메뉴 건너뛰기




Volumn 2, Issue 1, 2010, Pages 181-189

Temsirolimus in the treatment of relapsed and/or refractory mantle cell lymphoma

Author keywords

E4 BP1; mTOR rapamycin; P7056K; PI3K Akt

Indexed keywords

ALEMTUZUMAB; ALKYLATING AGENT; ANTHRACYCLINE; BORTEZOMIB; CHLORAMBUCIL; CLADRIBINE; CYCLOPHOSPHAMIDE; CYTARABINE; DEFOROLIMUS; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; EVEROLIMUS; FLUDARABINE; GEMCITABINE; LENALIDOMIDE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; METHOTREXATE; MITOXANTRONE; MK 8669; PREDNISONE; PROTEIN P21; RAF PROTEIN; RAPAMYCIN; RITUXIMAB; TEMSIROLIMUS; THALIDOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE;

EID: 77955407568     PISSN: None     EISSN: 11791322     Source Type: Book Series    
DOI: 10.2147/cmr.s7960     Document Type: Review
Times cited : (12)

References (82)
  • 1
    • 0028920013 scopus 로고
    • Patterns of survival in mantle cell lymphoma
    • Zucca E, Roggero E, Pinotti G, et al. Patterns of survival in mantle cell lymphoma. Ann Oncol. 1995;6(3):257-262.
    • (1995) Ann Oncol , vol.6 , Issue.3 , pp. 257-262
    • Zucca, E.1    Roggero, E.2    Pinotti, G.3
  • 2
    • 27244452464 scopus 로고    scopus 로고
    • High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine
    • Romaguera JE, Fayad L, Rodriguez MA, et al. High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine. J Clin Oncol. 2005;23(28):7013-7023.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 7013-7023
    • Romaguera, J.E.1    Fayad, L.2    Rodriguez, M.A.3
  • 3
    • 20144376591 scopus 로고    scopus 로고
    • Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: Results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG)
    • Lenz G, Dreyling M, Hoster E, et al. Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG). J Clin Oncol. 2005;23(9):1984-1992.
    • (2005) J Clin Oncol , vol.23 , Issue.9 , pp. 1984-1992
    • Lenz, G.1    Dreyling, M.2    Hoster, E.3
  • 4
    • 8744274334 scopus 로고    scopus 로고
    • The addition of rituximab to a combination of fludarabine, cyclophosphamide, mitoxantrone (FCM) significantly increases the response rate and prolongs survival as compared with FCM alone in patients with relapsed and refractory follicular and mantle cell lymphomas: Results of a prospective randomized study of the German Low-Grade Lymphoma Study Group
    • Forstpointner R, Dreyling M, Repp R, et al. The addition of rituximab to a combination of fludarabine, cyclophosphamide, mitoxantrone (FCM) significantly increases the response rate and prolongs survival as compared with FCM alone in patients with relapsed and refractory follicular and mantle cell lymphomas: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood. 2004;104(10):3064-3071.
    • (2004) Blood , vol.104 , Issue.10 , pp. 3064-3071
    • Forstpointner, R.1    Dreyling, M.2    Repp, R.3
  • 5
    • 70449727887 scopus 로고    scopus 로고
    • Phase II study of yttrium-90-ibritumomab tiuxetan in patients with relapsed or refractory mantle cell lymphoma
    • Wang M, Oki Y, Pro B, et al. Phase II study of yttrium-90-ibritumomab tiuxetan in patients with relapsed or refractory mantle cell lymphoma. J Clin Oncol. 2009;27(31):5213-5218.
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5213-5218
    • Wang, M.1    Oki, Y.2    Pro, B.3
  • 6
    • 61849128387 scopus 로고    scopus 로고
    • Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survivals compared with patients with relapsed disease following treatment with single agent bort-ezomib: Results of a multicentre Phase 2 clinical trial
    • O'Connor OA, Moskowitz C, Portlock C, et al. Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survivals compared with patients with relapsed disease following treatment with single agent bort-ezomib: results of a multicentre Phase 2 clinical trial. Br J Haematol. 2009;145(1):34-39.
    • (2009) Br J Haematol , vol.145 , Issue.1 , pp. 34-39
    • O'Connor, O.A.1    Moskowitz, C.2    Portlock, C.3
  • 7
    • 64149112784 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma
    • Habermann TM, Lossos IS, Justice G, et al. Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma. Br J Haematol. 2009;145(3): 344-349.
    • (2009) Br J Haematol , vol.145 , Issue.3 , pp. 344-349
    • Habermann, T.M.1    Lossos, I.S.2    Justice, G.3
  • 8
    • 68949165966 scopus 로고    scopus 로고
    • Mantle cell lymphoma: Are current therapies changing the course of disease?
