Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis

Journal of Pharmacy and Pharmacology

Volumn 62, Issue 9, 2010, Pages 1152-1157

  Wu, Xiang Gen ^a   Xin, Meng ^a   Chen, Hao ^a   Yang, Li Na ^a   Jiang, Hao Ran ^a  

^a SHANDONG EYE INSTITUTE   (China)

Author keywords

bacterial keratitis; Bletilla striata; levofloxacin; pharmacokinetics; polysaccharide

Indexed keywords

BLETILLA STRIATA POLYSACCHARIDE; LEVOFLOXACIN; POLYSACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; BACTERIAL KERATITIS; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISTRIBUTION VOLUME; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG HALF LIFE; DRUG PENETRATION; EXPERIMENTAL RABBIT; EYE IRRITATION; FEMALE; KERATITIS; MALE; MAXIMUM PLASMA CONCENTRATION; MUCOADHESION; NONHUMAN; STAPHYLOCOCCUS AUREUS; TIME TO MAXIMUM PLASMA CONCENTRATION;

ABSORPTION; ADMINISTRATION, TOPICAL; ANIMALS; ANTI-BACTERIAL AGENTS; AQUEOUS HUMOR; BACTERIAL LOAD; BIOLOGICAL AVAILABILITY; CELL LINE; CELL PROLIFERATION; CORNEA; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; EYE; FEMALE; HUMANS; KERATITIS; MALE; OFLOXACIN; OPHTHALMIC SOLUTIONS; ORCHIDACEAE; PLANT EXTRACTS; POLYSACCHARIDES; RABBITS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TEARS; TREATMENT OUTCOME;

EID: 77955249384     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2010.01137.x     Document Type: Article

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