메뉴 건너뛰기




Volumn 9, Issue , 2010, Pages

Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; FLUOROURACIL; MITOMYCIN; RETINOBLASTOMA PROTEIN;

EID: 77955172342     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-173     Document Type: Article
Times cited : (31)

References (41)
  • 1
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • 10.1016/0092-8674(95)90385-2, 7736585
    • Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995, 81:323-330. 10.1016/0092-8674(95)90385-2, 7736585.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 2
    • 58049202910 scopus 로고    scopus 로고
    • Risk of second malignancies in survivors of retinoblastoma: more than 40 years of follow-up
    • 10.1093/jnci/djn394, 19066271
    • Marees T, Moll AC, Imhof SM, de Boer MR, Ringens PJ, van Leeuwen FE. Risk of second malignancies in survivors of retinoblastoma: more than 40 years of follow-up. J Natl Cancer Inst 2008, 100:1771-1779. 10.1093/jnci/djn394, 19066271.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1771-1779
    • Marees, T.1    Moll, A.C.2    Imhof, S.M.3    de Boer, M.R.4    Ringens, P.J.5    van Leeuwen, F.E.6
  • 3
    • 0026729463 scopus 로고
    • The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression
    • Borg A, Zhang QX, Alm P, Olsson H, Sellberg G. The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression. Cancer Res 1992, 52:2991-2994.
    • (1992) Cancer Res , vol.52 , pp. 2991-2994
    • Borg, A.1    Zhang, Q.X.2    Alm, P.3    Olsson, H.4    Sellberg, G.5
  • 4
    • 0028946154 scopus 로고
    • Retinoblastoma gene mutations in primary human bladder cancer
    • 2033727, 7710951
    • Miyamoto H, Shuin T, Torigoe S, Iwasaki Y, Kubota Y. Retinoblastoma gene mutations in primary human bladder cancer. Br J Cancer 1995, 71:831-835. 2033727, 7710951.
    • (1995) Br J Cancer , vol.71 , pp. 831-835
    • Miyamoto, H.1    Shuin, T.2    Torigoe, S.3    Iwasaki, Y.4    Kubota, Y.5
  • 7
    • 0024286232 scopus 로고
    • Structural rearrangement of the retinoblastoma gene in human breast carcinoma
    • 10.1126/science.3175651, 3175651
    • T'Ang A, Varley JM, Chakraborty S, Murphree AL, Fung YK. Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science 1988, 242:263-266. 10.1126/science.3175651, 3175651.
    • (1988) Science , vol.242 , pp. 263-266
    • T'Ang, A.1    Varley, J.M.2    Chakraborty, S.3    Murphree, A.L.4    Fung, Y.K.5
  • 9
    • 59449086167 scopus 로고    scopus 로고
    • The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas
    • 10.1186/bcr2142, 2614508, 18782450
    • Herschkowitz JI, He X, Fan C, Perou CM. The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas. Breast Cancer Res 2008, 10:R75. 10.1186/bcr2142, 2614508, 18782450.
    • (2008) Breast Cancer Res , vol.10
    • Herschkowitz, J.I.1    He, X.2    Fan, C.3    Perou, C.M.4
  • 10
    • 70350460641 scopus 로고    scopus 로고
    • High prevalence of retinoblastoma protein loss in triple-negative breast cancers and its association with a good prognosis in patients treated with adjuvant chemotherapy
    • 10.1093/annonc/mdp209, 19556322
    • Trere D, Brighenti E, Donati G, Ceccarelli C, Santini D, Taffurelli M, Montanaro L, Derenzini M. High prevalence of retinoblastoma protein loss in triple-negative breast cancers and its association with a good prognosis in patients treated with adjuvant chemotherapy. Ann Oncol 2009, 20:1818-1823. 10.1093/annonc/mdp209, 19556322.
