Interaction between α1- and α2-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries

European Journal of Pharmacology

Volumn 643, Issue 2-3, 2010, Pages 239-246

  Sporkova, Alexandra ^b   Perez Rivera, Alex ^c   Galligan, James J ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Intracellular calcium; Splanchnic circulation; Sympathetic nervous system; Vasoconstriction; Vein; adrenoceptor

Indexed keywords

1,3,4,5',6,6',7,12B OCTAHYDRO 1',3' DIMETHYL 2H SPIRO[BENZO[B]FURO[2,3 A]QUINOLIZINE 2,4' PYRIMIDINE] 2' ONE; 2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 5 METHYLURAPIDIL; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1D ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; BRIMONIDINE; IMILOXAN; NORADRENALIN; PHENYLEPHRINE; PROPRANOLOL; YOHIMBINE;

ADRENERGIC ACTIVITY; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; MESENTERIC ARTERY; MESENTERIC VEIN; MOUSE; NONHUMAN; PRIORITY JOURNAL; VASOCONSTRICTION;

EID: 77955269960     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.021     Document Type: Article

References (49)

1. 2-adrenergic receptor-mediated contraction of vascular smooth muscle. Circ. Res. 1993, 72:778-785.
2. Anderson E.A., Sinkey C.A., Lawton W.J., Mark A.L. Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings. Hypertension 1989, 14:177-183.
3. 1C-adrenoceptor: studies in the isolated perfused kidney of rat. Br. J. Pharmacol. 1995, 115:283-294.
4. + channels. Microcirculation 2004, 11:279-293.
5. 1B-adrenoceptor mediating contraction of the rat spleen. Br. J. Pharmacol. 1995, 115:467-475.
6. Crowley C.M., Lee C.H., Gin S.A., Keep A.M., Cook R.C., Van Breemen C. The mechanism of excitation-contraction coupling in phenylephrine- stimulated human saphenous vein. Am. J. Physiol. 2002, 283:H1271-H1281.
7. Daniel E.E., Low A.M. Characterization of alpha-adrenoceptors in canine mesenteric vein. J. Cardiovasc. Pharmacol. 1997, 30:591-598.
8. 1)-adrenoceptor subtypes in mouse carotid arteries using knockout mice. Br. J. Pharmacol. 2005, 144:558-565.
9. 2-adrenoceptors. Eur. J. Pharmacol. 1998, 361:1-15.
10. Drukteinis J.S., Roman M.J., Fabsitz R.R., Lee E.T., Best L.G., Russel M., Devereux R.B. Cardiac and systemic hemodynamic characteristics of hypertension and prehypertension in adolescents and young adults: the Strong Heart Study. Circulation 2007, 115:221-227.
11. Ferrario C.M., Page I.H., Cubbin J.W. Increased cardiac output as a contributory factor in experimental renal hypertension in dogs. Circ. Res. 1970, 27:799-810.
12. Fink G.D. Sympathetic activity, vascular capacitance, and long-term regulation of arterial pressure. Hypertension 2009, 53:307-312.
13. Flavahan N.A., Rimele T.J., Cooke J.P., Vanhouette P.M. Characterization of postjunctional α1- and α2-adrenoceptors activated by exogenous or nerve-released norepinephrine in the canine saphenous vein. J. Pharmacol. Exp. Ther. 1984, 230:699-705.
14. Fukui D., Yang X.P., Chiba S. Neurogenic double-peaked vasoconstriction of human gastroepiploic artery is mediated by both α1- and α2-adrenoceptors. Br. J. Pharmacol. 2005, 144:737-742.
15. 2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn-Schmiedeberg's Arch. Pharmacol. 1997, 355:406-411.
16. 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins. Br. J. Pharmacol. 2007, 151:186-194.
17. Greenway C.V., Lautt W.W. Blood volume, the venous system, preload, and cardiac output. Can. J. Physiol. Pharmacol. 1986, 64:383-387.
18. Guyenet P.G. The sympathetic control of blood pressure. Nat. Rev. Neurosci. 2006, 7:335-346.
19. Guyton A.C. Determination of cardiac output by equating venous return curves with cardiac response curves. Physiol. Rev. 1955, 35:123-129.
20. 1B-adrenergic receptors. J. Biol. Chem. 2004, 279:15541-15549.
21. 1D-adrenergic receptors form a single functional entity. Mol. Pharmacol. 2006, 69:45-55.
