Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by toll-like receptor agonists

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Kuka, Mirela ^a,b   Baronio, Roberta ^a,c   Valentini, Sara ^a   Monaci, Elisabetta ^a   Muzzi, Alessandro ^a   Aprea, Susanna ^a   de Gregorio, Ennio ^a   D'Oro, Ugo ^a  

^a NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 12; INTERLEUKIN 23; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN C JUN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 8; IMIDAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; RESIQUIMOD; TOLL LIKE RECEPTOR;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION; TH17 CELL; UPREGULATION; BIOSYNTHESIS; CELL CULTURE; DNA MICROARRAY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FLOW CYTOMETRY; METABOLISM; POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DENDRITIC CELLS; FLOW CYTOMETRY; HUMANS; IMIDAZOLES; INTERLEUKIN-12; INTERLEUKIN-23; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; PYRIMIDINES; SRC-FAMILY KINASES; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 8; TOLL-LIKE RECEPTORS;

EID: 77955359472     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011491     Document Type: Article

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