New derivatives of 3,5-substituted-1,4,2-dioxazoles: Synthesis and activity against Entamoeba histolytica

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 926-936

  Bhat, Abdul R ^a   Athar, Fareeda ^a   Azam, Amir ^a  

^a JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

Author keywords

Antiamoebic activity; Dioxazole; Entamoeba histolytica; MTT assay

Indexed keywords

3,5 BIS(2 CHLOROPHENYL) 1,4,2 DIOXAZOLE; METRONIDAZOLE; OXAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENTAMOEBA HISTOLYTICA; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; ENTAMOEBA HISTOLYTICA; EPITHELIAL CELLS; HUMANS; KIDNEY; OXAZOLES; OXIMES; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60149084561     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.02.001     Document Type: Article

References (30)

1. Stanley Jr. S.L. Lancet 361 (2003) 1025-1034
2. World Health Organisation. Wkly Epidemiol. Rec. 72 (1997) 97-99
3. Leitsch D., Kolarich D., Wilson I.B.H., Altmann F., and Duchene M. PLoS Biol. 5 (2007) 1820-1834
4. Brandt H., and Pėrez R. Hum. Pathol. 1 (1970) 351-385
5. Rocco F.D., Sabatino G., Tamburrini G., Ranno O., Valentini P., and Caldarlli M. Acta Neurol. 146 (2004) 1271-1272
6. Roe F.J. Surgery 93 (1983) 158-164
7. Samuelson J.C., Burke A., and Courval J.M. Antimicrob. Agents Chemother. 36 (1992) 2392-2397
8. Adagu I.S., Nolder D., Warhurst D.C., and Rossignol J.F. J. Antimicrob. Chemother. 49 (2002) 103-111
9. Turan-Zitouni G., Ozdemir A., and Guven K. Arch. Pharm. (Weinheim) 338 (2005) 96-104
10. Wassmann C., Hellberg A., Tannich E., and Bruchhaus I. J. Biol. Chem. 274 (1999) 26051-26056
11. Azam A., and Agarwal S.M. Curr. Bioact. Compd. 3 (2007) 121-133
12. Sammelson R.E., Miller R.B., and Kurth M.J. J. Org. Chem. 65 (2000) 2225-2228
13. Nicolaides D.N., Fylaktakidou K.C., and Litinas K.E. J. Heterocycl. Chem. 33 (1996) 967-971
14. Nkusi G., and Neidlein R. J. Prakt. Chem. 334 (1992) 278-280
15. Bartlett R.R. Int. J. Immunopharmacol. 8 (1986) 199-204
16. Ryng S., and Glowiak T. J. Chem. Crystallogr. 28 (1998) 373-378
17. Sun Q., Zhang W., Xu J., Cao Y., Wu Q., Zhang D., Liu C., Yu S., and Jiang Y. Eur. J. Med. Chem. 42 (2007) 1151-1157
18. Kerridge D. Drugs Today 24 (1988) 705-715
19. Koltin Y. Annu. Rep. Med. Chem. 25 (1990) 141-148
20. Fromtling R.A. Drugs Today 20 (1986) 235-349
21. M. Kikuchi, H. Ishikawa, H. Horimoto, H. Tsubouchi, T. Shitsuta, H. Sasaki, M. Itotani, World Patent WO199,732,859, 1997.
22. Matsumoto M., Hasizume H., Tsubouchi H., Sasaki H., Itotani M., Kuroda H., Tomishige T., Kawasaki M., and Komatsu M. Curr. Trop. Med. 7 (2007) 499-507
23. Devasthale P.V., Chen S., Jeon Y., Qu F., Shao C., Wang W., Zhang H., Cap M., Farrelly D., Golla R., Grover G., Harrity T., Ma Z., Moore L., Ren J., Seethala R., Cheng L., Sleph P., Sun W., Tieman A., Wetterau J.R., Doweyko A., Chandrasena G., Chang S.Y., Humphreys G., Sasseville I.G., Biller S.A., Ryono D.E., Hariharan F.S.N., and Cheng P.T.W. J. Med. Chem. 48 (2005) 2248-2250
24. Kaffy J., Pontikis R., Carrez D., Croisy A., Monneret C., and Florent J. Bioorg. Med. Chem. 14 (2006) 4067-4077
25. Winer B.J. Statistical Principles in Experimental Design. second ed. vol. 22 (1971), McGraw-Hill Book Company pp. 45
26. Wright C.W., O'Neill M.J., Phillipson J.D., and Warhurst D.C. Antimicrob. Agents Chemother. 32 (1988) 1725-1729
27. Diamond L.S., Harlow D.R., and Cunnick C.C. Trans. R. Soc. Trop. Med. Hyg. 72 (1978) 431-432
28. Gillin F.D., Reiner D.S., and Suffness M. Antimicrob. Agents Chemother. 22 (1982) 342-345
29. Keen A.T., Harris A., Phillipson J.D., and Warhurst D.C. Planta Med. 4 (1986) 278-285
30. Mosmann T. J. Immunol. Methods 65 (1983) 55-63