Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 5007-5015

  Silva, Yolanda Karla Cupertino Da ^a   Augusto, Cristina Villarinho ^b   Barbosa, Maria Letícia De Castro ^b   Melo, Gabriela Muniz De Albuquerque ^a   Queiroz, Aline Cavalcanti De ^a   Dias, Thays De Lima Matos Freire ^a   Júnior, Walfrido Bispo ^a   Barreiro, Eliezer J ^b   Lima, Lídia Moreira ^b   Alexandre Moreira, Magna Suzana ^a  

^a FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Anti inflammatory; Antinociceptive; Arthritis; Bioactive N acylhydrazone

Indexed keywords

2 N' [(3,4,5 TRIMETHOXYPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CELECOXIB; HYDRAZONE DERIVATIVE; INDOMETACIN; MORPHINE; PROSTAGLANDIN SYNTHASE INHIBITOR; PYRAZINE DERIVATIVE; THALIDOMIDE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTHRITIS; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HOT PLATE TEST; INFLAMMATION; MOUSE; NONHUMAN; PAIN; PAW EDEMA;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS; EAR; EDEMA; FEMALE; FREUND'S ADJUVANT; HYDRAZONES; MALE; MICE; PAIN; PERITONITIS; PYRAZINES; RATS; RATS, WISTAR; ZYMOSAN;

ANIMALIA; MURINAE; RATTUS;

EID: 77955326956     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.002     Document Type: Article

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