Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma

British Journal of Haematology

Volumn 120, Issue 3, 2003, Pages 434-441

  Nagy, Bálint ^a,b   Lundán, Tuija ^a   Larramendy, Marcelo L ^a,c   Aalto, Yan ^a   Zhu, Ying ^a   Niini, Tarja ^a   Edgren, Henrik ^a   Ferrer, Anna ^a   Vilpo, Juhani ^d   Elonen, Erkki ^f   Vettenranta, Kim ^f   Franssila, Kaarle ^a   Knuutila, Sakari ^a,e  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c FACULTAD DE CIENCIAS NATURALES Y MUSEO   (Argentina)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF HELSINKI   (Finland)

^f NONE

Author keywords

Apoptotic genes; Gene expression; Haematological malignancies; Prognosis; Quantitative real time PCR

Indexed keywords

MYC PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL2A1; PROTEIN BCL2L1; PROTEIN DAPK1; PROTEIN MCL 1; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHROMOSOME 11Q; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HEMATOLOGIC MALIGNANCY; HUMAN; KARYOTYPE; MALE; MANTLE CELL LYMPHOMA; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE DIAGNOSIS; RNA ANALYSIS; STATISTICAL SIGNIFICANCE;

ADULT; AGED; APOPTOSIS; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 11; FEMALE; FOLLOW-UP STUDIES; GENE DELETION; GENE EXPRESSION; GENES, MYC; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA; LYMPHOMA, MANTLE-CELL; MALE; MIDDLE AGED; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 0037326715     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04121.x     Document Type: Article

References (40)

