메뉴 건너뛰기




Volumn 136, Issue 3, 2010, Pages 409-418

Secondary immunologic consequences in chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome)

Author keywords

Allergy; Antibody; Autoimmunity; B cells; DiGeorge syndrome; Th1; Th17; Th2

Indexed keywords

ADULT; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CHILD; CHROMOSOME 22Q; CHROMOSOME DELETION; CONTROLLED STUDY; DIGEORGE SYNDROME; DISEASE PREDISPOSITION; HOMEOSTASIS; HUMAN; IMMUNE SYSTEM; IMMUNOPHENOTYPING; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MEMORY CELL; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; TH1 CELL; TH17 CELL; TH2 CELL; TODDLER; VELOCARDIOFACIAL SYNDROME;

EID: 77955272462     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2010.04.011     Document Type: Article
Times cited : (77)

References (80)
  • 2
    • 0035098557 scopus 로고    scopus 로고
    • DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1
    • Jerome L.A., Papaioannou V.E. DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat. Genet. 2001, 27:286-291.
    • (2001) Nat. Genet. , vol.27 , pp. 286-291
    • Jerome, L.A.1    Papaioannou, V.E.2
  • 3
    • 0027370619 scopus 로고
    • Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndromes: implications for genetic counselling and prenatal diagnosis
    • Driscoll D.A., Salvin J., Sellinger B., Budarf M.L., McDonald-McGinn D.M., Zackai E.H., Emanuel B.S. Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndromes: implications for genetic counselling and prenatal diagnosis. J. Med. Genet. 1993, 30:813-817.
    • (1993) J. Med. Genet. , vol.30 , pp. 813-817
    • Driscoll, D.A.1    Salvin, J.2    Sellinger, B.3    Budarf, M.L.4    McDonald-McGinn, D.M.5    Zackai, E.H.6    Emanuel, B.S.7
  • 4
    • 0030444261 scopus 로고    scopus 로고
    • Chromosome 22q11.2 microdeletions in velocardiofacial syndrome patients with widely variable manifestations
    • Ravnan J.B., Chen E., Golabi M., Lebo R.V. Chromosome 22q11.2 microdeletions in velocardiofacial syndrome patients with widely variable manifestations. Am. J. Med. Genet. 1996, 66:250-256.
    • (1996) Am. J. Med. Genet. , vol.66 , pp. 250-256
    • Ravnan, J.B.1    Chen, E.2    Golabi, M.3    Lebo, R.V.4
  • 7
    • 27644554787 scopus 로고    scopus 로고
    • Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion
    • Xu H., Cerrato F., Baldini A. Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development 2005, 132:4387-4395.
    • (2005) Development , vol.132 , pp. 4387-4395
    • Xu, H.1    Cerrato, F.2    Baldini, A.3
  • 9
    • 0037091009 scopus 로고    scopus 로고
    • Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways
    • Vitelli F., Morishima M., Taddei I., Lindsay E.A., Baldini A. Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum. Mol. Genet. 2002, 11:915-922.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 915-922
    • Vitelli, F.1    Morishima, M.2    Taddei, I.3    Lindsay, E.A.4    Baldini, A.5
  • 12
    • 0031671548 scopus 로고    scopus 로고
    • A population study of chromosome 22q11 deletions in infancy
    • Goodship J., Cross I., LiLing J., Wren C. A population study of chromosome 22q11 deletions in infancy. Arch. Dis. Child. 1998, 79:348-351.
    • (1998) Arch. Dis. Child. , vol.79 , pp. 348-351
    • Goodship, J.1    Cross, I.2    LiLing, J.3    Wren, C.4
  • 16
    • 17644421861 scopus 로고    scopus 로고
    • Presenting phenotype in 100 children with the 22q11 deletion syndrome
    • Oskarsdottir S., Persson C., Eriksson B.O., Fasth A. Presenting phenotype in 100 children with the 22q11 deletion syndrome. Eur. J. Pediatr. 2005, 164:146-153.
    • (2005) Eur. J. Pediatr. , vol.164 , pp. 146-153
    • Oskarsdottir, S.1    Persson, C.2    Eriksson, B.O.3    Fasth, A.4
  • 17
    • 0035196580 scopus 로고    scopus 로고
    • Immunologic features of chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome)
    • Jawad A.F., McDonald-McGinn D.M., Zackai E., Sullivan K.E. Immunologic features of chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome). J. Pediatr. 2001, 139:715-723.
