RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells

Annals of the New York Academy of Sciences

Volumn 1201, Issue , 2010, Pages 129-136

  Holley, Aaron K ^a   Xu, Yong ^a   Clair, Daret K St ^a   Clair, William H St ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

manganese superoxide dismutase; prostate cancer; radiation resistance; RelB

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; ANTIOXIDANT; REACTIVE OXYGEN METABOLITE; RELB PROTEIN, HUMAN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELB;

CARCINOGENESIS; CELL PROTECTION; CONFERENCE PAPER; HUMAN; HUMAN CELL; IONIZING RADIATION; MODULATION; PROSTATE CANCER; PROTEIN EXPRESSION; RADIOSENSITIVITY; APOPTOSIS; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; MALE; METABOLISM; METHODOLOGY; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; RADIOTHERAPY; REVIEW;

ANTIOXIDANTS; APOPTOSIS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MITOCHONDRIA; MODELS, BIOLOGICAL; NF-KAPPA B; OXIDATIVE STRESS; PROSTATIC NEOPLASMS; RADIATION, IONIZING; RADIOTHERAPY; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELB;

EID: 77955292644     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05613.x     Document Type: Conference Paper

References (71)

1. Jemal, A. et al. 2009. Cancer Statistics, 2009. CA Cancer J. Clin. 59: 225-249.
2. Thompson, I. et al. 2007. Guideline for the management of clinically localized prostate cancer: 2007 update. J. Urolog. 177: 2106-2131.
3. FitzGerald, T.J. et al. 2008. Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev. Anticancer Ther. 8: 967-974.
4. Torlakovic, E. et al. 2005. Differential expression of steroid receptors in prostate tissues before and after radiation therapy for prostatic adenocarcinoma. Int. J. Cancer. 117: 381-386.
5. Mackey,T.J. et al. 1998. bcl-2/bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with prostate cancer. Urology. 52: 1085-1090.
6. Skvortsova, I. et al. 2008. Intracellular signaling pathways regulating radioresistance of human prostate carcinoma cells. Proteomics. 8: 4521-4533.
7. Lee, C.H. et al. 2007. NF-κB as a potential molecular target for cancer therapy. Biofactors. 29: 19-35.
8. Criswell, T. et al. 2003. Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene. 22: 5813-5827.
9. Ahmed, K.M. & J.J. Li. 2008. NF-κB-mediated adaptive resistance to ionizing radiation. Free Radic. Biol.Med. 44: 1-13.
10. Murley, J.S. et al. 2004. Delayed radioprotection by NFκB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. Rad. Res. 162: 536-546.
11. Fridovich, I. 1978. The biology of oxygen radicals. Science. 201: 875-880.
12. Forman, H.J., J.M. Fukuto & M. Torres. 2004. Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers. Am. J. Physiol., Cell Physiol. 287: C246-C256.
13. Droge,W. 2002. Free radicals in the physiological control of cell function. Physiol. Rev. 82: 47-95.
14. Kakkar, P. & B.K. Singh. 2007.Mitochondria: a hub of redox activities and cellular distress control. Mol. Cell. Biochem. 305: 235-253.
15. Mettler, F.A. & A.C. Upton. 2008. Medical Effects of Ionizing Radiation. Saunders Elsvier. Philadelphia, PA.
16. Halliwell, B. & J.M.C. Gutteridge. 2007. Free Radicals in Biology and Medicine. Oxford University Press. New York.
17. Kabe, Y. et al. 2005. Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus. Antiox. Redox Signal. 7: 395-403.
18. Poli, G. et al. 2004. Oxidative stress and cell signaling. Curr. Med. Chem. 11: 1163-1182.
19. Wang, X. et al. 1998. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signaling pathways on cell survival. Biochem. J. 333: 291-300.
20. Schafer, M. et al. 2003. Role of redox signaling in the autonomous proliferative response of endothelial cells to hypoxia. Circ. Res. 92: 1010-1015.
