A meta-analysis of the effectiveness of albendazole compared with metronidazole as treatments for infections with Giardia duodenalis

PLoS Neglected Tropical Diseases

Volumn 4, Issue 5, 2010, Pages

  Solaymani Mohammadi, Shahram ^a   Genkinger, Jeanine M ^b   Loffredo, Christopher A ^b   Singer, Steven M ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; METRONIDAZOLE; ANTIPROTOZOAL AGENT;

ABDOMINAL PAIN; ANOREXIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; GIARDIASIS; HUMAN; LOOSE FECES; META ANALYSIS; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; REVIEW; SINGLE DRUG DOSE; SYSTEMATIC REVIEW; TASTE DISORDER; TREATMENT DURATION; ARTICLE; COMPARATIVE STUDY; ECONOMICS; GIARDIA LAMBLIA; ISOLATION AND PURIFICATION; PARASITOLOGY; TREATMENT OUTCOME;

ALBENDAZOLE; ANTIPROTOZOAL AGENTS; GIARDIA LAMBLIA; GIARDIASIS; HUMANS; METRONIDAZOLE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 77955298063     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000682     Document Type: Review

References (72)

1. Adam RD (2001) Biology of Giardia labmlia. Clin Microbiol Rev 14: 447-475.
2. Farthing MJ (1994) Diarrhoeal disease: current concepts and future challenges. Pathogenesis of giardiasis. Trans R Soc Trop Med Hyg 3: 17-21.
3. Gillin FD, Reiner DS, McCaffery JM (1996) Cell biology of the primitive eukaryote Giardia lamblia. Annu Rev Microbiol 50: 679-705.
4. Flanagan PA (1992) Giardia-diagnosis, clinical course and epidemiology. A review. Epidemiol Infect 109: 1-22.
5. Wolfe MS (1992) Giardiasis. Clin Microbiol Rev 5: 93-100.
6. Kamda JD, Singer SM (2009) Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect Immun 77: 685-693.
7. Isaac-Renton JL. Laboratory diagnosis of giardiasis. Clin Lab Med 11: 811-827.
8. Gardner TB, Hill DR (2001) Treatment of giardiasis. Clin Microbiol Rev 14: 114-128.
9. Sullivan PS, DuPont HL, Arafat RR, Thornton SA, Selwyn BJ, et al. (1989) Illness and reservoirs associated with Giardia lamblia infection in rural Egypt: the case against treatment in developing world environments of high endemicity. Am J Epidemiol 127: 1272-1281.
10. Saffar MJ, Qaffari J, Khalilian AR, Kosarian M (2005) Rapid reinfection by Giardia lamblia after treatment in a hyperendemic area: the case against treatment. East Mediterr Health J 11: 73-78.
11. Andersson T, Forssell J, Sterner G (1972) Outbreak of giardiasis: effect of a new antiflagellate drug, tinidazole. Br Med J 2: 449-451.
12. Jokipii L, Jokipii AM (1979) Single-dose metronidazole and tinidazole as therapy for giardiasis: success rates, side effects, and drug absorption and elimination. J Infect Dis 140: 984-988.
13. Johnson G (2009) STEPS New Drug Review: Tinidazole for trichomoniasis and bacterial vaginosis. Am Fam Phys 79: 102-103.
14. Bassily S, Farid Z, Mikhail JW, Kent DC, Lehman JS (1970) The treatment of Giardia lamblia infection with mepacrine, metronidazole and furazolidone. J Trop Med Hyg 73: 15-18.
15. Jokipii L, Jokipii AMM (1978) Comparison of four dosage schedules in the treatment of giardiasis with metronidazole. Infection 6: 92-94.
16. Kavousi S (1979) Giardiasis in infancy and childhood: a prospective study of 160 cases with comparison of quinacrine (AtabrineH) and metronidazole (FlagylH). Am J Trop Med Hyg 28: 19-23.
17. Wright JM, Dunn LA, Upcroft P, Upcroft JA (2003) Efficacy of antigiardial drugs. Expert Opin Drug Saf 2: 529-541.
18. Selgrad M, Kandulski A, Malfertheiner P (2009) Helicobacter pylori: diagnosis and treatment. Curr Opin Gastroenterol 25: 549-556.
19. Lemée V, Zaharia I, Nevez G, Rabodonirina M, Brasseur P, et al. (2000) Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France. J Antimicrob Chemother 46: 819-821.
20. Shepherd RW, Boreham PFL (1986) Recent advances in the diagnosis and management of giardiasis. Scand J Gastroenterol Suppl 169: 60-64.
21. Boreham PFL, Benrimoj S, Ong M, Craig M, Shepherd RW, et al. (1986) A compliance study in pediatrics patients receiving treatment for giardiasis. Aus J Hosp Pharm 16: 138-142.
22. Hemphill A, Müller J (2009) Alveolar and cystic echinococcosis: towards novel chemotherapeutical treatment options. J Helminthol 83: 99-111.
