Removing a bottleneck in the Bacillus subtilis biotin pathway: BioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction

Biotechnology and Bioengineering

Volumn 91, Issue 1, 2005, Pages 75-83

  Van Arsdell, Scott W ^a,c   Perkins, John B ^b   Yocum, R Rogers ^a   Luan, Linda ^a   Howitt, C Linda ^a   Chatterjee, Nilu Prasad ^a   Pero, Janice G ^a  

^a OmniGene Bioproducts Inc   (United States)

^b DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

^c Thermo Fisher Scientific   (United States)

Author keywords

Bacillus subtilis; bioA; Biotin biosynthetic pathway; DAPA aminotransferase; Metabolic engineering

Indexed keywords

BIOASSAY; BIOSYNTHESIS; CATALYSIS; CELLS; ESCHERICHIA COLI; FERMENTATION; GENES; ORGANIC ACIDS; REACTION KINETICS;

AMINOTRANSFERASE; BIOTIN; MUTATION; SERRATIA MARCESCENS;

BACTERIA;

7,8 DIAMINOPELARGONIC ACID; 8 AMINO 7 OXONONANOIC ACID; AMINOTRANSFERASE; BIOTIN; LYSINE; NONANOIC ACID; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ARTICLE; BACILLUS SPHAERICUS; BACILLUS SUBTILIS; BIOTINYLATION; CHEMICAL MODIFICATION; ESCHERICHIA COLI; FERMENTATION TECHNIQUE; IN VITRO STUDY; METABOLIC ENGINEERING; NONHUMAN; SERRATIA MARCESCENS;

AMINO ACIDS; AMINO ACIDS, DIAMINO; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BIOTIN; GENE EXPRESSION REGULATION, BACTERIAL; LYSINE; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; S-ADENOSYLMETHIONINE; SIGNAL TRANSDUCTION; TRANSAMINASES;

BACILLUS SPHAERICUS; BACILLUS SUBTILIS; ESCHERICHIA COLI; SERRATIA MARCESCENS;

EID: 21344466098     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20488     Document Type: Article

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