Genotoxic effects of metronidazole

Mutation Research - Genetic Toxicology

Volumn 370, Issue 2, 1996, Pages 75-80

  Elizondo, Guillermo ^a   Gonsebatt, María E ^a   Salazar, Ana María ^a   Lares, Ismael ^b   Santiago, Pilar ^b   Herrera, Jorge ^c,d   Hong, Enrique ^d   Ostrosky Wegman, Patricia ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO NACIONAL DE PEDIATRÍA   (Mexico)

^c HOSPITAL GENERAL DR MIGUEL SILVA   (Mexico)

^d DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Cell proliferation kinetics; Chromosomal aberration; Human lymphocyte; Metronidazole

Indexed keywords

METRONIDAZOLE;

ADULT; ARTICLE; CELL CULTURE; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOGENETICS; DRUG BLOOD LEVEL; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

PROKARYOTA;

EID: 0030582451     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1218(96)00022-5     Document Type: Article

References (32)

1. Bähr, V. and U. Ullmann (1983) The influence of metronidazole and its two main metabolites on murine in vitro lymphocyte transformation, Eur. J. Clin. Microbiol., 2 (6), 568-570.
2. Bennett, L.J. (1991) In: Human Pharmacology, Molecular to Clinical, Wolfe Publishing Ltd, London.
3. Cohen, S.M., E. Ertürk, A.M. Von Esch, A.J. Crovetti and J.T. Bryan (1973) Carcinogenicity of 5-nitrofurans, 5-nitroimidazoles, 4-nitrobenzenes and related compounds, J. Natl. Cancer Inst., 51, 403-417.
4. Connor, H.T., M. Stöekel, J. Evrard and M.S. Legator (1977) The contribution of metronidazole and two metabolites to the mutagenic activity detected in urine of treated human and mice, Cancer Res., 37, 629-633.
5. De Meo, M., P, Vanelle, E. Bernadini, M. Laget, J. Maldonado, O. Jentzer, M.P. Crozet and G. Dumenil (1992) Evaluation on mutagenic and genotoxic activities of 48 nitroimidazoles and related imidazole derivatives by the Ames test and the SOS chromotest, Envior. Mol. Mut., 19, 167-170.
6. Dayan, J., M.C. Crajer and S. Deguingand (1982) Mutagenic activity of 4 active principle forms of pharmaceutical drugs, Mutation Res., 102, 1-12.
7. Edwards, D.I. (1977) The action of metronidazole in DNA, J. Antimicrob. Chemother., 3, 43-48.
8. Elizondo, G., R. Montero, J.E. Herrera, E. Hong and P. Ostrosky-Wegman (1994) Lymphocyte proliferation kinetics and sister chromatid exchanges in individuals treated with metronidazole, Mutation Res., 305, 133-137.
9. Ewan, J., T. Chrystal, R.L. Koch, M.A. McLafferty and P. Goldman (1980) Relationship between metroniazole metabolism and bacterial activity, Antimicrob. Agent Chemother., 18, 566-573.
10. Goldman, P. (1973) In: Origins of Human Cancer, Cold Spring Harbor, New York.
11. Hartley-Asp, B. (1979)a Absence of chromosomal damage in lymphocytes of patients treated with metronidazole for thricomoniasis vaginalis, Toxicol. Letters, 4, 15-19.
12. Hartley-Asp, B. (1979)b Metronidazole exhibits no cytogenetic effect in micronucleus test in mice or human lymphocytes in vitro, Mutation Res., 67, 193-196.
13. Lambert, B., A. Lindblad and V. Ringborg (1979) Absence of genotoxic effects of metronidazole and two of its urinary metabolites of human lymphocytes in vitro, Mutation Res., 67, 281-287.
14. Lanbeck, K. and B. Lindström (1979) Determination of metronidazole and tinidazole in plasma and feces by high performance liquid chromatography, J. Chromatography, 162, 117-121.