23. Carpio A (2002) Neurocysticercosis: an update. Lancet Infect Dis 2: 751-762.
24. Keiser J, Utzinger J (2008) Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 299: 1937-1948.
25. Bharti N, Husain K, Gonzalez Garza MT, Cruz-Vega DE, Castro-Garza J, et al. (2002) Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2- carboxaldehyde thiosemicarbazone derivatives. Bioorg Med Chem Lett 12: 3475-3478.
26. Reynoldson JA, Thompson RC, Meloni BP (1991) In vivo efficacy of albendazole against Giardia duodenalis in mice. Parasitol Res 77: 325-328.
27. Cedillo-Rivera R, Muñoz O (1992) In vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents. J Med Microbiol 37: 221-224.
28. Mank TG, Zaat JO (2001) Diagnostic advantages and therapeutic options for giardiasis. Expert Opin Investig Drugs 10: 1513-1519.
29. Misra PK, Kumar A, Agarwal V, Jagota SC (1995a) A comparative clinical trial of albendazole versus metronidazole in children with giardiasis. Indian Pediatr 32: 779-782.
30. Misra PK, Kumar A, Agarwal V, Jagota SC (1995b) A comparative clinical trial of albendazole versus metronidazole in giardiasis. Indian Pediatr 32: 291-294.
31. Meyer EK (1998) Adverse events associated with albendazole and other products used for treatment of giardiasis in dogs. J Am Vet Med Assoc 213: 44-46.
32. Bernal-Redondo R, Martínez-Méndez LG, Mendoza-Chavez A, Velasco-Perales D, Chavez-Munguia B (2004) Evaluation of the in vitro effect of albendazole, metronidazole and nitazoxanide on viability and structure of Giardia lamblia cysts. J Submicrosc Cytol Pathol 36: 241-245.
33. Reynoldson JA, Behnke JM, Gracey M, Horton RJ, Spargo R, et al. (1998) Efficacy of albendazole against Giardia and hookworm in a remote Aboriginal community in the north of Western Australia. Acta Trop 71: 27-44.
34. Pungpak S, Singhasivanon V, Bunnag D, Radomyos B, Nibaddhasopon P, et al. (1996) Albendazole as a treatment for Giardia infection. Ann Trop Med Parasitol 90: 563-565.
35. Baqai R, Zuberi SJ, Qureshi H, Ahmed W, Hafiz S (2001) Efficacy of albendazole in giardiasis. East Meditter Health J 7: 787-790.
36. Navarrete-Vázquez G, Yépez L, Hernández-Campos A, Tapia A, Hernández-Luis F, et al. (2003) Synthesis and antiparasitic activity of albendazole and mebendazole analogues. Bioorg Med Chem 11: 4615-4622.
37. Cacopardo B, Patamia I, Bonaccorso V, Di Paola O, Bonforte S, et al. (1995) Synergic effect of albendazole plus metronidazole association in the treatment of metronidazole-resistant giardiasis. Clin Ter 146: 761-767. [In Italian].
38. Hanevik K, Mørch K, Eide GE, Langeland N, Hausken T (2008) Effects of albendazole/metronidazole or tetracycline/folate treatments on persisting symptoms after Giardia infection: a randomized open clinical trial. Scand J Infect Dis 40: 517-522.
39. Alizadeh A, Ranjbar M, Kashani KM, Taheri MM, Bodaghi M (2006) Albendazole versus metronidazole in the treatment of patients with giardiasis in the Islamic Republic of Iran. East Meditter Health J 12: 548-554.
40. Karabay O, Tamer A, Gunduz H, Kayas D, Arinc H, et al. (2004) Albendazole versus metronidazole treatment of adult giardiasis: An open randomized clinical study. World J Gastroenterol 10: 1215-1217.
41. Yereli K, Balcioǧlu IC, Ertan P, Limoncu E, Onaǧ A (2004) Albendazole as an alternative therapeutic agent for childhood giardiasis in Turkey. Clin Microbiol Infect 10: 527-529.
42. Romero-Cabello R, Robert L, Muñoz-García R, Tanaka J (1995) Randomized study comparing the safety and efficacy of albendazole and metronidazole in the treatment of giardiasis in children. Rev Latinoam Microbiol 37: 315-323. [In Spanish].
43. Hall A, Nahar Q (1993a, b) Albendazole as a treatment for infections with Giardia duodenalis in children in Bangladesh. Trans R Soc Trop Med Hyg 87: 84-86.
44. Rodríguez-García R, Aburto-Bandala M, Sánchez-Maldonado MI (1996) Effectiveness of albendazole in the treatment of giardiasis in children. Bol Med Hosp Infant Méx 53: 173-177. [In Spanish].
45. Dutta AK, Phadke MA, Bagade AC, Joshi V, Gazder A, et al. (1994) A randomised multicentre study to compare the safety and efficacy of albendazole and metronidazole in the treatment of giardiasis in children. Indian J Pediatr 61: 689-693.
46. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, et al. (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17: 1-12.
47. Zaat JO, Mank TG, Assendelft WJ (1997) A systematic review on the treatment of giardiasis. Trop Med Int Health 2: 63-82.
48. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558.
49. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634.
50. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7: 177-188.
51. Jokipii L, Jokipii AM (1978) Comparison of four dosage schedules in the treatment of giardiasis with metronidazole. Infection 6: 92-94.
52. Jokipii L, Jokipii AM (1979) Single-dose metronidazole and tinidazole as therapy for giardiasis: success rates, side effects, and drug absorption and elimination. J Infect Dis 140: 984-988.
53. Rastegar-Lari A, Salek-Moghaddam A (1996) Single-dose secnidazole versus 10- day metronidazole therapy of giardiasis in Iranian children. J Trop Pediatr 42: 184-185.
54. Bulut BU, Gülnar SB, Aysev D (1996) Alternative treatment protocols in giardiasis: a pilot study. Scand J Infect Dis 28: 493-495.
55. Cantelli-Forti G, Aicardi G, Guerra MC, Barbaro AM, Biagi GL (1983) Mutagenicity of a series of 25 nitroimidazoles and two nitrothiazoles in Salmonella typhimurium. Teratog Carcinog Mutagen 3: 51-63.
56. De Méo M, Vanelle P, Bernadini E, Laget M, Maldonado J, et al. (1992) Evaluation of the mutagenic and genotoxic activities of 48 nitroimidazoles and related imidazole derivatives by the Ames test and the SOS chromotest. Environ Mol Mutagen 19: 167-181.
57. Reitz M, Rumpf M, Knitza R (1991) DNA single strand-breaks in lymphocytes after metronidazole therapy. Arzneimittelforschung 41: 155-156.
58. Elizondo G, Gonsebatt ME, Salazar AM, Lares I, Santiago P, et al. (1996) Genotoxic effects of metronidazole. Mutat Res 370: 75-80.
59. Krause JR, Ayuyang HQ, Ellis LD (1985) Occurrence of three cases of carcinoma in individuals with Crohn's disease treated with metronidazole. Am J Gastroenterol 80: 978-982.
60. Bendesky A, Menéndez D, Ostrosky-Wegman P (2002) Is metronidazole carcinogenic? Mutat Res 511: 133-144.
61. Hossain MM, Glass RI, Khan MR (1982) Antibiotic use in a rural community in Bangladesh. Int J Epidemiol 11: 402-405.
62. Tillonen J, Väkeväinen S, Salaspuro V, Zhang Y, Rautio M, et al. (2000) Metronidazole increases intracolonic but not peripheral blood acetaldehyde in chronic ethanol-treated rats. Alcohol Clin Exp Res 24: 570-575.
63. Jang GR, Harris RZ (2007) Drug interactions involving ethanol and alcoholic beverages. Expert Opin Drug Metab Toxicol 3: 719-731.
64. Lwin M, Targett GA, Doenhoff MG (1987) Reduced efficacy of chemotherapy of Plasmodium chabaudi in T cell-deprived mice. Trans R Soc Trop Med Hyg 81: 899-902.
65. Bjorkman A (1988) Interactions between chemotherapy and immunity to malaria. Prog Allergy 41: 331-356.
66. Mohan K, Sam HH, Stevenson MM (1999) Therapy with a combination of low doses of interleukin-12 and chloroquine completely cures blood-stage malaria, prevents severe anemia, and induces immunity to reinfection. Infect Immun 67: 513-519.
67. Cravo P, Culleton R, Hunt P, Walliker D, Mackinnon MJ (2001) Antimalarial drugs clear resistant parasites from partially immune hosts. Antimicrob Agents Chemother 45: 2897-2901.
68. Upcroft JA, Upcroft P (1993) Drug resistance and Giardia. Parasitol Today 9: 187-190.
69. Müller J, Ley S, Felger I, Hemphill A, Müller N (2008) Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole. J Antimicrob Chemother 62: 72-82.
70. Matthaiou DK, Panos G, Adamidi ES, Falagas ME (2008) Albendazole versus praziquantel in the treatment of neurocysticercosis: A meta-analysis of comparative trials. PLoS Negl Trop Dis 2: e194.
71. Naik SR, Rau NR, Vinayak VK (1978) A comparative evaluation of three stool samples, jejunal aspirate and jejunal mucosal impression smears in the diagnosis of giardiasis. Ann Trop Med Parasitol 72: 491-492.
72. Gordts B, Hemelhof W, Van Tilborgh K, Retore P, Cadranal S, et al. (1985) Evaluation of a new method for routine in vitro cultivation of Giardia lamblia from human duodenal fluid. J Clin Microbiol 22: 702-704.