    • (2001) J. Pediatr. , vol.139 , pp. 715-723
    • Jawad, A.F.1    McDonald-McGinn, D.M.2    Zackai, E.3    Sullivan, K.E.4
  • 21
    • 0024310736 scopus 로고
    • The DiGeorge sequence. II. Immunologic findings in partial and complete forms of the disorder
    • Muller W., Peter H.H., Kallfelz H.C., Franz A., Rieger C.H. The DiGeorge sequence. II. Immunologic findings in partial and complete forms of the disorder. Eur. J. Pediatr. 1989, 149:96-103.
    • (1989) Eur. J. Pediatr. , vol.149 , pp. 96-103
    • Muller, W.1    Peter, H.H.2    Kallfelz, H.C.3    Franz, A.4    Rieger, C.H.5
  • 24
    • 33645105072 scopus 로고    scopus 로고
    • Maturational alterations of peripheral T cell subsets and cytokine gene expression in 22q11.2 deletion syndrome
    • Kanaya Y., Ohga S., Ikeda K., Furuno K., Ohno T., Takada H., Kinukawa N., Hara T. Maturational alterations of peripheral T cell subsets and cytokine gene expression in 22q11.2 deletion syndrome. Clin. Exp. Immunol. 2006, 144:85-93.
    • (2006) Clin. Exp. Immunol. , vol.144 , pp. 85-93
    • Kanaya, Y.1    Ohga, S.2    Ikeda, K.3    Furuno, K.4    Ohno, T.5    Takada, H.6    Kinukawa, N.7    Hara, T.8
  • 26
    • 1642581677 scopus 로고    scopus 로고
    • T-cell homeostasis in humans with thymic hypoplasia due to chromosome 22q11.2 deletion syndrome
    • Piliero L.M., Sanford A.N., McDonald-McGinn D.M., Zackai E.H., Sullivan K.E. T-cell homeostasis in humans with thymic hypoplasia due to chromosome 22q11.2 deletion syndrome. Blood 2004, 103:1020-1025.
    • (2004) Blood , vol.103 , pp. 1020-1025
    • Piliero, L.M.1    Sanford, A.N.2    McDonald-McGinn, D.M.3    Zackai, E.H.4    Sullivan, K.E.5
  • 27
    • 70249143637 scopus 로고    scopus 로고
    • Homeostatic proliferation and survival of naive and memory T cells
    • Boyman O., Letourneau S., Krieg C., Sprent J. Homeostatic proliferation and survival of naive and memory T cells. Eur. J. Immunol. 2009, 39:2088-2094.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2088-2094
    • Boyman, O.1    Letourneau, S.2    Krieg, C.3    Sprent, J.4
  • 29
    • 0033539516 scopus 로고    scopus 로고
    • Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands
    • Kieper W.C., Jameson S.C. Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands. Proc. Natl. Acad. Sci. USA 1999, 96:13306-13311.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13306-13311
    • Kieper, W.C.1    Jameson, S.C.2
  • 30
    • 0036672918 scopus 로고    scopus 로고
    • Maintaining the norm: T-cell homeostasis
    • Jameson S.C. Maintaining the norm: T-cell homeostasis. Nat. Rev. Immunol. 2002, 2:547-556.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 547-556
    • Jameson, S.C.1
  • 31
    • 0035889933 scopus 로고    scopus 로고
    • Homeostatic expansion occurs independently of costimulatory signals
    • Prlic M., Blazar B.R., Khoruts A., Zell T., Jameson S.C. Homeostatic expansion occurs independently of costimulatory signals. J. Immunol. 2001, 167:5664-5668.
    • (2001) J. Immunol. , vol.167 , pp. 5664-5668
    • Prlic, M.1    Blazar, B.R.2    Khoruts, A.3    Zell, T.4    Jameson, S.C.5
  • 32
    • 0037124366 scopus 로고    scopus 로고
    • Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells
    • Tan J.T., Ernst B., Kieper W.C., LeRoy E., Sprent J., Surh C.D. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J. Exp. Med. 2002, 195:1523-1532.
