Evaluation of the in vitro effect of albendazole, metronidazole and nitazoxanide on viability and structure of Giardia lamblia cysts

Journal of Submicroscopic Cytology and Pathology

Volumn 36, Issue 3-4, 2004, Pages 241-245

  Bernal Redondo, R ^a,c   Martinez Mendez L G ^a   Mendoza Chavez, A ^a   Velasco Perales, D ^a   Chavez Munguia, B ^b  

^a Hospital de Mexico   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^c HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

Author keywords

Albendazole; Giardia lamblia; Giardiasis; Metronidazole; Nitazoxanide; Ultrastructure; Viability

Indexed keywords

ALBENDAZOLE; METRONIDAZOLE; NITAZOXANIDE;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPLASM; DRUG EFFECT; DRUG POTENCY; GIARDIA LAMBLIA; GIARDIASIS; HUMAN; IN VITRO STUDY; INCUBATION TIME; MORPHOLOGY; NONHUMAN; PARASITE ISOLATION;

ALBENDAZOLE; ANIMALS; ANTIPROTOZOAL AGENTS; GIARDIA LAMBLIA; METRONIDAZOLE; MICROSCOPY, ELECTRON, TRANSMISSION; THIAZOLES;

EID: 17444408833     PISSN: 11229497     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. ADAGU I.S., NOLDER D., WARHURST C.D. and ROSSIGNOL J.F., 2002. In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. J. Antimicrob. Chemother., 49, 103-111.
2. BERNAL R., 1994. Giardia lamblia. In: 'Diagnóstico de Laboratorio de Infecciones Gastrointestinales', Giono S., Escobar A. and Valdespino J.L. eds., INDRE-SS México, D.F465-475.
3. BERNAL R., TOVAR R., SANTOS J.I. and MUÑOZ M.L., 1998. Possible role of calmodulin in excystation of Giardia lamblia. Parasitol. Res., 84, 687-693.
4. BINGHAM A.K. and MEYER E.A., 1979. Giardia excystation can be induced in vitro in acidic solutions. Nature, 277, 301-302.
5. BINGHAM A.K., JARROL E.L., MEYER E.A. and RADULESCU S., 1979. Giardia sp.: Physical factors of encystation in vitro, and excystation vs. eosin exclusion as determinants of viability. Exp. Parasitol., 47, 284-291.
6. CASADO N., MORENO M.J., URREA-PARIS M.A. and RODRIGUEZ-CABEIRO F., 2002. Could ivermectin have a synergic effect with albendazole in hydatidosis therapy? Parasitol. Res., 88, 153-159.
7. CEDILLO-RIVERA R., CHAVEZ B., GONZALEZ-ROBLES A., TAPIA A. and YEPEZ MULIA L., 2002. In vitro effect of nitazoxanide against Entamoeba histolytyca, Giardia intestinales and Trichomonas vaginalis trophozoites. J. Eukaryot. Microbiol., 49, 201-208.
8. CHAVEZ-MUNGUIA B., CEDILLO-RIVERA R. and MARTÍNEZ-PALOMO A., 1992. Giardia intestinalis: ultrastructural study of the in vitro effect of benzimidazoles. J. Protozol., 39, 510-515.
9. CHAVEZ-MUNGUIA B., CEDILLO-RIVERA R. and MARTÍNEZ-PALOMO A., 2004. The ultrastructure of the cyst wall of Giardia lamblia. J. Eukaryot. Microbiol., 51, 220-226.
10. GILLES H.M. and HOFFMAN P.S., 2002. Treatment of intestinal parasitic infections: a review of nitazoxanide. Trends Parasitol., 18, 95-97.
11. JARROL E.L. JR., BINGHAM A.K. and MEYER E.A., 1980. Giardia cyst destruction: effectiveness of six small-quantity water disinfection methods. Am. J. Trop. Med. Hyg., 29, 8-11.
12. LACEY E., 1990. Mode of action of benzimidazoles. Parasitol. Today, 6, 112-115.
13. MALATESTA M., ZANCANARO C., BALDELLI B. and GAZZANELLI G., 2002. Quantitative ultrastructural changes of hepatocyte constituents in euthermic, hibernating and arousing dormice (Muscardinus avellanarius). Tissue Cell, 39, 394-405.
14. ORTIZ J.J., AYOUB A., GARGALA G., CHEGNE N.L. and FAVENNEC L., 2001. Randomized clinical study of nitazoxanide compared to metronidazole in the treatment of symptomatic giardiasis in children from Northern Peru. Aliment. Pharmacol. Ther., 15, 1409-1415.
15. PUNGPAK S., SINGHASIVANON V., BUNNAG D., RADOMYOS B., NIBADHASOPON P. and HARINALTA K., 1996. Albendazole as a treatment for Giardia infection. Ann. Trop. Med. Parasitol., 90, 563-565.
16. ROMERO-CABELLO R., ROBERTS G.L., MUÑOZ G.M.R. and GEYNE C.A., 1997. Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico. Trans. R. Soc. Trop. Med. Hyg., 92, 103-104.
17. ROSSIGNOL J.F. and CAVIER R., 1976. New derivatives of 2-benzamido-5-nitrothiazole. United States Patent No 3,950,351.
18. SCHAEFFER III W.F., RICE W.E. and HOFF C.J., 1984. Factors promoting in vitro excystation of Giardia muris cysts. Trans. R. Soc. Trop. Med. Hyg., 78, 795-800.
19. UPCROFT P. and UPCROFT J.A., 2001. Drug targets and mechanism of resistance in the anaerobic protozoa. Clin. Microbiol. Rev., 14, 150-164.