Integrin β4 was downregulated on the airway epithelia of asthma patients

Acta Biochimica et Biophysica Sinica

Volumn 42, Issue 8, 2010, Pages 538-547

  Liu, Chi ^a   Xiang, Yang ^a   Liu, Huijun ^a   Li, Yun ^b   Tan, Yurong ^a   Zhu, Xiaolin ^a   Zeng, Dan ^a   Li, Menglan ^a   Zhang, Liwen ^a   Qin, Xiaoqun ^a  

^a Central South University   (China)

^b Hunan People's Hospital   (China)

Author keywords

airway epithelia; asthma; integrin 4; siRNA

Indexed keywords

LENTIVIRUS;

BETA4 INTEGRIN;

ADULT; AGED; APOPTOSIS; ARTICLE; ASTHMA; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DOWN REGULATION; EPITHELIUM; EPITHELIUM CELL; FLOW CYTOMETRY; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; PATHOLOGY; RESPIRATORY TRACT MUCOSA; RNA INTERFERENCE; WESTERN BLOTTING;

ADULT; AGED; APOPTOSIS; ASTHMA; BLOTTING, WESTERN; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DOWN-REGULATION; EPITHELIAL CELLS; EPITHELIUM; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN BETA4; MIDDLE AGED; RESPIRATORY MUCOSA; RNA INTERFERENCE;

EID: 77955225850     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmq058     Document Type: Article

References (27)

1. Parks WC, Wilson CL and Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 2004, 4: 617-629.
2. Holgate ST. Epithelium dysfunction in asthma. J Allergy Clin Immunol 2007, 120: 1233-1244.
3. Busse W, Elias J, Sheppard D and Banks-Schlegel S. Airway remodeling and repair. Am J Respir Crit Care Med 1999, 160: 1035-1042.
4. Barbato A, Turato G, Baraldo S, Bazzan E, Calabrese F, Panizzolo C and Zanin ME, et al. Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med 2006, 174: 975-981.
5. Kicic A, Sutanto EN, Stevens PT, Knight DA and Stick SM. Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma. Am J Respir Crit Care Med 2006, 174: 1110-1118.
6. Bergeron C and Boulet LP. Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation. Chest 2006, 129: 1068-1087.
7. Hackett TL and Knight DA. The role of epithelial injury and repair in the origins of asthma. Curr Opin Allergy Clin Immunol 2007, 7: 63-68.
8. Bucchieri FLJ, Richter A and Buchanan D. Increased sensitivity of asthmatic bronchial epithelial cells to oxidant-induced injury. Am J Respir Crit Care Med 2000, 161: A153.
9. Relova AJ, Kampf C and Roomans GM. Effects of Th-2 type cytokines on human airway epithelial cells: interleukins-4, -5, and -13. Cell Biol Int 2001, 25: 563-566.
10. Holgate ST. The epithelium takes centre stage in asthma and atopic dermatitis. Trends Immunol 2007, 28: 248-251.
11. Charalambopoulos K and Karachalios G. Adhesion molecules and lung disease. Pneumon 2000, 13: 50-56.
12. Zhou X, Tan YR, Xiang Y, Liu HJ, Qu F, Liu C and Qin XQ. The correlation of integrin beta 4 expression and asthma. Cell Biol Int 2008, 32: S67.
13. Sheppard D. Functions of pulmonary epithelial integrins: from development to disease. Physiol Rev 2003, 83: 673-686.
14. Watt FM. Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J 2002, 21: 3919-3926.
15. Dowling J, Yu QC and Fuchs E. Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol 1996, 134: 559-572.
16. Niimi A, Matsumoto H, Takemura M, Ueda T, Chin K and Mishima M. Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma. Am J Respir Crit Care Med 2003, 168: 983-988.
17. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411: 494-498.
18. Tan YR, Qi MM, Qin XQ, Xiang Y, Li X, Wang Y and Qu F, et al. Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation. Peptides 2006, 27: 1852-1858.
19. Hargreave FE and Parameswaran K. Asthma, COPD and bronchitis are just components of airway disease. Eur Respir J 2006, 28: 264-267.
20. Rousselle P, Lunstrum GP, Keene DR and Burgeson RE. Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol 1991, 114: 567-576.
21. Westergren-Thorsson G, Chakir J, Lafreniere-Allard MJ, Boulet LP and Tremblay GM. Correlation between airway responsiveness and proteoglycan production by bronchial fibroblasts from normal and asthmatic subjects. Int J Biochem Cell Biol 2002, 34: 1256-1267.
22. Huang CD, Chen HH, Wang CH, Chou CL, Lin SM, Lin HC and Kuo HP. Human neutrophil-derived elastase induces airway smooth muscle cell proliferation. Life Sci 2004, 74: 2479-2492.
23. Mercurio AM, Rabinovitz I and Shaw LM. The alpha 6 beta 4 integrin and epithelial cell migration. Curr Opin Cell Biol 2001, 13: 541-545.
24. Puddicombe SM, Polosa R, Richter A, Krishna MT, Howarth PH, Holgate ST and Davies DE. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 2000, 14: 1362-1374.
25. Trautmann A, Schmid-Grendelmeier P, Kruger K, Crameri R, Akdis M, Akkaya A and Brocker EB, et al. T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma. J Allergy Clin Immunol 2002, 109: 329-337.
26. Wadsworth SJ, Freyer AM, Corteling RL and Hall IP. Biosynthesized matrix provides a key role for survival signaling in bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2004, 286: L596-L603.
27. Trautmann A, Kruger K, Akdis M, Muller-Wening D, Akkaya A, Brocker EB and Blaser K, et al. Apoptosis and loss of adhesion of bronchial epithelial cells in asthma. Int Arch Allergy Immunol 2005, 138: 142-150.