    • Geisler C. Mantle cell lymphoma: are current therapies changing the course of disease? Curr Oncol Rep. 2009;11(5):371-377.
    • (2009) Curr Oncol Rep , vol.11 , Issue.5 , pp. 371-377
    • Geisler, C.1
  • 9
    • 0016713286 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
    • Sehgal SN, Baker H, Vézina C. Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot (Tokyo). 1975;28(10):727-732.
    • (1975) J Antibiot (Tokyo) , vol.28 , Issue.10 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vézina, C.3
  • 10
    • 40349095131 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) pathway signalling in lymphomas
    • Drakos E, Rassidakis GZ, Medeiros LJ. Mammalian target of rapamycin (mTOR) pathway signalling in lymphomas. Expert Rev Mol Med. 2008;10:e4.
    • (2008) Expert Rev Mol Med , vol.10
    • Drakos, E.1    Rassidakis, G.Z.2    Medeiros, L.J.3
  • 11
    • 38949172405 scopus 로고    scopus 로고
    • Immunosuppression and tumor development in organ transplant recipients: The emerging dualistic role of rapamycin
    • Gaumann A, Schlitt HJ, Geissler EK. Immunosuppression and tumor development in organ transplant recipients: the emerging dualistic role of rapamycin. Transpl Int. 2008;21(3):207-217.
    • (2008) Transpl Int , vol.21 , Issue.3 , pp. 207-217
    • Gaumann, A.1    Schlitt, H.J.2    Geissler, E.K.3
  • 12
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer. 2004;4(5):335-348.
    • (2004) Nat Rev Cancer , vol.4 , Issue.5 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 13
    • 72049117072 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: Discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth
    • Gibbons JJ, Abraham RT, Yu K. Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth. Semin Oncol. 2009;36 Suppl 3:S3-S17.
    • (2009) Semin Oncol , vol.36 , Issue.3 SUPPL. 3
    • Gibbons, J.J.1    Abraham, R.T.2    Yu, K.3
  • 14
    • 0028344699 scopus 로고
    • Yeast TOR (DRR) proteins: Amino-acid sequence alignment and identification of structural motifs
    • Cafferkey R, McLaughlin MM, Young PR, Johnson RK, Livi G P. Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs. Gene. 1994;141(1):133-136.
    • (1994) Gene , vol.141 , Issue.1 , pp. 133-136
    • Cafferkey, R.1    McLaughlin, M.M.2    Young, P.R.3    Johnson, R.K.4    Livi, G.P.5
  • 15
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18(16):1926-1945.
    • (2004) Genes Dev , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 16
    • 29244481490 scopus 로고    scopus 로고
    • Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway
    • Jozwiak J, Jozwiak S, Grzela T, Lazarczyk M. Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway. Neuromolecular Med. 2005;7(4):287-296.
    • (2005) Neuromolecular Med , vol.7 , Issue.4 , pp. 287-296
    • Jozwiak, J.1    Jozwiak, S.2    Grzela, T.3    Lazarczyk, M.4
  • 17
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol. 2002;4(9):658-665.
    • (2002) Nat Cell Biol , vol.4 , Issue.9 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 18
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006;124(3):471-484.
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 19
    • 18144399578 scopus 로고    scopus 로고
    • MTOR-targeted therapy of cancer with rapamycin derivatives
    • Vignot S, Faivre S, Aguirre D, Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol. 2005;16(4):525-537.
    • (2005) Ann Oncol , vol.16 , Issue.4 , pp. 525-537
    • Vignot, S.1    Faivre, S.2    Aguirre, D.3    Raymond, E.4
  • 20
    • 24744439255 scopus 로고    scopus 로고
    • Molecular organization of target of rapamycin complex 2
    • Wullschleger S, Loewith R, Oppliger W, Hall MN. Molecular organization of target of rapamycin complex 2. J Biol Chem. 2005; 280(35):30697-30704.
    • (2005) J Biol Chem , vol.280 , Issue.35 , pp. 30697-30704
    • Wullschleger, S.1    Loewith, R.2    Oppliger, W.3    Hall, M.N.4
  • 21
    • 75749105049 scopus 로고    scopus 로고
    • MTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
    • Julien LA, Carriere A, Moreau J, Roux P P. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol. 2010;30(4):908-921.
    • (2010) Mol Cell Biol , vol.30 , Issue.4 , pp. 908-921
    • Julien, L.A.1    Carriere, A.2    Moreau, J.3    Roux, P.P.4
  • 22
    • 0033153166 scopus 로고    scopus 로고
    • Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
    • Gingras AC, Gygi S P, Raught B, et al. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999;13(11): 1422-1437.