1. Sakari Knuutila, , , ,Aalto, Y., El-Rifai, W., Vilpo. L., Ollila, J., Nagy, B., Vihinen, M., Vilpo, J. & Knuutila, S. (2001) Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion. Leukemia. 15, 1721-1728.
2. Adams, J.M. & Cory, S. (1998) The BCL-2 protein family: arbiters of cell survival. Science, 281, 1322-1326.
3. Bae, J., Leo, C.P., Hsu, S.Y. & Hsueh, A.J. (2000) MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. Journal of Biological Chemistry, 275, 25255-25261.
4. Bea, S., Ribas, M., Hernandez, J.M., Bosch, F., Pinyol, M., Hernandez, L., Garcia, J.L., Flores, T., Gonzalez, M., Lopez-Guillermo, A., Piris, M.A., Cardesa, A., Montserrat, E., Miro, R. & Campo, E. (1999) Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants. Blood. 93, 4365-4374.
5. Bernard, M., Gressin, R., Lefrére, F. Drénou, B., Branger, B., Caulet-Maugendre, S., Tass, P., Brousse, N., Valensi, F., Milpied, N., Voilat, L., Sadoun, A., Ghandour, C., Hunault, M., Leloup, R., Mannone, L., Hermine, O. & Lamy, T. (2001) Blastic variant of mantle cell lymphoma: a rare but highly aggressive subtype. Leukemia. 15, 1785-1791.
6. Blay, J., Gomez, F., Sebban, C., Bachelot, T., Biron, P., Guglielmi, C., Hagenbeek, A., Somers, R., Chauvin, F. & Philip, T. (1998) The International Prognostic Index correlates to survival in patients with aggressive lymphoma in relapse: analysis of the PARMA trial. PARMA Group. Blood. 92, 3562-3568.
7. Boise, L.H., Gonzalez-Garcia, M., Postema, C.E., Ding, L., Lindsten, T., Turka, L.A., Mao, X., Nunez, G. & Thompson, C.B. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597-608.
8. Chao, D.T. & Korsmeyer, S.J. (1998) BCL-2 family: regulator of cell death. Annual Review of Immunology, 16, 395-419.
9. Cole, M.D. (1986) The myc oncogene: its role in transformation and differentiation. Annual Review of Genetics, 20, 361-384.
10. Craig, W.R. (2002) MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis. Leukemia, 16, 444-454.
11. D'Sa-Eipper, C., Subramanian, T. & Chinnadurai, G. (1996) Bfl-1, a bcl-2 homologue, suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity. Cancer Research, 56, 3879-3882.
12. Deiss, L.P., Feinstein, E., Berissi, H., Cohen, O. & Kimchi, A. (1995) Identification of novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes and Development, 9, 15-30.
13. Di Bona, E., Sartori, R., Zambello, R., Guercini, N., Madeo, D. & Rodeghiero, F. (2002) Prognostic significance of CD56 antigen expression in acute myeloid leukemia. Haematologica, 87, 250-256.
14. + B cells the expression of BCL-2 gene family is shifted towards protection of apoptosis. British Journal of Haematology, 94, 612-618.
15. Grimwade, D., Walker, H., Oliver, F., Wheatley, K., Harrison, C.G., Harrison, G.J., Rees, J., Hann, I., Stevens, R., Burnett, A. & Goldstone, A. (1998) The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood, 92, 2322-2333.
16. Hernandez, L., Hernandez, S., Bea, S., Pinyol, M., Ferrer, A., Bosch, F., Nadal, A., Fernandez, P.L., Palacin, A., Montserrat, E. & Campo, E. (1999) c-myc mRNA expression and genomic alterations in mantle cell lymphomas and other nodal non-Hodgkin's lymphomas. Leukemia, 13, 2087-2093.
17. Hofmann, W.-K., de Vos, S., Tsukasaki, K., Wachsman, W., Pinkus, G.S., Said, J.W. & Koeffler, H.P. (2001) Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray. Blood, 98, 787-794.
18. Jacobson, M.D., Burne, J.F., King, M.P., Miyashita, T., Reed, J.C. & Raff, M.C. (1993) Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature, 361, 365-369.
19. Kaufmann, S.H., Karp, J.E., Svingen, P.A., Krajewski, S., Burke, P.J., Gore, S.D. & Reed, J.C. (1998) Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse. Blood, 91, 991-1000.
20. Korsmeyer, S.J. (1999) BCL-2 gene family and the regulation of programmed cell death. Cancer Research, 59, 1693s-1700s.
21. Kozopas, K.M., Yang, T., Buchan, H.L., Zhou, P. & Craig, R.W. (1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proceedings of the National Academy of Sciences of the United States of America, 90, 3516-3520.
22. Krajewski, S., Bodrug, S., Krajewska, M., Shabaik, A., Gascoyne, R., Berean, K. & Reed, J.C. (1995) Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. American Journal of Pathology, 146, 1309-1319.
23. Larramendy, M.L., Nüni, T., Elonen, E., Nagy, B., Olilla, J., Vihinen, M. & Knuutila, S. (2002) Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, DEK and BCL2, but absence of translocations in acute myeloid leukemia: a micro-array analysis. Haematologica, 87, 568-576.
24. Lomo, J., Blomhoff, H.K., Jacobsen, S.E., Krajewski, S., Reed, J.C. & Smeland, E.B. (1997) Interleukin 13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: upregulation of Bcl-xL and Mcl-1. Blood, 89, 4415-4424.
25. Marcu, K., Bossone, S. & Patel, A. (1992) Myc function and regulation. Annual Review of Biochemistry, 61, 809-860.
26. Meijerink, J.P., Mensink, E.J., Wang, Y., Sedlak, T.W., Sloetjes, A.W., de Witte, T., Waksman, G. & Korsmeyer, S.J. (1998) Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood, 91, 2991-2997.
27. Monni, O., Zhu, Y., Franssila, K., Oinonen, R., Hoglund, P., Elonen, E., Joensuu, H. & Knuutila, S. (1999) Molecular characterization of deletion at 11q22.1-23.3 in mantle cell lymphoma. British Journal of Haematology, 104, 665-671.
28. Nicot, C., Mahieux, R., Takemoto, S. & Franchini, G. (2000) Bcl-X (L) is upregulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples. Blood, 96, 275-281.
29. Oltvai, Z.N., Milliman, C.L. & Korsmeyer, S.J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74, 609-619.
30. Pepper, C., Bentley, P. & Hoy, T. (1996) Regulation of clinical chemoresistance by bcl-2 and bax oncoproteins in B-cell chronic lymphocytic leukemia. British Journal of Haematology, 95, 513-517.
31. Reed, J.C. (1998) Bcl-2 family proteins. Oncogene, 17, 3225-3236.
32. Reed, J.C. (1999) Dysregulation of apoptosis in cancer. Journal of Clinical Oncology, 17, 2941-2953.
33. Reed, J.C. (2000) Mechanisms of apoptosis. American Journal of Pathology, 157, 1415-1430.
34. Sakamuro, D. & Prendergast, G.C. (1999) New Myc-interacting proteins: a second Myc network emerges. Oncogene, 18, 2942-2954.
35. Schimmer, A.D., Hedley, D.W., Penn, L.Z. & Minden, M.D. (2001) Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view. Blood, 98, 3541-3553.
36. Shimizu, S., Narita, M. & Tsujimoto, Y. (1999) Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature, 399, 483-487.
37. 2-terminal kinase activity, and apoptosis. Molecular and Cellular Biology, 19, 5659-5674.
38. Tsujimoto, Y., Cossman, J., Jaffe, E. & Croce, C. (1985) Involvement of the Bcl-2 gene in human follicular lymphoma. Science, 228, 1440-1443.
39. Zhu, Y., Monni, O., Franssila, K., Elonen, E., Vilpo, J., Joensuu, H. & Knuutila, S. (2000) Deletions at 11q23 in different lymphoma subtypes. Haematologica, 85, 908-912.
40. Zhu, Y., Hollmén, J., Räty, R., Aalto, Y., Nagy, B., Elonen, E., Kere, J., Mannila, H., Franssila, K. & Knuutila, S. (2002) Investigatory and analytical approaches to differential gene expression profiling in mantle cell lymphoma. British Journal of Haematology, 119, 905-915.