Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1

Leukemia Research

Volumn 34, Issue 9, 2010, Pages 1203-1213

  Oakford, Phillippa C ^a   James, Sally R ^b   Qadi, Abeer ^a   West, Alison C ^a   Ray, Shannon N ^a   Bert, Andrew G ^c   Cockerill, Peter N ^b   Holloway, Adele F ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c SA PATHOLOGY   (Australia)

Author keywords

Chromatin; GM CSF; Oncoprotein; RUNX1; Transcription

Indexed keywords

DEOXYRIBONUCLEASE I; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTONE; ONCOPROTEIN; PROTEIN ETO; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACETYLATION; ACUTE GRANULOCYTIC LEUKEMIA; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BONE MARROW CULTURE; CARBOXY TERMINAL SEQUENCE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DENSITOMETRY; DNA PURIFICATION; DOWN REGULATION; EPIGENETICS; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE MAPPING; HUMAN; HUMAN CELL; INTRON; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MODIFICATION; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 77955277016     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.03.029     Document Type: Article

References (60)

1. Friedman A.D. Leukemogenesis by CBF oncoproteins. Leukemia 1999, 13:1932-1942.
2. Look A.T. Oncogenic transcription factors in the human acute leukemias. Science 1997, 278:1059-1064.
3. Nimer S.D., Moore M.A. Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells. Oncogene 2004, 23:4249-4254.
4. Peterson L.F., Zhang D.E. The 8;21 translocation in leukemogenesis. Oncogene 2004, 23:4255-4262.
5. Bennett J.M., Catovsky D., Daniel M.T., et al. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group. Ann Intern Med 1985, 103:620-625.
6. Erickson P., Gao J., Chang K.S., et al. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 1992, 80:1825-1831.
7. Miyoshi H., Kozu T., Shimizu K., et al. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J 1993, 12:2715-2721.
8. Di Croce L. Chromatin modifying activity of leukaemia associated fusion proteins. Hum Mol Genet 2005, 14(Spec. no. 1):R77-R84.
9. Okuda T., van Deursen J., Hiebert S.W., Grosveld G., Downing J.R. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 1996, 84:321-330.
10. Yergeau D.A., Hetherington C.J., Wang Q., et al. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet 1997, 15:303-306.
11. Cockerill P.N., Osborne C.S., Bert A.G., Grotto R.J. Regulation of GM-CSF gene transcription by core-binding factor. Cell Growth Differ 1996, 7:917-922.
12. Frank R., Zhang J., Uchida H., Meyers S., Hiebert S.W., Nimer S.D. The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. Oncogene 1995, 11:2667-2674.
13. Takahashi A., Satake M., Yamaguchi-Iwai Y., et al. Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2. Blood 1995, 86:607-616.
14. Liu S., Shen T., Huynh L., et al. Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. Cancer Res 2005, 65:1277-1284.
15. Taylor D.S., Laubach J.P., Nathan D.G., Mathey-Prevot B. Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. J Biol Chem 1996, 271:14020-14027.
16. Uchida H., Zhang J., Nimer S.D. AML1A and AML1B can transactivate the human IL-3 promoter. J Immunol 1997, 158:2251-2258.
17. Follows G.A., Tagoh H., Lefevre P., Hodge D., Morgan G.J., Bonifer C. Epigenetic consequences of AML1-ETO action at the human c-FMS locus. EMBO J 2003, 22:2798-2809.
18. Zhang D.E., Fujioka K., Hetherington C.J., et al. Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). Mol Cell Biol 1994, 14:8085-8095.
19. Tenen D.G. Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer 2003, 3:89-101.
20. Dunne J., Cullmann C., Ritter M., et al. siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts. Oncogene 2006, 25:6067-6078.
21. Hohaus S., Petrovick M.S., Voso M.T., Sun Z., Zhang D.E., Tenen D.G. PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene. Mol Cell Biol 1995, 15:5830-5845.
22. Pabst T., Mueller B.U., Harakawa N., et al. AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia. Nat Med 2001, 7:444-451.
23. Westendorf J.J., Hiebert S.W. Mammalian runt-domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia. J Cell Biochem 1999, (Suppl. 32-33):51-58.
24. Durst K.L., Hiebert S.W. Role of RUNX family members in transcriptional repression and gene silencing. Oncogene 2004, 23:4220-4224.
25. Otto F., Lubbert M., Stock M. Upstream and downstream targets of RUNX proteins. J Cell Biochem 2003, 89:9-18.
26. Wildonger J., Mann R.S. The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor. Development 2005, 132:2263-2272.
27. Berg T., Fliegauf M., Burger J., et al. Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO. Haematologica 2008, 93:1728-1733.
28. Hines R., Boyapati A., Zhang D.E. Cell type dependent regulation of multidrug resistance-1 gene expression by AML1-ETO. Blood Cells Mol Dis 2007, 39:297-306.
29. Kitabayashi I., Yokoyama A., Shimizu K., Ohki M. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation. EMBO J 1998, 17:2994-3004.
30. Chan H.M., La Thangue N.B. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J Cell Sci 2001, 114:2363-2373.