    • (2009) Ann Oncol , vol.20 , pp. 1818-1823
    • Trere, D.1    Brighenti, E.2    Donati, G.3    Ceccarelli, C.4    Santini, D.5    Taffurelli, M.6    Montanaro, L.7    Derenzini, M.8
  • 11
    • 33845972969 scopus 로고    scopus 로고
    • The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer
    • 10.1172/JCI28803, 1679964, 17160137
    • Bosco EE, Wang Y, Xu H, Zilfou JT, Knudsen KE, Aronow BJ, Lowe SW, Knudsen ES. The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer. J Clin Invest 2007, 117:218-228. 10.1172/JCI28803, 1679964, 17160137.
    • (2007) J Clin Invest , vol.117 , pp. 218-228
    • Bosco, E.E.1    Wang, Y.2    Xu, H.3    Zilfou, J.T.4    Knudsen, K.E.5    Aronow, B.J.6    Lowe, S.W.7    Knudsen, E.S.8
  • 12
    • 42249095837 scopus 로고    scopus 로고
    • Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure
    • 10.1158/1078-0432.CCR-07-2065, 18381962
    • Derenzini M, Donati G, Mazzini G, Montanaro L, Vici M, Ceccarelli C, Santini D, Taffurelli M, Trere D. Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure. Clin Cancer Res 2008, 14:2199-2209. 10.1158/1078-0432.CCR-07-2065, 18381962.
    • (2008) Clin Cancer Res , vol.14 , pp. 2199-2209
    • Derenzini, M.1    Donati, G.2    Mazzini, G.3    Montanaro, L.4    Vici, M.5    Ceccarelli, C.6    Santini, D.7    Taffurelli, M.8    Trere, D.9
  • 13
    • 34548161624 scopus 로고    scopus 로고
    • Breast cancer prognostication and prediction in the postgenomic era
    • 10.1093/annonc/mdm013, 17317675
    • Lonning PE, Knappskog S, Staalesen V, Chrisanthar R, Lillehaug JR. Breast cancer prognostication and prediction in the postgenomic era. Ann Oncol 2007, 18:1293-1306. 10.1093/annonc/mdm013, 17317675.
    • (2007) Ann Oncol , vol.18 , pp. 1293-1306
    • Lonning, P.E.1    Knappskog, S.2    Staalesen, V.3    Chrisanthar, R.4    Lillehaug, J.R.5
  • 14
    • 0029050533 scopus 로고
    • Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis
    • 10.1073/pnas.92.12.5436, 41709, 7777526
    • Almasan A, Yin Y, Kelly RE, Lee EY, Bradley A, Li W, Bertino JR, Wahl GM. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci USA 1995, 92:5436-5440. 10.1073/pnas.92.12.5436, 41709, 7777526.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5436-5440
    • Almasan, A.1    Yin, Y.2    Kelly, R.E.3    Lee, E.Y.4    Bradley, A.5    Li, W.6    Bertino, J.R.7    Wahl, G.M.8
  • 16
    • 43549118398 scopus 로고    scopus 로고
    • RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agents
    • Stengel KR, Dean JL, Seeley SL, Mayhew CN, Knudsen ES. RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agents. Cell Cycle 2008, 7:1095-1103.
    • (2008) Cell Cycle , vol.7 , pp. 1095-1103
    • Stengel, K.R.1    Dean, J.L.2    Seeley, S.L.3    Mayhew, C.N.4    Knudsen, E.S.5
  • 17
    • 34548591325 scopus 로고    scopus 로고
    • Retinoblastoma deficiency increases chemosensitivity in lung cancer
    • 10.1158/0008-5472.CAN-06-4753, 17804741
    • Zagorski WA, Knudsen ES, Reed MF. Retinoblastoma deficiency increases chemosensitivity in lung cancer. Cancer Res 2007, 67:8264-8273. 10.1158/0008-5472.CAN-06-4753, 17804741.
    • (2007) Cancer Res , vol.67 , pp. 8264-8273
    • Zagorski, W.A.1    Knudsen, E.S.2    Reed, M.F.3
  • 18
    • 34447121974 scopus 로고    scopus 로고
    • Retinoblastoma tumor suppressor status is a critical determinant of therapeutic response in prostate cancer cells
    • 10.1158/0008-5472.CAN-06-4424, 17616676
    • Sharma A, Comstock CE, Knudsen ES, Cao KH, Hess-Wilson JK, Morey LM, Barrera J, Knudsen KE. Retinoblastoma tumor suppressor status is a critical determinant of therapeutic response in prostate cancer cells. Cancer Res 2007, 67:6192-6203. 10.1158/0008-5472.CAN-06-4424, 17616676.
