Induction of lymphocyte apoptosis in rat liver allograft by adenoviral gene transfection of human interleukin-10

European Surgical Research

Volumn 44, Issue 3-4, 2010, Pages 133-141

  Li, Jie Qun ^a   Qi, Hai Zhi ^a   He, Zhi Jun ^a   Hu, Wei ^a   Si, Zhong Zhou ^a   Li, Yi Ning ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Allograft rejection; Apoptosis; Gene transfer; IL 10; Liver transplantation

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CYCLOSPORIN A; FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; FLOW CYTOMETRY; GENETIC TRANSFECTION; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; LIVER GRAFT; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BASE SEQUENCE; DNA PRIMERS; GENE THERAPY; GENETIC VECTORS; GRAFT REJECTION; HUMANS; INTERLEUKIN-10; LIVER TRANSPLANTATION; LYMPHOCYTES; MALE; RATS; RATS, INBRED LEW; RATS, INBRED STRAINS; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSFECTION; TRANSPLANTATION, HOMOLOGOUS;

EID: 77955138841     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000276989     Document Type: Article

References (36)

1. Chen D, Sung R, Bromberg JS: Gene therapy in transplantation. Transpl Immunol 2002; 9: 301-314.
2. Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR: Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 1990; 248: 1230-1234.
3. De Waal Malefyt R, Haanen J, Spits H, Roncarolo MG, te Velde A, Figdor C, Johnson K, Kastelein R, Yssel H, De Vries JE: Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991; 174: 915-924.
4. Del Prete G, De Carli M, Almerigogna F, Giudizi MG, Biagiotti R, Romagnani S: Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993; 150: 353-360.
5. De Waal Malefyt R, Abrams J, Bennett B, Figdor CG, De Vries JE: Interleukin 10 (IL- 10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-1220.
6. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM: IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993; 151: 1224-1234.
7. Tashiro H, Shinozaki K, Yahata H, Hayamizu K, Okimoto T, Tanji H, Fudaba Y, Yamamoto H, Fan X, Ito H, Asahara T: Prolongation of liver allograft survival after interleukin-10 gene transduction 24-48 h before donation. Transplantation 2000; 70: 336-339.
8. Shinozaki K, Yahata H, Tanji H, Sakaguchi T, Ito H, Dohi K: Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation. Gene Ther 1999; 6: 816-822.
9. Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB: Blocking both signal 1 and signal 2 of T cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999; 5: 1298-1302.
10. Wells AD, Li XC, Li Y, Walsh MC, Zheng XX, Wu Z, Nuñez G, Tang A, Sayegh M, Hancock WW, Strom TB, Turka LA: Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med 1999; 5: 1303-1307.
11. Qian S, Lu L, Fu F, Li Y, Li W, Starzl TE, Fung JJ, Thomson AW: Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction. J Immunol 1997; 158: 4654-4661.
12. Pan TL, Goto S, Lin YC, Lord R, Chiang KC, Lai CY, Chen YS, Eng HL, Cheng YF, Tatsuma T, Kitano S, Lin CL, Chen CL: The fas and fas ligand pathways in liver allograft tolerance. Clin Exp Immunol 1999; 118: 180-187.
13. Uchiyama H, Kishihara K, Minagawa R, Hashimoto K, Sugimachi K, Nomoto K: Crucial Fas-Fas ligand interaction in spontaneous acceptance of hepatic allografts in mice. Immunology 2002; 105: 450-457.
14. Tripathy SK, Black HB, Goldwasser E, Leiden JM: Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nat Med 1996; 2: 545-550.
15. Takehara M, Murakami M, Inobe M, Tanaka K, Chikuma S, Saito I, Kanegae Y, Yasunami Y, Nakano M, Yamashita K, Todo S, Uede T: Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4IgG and loxP. Hum Gene Ther 2001; 12: 415-426.