    • (1999) Genes Dev , vol.13 , Issue.11 , pp. 1422-1437
    • Gingras, A.C.1    Gygi, S.P.2    Raught, B.3
  • 23
    • 33748752709 scopus 로고    scopus 로고
    • Malignant hematopoietic cells induce an increased expression of VEGFR-1 and VEGFR-3 on bone marrow endothelial cells via AKT and mTOR signalling pathways
    • Mirshahi P, Toprak SK, Faussat AM, et al. Malignant hematopoietic cells induce an increased expression of VEGFR-1 and VEGFR-3 on bone marrow endothelial cells via AKT and mTOR signalling pathways. Biochem Biophys Res Commun. 2006;349(3):1003-1010.
    • (2006) Biochem Biophys Res Commun , vol.349 , Issue.3 , pp. 1003-1010
    • Mirshahi, P.1    Toprak, S.K.2    Faussat, A.M.3
  • 24
    • 57449111076 scopus 로고    scopus 로고
    • Marastoni S. mTOR pathway and mTOR inhibitors as agents for cancer therapy
    • Baldo P, Cecco S, Giacomin E, Lazzarini R, Ros B, Marastoni S. mTOR pathway and mTOR inhibitors as agents for cancer therapy. Curr Cancer Drug Targets. 2008;8(8):647-665.
    • (2008) Curr Cancer Drug Targets , vol.8 , Issue.8 , pp. 647-665
    • Baldo, P.1    Cecco, S.2    Giacomin, E.3    Lazzarini, R.4    Ros, B.5
  • 25
    • 61849157793 scopus 로고    scopus 로고
    • Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease
    • Brown VI, Seif AE, Reid GS, Teachey DT, Grupp SA. Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease. Immunol Res. 2008;42(1-3):84-105.
    • (2008) Immunol Res , vol.42 , Issue.1-3 , pp. 84-105
    • Brown, V.I.1    Seif, A.E.2    Reid, G.S.3    Teachey, D.T.4    Grupp, S.A.5
  • 26
    • 23744494993 scopus 로고    scopus 로고
    • Rapamycin stimulates apop-tosis of childhood acute lymphoblastic leukemia cells
    • Avellino R, Romano S, Parasole R, et al. Rapamycin stimulates apop-tosis of childhood acute lymphoblastic leukemia cells. Blood. 2005; 106(4):1400-1406.
    • (2005) Blood , vol.106 , Issue.4 , pp. 1400-1406
    • Avellino, R.1    Romano, S.2    Parasole, R.3
  • 27
    • 65349114832 scopus 로고    scopus 로고
    • Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia
    • Crazzolara R, Cisterne A, Thien M, et al. Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia. Blood. 2009;113(14):3297-3306.
    • (2009) Blood , vol.113 , Issue.14 , pp. 3297-3306
    • Crazzolara, R.1    Cisterne, A.2    Thien, M.3
  • 28
    • 56349118798 scopus 로고    scopus 로고
    • Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mTOR signaling pathway, enhancing G1 cell cycle arrest and apoptosis
    • Gu L, Gao J, Li Q, et al. Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mTOR signaling pathway, enhancing G1 cell cycle arrest and apoptosis. Leukemia. 2008;22(11):2091-2096.
    • (2008) Leukemia , vol.22 , Issue.11 , pp. 2091-2096
    • Gu, L.1    Gao, J.2    Li, Q.3
  • 29
    • 2542504461 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells
    • Kharas MG, Deane JA, Wong S, et al. Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood. 2004;103(11):4268-4275.
    • (2004) Blood , vol.103 , Issue.11 , pp. 4268-4275
    • Kharas, M.G.1    Deane, J.A.2    Wong, S.3
  • 30
    • 0042744837 scopus 로고    scopus 로고
    • Survival of acute myeloid leukemia cells requires PI3 kinase activation
    • Xu Q, Simpson SE, Scialla TJ, Bagg A, Carroll M. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood. 2003; 102(3):972-980.
    • (2003) Blood , vol.102 , Issue.3 , pp. 972-980
    • Xu, Q.1    Simpson, S.E.2    Scialla, T.J.3    Bagg, A.4    Carroll, M.5
  • 31
    • 34249308840 scopus 로고    scopus 로고
    • The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelo-dysplastic syndromes and infuences cell survival and proliferation
    • Follo MY, Mongiorgi S, Bosi C, et al. The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelo-dysplastic syndromes and infuences cell survival and proliferation. Cancer Res. 2007;67(9):4287-4294.
