Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes

Life Sciences

Volumn 87, Issue 7-8, 2010, Pages 261-268

  Hanioka, Nobumitsu ^a   Tanabe, Natsuko ^a   Jinno, Hideto ^b   Tanaka Kagawa, Toshiko ^b   Nagaoka, Kenjiro ^a   Naito, Shinsaku ^c   Koeda, Akiko ^d   Narimatsu, Shizuo ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^d N   (Japan)

Author keywords

7 Ethyl 10 hydroxycamptothecin (SN 38); 7 Hydroxy 4 trifluoromethylcoumarin (7 HFC); Cynomolgus monkey; Estradiol at 3 hydroxy position (E 3OH); Human; UDP glucuronosyltransferase (UGT); UGT1A1

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 HYDROXY 4 TRIFLUOROMETHYLCOUMARIN; COUMARIN DERIVATIVE; ESTRADIOL; GLUCURONOSYLTRANSFERASE 1A1; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; GLUCURONIDATION; HUMAN; LIVER MICROSOME; MICHAELIS MENTEN KINETICS; MONKEY; NONHUMAN; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; CAMPTOTHECIN; COUMARINS; ESTRADIOL; GENE EXPRESSION; GLUCURONOSYLTRANSFERASE; HUMANS; MACACA FASCICULARIS; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

ANIMALIA; HEXAPODA; MACACA FASCICULARIS;

EID: 77955273136     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.07.001     Document Type: Article

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