16. DeMatteo RP, Chu G, Ahn M, Chang E, Burke C, Raper SE, Barker CF, Markmann JF: Immunologic barriers to hepatic adenoviral gene therapy for transplantation. Transplantation 1997; 63: 315-319.
17. Chia SH, Geller DA, Kibbe MR, Watkins SC, Fung JJ, Starzl TE, Murase N: Adenovirusmediated gene transfer to liver grafts: an improved method to maximize infectivity. Transplantation 1998; 66: 1545-1551.
18. Kamada N, Calne RY: A surgical experience with five hundred thirty liver transplants in the rat. Surgery 1983; 93: 64-69.
19. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997; 25: 658-663.
20. Lu L, Woo J, Rao AS, Li Y, Watkins SC, Qian S, Starzl TE, Demetris AJ, Thomson AW: Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/ macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen. J Exp Med 1994; 179: 1823-1834.
21. Li XK, Tamura A, Fujino M, Guo L, Kakefuda T, Funeshima N, Enosawa S, Amari M, Naoe S, Amemiya H, Suzuki S: Induction of lymphocyte apoptosis in rat liver allograft with ongoing rejection by FTY720. Clin Exp Immunol 2001; 123: 331-339.
22. Ke B, Ritter T, Kato H, Zhai Y, Li J, Lehmann M, Busuttil RW, Volk HD, Kupiec-Weglinski JW: Regulatory cells potentiate the efficacy of IL-4 gene transfer by upregulating Th2- dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients. J Immunol 2000; 164: 5739-5745.
23. Fujisawa K, Saito S, Okada Y, Fujiwara T, Yagi T, Iwagaki H, Tanaka N: Suppression of allogeneic response by viral IL-10 gene transfer. Cell Transplant 2003; 12: 379-387.
24. Shinozaki K, Yahata H, Hayamizu K, Tashiro H, Fan X, Okimoto T, Tanji H, Sakaguchi T, Ito H, Asahara T: Adenovirus-mediated allograft transduction of interleukin-10: role in the induction phase of liver allograft acceptance. Transplant Proc 2000; 32: 247-248.
25. Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC: A role for CD95 ligand in preventing graft rejection. Nature 1995; 377: 630-632.
26. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA: Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 1995; 270: 1189-1192.
27. Zheng L, Fisher G, Miller RE, Peschon J, Lynch DH, Lenardo MJ: Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 1995; 377: 348-351.
28. Alderson MR, Tough TW, Davis-Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, Lynch DH: Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp Med 1995; 181: 71-77.
29. Georgescu L, Vakkalanka RK, Elkon KB, Crow MK: Interleukin-10 promotes activation- induced cell death of SLE lymphocytes mediated by Fas ligand. J Clin Invest 1997; 100: 2622-2633.
30. Li XC, Wells AD, Strom TB, Turka LA: The role of T cell apoptosis in transplantation tolerance. Curr Opin Immunol 2000; 12: 522-527.
31. Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC: A role for CD95 ligand in preventing graft rejection. Nature 1995; 377: 630-632.
32. Kabelitz D: Apoptosis, graft rejection, and transplantation tolerance. Transplantation 1998; 65: 869-875.
33. Schmidt M, Lügering N, Pauels HG, Schulze- Osthoff K, Domschke W, Kucharzik T: IL-10 induces apoptosis in human monocytes involving the CD95 receptor/ligand pathway. Eur J Immunol 2000; 30: 1769-1777.
34. Oshima K, Sen L, Cui G, Tung T, Sacks BM, Arellano-Kruse A, Laks H: Localized interleukin-10 gene transfer induces apoptosis of alloreactive T cells via FAS/FASL pathway, improves function, and prolongs survival of cardiac allograft. Transplantation 2002; 73: 1019-1026.
35. Tung TC, Oshima K, Cui G, Laks H, Sen L: Dual upregulation of Fas and Bax promotes alloreactive T cell apoptosis in IL-10 gene targeting of cardiac allografts. Am J Physiol Heart Circ Physiol 2003; 285:H964-H973.
36. Yap J, O'Brien T, Tazelaar HD, McGregor CG: Immunosuppression prolongs adenoviral mediated transgene expression in cardiac allograft transplantation. Cardiovasc Res 1997; 35: 529-535.