    • (2007) Cancer Res , vol.67 , Issue.9 , pp. 4287-4294
    • Follo, M.Y.1    Mongiorgi, S.2    Bosi, C.3
  • 33
    • 34147104488 scopus 로고    scopus 로고
    • AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells
    • Frost P, Shi Y, Hoang B, Lichtenstein A. AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells. Oncogene. 2007;26(16):2255-2262.
    • (2007) Oncogene , vol.26 , Issue.16 , pp. 2255-2262
    • Frost, P.1    Shi, Y.2    Hoang, B.3    Lichtenstein, A.4
  • 34
    • 68649117850 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma
    • Farag SS, Zhang S, Jansak BS, et al. Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma. Leuk Res. 2009;33(11):1475-1480.
    • (2009) Leuk Res , vol.33 , Issue.11 , pp. 1475-1480
    • Farag, S.S.1    Zhang, S.2    Jansak, B.S.3
  • 35
    • 14944339657 scopus 로고    scopus 로고
    • Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR
    • Dutton A, Reynolds GM, Dawson CW, Young LS, Murray PG. Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR. J Pathol. 2005;205(4):498-506.
    • (2005) J Pathol , vol.205 , Issue.4 , pp. 498-506
    • Dutton, A.1    Reynolds, G.M.2    Dawson, C.W.3    Young, L.S.4    Murray, P.G.5
  • 36
    • 70449494636 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2
    • Gupta M, Ansell SM, Novak AJ, Kumar S, Kaufmann SH, Witzig TE. Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2. Blood. 2009;114(14):2926-2935.
    • (2009) Blood , vol.114 , Issue.14 , pp. 2926-2935
    • Gupta, M.1    Ansell, S.M.2    Novak, A.J.3    Kumar, S.4    Kaufmann, S.H.5    Witzig, T.E.6
  • 37
    • 68449088229 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines
    • Pop I V, Pop LM, Ghetie MA, Vitetta ES. Targeting mammalian target of rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines. Leuk Lymphoma. 2009;50(7):1155-1162.
    • (2009) Leuk Lymphoma , vol.50 , Issue.7 , pp. 1155-1162
    • Pop, I.V.1    Pop, L.M.2    Ghetie, M.A.3    Vitetta, E.S.4
  • 38
    • 70350100969 scopus 로고    scopus 로고
    • Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma
    • Gasperini P, Tosato G. Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma. Leukemia. 2009;23(10):1867-1874.
    • (2009) Leukemia , vol.23 , Issue.10 , pp. 1867-1874
    • Gasperini, P.1    Tosato, G.2
  • 39
    • 0042090489 scopus 로고    scopus 로고
    • Rapamycin inhibits the interleukin 10 signal transduc-tion pathway and the growth of Epstein Barr virus B-cell lymphomas
    • Nepomuceno RR, Balatoni CE, Natkunam Y, Snow AL, Krams SM, Martinez OM. Rapamycin inhibits the interleukin 10 signal transduc-tion pathway and the growth of Epstein Barr virus B-cell lymphomas. Cancer Res. 2003;63(15):4472-4480.
    • (2003) Cancer Res , vol.63 , Issue.15 , pp. 4472-4480
    • Nepomuceno, R.R.1    Balatoni, C.E.2    Natkunam, Y.3    Snow, A.L.4    Krams, S.M.5    Martinez, O.M.6
  • 40
    • 33845500278 scopus 로고    scopus 로고
    • Syk-dependent mTOR activation in follicular lymphoma cells
    • Leseux L, Hamdi SM, Al Saati T, et al. Syk-dependent mTOR activation in follicular lymphoma cells. Blood. 2006;108(13):4156-4162.
    • (2006) Blood , vol.108 , Issue.13 , pp. 4156-4162
    • Leseux, L.1    Hamdi, S.M.2    Saati, T.A.3
  • 41
    • 67149099805 scopus 로고    scopus 로고
    • A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation
    • Gupta M, Dillon SR, Ziesmer SC, et al. A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation. Blood. 2009;113(21): 5206-5216.
    • (2009) Blood , vol.113 , Issue.21 , pp. 5206-5216
    • Gupta, M.1    Dillon, S.R.2    Ziesmer, S.C.3
  • 42
    • 12744279721 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: A new therapeutic option
    • Ringshausen I, Peschel C, Decker T. Mammalian target of rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: a new therapeutic option. Leuk Lymphoma. 2005;46(1):11-19.
    • (2005) Leuk Lymphoma , vol.46 , Issue.1 , pp. 11-19
    • Ringshausen, I.1    Peschel, C.2    Decker, T.3
  • 43
    • 0037207525 scopus 로고    scopus 로고
    • Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin
    • Decker T, Hipp S, Ringshausen I, et al. Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin. Blood. 2003;101(1):278-285.