21. Waris, G. & H. Ahsan. 2006. Reactive oxygen species: role in the development of cancer and various chronic conditions. J. Carcinogen. 5: 14-21.
22. Gius, D. & D.R. Spitz. 2006. Redox signaling in cancer biology. Antiox. Redox Signal. 8: 1249-1252.
23. Andreyev,A.Y.,Y.E.Kushnareva & A.A. Starkov. 2005.Mitochondrial metabolism of reactive oxygen species. Biochem. (Moscow). 70: 246-264.
24. Sun, J. et al. 1998. Role of antioxidant enzymes on ionizing radiation resistance. Free Radic. Biol. Med. 24: 586-593.
25. Zhang, X. et al. 2008. Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene. Human Gene Ther. 19: 820-826.
26. Fisher, C.J. & P.C. Goswami. 2008. Mitochondria-targeted antioxidant enzyme activity regulates radioresistance in human pancreatic cancer cells. Cancer Biol. Ther. 7: 1271-1279.
27. Kalen, A.L. et al. 2006. Mn-superoxide dismutase overexpression enhances G2 accumulation and radioresistance in human oral squamous carcinoma cells. Antiox. Redox Signal. 8: 1273-1281.
28. Bonizzi, G. & M. Karin. 2004. The two NF-κB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25: 280-288.
29. Ghosh, S., M.J. May & E.B. Kopp. 1998. NF-kB and Rel proteins: evolutionarily conserved mediators of immune response. Ann. Rev. Immunol. 16: 225-260.
30. Karin, M. & Y. Ben-Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Ann. Rev. Immunol. 18: 621-633.
31. Li, Z.-W. et al. 1999. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis. J. Exp. Med. 189: 1839-1845.
32. Sigala, J.L.D. et al. 2004. Activation of transcription factor NF-κB requires ELKS, and IκB kinase regulatory subunit. Science. 304: 1963-1967.
33. Chen, G., P. Cao & D.V. Goeddel. 2002. TNF-induced recruitment and activation of the IKK complex require cdc37 and hsp90. Mol. Cell. 9: 401-410.
34. Xiao, G., E.W. Harhaj & S.-C. Sun. 2001. NF-κB-inducing kinase regulates the processing of NF-κB2 p100. Mol. Cell. 7: 401-409.
35. Senftleben, U. et al. 2001. Activation by IKKβ of a second, evolutionary conserved, NF-κB signaling pathway. Science. 293: 1495-1499.
36. Pahl, H.L. 1999. Activators and target genes of Rel/NF-κB transcription factors. Oncogene. 18: 6853-6866.
37. Dejardin, E. 2006. The alternative NF-κBpathway frombiochemistry to biology: pitfalls and promises for future drug development. Biochem. Pharmacol. 72: 1161-1179.
38. Alcamo, E. et al. 2001. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-κB in leukocyte recruitment. J. Immunol. 167: 1592-1600.
39. Chen, C., L.C. Edelstein & C. Gelinas. 2000. The Rel/NF-κB family directly activates expression of the apoptosis inhibitor Bcl-xL. Mol. Cell. Biol. 20: 2687-2695.
40. Chilov, D. et al. 1997. Genomic organization of human and mouse genes for vascular endothelial growth factor C. J. Biol. Chem. 272: 25176-25183.
41. Guttridge, D.C. et al. 1999. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 19: 5785-5799.
42. Kunsch, C. & C. A. Rosen. 1993. NF-κB subunit-specific regulation of the interleukin-8 promoter.Mol. Cell. Biol. 13: 6137-6146.
43. -/- mice causes impared lymph node development and lymphocyte recruitment. J. Immunol. 173: 2271-2279.
44. Lo, J. C. et al. 2006. Coordination between NF-κB family members p50 and p52 is essential for mediating LTβR signals in the development and organization of secondary lymphoid tissues. Blood. 107: 1048-1055.
45. Kinoshita, D. et al. 2006. Essential role of IκB kinase α in the thymic organogenesis required for the establishment of self-tolerance. J. Immunol. 176: 3995-4002.
46. Kaisho, B. T. et al. 2001. IκB kinase α is essential for mature B cell development and function. J. Exp.Med. 193: 417-426.
47. Felx, M. et al. 2006. Endothelin-I (ET-I) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-κB in human osteosarcoma. Clin. Sci. 110: 645-654.
48. Shukla, S. et al. 2005. Constitutive activation of PI3KAKT and NF-κB during prostate cancer progression in autochthonous transgenic mouse model. Prostate. 64: 224-239.
