Increased Reactivity of Murine Mesenteric Veins to Adrenergic Agonists: Functional Evidence Supporting Increased α1-Adrenoceptor Reserve in Veins Compared with Arteries

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 1, 2004, Pages 350-357

  Pérez Rivera, Alex A ^a   Fink, Gregory D ^a   Galligan, James J ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; CLONIDINE; DEOXYCORTICOSTERONE ACETATE; NORADRENALIN; PHENOXYBENZAMINE; PHENYLEPHRINE;

ADRENERGIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DRUG MECHANISM; DRUG SENSITIVITY; MALE; MESENTERIC ARTERY; MESENTERIC VEIN; MOUSE; NONHUMAN; PRIORITY JOURNAL; TIME SERIES ANALYSIS;

ADRENERGIC AGONISTS; ALKYLATION; ANIMALS; ARTERIES; MALE; MESENTERIC VEINS; MICE; MICE, INBRED C57BL; PHENOXYBENZAMINE; RECEPTORS, ADRENERGIC, ALPHA-1; VASOCONSTRICTION;

EID: 0345866775     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.056184     Document Type: Article

References (37)

1. Beevers G, Lip GYH, and O'Brien EO (2001) ABC of hypertension: the pathophysiology of hypertension. BMJ 322:912-916.
2. 1-adrenoceptor subtypes. Mol Pharmacol 61: 1008-1016.
3. Civantos Calzada B and Aleixandre de Artinano A (2001) Alpha-adrenoceptor subtypes. Pharmacol Res 44:195-208.
4. Daly CJ, Deighan C, McGee A, Mennie D, Ali Z, McBride M, and McGrath JC (2002) A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse. Physiol Genomics 9:85-91.
5. de Champlain J (1990) Pre- and postsynaptic adrenergic dysfunctions in hypertension. J Hypertens 8 (Suppl 7):S77-S85.
6. Douglas SA, Sulpizio AC, Piercy V, Sarau HM, Ames RS, Aiyar NV, Ohlstein EH, and Willette RN (2000) Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmose and cynomolgus monkey. Br J Pharmacol 131:1262-1274.
7. Edmunds ME, Russell GI, and Swales JD (1989) Vascular capacitance and reversal of 2-kidney, 1-clip hypertension in rats. Am J Physiol 256:H502-H507.
8. Eid H and de Champlain J (1988) Increased inositol monophosphate production in cardiovascular tissues of DOCA-salt hypertensive rats. Hypertension 12:122-128.
9. Ekas RD Jr and Lokhandwala MF (1980) Sympathetic nerve function and vascular reactivity in DOCA-salt hypertensive rats. Am J Physiol 239:R303-R308.
10. Ferrario CM, Page IH, and McCubbin JW (1970) Increased cardiac-output as a contributory factor in experimental renal hypertension in dogs. Circ Res 27:799-810.
11. Fink GD, Johnson RJ, and Galligan JJ (2000) Mechanisms of increased venous smooth muscle tone in desoxycorticosterone acetate-salt hypertension. Hypertension 35:464-469.
12. Greenway CV (1983) Role of splanchnic venous system in overall cardiovascular homeostasis. Fed Proc 42:1678-1684.
13. Hermsmeyer K, Abel PW, and Trapani AJ (1982) Norepinephrine sensitivity and membrane potentials of caudal arterial muscle in DOCA-salt Dahl and SHR hypertension in rat. Hypertension 4:49-51.
14. Hottenstein OD and Kreulen DL (1987) Comparison of the frequency dependence of venous and arterial responses to sympathetic nerve stimulation guinea-pigs. J Physiol 384:153-167.
15. 2 signaling pathways have different receptor reserves. J Pharmacol Exp Ther 304: 229-237.
16. Lind H, Erilnge D, Brunkwall J, and Edvinsson L (1997) Attenuation of contractile responses to sympathetic co-transmitters in veins from subject with essential hypertension. Clin Auton Res 7:69-76.
17. Longhurst PA, Rice PJ, Taylor DA, and Fleming WW (1988) Sensitivity of caudal arteries and the mesenteric vascular bed to norepinephrine in DOCA-salt hypertension. Hypertension 12:133-142.