    • (2003) Blood , vol.101 , Issue.1 , pp. 278-285
    • Decker, T.1    Hipp, S.2    Ringshausen, I.3
  • 44
    • 59049091983 scopus 로고    scopus 로고
    • A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL
    • Decker T, Sandherr M, Goetze K, Oelsner M, Ringshausen I, Peschel C. A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL. Ann Hematol. 2009;88(3):221-227.
    • (2009) Ann Hematol , vol.88 , Issue.3 , pp. 221-227
    • Decker, T.1    Sandherr, M.2    Goetze, K.3    Oelsner, M.4    Ringshausen, I.5    Peschel, C.6
  • 45
    • 34648824397 scopus 로고    scopus 로고
    • Genetic and molecular pathogenesis of mantle cell lymphoma: Perspectives for new targeted therapeutics
    • Jares P, Colomer D, Campo E. Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics. Nat Rev Cancer. 2007;7(10):750-762.
    • (2007) Nat Rev Cancer , vol.7 , Issue.10 , pp. 750-762
    • Jares, P.1    Colomer, D.2    Campo, E.3
  • 46
    • 0036231124 scopus 로고    scopus 로고
    • Mantle cell lymphoma: A biological and therapeutic paradigm
    • Decaudin D. Mantle cell lymphoma: a biological and therapeutic paradigm. Leuk Lymphoma. 2002;43(4):773-781.
    • (2002) Leuk Lymphoma , vol.43 , Issue.4 , pp. 773-781
    • Decaudin, D.1
  • 47
    • 0029071657 scopus 로고
    • D-type cyclins
    • Sherr CJ. D-type cyclins. Trends Biochem Sci. 1995;20(5):187-190.
    • (1995) Trends Biochem Sci , vol.20 , Issue.5 , pp. 187-190
    • Sherr, C.J.1
  • 48
    • 46749155539 scopus 로고    scopus 로고
    • Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma
    • Dal Col J, Zancai P, Terrin L, et al. Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma. Blood. 2008;111(10):5142-5151.
    • (2008) Blood , vol.111 , Issue.10 , pp. 5142-5151
    • Dal, C.J.1    Zancai, P.2    Terrin, L.3
  • 49
    • 33747846726 scopus 로고    scopus 로고
    • Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma
    • Rudelius M, Pittaluga S, Nishizuka S, et al. Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood. 2006;108(5):1668-1676.
    • (2006) Blood , vol.108 , Issue.5 , pp. 1668-1676
    • Rudelius, M.1    Pittaluga, S.2    Nishizuka, S.3
  • 50
    • 33846516354 scopus 로고    scopus 로고
    • Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
    • Haritunians T, Mori A, O'Kelly J, Luong QT, Giles FJ, Koeffer H P. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia. 2007; 21(2):333-339.
    • (2007) Leukemia , vol.21 , Issue.2 , pp. 333-339
    • Haritunians, T.1    Mori, A.2    O'Kelly, J.3    Luong, Q.T.4    Giles, F.J.5    Koeffer, H.P.6
  • 51
    • 38049151149 scopus 로고    scopus 로고
    • PKC zeta mTOR pathway: A new target for rituximab therapy in follicular lymphoma
    • Leseux L, Laurent G, Laurent C, et al. PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma. Blood. 2008; 111(1):285-291.
    • (2008) Blood , vol.111 , Issue.1 , pp. 285-291
    • Leseux, L.1    Laurent, G.2    Laurent, C.3
  • 52
    • 48249090836 scopus 로고    scopus 로고
    • Therapeutic activity of mTOR inhibitors in mantle cell lymphoma
    • Younes A. Therapeutic activity of mTOR inhibitors in mantle cell lymphoma. Autophagy 2008;4(5):707-709.
    • (2008) Autophagy , vol.4 , Issue.5 , pp. 707-709
    • Younes, A.1
  • 53
    • 34248647440 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma
    • Peponi E. Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma. Am J Pathol. 2006;169(6):2171-2180.
    • (2006) Am J Pathol , vol.169 , Issue.6 , pp. 2171-2180
    • Peponi, E.1
  • 54
    • 27144455334 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells
    • Hipp S, Ringshausen I, Oelsner M, Bogner C, Peschel C, Decker T. Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells. Haematologica. 2005; 90(10):1433-1434.
