A side reaction of alanine racemase: Transamination of cycloserine

Biochemistry

Volumn 42, Issue 19, 2003, Pages 5775-5783

  Fenn, Timothy D ^a   Stamper, Geoffrey F ^a,b   Morollo, Anthony A ^a,c   Ringe, Dagmar ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b ABBOTT LABORATORIES   (United States)

^c GPC Biotech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL REACTIONS; ENZYME INHIBITION; ISOMERS; MOLECULAR ORIENTATION;

TAUTOMERIZATION;

ENZYMES;

3 HYDROXYISOXAZOLE PYRIDOXAMINE DERIVATIVE; ALANINE; ALANINE RACEMASE; AMINOTRANSFERASE; ANTIINFECTIVE AGENT; CARBON; CYCLOSERINE; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; GEOBACILLUS STEAROTHERMOPHILUS; ISOMERISM; KINETICS; PRIORITY JOURNAL; SPECTROSCOPY; STEREOCHEMISTRY; TRANSAMINATION;

ALANINE RACEMASE; BACILLUS STEAROTHERMOPHILUS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLOSERINE; ELECTROSTATICS; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SPECTROPHOTOMETRY; STEREOISOMERISM;

BACTERIA (MICROORGANISMS); GEOBACILLUS STEAROTHERMOPHILUS;

EID: 0037952855     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi027022d     Document Type: Article

References (25)

1. Mathews, C. K., and van Holde, K. E. (1996) Biochemistry, Benjamin/Cummings, Menlo Park, CA.
2. Adams, E. (1976) Adv. Enzymol. Relat. Areas Mol. Biol. 44, 69-138.
3. John, R. A. (1995) Biochim. Biophys. Acta 1248, 81-96.
4. Stamper, G. F., Morollo, A. A., and Ringe, D. (1998) Biochemistry 37(29), 10438-10445.
5. Sun, S., and Toney, M. D. (1999) Biochemistry 38(13), 4058- 4065.
6. Johnston, R. B., Scholz, J. J., Diven, W. F., and Shephard, S. (1968) in Pyridoxal Catalysis: Enzymes and Model Systems (Snell, E. E., Braunstein, A. E., Severin, E. S. and Torchinsky, Y. M., Eds.) pp 537-547, John Wiley & Sons, New York.
7. Soper, T. S., and Manning, J. M. (1981) J. Biol. Chem. 256, 4263-4268.
8. Wang, E., and Walsh, C. (1978) Biochemistry 17(7), 1313-1321.
9. Peisach, D., Chipman, D. M., van Ophem, P. W., Manning, J. M., and Ringe, D. (1998) J. Am. Chem. Soc. 120, 2268-2274.
10. Malashkevich, V. N., Strop, P., Keller, J. W., Jansonius, J. N., and Toney, M. D. (1999) J. Mol. Biol. 294, 193-200.
11. Kurokawa, Y., Watanabe, A., Yoshimura, T., Esaki, N., and Soda, K. (1998) J. Biochem. 124(6), 1163-1169.
12. Kirsch, J. F., Apicella, C., and Handel, T. (1999) in Enzymatic Mechanisms (Frey, P. A., and Northrop, D. B., Eds.) pp 198-203, IOS Press, Washington, DC.
13. Watanabe, A., Yoshimura, T., Mikami, B., Hayashi, H., Kagamiyama, H., and Esaki, N. (2002) J. Biol. Chem. 277(21), 19166-19172.
14. Morollo, A. A., Petsko, G. A., and Ringe, D. (1999) Biochemistry 38(11), 3293-3301.
15. Shaw, J. P., Petsko, G. A., and Ringe, D. (1997) Biochemistry 36(6), 1329-1342.
16. Otwinowski, W., and Minor, W. (1997) Methods Enzymol. 276, 307-326.
17. Brünger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grosse-Kunstlever, R. W., Jiang, J. S., Kuszeqski, J., Nilges, N., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D54, 905-921.
18. Read, R. (1986) Acta Crystallogr. A42. 140-149.
19. Kleywegt, G. J., and Brünger, A. T. (1996) Structure 4, 897-904.
20. Hodel, A., Kim, S. H., and Brünger, A. T. (1992) Acta Crystallogr. A48, 851-859.
21. Watanabe, A., Yoshimura, T., Mikami, B., and Esaki, N. (1999) J. Biochem. 126, 781-786.
22. Kallen, R. G., Korpela, T., Martell, A. E., Matsushima, Y., Metzler, C. M., Metzler, D. E., Morozov, Y. V., Ralston, I. M., Savin, F. A., Torchinsky, Y. M., and Ueno, H. (1985) in Transaminases (Christen, P., and Metzler, D. E., Eds.) Vol. 2, pp 37-108, John Wiley & Sons, New York.
23. Ondrechen, M. J., Briggs, J. M., and McCammon, J. A. (2001) J. Am. Chem. Soc. 123(12), 2830-2834.
24. Plapp, B. V. (1982) in Contemporary Enzyme Kinetics and Mechanism (Purich, D. L., Ed.) pp 321-352, Academic Press Inc., Orlando, FL.
25. Brünger, A. T. (1992) Nature 355, 472-475.