18. Luo M, Hess MC, Fink GD, Olson LK, Rogers J, Kreulen DL, Dai X, and Galligan JJ (2003) Differential alterations in sympathetic neurotransmission in mesenteric arteries and veins in DOCA-salt hypertensive rats. Auton Neurosci 104:47-57.
19. Martin DS, Rodrigo MC, and Appelt CW (1998) Venous tone in the developmental stages of spontaneous hypertension. Hypertension 31:139-144.
20. McCafferty GP, Naselky DP, and Hieble JP (1999) Characterization of postjunctional alpha-adrenoceptors in the pithed mouse. Gen Pharmacol 33:99-105.
21. McCulloch KM and McGrath JC (1998) Neurohumoral regulation of vascular tone, in An Introduction to Vascular Biology: From Physiology to Pathophysiology (Halliday A, Hunt BJ, Poston L and Schachter M eds) pp 71-88, Cambridge University Press, Cambridge, UK.
22. Meggs LG, Stitzel R, Ben-Ari J, Chander P, Gammon D, Goodman AI, and Head R (1988) Upregulation of the vascular alpha-1 receptor in malignant DOCA-salt hypertension. Clin Exp Hypertens [A] 10:229-247.
23. Nabata H, Aono J, Ishizuka N, and Sakai K (1985) Antihypertensive effects of a novel phenylpiperazine derivative SGB-1534, on several hypertensive models of rats. Arch Int Pharmacodyn Ther 277:104-118.
24. Naito Y, Yoshida H, Konishi C, and Ohara N (1998) Differences in responses to norepinephrine and adenosine triphosphatein isolated, perfused mesenteric vascular beds between normotensive and spontaneously hypertensive rats. J Cardiovasc Pharmacol 32:807-818.
25. Pang CC (2001) Autonomic control of the venous system in health and disease: effects of drugs. Pharmacol Ther 90:179-230.
26. Peng H, Carretero OA, Alfie Me, Masura JA, and Rhaleb N (2001) Effects of angiotensin-converting enzyme inhibitor and angiotensin type 1 receptor antagonist in deoxycorticosterone acetate-salt hypertensive mice lacking ren-2 gene. Hypertension 37:974-980.
27. Pérez DM, DeYoung MB, and Graham RM (1993) Coupling of expressed α1B- and α1D-adrenergic receptor to multiple signaling pathways is both G protein and cell type specific. Mol Pharmacol 44:784-795.
28. Perry PA and Webb RC (1988) Sensitivity and adrenoceptor affinity in the mesenteric artery of the deoxycorticosterone acetate hypertensive rat. Can J Physiol Pharmacol 66:1095-1099.
29. 1-Adrenergic receptors: new insights and directions. J Pharmacol Exp Ther 298:403-410.
30. Ricksten SE, Yao T, and Thoren P (1981) Peripheral and central vascular compliances in conscious normotensive and spontaneously hypertensive rats. Acta Physiol Scand 112:169-177.
31. Schobel HP, Schmieder RE, Gatzka CD, and Messerli FH (1993) A centripetal shift in intravascular volume triggers the onset of early cardiac adaptation in hypertension. J Hypertens 11 (Suppl 5):S94-S95.
32. Smith TL and Hutchins PM (1979) Central hemodynamics in the developmental stage of spontaneous hypertension in the unanesthetized rat. Hypertension 1:508-517.
33. Takata Y, Yoshida Y, Ozaki S, and Kato H (1989) Increases in vascular alpha 1-adrenoceptor affinity and PI turnover in DOCA-salt hypertensive rats. Eur J Pharmacol 164:365-368.
34. 2B receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate-salt hypertensive rats. J Pharmacol Exp Ther 277:1103-1113.
35. Yamamoto K and Koike K (2001) Alpha(1)-adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta. Br J Pharmacol 134:1045-1054.
36. Young M, Fullerton M, Dilley R, and Funder J (1994) Mineralocorticoids, hypertension and cardiac fibrosis. J Clin Investig 93:2578-2583.
37. Zhang YY, Tian B, Chen SH, Li YF, and Han QD (1997) Different susceptibilities to desensitization of three alpha 1-adrenoceptor subtypes induced by sustained norepinephrine stimulation. Sheng Li Xue Bao 49:1-6.