    • (2005) Haematologica , vol.90 , Issue.10 , pp. 1433-1434
    • Hipp, S.1    Ringshausen, I.2    Oelsner, M.3    Bogner, C.4    Peschel, C.5    Decker, T.6
  • 55
    • 0032878975 scopus 로고    scopus 로고
    • CDK1 and cyclin A expression is linked to cell proliferation and associated with prognosis in non-Hodgkin's lymphomas
    • Wolowiec D, Berger F, Ffrench P, Bryon PA, Ffrench M. CDK1 and cyclin A expression is linked to cell proliferation and associated with prognosis in non-Hodgkin's lymphomas. Leuk Lymphoma. 1999;35(1-2):147-157.
    • (1999) Leuk Lymphoma , vol.35 , Issue.1-2 , pp. 147-157
    • Wolowiec, D.1    Berger, F.2    Ffrench, P.3    Bryon, P.A.4    Ffrench, M.5
  • 56
    • 58149382600 scopus 로고    scopus 로고
    • Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma
    • Gelebart P, Anand M, Armanious H, et al. Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. Blood. 2008; 112(13):5171-5179.
    • (2008) Blood , vol.112 , Issue.13 , pp. 5171-5179
    • Gelebart, P.1    Anand, M.2    Armanious, H.3
  • 57
    • 40749094917 scopus 로고    scopus 로고
    • Temsirolimus downregu-lates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma
    • Yazbeck V Y, Buglio D, Georgakis G V, et al. Temsirolimus downregu-lates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma. Exp Hematol. 2008;36(4):443-450.
    • (2008) Exp Hematol , vol.36 , Issue.4 , pp. 443-450
    • Yazbeck, V.Y.1    Buglio, D.2    Georgakis, G.V.3
  • 58
    • 58949086093 scopus 로고    scopus 로고
    • Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation
    • Giatromanolaki A, Koukourakis MI, Pezzella F, et al. Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation. Hematol Oncol. 2008;26(4):219-224.
    • (2008) Hematol Oncol , vol.26 , Issue.4 , pp. 219-224
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Pezzella, F.3
  • 59
    • 0035186128 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real-time quantitative polymerase chain reaction
    • Koomagi R, Zintl F, Sauerbrey A, Volm M. Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real-time quantitative polymerase chain reaction. Clin Cancer Res. 2001;7(11):3381-3384.
    • (2001) Clin Cancer Res , vol.7 , Issue.11 , pp. 3381-3384
    • Koomagi, R.1    Zintl, F.2    Sauerbrey, A.3    Volm, M.4
  • 60
    • 0242550768 scopus 로고    scopus 로고
    • Prognostic significance of microvessel density and vascular endothelial growth factor (VEGF) expression in non-Hodgkin's lymphoma
    • Hazar B, Paydas S, Zorludemir S, Sahin B, Tuncer I. Prognostic significance of microvessel density and vascular endothelial growth factor (VEGF) expression in non-Hodgkin's lymphoma. Leuk Lymphoma. 2003;44(12):2089-2093.
    • (2003) Leuk Lymphoma , vol.44 , Issue.12 , pp. 2089-2093
    • Hazar, B.1    Paydas, S.2    Zorludemir, S.3    Sahin, B.4    Tuncer, I.5
  • 61
    • 0036162385 scopus 로고    scopus 로고
    • High expression of MCL1 gene related to vascular endothelial growth factor is associated with poor outcome in non-Hodgkin's lymphoma
    • Kuramoto K, Sakai A, Shigemasa K, et al. High expression of MCL1 gene related to vascular endothelial growth factor is associated with poor outcome in non-Hodgkin's lymphoma. Br J Haematol. 2002;116 (1): 158-161.
    • (2002) Br J Haematol , vol.116 , Issue.1 , pp. 158-161
    • Kuramoto, K.1    Sakai, A.2    Shigemasa, K.3
  • 62
    • 0036765823 scopus 로고    scopus 로고
    • Immunohistochemical detection of C-kit (CD117) and vascular endothelial growth factor (VEGF) overexpres-sion in mantle cell lymphoma
    • Potti A, Ganti AK, Kargas S, Koch M. Immunohistochemical detection of C-kit (CD117) and vascular endothelial growth factor (VEGF) overexpres-sion in mantle cell lymphoma. Anticancer Res. 2002;22(5):2899-2901.
    • (2002) Anticancer Res , vol.22 , Issue.5 , pp. 2899-2901
    • Potti, A.1    Ganti, A.K.2    Kargas, S.3    Koch, M.4
  • 63
    • 72149134653 scopus 로고    scopus 로고
    • Vascular endothelial growth factor polymorphisms in mantle cell lymphoma
    • Galimberti S, Nagy B, Palumbo GA, et al. Vascular endothelial growth factor polymorphisms in mantle cell lymphoma. Acta Haematol. 2010; 123(2):91-95.
