Pharmacokinetics and tissue distribution of 14C-Labeled grape polyphenols in the periphery and the central nervous system following oral administration

Journal of Medicinal Food

Volumn 13, Issue 4, 2010, Pages 926-933

  Janle, Elsa M ^a   Lila, Mary Ann ^b   Grannan, Michael ^a   Wood, Lauren ^a   Higgins, Aine ^a   Yousef, Gad G ^b   Rogers, Randy B ^b   Kim, Helen ^c   Jackson, George S ^a   Ho, Lap ^d,e   Weaver, Connie M ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c University of Alabama at Birmingham   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

blood brain barrier; brain kinetics; grape; grape cell culture; interstitial fluid kinetics; neurodegenerative diseases; pharmacokinetics; polyphenols; tissue distribution

Indexed keywords

CARBON 14; GRAPEFRUIT EXTRACT; POLYPHENOL; RADIOISOTOPE; SUCROSE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; BIOSYNTHESIS; BLOOD; BLOOD BRAIN BARRIER; BRAIN; BRAIN TISSUE; CELL CULTURE; CELL SUSPENSION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEGENERATIVE DISEASE; DIETARY INTAKE; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; FRACTIONATION; GRAPE; INTERSTITIAL FLUID; ISOTOPE LABELING; MALE; METABOLITE; MICRODIALYSIS; NEUROPROTECTION; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; ANIMALS; CARBON RADIOISOTOPES; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; EXTRACELLULAR FLUID; FLAVONOIDS; HUMANS; MALE; PHENOLS; PLANT EXTRACTS; POLYPHENOLS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; VITIS;

VITACEAE;

EID: 77955216388     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2009.0157     Document Type: Article

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