PDCD2, a protein whose expression is repressed by BCL6, induces apoptosis in human cells by activation of the caspase cascade

Blood Cells, Molecules, and Diseases

Volumn 45, Issue 2, 2010, Pages 169-175

  Baron, Beverly W ^a   Hyjek, Elizabeth ^a   Gladstone, Betty ^a   Thirman, Michael J ^a   Baron, Joseph M ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Apoptosis; Caspase cascade; PDCD2

Indexed keywords

CASPASE; MEMBRANE RECEPTOR; PROGRAMMED CELL DEATH PROTEIN 2; PROTEIN BCL 6; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BURKITT LYMPHOMA; CANCER CELL CULTURE; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOID TISSUE; LYMPHOMA; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 3; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; K562 CELLS; KIDNEY; LYMPHOMA; PROTO-ONCOGENE PROTEINS C-BCL-6; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; ZINC FINGERS;

MAMMALIA;

EID: 77955276855     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2010.04.007     Document Type: Article

References (39)

1. Baron B.W., Anastasi J., Thirman M.J., et al. The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. Proc. Natl. Acad. Sci. USA 2002, 99:2860-2865.
2. Baron B.W., Zeleznik-Le N., Baron M.J., et al. Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas. Proc. Natl. Acad. Sci. USA 2007, 104:7449-7454.
3. Minakhina S., Druzhinina M., Steward R. Zfrp8, the Drosophila ortholog of PDCD2, functions in lymph gland development and controls cell proliferation. Development 2007, 134:2387-2396.
4. Kawakami T., Furukawa Y., Sudo K., et al. Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death. Cytogenet. Cell Genet. 1995, 71:41-43.
5. Owens G.P., Hahn W.E., Cohen J.J. Identification of mRNAs associated with programmed cell death in immature thymocytes. Mol. Cell. Biol. 1991, 11:4177-4188.
6. Scarr R.B., Sharp P.A. PDCD2 is a negative regulator of HCF-1 (C1). Oncogene 2002, 21:5245-5254.
7. Baron B.W., Desai M., Baber L.J., et al. BCL6 can repress transcription from the human immunodeficiency virus type 1 promoter/enhancer region. Genes Chromosom. Cancer 1997, 19:14-21.
8. Kerckaert J.-P., Deweindt C., Tilly H., et al. LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nat. Genet. 1993, 5:66-70.
9. Allman D., Jain A., Dent A., et al. BCL-6 expression during B-cell activation. Blood 1996, 87:5257-5268.
10. Phan R.T., Dalla-Favera R. The BCL6 proto-oncogene suppresses p53 expression in germinal centre B cells. Nature 2004, 432:635-639.
11. Baron B.W., Nucifora G., McCabe N., et al. Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. Proc. Natl. Acad. Sci. USA 1993, 90:5262-5266.
12. Ye B.H., Lista F., Lo Coco F., et al. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 1993, 262:747-750.
13. Pasqualucci L., Migliazza A., Basso K., et al. Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood 2003, 101:2914-2923.
14. Baron B.W., Anastasi J., Montag A., et al. The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc. Natl. Acad. Sci. USA 2004, 101:14198-14203.
15. Cattoretti G., Pasqualucci L., Ballon G., et al. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell 2005, 7:445-455.
16. Dent A.L., Shaffer A.L., Yu X., et al. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997, 276:589-592.
17. Ye B.H., Cattoretti B., Shen Q., et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 1997, 16:161-170.
18. Hyjek E., Chadburn A., Liu Y.F., et al. BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. Blood 2001, 97:270-276.
19. Kawamata N., Miki T., Ohashi K., et al. Recognition DNA sequence of a novel putative transcription factor, BCL6. Biochem. Biophys. Res. Commun. 1994, 294:366-374.
20. Baron B.W., Stanger R.R., Hume E., et al. BCL6 encodes a sequence-specific DNA-binding protein. Genes Chromosom. Cancer 1995, 13:221-224.
21. Deweindt C., Albagli O., Bernardin F., et al. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 1995, 6:1495-1503.
22. Chang C.C., Ye B.H., Chaganti R.S.K., Dalla-Favera R. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl. Acad. Sci. USA 1996, 93:6947-6952.
23. Seyfert V.L., Allman D., He Y., Staudt L.M. Transcriptional repression by the proto-oncogene BCL-6. Oncogene 1996, 12:2331-2342.
24. Shaffer A.L., Yu X., He Y., et al. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 2000, 13:199-212.
25. Ci W., Polo J.M., Cerchietti L., et al. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood 2009, 113:5536-5548.
26. Basso K., Saito M., Sumazin P., et al. Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells. Blood 2010, 115:975-984.
27. Kozu T., Fukuyama T., Yamami T., et al. MYND-less splice variants of AML1-MTG8 (RUNX1-CBFA2T1) are expressed in leukemia with t(8:21). Genes Chromosom. Cancer 2005, 43:45-53.
28. Huynh K.D., Fischle W., Verdin E., Bardwell V.J. BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 2000, 14:1810-1823.
29. Merup M., Moreno T.C., Heyman M., et al. 6q deletions in acute lymphoblastic leukemia and non-Hodgkin's lymphomas. Blood 1998, 91:3397-3400.
30. Mahalik T.J., Hahn W.E., Clayton G.H., Owens G.P. Programmed cell death in developing grafts of fetal substantia nigra. Exp. Neurol. 1994, 129:27-36.
31. D'Mello S.R., Galli C. SGP2, ubiquitin, 14K lectin, and RP8 mRNAs are not induced in neuronal apoptosis. NeuroReport 1993, 4:355-358.
32. Vaux D.L., Hacker G. Cloning of mouse RP-8 and its expression during apoptosis of lymphoid and myeloid cells. DNA Cell Biol. 1995, 14:189-193.
33. Hasegawa H., Yamada Y., Iha H., et al. Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-leukemia cells. Leukemia 2009, 23:2090-2101.
34. Nelyudova A., Aksenov N., Pospelov V., Pospelova T. By blocking apoptosis, Bcl-2 in p38-dependent manner promotes cell cycle arrest and accelerates senescence after DNA damage and serum withdrawal. Cell Cycle 2007, 6:2171-2177.
35. Kusam S., Munugalavadla V., Sawant D., Dent A. BCL6 cooperates with CD 40 stimulation and loss of p53 function to rapidly transform primary B cells. Int. J. Cancer 2009, 125:977-981.
36. Castejon R., Vargas J.A., Romero Y., et al. Modulation of apoptosis by cytokines in B-cell chronic lymphocytic leukemia. Cytometry 1999, 38:224-230.
37. Gojo I., Zhang B., Fenton R.G. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin. Cancer Res. 2002, 8:3527-3528.
38. Senkel S., Waldner C., Ryffel G.U., Thomas H. Improved conditional expression systems resulting in physiological level of HNF4α expression confirm HNF4α induced apoptosis in the pancreatic beta-cell line INS-1. BMC Res. Notes 2009, 2:210-216.
39. Lossos I.S., Warnke R., Levy R. BCL-6 mRNA expression in higher grade transformation of follicle center lymphoma: correlation with somatic mutations in the 5' regulatory region of the BCL-6 gene. Leukemia 2002, 16:1857-1862.