    • (2010) Acta Haematol , vol.123 , Issue.2 , pp. 91-95
    • Galimberti, S.1    Nagy, B.2    Palumbo, G.A.3
  • 64
    • 34347242470 scopus 로고    scopus 로고
    • RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
    • Roux P P, Shahbazian D, Vu H, et al. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem. 2007;282(19):14056-14064.
    • (2007) J Biol Chem , vol.282 , Issue.19 , pp. 14056-14064
    • Roux, P.P.1    Shahbazian, D.2    Vu, H.3
  • 65
    • 0025237563 scopus 로고
    • V-myc and v-raf act synergistically to induce B-cell tumors in pristane-primed adult BALBC mice
    • Kurie JM, Morse HC III, Principato MA, et al. v-myc and v-raf act synergistically to induce B-cell tumors in pristane-primed adult BALBC mice. Oncogene. 1990;5(4):577-582.
    • (1990) Oncogene , vol.5 , Issue.4 , pp. 577-582
    • Kurie, J.M.1    Morse, H.C.2    Principato, M.A.3
  • 66
    • 35548974781 scopus 로고    scopus 로고
    • RAF-1 over-expression does condition survival of patients affected by aggressive mantle cell lymphoma
    • Nagy B, Galimberti S, Benedetti E, et al. RAF-1 over-expression does condition survival of patients affected by aggressive mantle cell lymphoma. Leuk Res. 2007;31(11):1595-1597.
    • (2007) Leuk Res , vol.31 , Issue.11 , pp. 1595-1597
    • Nagy, B.1    Galimberti, S.2    Benedetti, E.3
  • 67
    • 0037326715 scopus 로고    scopus 로고
    • Abnormal expression of apoptosis-related genes in hematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
    • Nagy B, Lundán T, Larramendy ML, et al. Abnormal expression of apoptosis-related genes in hematological malignancies: overexpression of MYC is poor prognostic sign in mantle cell lymphoma. Br J Haematol. 2003;120(3):4434-4441.
    • (2003) Br J Haematol , vol.120 , Issue.3 , pp. 4434-4441
    • Nagy, B.1    Lundán, T.2    Larramendy, M.L.3
  • 68
    • 49449108291 scopus 로고    scopus 로고
    • MTORC1 promotes survival through translational control of Mcl-1
    • Mills JR, Hippo Y, Robert F, et al. mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A. 2008; 105(31): 10853-10858.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.31 , pp. 10853-10858
    • Mills, J.R.1    Hippo, Y.2    Robert, F.3
  • 69
    • 33644851486 scopus 로고    scopus 로고
    • Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma
    • Rinaldi A, Kwee I, Taborelli M, et al. Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma. Br J Haematol. 2006;132(3):303-316.
    • (2006) Br J Haematol , vol.132 , Issue.3 , pp. 303-316
    • Rinaldi, A.1    Kwee, I.2    Taborelli, M.3
  • 70
    • 72049097131 scopus 로고    scopus 로고
    • Clinical trial experience with temsirolimus in patients with advanced renal cell carcinoma
    • Hudes GR, Berkenblit A, Feingold J, Atkins MB, Rini BI, Dutcher J. Clinical trial experience with temsirolimus in patients with advanced renal cell carcinoma. Semin Oncol. 2009;36 Suppl 3:S26-S36.
    • (2009) Semin Oncol , vol.36 , Issue.SUPPL. 3
    • Hudes, G.R.1    Berkenblit, A.2    Feingold, J.3    Atkins, M.B.4    Rini, B.I.5    Dutcher, J.6
  • 71
    • 0042197413 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: A new molecular target for breast cancer
    • Mita MM, Mita A, Rowinsky EK. Mammalian target of rapamycin: a new molecular target for breast cancer. Clin Breast Cancer. 2003;4(2):126-137.
    • (2003) Clin Breast Cancer , vol.4 , Issue.2 , pp. 126-137
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 72
    • 34447293996 scopus 로고    scopus 로고
    • The role of mTOR inhibitors for treatment of sarcomas
    • Mita MM, Tolcher AW. The role of mTOR inhibitors for treatment of sarcomas. Curr Oncol Rep. 2007;9(4):316-322.
    • (2007) Curr Oncol Rep , vol.9 , Issue.4 , pp. 316-322
    • Mita, M.M.1    Tolcher, A.W.2
  • 73
    • 0346499118 scopus 로고    scopus 로고
    • Novel therapeutic molecular targets for prostate cancer: The mTOR signaling pathway and epidermal growth factor receptor
    • discussion S44
    • Tolcher AW. Novel therapeutic molecular targets for prostate cancer: the mTOR signaling pathway and epidermal growth factor receptor. J Urol. 2004;171:S41-S43; discussion S44.