15. LaRusso, N.F., M. Tomasz, M. Müller and R. Lipman (1977) Interaction of metronidazole with nucleic acid in vitro, Mol. Pharmacol., 13, 872-882.
16. Loft, F., S.V. Otton, M.S. Lennard, G.T. Tucker and H.E. Poulsen (1990) Characterization of metronidazole metabolism by human liver microsome, Biochem. Pharmacol., 41, 1127-1136.
17. Ludlum, D.B., R.J. Colinas, M.C. Kirk and J.R. Mehta (1988) Reaction of reduced metronidazole with guanosine to form an unstable adduct, Carcinogen., 9, 593-596.
18. Martelli, A., A. Allavena, L. Robbiano, F. Mattioli and G. Brambilla (1990) Comparison of sensitivity of human and rat hepatocytes to the genotoxic effects of metronidazole, Pharmacol. Toxicol., 66, 329-334.
19. Mitelman, F., B. Hartley-Asp and B. Ursing (1976) Chromosome aberration and metronidazole, Lancet, 2, 802.
20. Mitelman, F, B. Strömbeck and B. Ursing (1980) No cytogenetic effect of metronidazole, Lancet, 1, 1249-1250.
21. Mitelman, F, B. Strömbeck, B. Ursing, O. Nordle and B. Hartley-Asp (1982) Metronidazole exhibit no clastogenic activity in a double blind cross over study on Crohn's patients, Hereditas, 96, 280-285.
22. Natarajan, A.T. and G. Obe (1983) Influence of DNA repair on radiation-induced chromosomal aberrations in human peripheral lymphocytes, Radiation-Induced Chromosome Damage in Man, pp 127-140. Alan. Riss, Inc. New York.
23. Neal, S.B. and G.S. Probst (1984) Assessment of sister chromatid exchange in spermatogonia and intestinal epithelium in Chinese hamster, Basic Life Sci., 29, 613-628.
24. Ostrosky-Wegman P., M.E. Gonsebatt, R. Montera, L. Vega, H. Barba, J. Espinosa, A. Palao, C. Cortinas, G. García-Vargas, L.M. Del Razo and M. Cebrián (1991) Lymphocyte proliferation kinetics and genotoxic findings in a pilot study on individuals chronically exposed to arsenic in Mexico, Mutation Res., 250, 477-482.
25. Ostrosky-Wegman P., I. Lares, P. Santiago, G. Elizondo, and R. Montera (1994) Metronidazole hprt mutation induction in sheep and the relationship with its elimination rate, Mutation Res., 307, 253-259.
26. Perry, P. and S. Wolff (1974) New Giemsa method for the differential staining of sister chromatid, Nature (London), 251, 156-158.
27. Reitz, M., M. Rumpf and R. Knitza (1991) DNA single strand breaks in lymphocytes after metronidazole therapy, Arzneim., 4, 155-156.
28. Rustia, M, and P. Shubik (1972) Inductions of lung tumors and malignant lymphomas in mice by metronidazole, J. Nat. Cancer Inst., 48, 721-729.
29. Salamanca, F., G. Castañeda, J. Farfán, M.C. Santillán, O. Muñoz and S. Armendares (1980) Chromosome studies of bone marrow cells from metronidazole treated patients, Ann. Gènèt., 23, 63-64.
30. Voogd, C.E., J.J. Van der Stel and J.A. Jacobs (1974) The mutagenic action of nitroimidazoles: metronidazole, nimorazole, dimetridazole and ronidazole, Mutation Res., 26, 483-490.
31. Wheeler, L.A., M. De Meo, M. Halula, L. George and P Heseltine (1977) Use of High-Pressure Liquid Chromatography to determine plasma levels of metronidazole and metabolites after intravenous administration, Antimicrob. Agents Chemother., 13, 205-209.
32. WHO (1985) Guidelines for the study of genetics effects in human population, Env. Health Criteria, 46, Geneve.