hess G, Romaguera J, Herbrecht R, et al. Temsirolimus for the treatment of patients with relapsed or refractory mantle cell lymphoma. Supportive effcacy analyses from the phase 3 study. Haematologica. 2009;94 Suppl 2:S391. Abstract 0973.
-
(2009)
Haematologica
, vol.94
, Issue.SUPPL. 2
-
-
Hess, G.1
Romaguera, J.2
Herbrecht, R.3
-
81
-
-
77955373093
-
A phase II study of temsirolimus (CCI-779) in combination with rituximab in patients with relapsed or refractory mantle cell lymphoma [ASH Annual Meeting Abstracts]
-
Ansell SM, Tang H, Kurtin P, et al. A phase II study of temsirolimus (CCI-779) in combination with rituximab in patients with relapsed or refractory mantle cell lymphoma [ASH Annual Meeting Abstracts]. Blood. 2009;114:1665.
-
(2009)
Blood
, vol.114
, pp. 1665
-
-
Ansell, S.M.1
Tang, H.2
Kurtin, P.3
-
82
-
-
57449107677
-
A phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed aggressive non-Hodgkin lymphoma (NHL) [ASH Annual Meeting Abstracts]
-
Reeder CB, Gornet MK, Habermann TM, et al. A phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed aggressive non-Hodgkin lymphoma (NHL) [ASH Annual Meeting Abstracts]. Blood. 2007;110:121.
-
(2007)
Blood
, vol.110
, pp. 121
-
-
Reeder, C.B.1
Gornet, M.K.2
Habermann, T.M.3
|