    • (2004) J Urol , vol.171
    • Tolcher, A.W.1
  • 74
    • 72049083386 scopus 로고    scopus 로고
    • Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies
    • Coiffer B, Ribrag V. Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies. Leuk Lymphoma. 2009;50(12):1916-1930.
    • (2009) Leuk Lymphoma , vol.50 , Issue.12 , pp. 1916-1930
    • Coiffer, B.1    Ribrag, V.2
  • 75
    • 72049114956 scopus 로고    scopus 로고
    • Intravenous temsirolimus in cancer patients: Clinical pharmacology and dosing considerations
    • Boni J P, Hug B, Leister C, Sonnichsen D. Intravenous temsirolimus in cancer patients: clinical pharmacology and dosing considerations. Semin Oncol. 2009;36 Suppl 3:S18-S25.
    • (2009) Semin Oncol , vol.36 , Issue.SUPPL. 3
    • Boni, J.P.1    Hug, B.2    Leister, C.3    Sonnichsen, D.4
  • 76
    • 23944481410 scopus 로고    scopus 로고
    • Phase II trial of singleagent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
    • Witzig TE, Geyer SM, Ghobrial I, et al. Phase II trial of singleagent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J Clin Oncol. 2005;23(23):5347-5356.
    • (2005) J Clin Oncol , vol.23 , Issue.23 , pp. 5347-5356
    • Witzig, T.E.1    Geyer, S.M.2    Ghobrial, I.3
  • 77
    • 67349127898 scopus 로고    scopus 로고
    • The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents
    • Sankhala K, Mita A, Kelly K, Mahalingam D, Giles F, Mita M. The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents. Target Oncol. 2009;4(2):135-142.
    • (2009) Target Oncol , vol.4 , Issue.2 , pp. 135-142
    • Sankhala, K.1    Mita, A.2    Kelly, K.3    Mahalingam, D.4    Giles, F.5    Mita, M.6
  • 78
    • 49049087320 scopus 로고    scopus 로고
    • Lowdose, single-agent temsirolimus for relapsed mantle cell lymphoma: A phase 2 trial in the North Central Cancer Treatment Group
    • Ansell SM, Inwards DJ, Rowland KM Jr, et al. Lowdose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the North Central Cancer Treatment Group. Cancer. 2008;113(3):508-514.
    • (2008) Cancer , vol.113 , Issue.3 , pp. 508-514
    • Ansell, S.M.1    Inwards, D.J.2    Rowland Jr, K.M.3
  • 79
    • 68949102180 scopus 로고    scopus 로고
    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • Hess G, Herbrecht R, Romaguera J, et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol. 2009;27(23):3822-3829.
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3822-3829
    • Hess, G.1    Herbrecht, R.2    Romaguera, J.3
  • 80
    • 77955347818 scopus 로고    scopus 로고
    • Temsirolimus for the treatment of patients with relapsed or refractory mantle cell lymphoma. Supportive effcacy analyses from the phase 3 study
    • Abstract 0973
    • Hess G, Romaguera J, Herbrecht R, et al. Temsirolimus for the treatment of patients with relapsed or refractory mantle cell lymphoma. Supportive effcacy analyses from the phase 3 study. Haematologica. 2009;94 Suppl 2:S391. Abstract 0973.
    • (2009) Haematologica , vol.94 , Issue.SUPPL. 2
    • Hess, G.1    Romaguera, J.2    Herbrecht, R.3
  • 81
    • 77955373093 scopus 로고    scopus 로고
    • A phase II study of temsirolimus (CCI-779) in combination with rituximab in patients with relapsed or refractory mantle cell lymphoma [ASH Annual Meeting Abstracts]
    • Ansell SM, Tang H, Kurtin P, et al. A phase II study of temsirolimus (CCI-779) in combination with rituximab in patients with relapsed or refractory mantle cell lymphoma [ASH Annual Meeting Abstracts]. Blood. 2009;114:1665.
    • (2009) Blood , vol.114 , pp. 1665
    • Ansell, S.M.1    Tang, H.2    Kurtin, P.3
  • 82
    • 57449107677 scopus 로고    scopus 로고
    • A phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed aggressive non-Hodgkin lymphoma (NHL) [ASH Annual Meeting Abstracts]
    • Reeder CB, Gornet MK, Habermann TM, et al. A phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed aggressive non-Hodgkin lymphoma (NHL) [ASH Annual Meeting Abstracts]. Blood. 2007;110:121.
    • (2007) Blood , vol.110 , pp. 121
    • Reeder, C.B.1    Gornet, M.K.2    Habermann, T.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.