    • (2007) Cancer Res , vol.67 , pp. 6192-6203
    • Sharma, A.1    Comstock, C.E.2    Knudsen, E.S.3    Cao, K.H.4    Hess-Wilson, J.K.5    Morey, L.M.6    Barrera, J.7    Knudsen, K.E.8
  • 21
    • 0344198117 scopus 로고    scopus 로고
    • TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer
    • Geisler S, Borresen-Dale AL, Johnsen H, Aas T, Geisler J, Akslen LA, Anker G, Lonning PE. TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer. Clin Cancer Res 2003, 9:5582-5588.
    • (2003) Clin Cancer Res , vol.9 , pp. 5582-5588
    • Geisler, S.1    Borresen-Dale, A.L.2    Johnsen, H.3    Aas, T.4    Geisler, J.5    Akslen, L.A.6    Anker, G.7    Lonning, P.E.8
  • 22
    • 0037338906 scopus 로고    scopus 로고
    • Study of suboptimum treatment response: lessons from breast cancer
    • 10.1016/S1470-2045(03)01022-2, 12623363
    • Lonning PE. Study of suboptimum treatment response: lessons from breast cancer. Lancet Oncol 2003, 4:177-185. 10.1016/S1470-2045(03)01022-2, 12623363.
    • (2003) Lancet Oncol , vol.4 , pp. 177-185
    • Lonning, P.E.1
  • 23
    • 2642601106 scopus 로고    scopus 로고
    • Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7
    • 10.1038/36038, 9495340
    • Lee JO, Russo AA, Pavletich NP. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 1998, 391:859-865. 10.1038/36038, 9495340.
    • (1998) Nature , vol.391 , pp. 859-865
    • Lee, J.O.1    Russo, A.A.2    Pavletich, N.P.3
  • 24
    • 0031574072 scopus 로고    scopus 로고
    • The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools
    • 10.1093/nar/25.24.4876, 147148, 9396791
    • Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 1997, 25:4876-4882. 10.1093/nar/25.24.4876, 147148, 9396791.
    • (1997) Nucleic Acids Res , vol.25 , pp. 4876-4882
    • Thompson, J.D.1    Gibson, T.J.2    Plewniak, F.3    Jeanmougin, F.4    Higgins, D.G.5
  • 25
    • 0032146778 scopus 로고    scopus 로고
    • Radiation-induced apoptosis mediated by retinoblastoma protein
    • Bowen C, Spiegel S, Gelmann EP. Radiation-induced apoptosis mediated by retinoblastoma protein. Cancer Res 1998, 58:3275-3281.
    • (1998) Cancer Res , vol.58 , pp. 3275-3281
    • Bowen, C.1    Spiegel, S.2    Gelmann, E.P.3
  • 26
    • 0033575960 scopus 로고    scopus 로고
    • The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death
    • 10.1038/sj.onc.1202910, 10498874
    • Knudsen KE, Weber E, Arden KC, Cavenee WK, Feramisco JR, Knudsen ES. The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death. Oncogene 1999, 18:5239-5245. 10.1038/sj.onc.1202910, 10498874.
    • (1999) Oncogene , vol.18 , pp. 5239-5245
    • Knudsen, K.E.1    Weber, E.2    Arden, K.C.3    Cavenee, W.K.4    Feramisco, J.R.5    Knudsen, E.S.6
  • 27
    • 0026666661 scopus 로고
    • No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung
    • 10.1002/gcc.2870050202, 1381957
    • Hovig E, Smith-Sorensen B, Gebhardt MC, Ryberg D, Lothe R, Borresen AL. No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung. Genes Chromosomes Cancer 1992, 5:97-103. 10.1002/gcc.2870050202, 1381957.