22. Haynes J.M., Hill S.J. Alpha-adrenoceptor mediated responses of the cauda epididymis of the guinea-pig. Br. J. Pharmacol. 1996, 119:1203-1210.
23. Hottenstein O.D., Kreulen D.L. Comparison of the frequency dependence of venous and arterial responses to sympathetic nerve stimulation in guinea-pigs. J. Physiol. 1987, 384:153-167.
24. 1-adrenoceptor subtypes mediating contractions to phenylephrine in rat thoracic aorta, mesenteric artery and pulmonary artery. Br. J. Pharmacol. 1997, 122:849-858.
25. 1B)-adrenoceptors are involved in noradrenaline-induced contractions of rat tail artery. Eur. J. Pharmacol. 2004, 19(488):157-167.
26. Levac B.A., O'Dowd B.F., George S.R. Oligomerization of opioid receptors: generation of novel signaling units. Curr. Opin. Pharmacol. 2002, 2:76-81.
27. 2c-adrenoceptor homolog. Mol. Pharmacol. 1995, 48:48-55.
28. London G.M., Safar M.E., Safar A.L., Simon A.C. Blood pressure in the "low-pressure system" and cardiac performance in essential hypertension. J. Hypertens. 1985, 3:337-342.
29. Luo M., Hess M.C., Fink G.D., Olson L.K., Kreulen D.L., Galligan J.J. Differential alterations in sympathetic neurotransmission in mesenteric arteries and veins in DOCA-salt hypertensive rats. Auton. Neurosci. 2003, 104:47-57.
30. 1A-adrenoceptor mediating contraction of rat epididymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonist RS 17053. Br. J. Pharmacol. 1996, 119:407-415.
31. Martin D.S., Rodrigo M.C., Appelt C.W. Venous tone in the developmental stages of spontaneous hypertension. Hypertension 1998, 31:139-144.
32. Milligan G., Ramsay D., Pascal G., Carrillo J.J. GPCR dimerisation. Life Sci. 2003, 74:181-188.
33. Milligan G., Canals M., Pediani J.D., Ellis J., Lopes-Gimenez J.F. The role of GPCR dimerisation/oligomerisation in receptor signaling. Ernst Schering Found. Symp. Proc. 2006, 2:145-161.
34. Pang C.C. Autonomic control of the venous system in health and disease: effects of drugs. Pharmacol. Ther. 2001, 90:179-230.
35. Park J., Galligan J.J., Fink G.D., Swain G.M. Differences in sympathetic neuroeffector transmission to rat mesenteric arteries and veins as probed by in vitro continuous amperometry and video imaging. J. Physiol. 2007, 584:819-834.
36. 1b adrenergic receptor antagonist. J. Med. Chem. 1998, 41:1205-1208.
37. Patel P., Bose D., Greenway C. Effects of prazosin and phenoxybenzamine on alpha- and beta-receptor-mediated responses in intestinal resistance and capacitance vessels. J. Cardiovasc. Pharmacol. 1981, 3:1050-1059.
38. 1-adrenoceptor reserve in veins compared with arteries. J. Pharmacol. Exp. Ther. 2004, 308:350-357.
39. 2 adrenoceptors to vasoconstriction in mesenteric arteries and veins of normal and hypertensive mice. Vascul. Pharmacol. 2007, 46:373-382.
40. 1-adrenoceptors. Br. J. Pharmacol. 2000, 129:1339-1346.
41. Ricksten S.E., Yao T., DiBona G.F., Thoren P. Renal nerve activity and exaggerated natriuresis in conscious spontaneously hypertensive rats. Acta Physiol. Scand. 1981, 112:161-167.
42. 2- adrenergic receptors. J. Biol. Chem. 1999, 274:16701-16708.
43. Ruffolo R.R. Spare alpha adrenoceptors in the peripheral circulation: excitation-contraction coupling. Fed. Proc. 1986, 45:2341-2346.
44. Smyth L., Bobalova J., Ward S.M., Keef K.D., Mutafova-Yambolieva V.N. Co-transmission from sympathetic vasoconstrictor neurons: differences in guinea-pig mesenteric artery and vein. Auton. Neurosci. 2000, 86:18-29.
45. 2D-adrenoceptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 1996, 353:245-249.
46. 1D-adrenergic receptors. J. Pharmacol. Exp. Ther. 2005, 313:16-23.
47. 2A-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries. Invest. Ophthalmol. Vis. Sci. 2001, 42:2049-2055.
48. 3H-inositol phosphate formation in primary glial cell cultures. J. Neurochem. 1991, 56:953-960.
49. 1D-adrenoceptors in contraction of femoral resistance arteries using knockout mice. Br. J. Pharmacol. 2005, 146:942-951.