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77955155999
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The original condition was 110-130 °C in neat condition with 1.5 equiv of AgOAc. A newer condition without Ag salt at 90 °C was recently reported (ref 8c). Although many C-H activations in AcOH and TFA have been developed, neutral and low boiling point solvents are more favorable for practical synthesis
-
The original condition was 110-130 °C in neat condition with 1.5 equiv of AgOAc. A newer condition without Ag salt at 90 °C was recently reported (ref 8c). Although many C-H activations in AcOH and TFA have been developed, neutral and low boiling point solvents are more favorable for practical synthesis.
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77955150041
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-
2O) data compiled by R. Wiliams
-
2O) data compiled by R. Wiliams.
-
-
-
-
56
-
-
77955159205
-
-
See discussion on proton shuttle in ref 14a
-
See discussion on proton shuttle in ref 14a.
-
-
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57
-
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77955150263
-
-
2 is added to prevent t-BuOH from freezing
-
2 is added to prevent t-BuOH from freezing.
-
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58
-
-
77955144464
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Higher yield (60-80%) can be achieved with AcOH or PivOH at 110°C
-
Higher yield (60-80%) can be achieved with AcOH or PivOH at 110°C.
-
-
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59
-
-
77955149575
-
-
3 C-H bonds at room temperature
-
3 C-H bonds at room temperature
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60
-
-
77955144953
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ref 3f
-
ref 3f.
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61
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68249154737
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IV intermediate, and the dissociation for oxidative addition has not been discussed. See
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IV intermediate, and the dissociation for oxidative addition has not been discussed. See: Racowski, J. M.; Dick, A. R.; Sanford, M. S. J. Am. Chem. Soc. 2009, 131, 10974-10983
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77955143228
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II/IV oxidative addition
-
II/IV oxidative addition.
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