    • (1992) Genes Chromosomes Cancer , vol.5 , pp. 97-103
    • Hovig, E.1    Smith-Sorensen, B.2    Gebhardt, M.C.3    Ryberg, D.4    Lothe, R.5    Borresen, A.L.6
  • 28
    • 0034964014 scopus 로고    scopus 로고
    • Retinoblastoma protein partners
    • full_text, 11447760
    • Morris EJ, Dyson NJ. Retinoblastoma protein partners. Adv Cancer Res 2001, 82:1-54. full_text, 11447760.
    • (2001) Adv Cancer Res , vol.82 , pp. 1-54
    • Morris, E.J.1    Dyson, N.J.2
  • 29
    • 0031930466 scopus 로고    scopus 로고
    • Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
    • 10.1101/gad.12.1.95, 316399, 9420334
    • Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ, Lassar AB, Kaelin WG. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev 1998, 12:95-106. 10.1101/gad.12.1.95, 316399, 9420334.
    • (1998) Genes Dev , vol.12 , pp. 95-106
    • Sellers, W.R.1    Novitch, B.G.2    Miyake, S.3    Heith, A.4    Otterson, G.A.5    Kaye, F.J.6    Lassar, A.B.7    Kaelin, W.G.8
  • 30
    • 0025009110 scopus 로고
    • A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding
    • 10.1073/pnas.87.17.6922, 54650, 2168563
    • Kaye FJ, Kratzke RA, Gerster JL, Horowitz JM. A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding. Proc Natl Acad Sci USA 1990, 87:6922-6926. 10.1073/pnas.87.17.6922, 54650, 2168563.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6922-6926
    • Kaye, F.J.1    Kratzke, R.A.2    Gerster, J.L.3    Horowitz, J.M.4
  • 31
    • 27844480644 scopus 로고    scopus 로고
    • RB1 gene mutation up-date, a meta-analysis based on 932 reported mutations available in a searchable database
    • 10.1186/1471-2156-6-53, 1298292, 16269091
    • Valverde JR, Alonso J, Palacios I, Pestana A. RB1 gene mutation up-date, a meta-analysis based on 932 reported mutations available in a searchable database. BMC Genet 2005, 6:53. 10.1186/1471-2156-6-53, 1298292, 16269091.
    • (2005) BMC Genet , vol.6 , pp. 53
    • Valverde, J.R.1    Alonso, J.2    Palacios, I.3    Pestana, A.4
  • 32
    • 17444449193 scopus 로고    scopus 로고
    • Identification of four novel RB1 germline mutations in Korean retinoblastoma patients
    • 10.1002/humu.1184, 11524739
    • Yu YS, Kim IJ, Ku JL, Park JG. Identification of four novel RB1 germline mutations in Korean retinoblastoma patients. Hum Mutat 2001, 18:252. 10.1002/humu.1184, 11524739.
    • (2001) Hum Mutat , vol.18 , pp. 252
    • Yu, Y.S.1    Kim, I.J.2    Ku, J.L.3    Park, J.G.4
  • 33
    • 0028907719 scopus 로고
    • Spectrum of Germline Mutations in the Rb1 Gene - a Study of 232 Patients with Hereditary and Non Hereditary Retinoblastoma
    • 10.1093/hmg/4.3.383, 7795591
    • Blanquet V, Turleau C, Grossmorand MS, Beaufort CS, Doz F, Besmond C. Spectrum of Germline Mutations in the Rb1 Gene - a Study of 232 Patients with Hereditary and Non Hereditary Retinoblastoma. Human Molecular Genetics 1995, 4:383-388. 10.1093/hmg/4.3.383, 7795591.
    • (1995) Human Molecular Genetics , vol.4 , pp. 383-388
    • Blanquet, V.1    Turleau, C.2    Grossmorand, M.S.3    Beaufort, C.S.4    Doz, F.5    Besmond, C.6
  • 34
    • 33745026748 scopus 로고    scopus 로고
    • P53 and Retinoblastoma protein (pRb): a complex network of interactions
    • 10.1007/s10495-006-5543-y, 16554964
    • Godefroy N, Lemaire C, Mignotte B, Vayssiere JL. p53 and Retinoblastoma protein (pRb): a complex network of interactions. Apoptosis 2006, 11:659-661. 10.1007/s10495-006-5543-y, 16554964.