    • (2002) J. Exp. Med. , vol.195 , pp. 1523-1532
    • Tan, J.T.1    Ernst, B.2    Kieper, W.C.3    LeRoy, E.4    Sprent, J.5    Surh, C.D.6
  • 35
    • 33846287885 scopus 로고    scopus 로고
    • Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease
    • Milner J.D., Ward J.M., Keane-Myers A., Paul W.E. Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease. Proc. Natl. Acad. Sci. USA 2007, 104:576-581.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 576-581
    • Milner, J.D.1    Ward, J.M.2    Keane-Myers, A.3    Paul, W.E.4
  • 36
    • 57449097558 scopus 로고    scopus 로고
    • Homeostasis of naive and memory T cells
    • Surh C.D., Sprent J. Homeostasis of naive and memory T cells. Immunity 2008, 29:848-862.
    • (2008) Immunity , vol.29 , pp. 848-862
    • Surh, C.D.1    Sprent, J.2
  • 40
    • 1642415714 scopus 로고    scopus 로고
    • Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire
    • Min B., Foucras G., Meier-Schellersheim M., Paul W.E. Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire. Proc. Natl. Acad. Sci. USA 2004, 101:3874-3879.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3874-3879
    • Min, B.1    Foucras, G.2    Meier-Schellersheim, M.3    Paul, W.E.4
  • 41
    • 1942453326 scopus 로고    scopus 로고
    • Homeostatic expansion of T cells during immune insufficiency generates autoimmunity
    • King C., Ilic A., Koelsch K., Sarvetnick N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 2004, 117:265-277.
    • (2004) Cell , vol.117 , pp. 265-277
    • King, C.1    Ilic, A.2    Koelsch, K.3    Sarvetnick, N.4
  • 42
    • 32444447027 scopus 로고    scopus 로고
    • Prevention of spontaneous arthritis by inhibiting homeostatic expansion of autoreactive CD4+ T cells in the K/BxN mouse model
    • Jang E., Kim H.R., Cho S.H., Paik D.J., Kim J.M., Lee S.K., Youn J. Prevention of spontaneous arthritis by inhibiting homeostatic expansion of autoreactive CD4+ T cells in the K/BxN mouse model. Arthritis Rheum. 2006, 54:492-498.
    • (2006) Arthritis Rheum. , vol.54 , pp. 492-498
    • Jang, E.1    Kim, H.R.2    Cho, S.H.3    Paik, D.J.4    Kim, J.M.5    Lee, S.K.6    Youn, J.7
  • 43
    • 24744441702 scopus 로고    scopus 로고
    • T cell homeostasis in tolerance and immunity
    • Marleau A.M., Sarvetnick N. T cell homeostasis in tolerance and immunity. J. Leukoc. Biol. 2005, 78:575-584.
    • (2005) J. Leukoc. Biol. , vol.78 , pp. 575-584
    • Marleau, A.M.1    Sarvetnick, N.2
  • 48
    • 0030806253 scopus 로고    scopus 로고
    • Oligoclonal expansion of CD45RO+T lymphocytes in Omenn syndrome
    • Harville T.O., Adams D.M., Howard T.A., Ware R.E. Oligoclonal expansion of CD45RO+T lymphocytes in Omenn syndrome. J. Clin. Immunol. 1997, 17:322-332.
    • (1997) J. Clin. Immunol. , vol.17 , pp. 322-332
    • Harville, T.O.1    Adams, D.M.2    Howard, T.A.3    Ware, R.E.4
  • 49
    • 0032910344 scopus 로고    scopus 로고
    • T-cell receptor analysis in Omenn's syndrome: evidence for defects in gene rearrangement and assembly
    • Brooks E.G., Filipovich A.H., Padgett J.W., Mamlock R., Goldblum R.M. T-cell receptor analysis in Omenn's syndrome: evidence for defects in gene rearrangement and assembly. Blood 1999, 93:242-250.
    • (1999) Blood , vol.93 , pp. 242-250
    • Brooks, E.G.1    Filipovich, A.H.2    Padgett, J.W.3    Mamlock, R.4    Goldblum, R.M.5
  • 50
  • 52
    • 0034790618 scopus 로고    scopus 로고
    • Juvenile idiopathic polyarticular arthritis and IgA deficiency in the 22q11 deletion syndrome
    • Davies K., Stiehm E.R., Woo P., Murray K.J. Juvenile idiopathic polyarticular arthritis and IgA deficiency in the 22q11 deletion syndrome. J. Rheumatol. 2001, 28:2326-2334.