31. Amann J.M., Nip J., Strom D.K., et al. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol 2001, 21:6470-6483.
32. Gelmetti V., Zhang J., Fanelli M., Minucci S., Pelicci P.G., Lazar M.A. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol 1998, 18:7185-7191.
33. Cockerill P.N. Mechanisms of transcriptional regulation of the human IL-3/GM-CSF locus by inducible tissue-specific promoters and enhancers. Crit Rev Immunol 2004, 24:385-408.
34. Shannon M.F., Coles L.S., Vadas M.A., Cockerill P.N. Signals for activation of the GM-CSF promoter and enhancer in T cells. Crit Rev Immunol 1997, 17:301-323.
35. Brettingham-Moore K.H., Sprod O.R., Chen X., Oakford P., Shannon M.F., Holloway A.F. Determinants of a transcriptionally competent environment at the GM-CSF promoter. Nucleic Acids Res 2008.
36. Bert A.G., Johnson B.V., Baxter E.W., Cockerill P.N. A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling. Mol Cell Biol 2007, 27:2870-2885.
37. Brettingham-Moore K.H., Rao S., Juelich T., Shannon M.F., Holloway A.F. GM-CSF promoter chromatin remodelling and gene transcription display distinct signal and transcription factor requirements. Nucleic Acids Res 2005, 33:225-234.
38. Chen X., Wang J., Woltring D., Gerondakis S., Shannon M.F. Histone dynamics on the interleukin-2 gene in response to T-cell activation. Mol Cell Biol 2005, 25:3209-3219.
39. Cockerill P.N., Bert A.G., Roberts D., Vadas M.A. The human granulocyte-macrophage colony-stimulating factor gene is autonomously regulated in vivo by an inducible tissue-specific enhancer. Proc Natl Acad Sci USA 1999, 96:15097-15102.
40. Holloway A.F., Rao S., Chen X., Shannon M.F. Changes in chromatin accessibility across the GM-CSF promoter upon T cell activation are dependent on nuclear factor kappaB proteins. J Exp Med 2003, 197:413-423.
41. Johnson B.V., Bert A.G., Ryan G.R., Condina A., Cockerill P.N. Granulocyte-macrophage colony-stimulating factor enhancer activation requires cooperation between NFAT and AP-1 elements and is associated with extensive nucleosome reorganization. Mol Cell Biol 2004, 24:7914-7930.
42. Osborne C.S., Vadas M.A., Cockerill P.N. Transcriptional regulation of mouse granulocyte-macrophage colony-stimulating factor/IL-3 locus. J Immunol 1995, 155:226-235.
43. Meyers S., Lenny N., Hiebert S.W. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol 1995, 15:1974-1982.
44. Hung H.L., Lau J., Kim A.Y., Weiss M.J., Blobel G.A. CREB-binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites. Mol Cell Biol 1999, 19:3496-3505.
45. Furley A.J., Reeves B.R., Mizutani S., et al. Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines. Blood 1986, 68:1101-1107.
46. Asou H., Tashiro S., Hamamoto K., Otsuji A., Kita K., Kamada N. Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation. Blood 1991, 77:2031-2036.
47. Holloway A.F., Occhiodoro F., Mittler G., Meisterernst M., Shannon M.F. Functional interaction between the HIV transactivator Tat and the transcriptional coactivator PC4 in T cells. J Biol Chem 2000, 275:21668-21677.
48. Rao S., Procko E., Shannon M.F. Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene. J Immunol 2001, 167:4494-4503.
49. Bowers S.R., Mirabella F., Calero-Nieto F.J., et al. A conserved insulator that recruits CTCF and cohesin exists between the closely related but divergently regulated interleukin-3 and granulocyte-macrophage colony-stimulating factor genes. Mol Cell Biol 2009, 29:1682-1693.
50. Bert A.G., Burrows J., Hawwari A., Vadas M.A., Cockerill P.N. Reconstitution of T cell-specific transcription directed by composite NFAT/Oct elements. J Immunol 2000, 165:5646-5655.
51. St Louis D.C., Woodcock J.B., Franzoso G., et al. Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model. J Immunol 1999, 162:3237-3248.
52. Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou M.M. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure 2008, 16:643-652.
53. Wang J., Hoshino T., Redner R.L., Kajigaya S., Liu J.M. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Proc Natl Acad Sci USA 1998, 95:10860-10865.
54. Black J.C., Choi J.E., Lombardo S.R., Carey M. A mechanism for coordinating chromatin modification and preinitiation complex assembly. Mol Cell 2006, 23:809-818.
55. Yamaguchi Y., Kurokawa M., Imai Y., et al. AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues. J Biol Chem 2004, 279:15630-15638.
56. Zhang Y., Biggs J.R., Kraft A.S. Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation. J Biol Chem 2004, 279:53116-53125.
57. Claus R., Fliegauf M., Stock M., Duque J.A., Kolanczyk M., Lubbert M. Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. J Leukoc Biol 2006, 80:1462-1472.
58. Klisovic M.I., Maghraby E.A., Parthun M.R., et al. Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells. Leukemia 2003, 17:350-358.
59. Wang J., Saunthararajah Y., Redner R.L., Liu J.M. Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells. Cancer Res 1999, 59:2766-2769.
60. Kita K., Shirakawa S., Kamada N. Cellular characteristics of acute myeloblastic leukemia associated with t(8;21)(q22;q22). The Japanese Cooperative Group of Leukemia/Lymphoma. Leuk Lymphoma 1994, 13:229-234.