49. Suh, J. et al. 2002. Mechanisms of constitutive NF-κB activation in human prostate cancer cells. Prostate. 52: 183-200.
50. Zerbini, L.F. et al. 2003. Constitutive activation of nuclear factor κB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. Cancer Res. 63: 2206-2215.
51. Wharry, C.E. et al. 2009. Constitutive non-canonical NFkB signaling in pancreatic cancer cells. Cancer Biol. Ther. 8: 1567-1576.
52. Nishina, T. et al. 2009. NIK is involved in constitutive activation of the alternaitve NF-κB pathway and proliferation of pancreatic cancer cells. Biochem. Biophys. Res. Commun. 388: 96-101.
53. Keats, J.J. et al. 2007. Promiscuous mutations activate the noncanonical NF-κB pathway in multiple myeloma. Cancer Cell. 12: 131-144.
54. Dejardin, E. et al. 1995. Highly-expressed p100/p52 (NFKB2) sequesters other NF-kappa B-related proteins in the cytoplasm of human breast cancer cells. Oncogene. 11: 1835-1841.
55. Mineva, N.D. et al. 2007. CD40 ligand-mediated activation of the deNovo RelBNF-κB synthesis pathway in transformed B cells promotes rescue from apoptosis. J. Biol. Chem. 282: 17475-17485.
56. Lessard, L. et al. 2005. Nuclear localisation of nuclear factorkappaB transcription factors in prostate cancer: an immunohistochemical study. Brit. J. Cancer. 93: 1019-1023.
57. Lessard, L. et al. 2007. NF-kB2 processing and p52 nuclear accumulation after androgenic stimulation of LNCaP prostate cancer cells. Cellular Signaling. 19: 1093-1100.
58. Brach, M.A. et al. 1991. Ionizing radiation induces expression and binding activity of the nuclear factor κB. J. Clin. Invest. 88: 691-695.
59. Zhou, D. et al. 1999. A high dose of ionizing radiation induces tissue-specific activation of nuclear factor- κB in vivo. Rad. Res. 151: 703-709.
60. Fan, M. et al. 2007. Nuclear factor- κB and manganese superoxide dismutase mediate adaptive radioresistance in lowdose irradiated mouse skin epithelial cells. Cancer Res. 67: 3220-3228.
61. Kim, B.Y. et al. 2005. NF-κB inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation. Carcinogenesis. 26: 1395-1403.
62. Chendil, D. et al. 2002. Par-4, a pro-apoptotic gene, inhibits radiation-induced NFκB- activity and bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3. Cancer Biol. Ther. 1: 152-160.
63. Xu, Y. et al. 1999. An intronic NF-κB element is essential for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-α and interleukin-1β. DNA Cell Biol 18: 709-722.
64. Kiningham, K.K., C. Daosukho & D.K. St. Clair. 2004. IκBα (inhibitory κBα) identified as labile repressor of MnSOD (manganese superoxide dismutase) expression. Biochem. J. 384: 543-549.
65. Kiningham, K.K. et al. 2001. Nuclear factor κB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2. Biochem. J. 353: 147-156.
66. Dhar, S. K. et al. 2004. Identification of nucleophosmin as an NF-κB co-activator for the induction of the human SOD2 gene. J. Biol. Chem. 279: 28209-28219.
67. Guo, G. et al. 2003. Manganese superoxide dismutasemediated gene expression in radiation-induced adaptive responses. Mol. Cell. Biol. 23: 2362-2378.
68. Josson, S. et al. 2006. RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells. Oncogene. 25: 1554-1559.
69. Xu, Y. et al. 2009. RelB enhances prostate cancer growth: implications for the role of the nuclear factor- κB alternative pathway in tumorigenicity. Cancer Res. 69: 3267-3271.
70. Xu, Y. et al. 2008. SN52, a novel nuclear factor- κB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation.Mol. Cancer Ther. 7: 2367-2376.
71. Xu, Y. et al. 2007. Suppression of RelB-mediated manganse superoxide dismutase expression reveals a primary mechanismC for radiosensitization effect of 1β-25-dihydroxyvitamin D3 in prostate cancer cells. Mol. Cancer Ther. 6: 2048-2056.