    • (2001) J. Rheumatol. , vol.28 , pp. 2326-2334
    • Davies, K.1    Stiehm, E.R.2    Woo, P.3    Murray, K.J.4
  • 55
    • 18344383720 scopus 로고    scopus 로고
    • Allergies in patients with chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome) and patients with chronic granulomatous disease
    • Staple L., Andrews T., McDonald-McGinn D., Zackai E., Sullivan K.E. Allergies in patients with chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome) and patients with chronic granulomatous disease. Pediatr. Allergy Immunol. 2005, 16:226-230.
    • (2005) Pediatr. Allergy Immunol. , vol.16 , pp. 226-230
    • Staple, L.1    Andrews, T.2    McDonald-McGinn, D.3    Zackai, E.4    Sullivan, K.E.5
  • 57
    • 0031833947 scopus 로고    scopus 로고
    • Increased prevalence of immunoglobulin A deficiency in patients with the chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome)
    • Smith C.A., Driscoll D.A., Emanuel B.S., McDonald-McGinn D.M., Zackai E.H., Sullivan K.E. Increased prevalence of immunoglobulin A deficiency in patients with the chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome). Clin. Diagn. Lab. Immunol. 1998, 5:415-417.
    • (1998) Clin. Diagn. Lab. Immunol. , vol.5 , pp. 415-417
    • Smith, C.A.1    Driscoll, D.A.2    Emanuel, B.S.3    McDonald-McGinn, D.M.4    Zackai, E.H.5    Sullivan, K.E.6
  • 58
    • 0026782016 scopus 로고
    • Selective polysaccharide antibody deficiency in familial DiGeorge syndrome
    • Schubert M.S., Moss R.B. Selective polysaccharide antibody deficiency in familial DiGeorge syndrome. Ann. Allergy 1992, 69:231-238.
    • (1992) Ann. Allergy , vol.69 , pp. 231-238
    • Schubert, M.S.1    Moss, R.B.2
  • 61
    • 0029151334 scopus 로고
    • Humoral immunity in DiGeorge syndrome
    • Junker A.K., Driscoll D.A. Humoral immunity in DiGeorge syndrome. J. Pediatr. 1995, 127:231-237.
    • (1995) J. Pediatr. , vol.127 , pp. 231-237
    • Junker, A.K.1    Driscoll, D.A.2
  • 62
    • 0024332925 scopus 로고
    • Hypogammaglobulinaemia in DiGeorge sequence [letter; comment]
    • Etzioni A., Pollack S. Hypogammaglobulinaemia in DiGeorge sequence [letter; comment]. Eur. J. Pediatr. 1989, 149:143-144.
    • (1989) Eur. J. Pediatr. , vol.149 , pp. 143-144
    • Etzioni, A.1    Pollack, S.2
  • 64
    • 0030742534 scopus 로고    scopus 로고
    • In vivo longitudinal analysis of a dominant TCR repertoire selected in human response to influenza virus
    • Prevost-Blondel A., Lengagne R., Letourneur F., Pannetier C., Gomard E., Guillet J.G. In vivo longitudinal analysis of a dominant TCR repertoire selected in human response to influenza virus. Virology 1997, 233:93-104.
    • (1997) Virology , vol.233 , pp. 93-104
    • Prevost-Blondel, A.1    Lengagne, R.2    Letourneur, F.3    Pannetier, C.4    Gomard, E.5    Guillet, J.G.6
  • 65
    • 0027251463 scopus 로고
    • The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments
    • Pannetier C., Cochet M., Darche S., Casrouge A., Zoller M., Kourilsky P. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad. Sci. USA 1993, 90:4319-4323.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4319-4323
    • Pannetier, C.1    Cochet, M.2    Darche, S.3    Casrouge, A.4    Zoller, M.5    Kourilsky, P.6
  • 68
    • 21244439896 scopus 로고    scopus 로고
    • Post-natal ontogenesis of the T-cell receptor CD4 and CD8 Vbeta repertoire and immune function in children with DiGeorge syndrome
    • Cancrini C., Romiti M.L., Finocchi A., Di Cesare S., Ciaffi P., Capponi C., Pahwa S., Rossi P. Post-natal ontogenesis of the T-cell receptor CD4 and CD8 Vbeta repertoire and immune function in children with DiGeorge syndrome. J. Clin. Immunol. 2005, 25:265-274.