    • (2006) Apoptosis , vol.11 , pp. 659-661
    • Godefroy, N.1    Lemaire, C.2    Mignotte, B.3    Vayssiere, J.L.4
  • 35
    • 1442348266 scopus 로고    scopus 로고
    • Genes causing inherited cancer as beacons to identify the mechanisms of chemoresistance
    • 10.1016/j.molmed.2004.01.005, 15102353
    • Lonning PE. Genes causing inherited cancer as beacons to identify the mechanisms of chemoresistance. Trends Mol Med 2004, 10:113-118. 10.1016/j.molmed.2004.01.005, 15102353.
    • (2004) Trends Mol Med , vol.10 , pp. 113-118
    • Lonning, P.E.1
  • 36
    • 0029956081 scopus 로고    scopus 로고
    • Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
    • 10.1038/nm0796-811, 8673929
    • Aas T, Borresen AL, Geisler S, Smith-Sorensen B, Johnsen H, Varhaug JE, Akslen LA, Lonning PE. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat Med 1996, 2:811-814. 10.1038/nm0796-811, 8673929.
    • (1996) Nat Med , vol.2 , pp. 811-814
    • Aas, T.1    Borresen, A.L.2    Geisler, S.3    Smith-Sorensen, B.4    Johnsen, H.5    Varhaug, J.E.6    Akslen, L.A.7    Lonning, P.E.8
  • 37
    • 27744565436 scopus 로고    scopus 로고
    • Percentage density, Wolfe's and Tabar's mammographic patterns: agreement and association with risk factors for breast cancer
    • 10.1186/bcr1308, 1242160, 16168132
    • Gram IT, Bremnes Y, Ursin G, Maskarinec G, Bjurstam N, Lund E. Percentage density, Wolfe's and Tabar's mammographic patterns: agreement and association with risk factors for breast cancer. Breast Cancer Res 2005, 7:R854-861. 10.1186/bcr1308, 1242160, 16168132.
    • (2005) Breast Cancer Res , vol.7
    • Gram, I.T.1    Bremnes, Y.2    Ursin, G.3    Maskarinec, G.4    Bjurstam, N.5    Lund, E.6
  • 38
    • 0035334774 scopus 로고    scopus 로고
    • Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNA
    • 10.1016/S0165-4608(00)00433-7, 11408068
    • Skotheim RI, Diep CB, Kraggerud SM, Jakobsen KS, Lothe RA. Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNA. Cancer Genet Cytogenet 2001, 127:64-70. 10.1016/S0165-4608(00)00433-7, 11408068.
    • (2001) Cancer Genet Cytogenet , vol.127 , pp. 64-70
    • Skotheim, R.I.1    Diep, C.B.2    Kraggerud, S.M.3    Jakobsen, K.S.4    Lothe, R.A.5
  • 40
    • 0034161905 scopus 로고    scopus 로고
    • Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island
    • Simpson DJ, Hibberts NA, McNicol AM, Clayton RN, Farrell WE. Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island. Cancer Res 2000, 60:1211-1216.
    • (2000) Cancer Res , vol.60 , pp. 1211-1216
    • Simpson, D.J.1    Hibberts, N.A.2    McNicol, A.M.3    Clayton, R.N.4    Farrell, W.E.5
  • 41
    • 77249090660 scopus 로고    scopus 로고
    • Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity
    • 10.1016/j.bbamcr.2010.01.005, 20080130
    • Berge EO, Staalesen V, Straume AH, Lillehaug JR, Lonning PE. Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity. Biochim Biophys Acta 2010, 1803:386-395. 10.1016/j.bbamcr.2010.01.005, 20080130.
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 386-395
    • Berge, E.O.1    Staalesen, V.2    Straume, A.H.3    Lillehaug, J.R.4    Lonning, P.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.