    • (2005) J. Clin. Immunol. , vol.25 , pp. 265-274
    • Cancrini, C.1    Romiti, M.L.2    Finocchi, A.3    Di Cesare, S.4    Ciaffi, P.5    Capponi, C.6    Pahwa, S.7    Rossi, P.8
  • 71
    • 0037416830 scopus 로고    scopus 로고
    • Impaired thymic output and restricted T-cell repertoire in two infants with immunodeficiency and early-onset generalized dermatitis
    • Pirovano S., Mazzolari E., Pasic S., Albertini A., Notarangelo L.D., Imberti L. Impaired thymic output and restricted T-cell repertoire in two infants with immunodeficiency and early-onset generalized dermatitis. Immunol. Lett. 2003, 86:93-97.
    • (2003) Immunol. Lett. , vol.86 , pp. 93-97
    • Pirovano, S.1    Mazzolari, E.2    Pasic, S.3    Albertini, A.4    Notarangelo, L.D.5    Imberti, L.6
  • 72
    • 0036733569 scopus 로고    scopus 로고
    • CD4(+) CD25(+) T-cell production in healthy humans and in patients with thymic hypoplasia
    • Sullivan K.E., McDonald-McGinn D., Zackai E.H. CD4(+) CD25(+) T-cell production in healthy humans and in patients with thymic hypoplasia. Clin. Diagn. Lab. Immunol. 2002, 9:1129-1131.
    • (2002) Clin. Diagn. Lab. Immunol. , vol.9 , pp. 1129-1131
    • Sullivan, K.E.1    McDonald-McGinn, D.2    Zackai, E.H.3
  • 73
    • 0034919754 scopus 로고    scopus 로고
    • B cell co-receptors regulating T cell-dependent antibody production in common variable immunodeficiency: CD27 pathway defects identify subsets of severely immuno-compromised patients
    • Jacquot S., Macon-Lemaitre L., Paris E., Kobata T., Tanaka Y., Morimoto C., Schlossman S.F., Tron F. B cell co-receptors regulating T cell-dependent antibody production in common variable immunodeficiency: CD27 pathway defects identify subsets of severely immuno-compromised patients. Int. Immunol. 2001, 13:871-876.
    • (2001) Int. Immunol. , vol.13 , pp. 871-876
    • Jacquot, S.1    Macon-Lemaitre, L.2    Paris, E.3    Kobata, T.4    Tanaka, Y.5    Morimoto, C.6    Schlossman, S.F.7    Tron, F.8
  • 74
    • 0037073930 scopus 로고    scopus 로고
    • Maintenance of serological memory by polyclonal activation of human memory B cells
    • Bernasconi N.L., Traggiai E., Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002, 298:2199-2202.
    • (2002) Science , vol.298 , pp. 2199-2202
    • Bernasconi, N.L.1    Traggiai, E.2    Lanzavecchia, A.3
  • 76
    • 31144443212 scopus 로고    scopus 로고
    • Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity
    • Cuss A.K., Avery D.T., Cannons J.L., Yu L.J., Nichols K.E., Shaw P.J., Tangye S.G. Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity. J. Immunol. 2006, 176:1506-1516.
    • (2006) J. Immunol. , vol.176 , pp. 1506-1516
    • Cuss, A.K.1    Avery, D.T.2    Cannons, J.L.3    Yu, L.J.4    Nichols, K.E.5    Shaw, P.J.6    Tangye, S.G.7
  • 77
    • 0036493366 scopus 로고    scopus 로고
    • Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease
    • Warnatz K., Denz A., Drager R., Braun M., Groth C., Wolff-Vorbeck G., Eibel H., Schlesier M., Peter H.H. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 2002, 99:1544-1551.
    • (2002) Blood , vol.99 , pp. 1544-1551
    • Warnatz, K.1    Denz, A.2    Drager, R.3    Braun, M.4    Groth, C.5    Wolff-Vorbeck, G.6    Eibel, H.7    Schlesier, M.8    Peter, H.H.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.